{"id":"https://openalex.org/W1989699495","doi":"https://doi.org/10.1172/jci200420384","title":"Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate","display_name":"Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate","publication_year":2004,"publication_date":"2004-06-15","ids":{"openalex":"https://openalex.org/W1989699495","doi":"https://doi.org/10.1172/jci200420384","mag":"1989699495","pmid":"https://pubmed.ncbi.nlm.nih.gov/15199404","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/420504"},"language":"en","primary_location":{"id":"doi:10.1172/jci200420384","doi":"https://doi.org/10.1172/jci200420384","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci200420384","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/20384/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111696731","display_name":"Ritva Rice","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ritva Rice","raw_affiliation_strings":["Departments of Craniofacial Development and Orthodontics, King's College, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Craniofacial Development and Orthodontics, King's College, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082162425","display_name":"Bradley Spencer\u2010Dene","orcid":"https://orcid.org/0000-0001-9533-5839","observed_orcids":["https://orcid.org/0000-0001-9533-5839"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["FI","GB"],"is_corresponding":false,"raw_author_name":"Bradley Spencer-Dene","raw_affiliation_strings":["Viral Carcinogenesis Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Viral Carcinogenesis Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063851934","display_name":"Elaine C. Connor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elaine C. Connor","raw_affiliation_strings":["Departments of Craniofacial Development and Orthodontics, King's College, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Craniofacial Development and Orthodontics, King's College, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000082303","display_name":"Amel Gritli-Linde","orcid":"https://orcid.org/0000-0001-6489-1269","observed_orcids":["https://orcid.org/0000-0001-6489-1269"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["GB","SE"],"is_corresponding":false,"raw_author_name":"Amel Gritli-Linde","raw_affiliation_strings":["Department of Oral Biochemistry, G\u00f6teborg University, G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biochemistry, G\u00f6teborg University, G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003394161","display_name":"Andrew P. McMahon","orcid":"https://orcid.org/0000-0002-3779-1729","observed_orcids":["https://orcid.org/0000-0002-3779-1729"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"Andrew P. McMahon","raw_affiliation_strings":["Department of Molecular and Cellular Biology,","The Biolabs, Harvard University, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology,","institution_ids":[]},{"raw_affiliation_string":"The Biolabs, Harvard University, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037675485","display_name":"Clive Dickson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["FI","GB"],"is_corresponding":false,"raw_author_name":"Clive Dickson","raw_affiliation_strings":["Viral Carcinogenesis Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Viral Carcinogenesis Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059737089","display_name":"Irma Thesleff","orcid":"https://orcid.org/0000-0001-7621-8952","observed_orcids":["https://orcid.org/0000-0001-7621-8952"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["FI","US"],"is_corresponding":false,"raw_author_name":"Irma Thesleff","raw_affiliation_strings":["Developmental Biology Programme,","Institute of Biotechnology, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Biology Programme,","institution_ids":[]},{"raw_affiliation_string":"Institute of Biotechnology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062441392","display_name":"David P. C. Rice","orcid":"https://orcid.org/0000-0001-9301-3078","observed_orcids":["https://orcid.org/0000-0001-9301-3078"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David P.C. Rice","raw_affiliation_strings":["King \u2018s College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King \u2018s College London","institution_ids":["https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":9.587,"has_fulltext":true,"cited_by_count":363,"citation_normalized_percentile":{"value":0.98817717,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"113","issue":"12","first_page":"1692","last_page":"1700"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11374","display_name":"Cleft Lip and Palate Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11374","display_name":"Cleft Lip and Palate Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cleft-palate","display_name":"cleft palate","score":0.9929999709129333},{"id":"https://openalex.org/keywords/fgf10","display_name":"FGF10","score":0.8980000019073486},{"id":"https://openalex.org/keywords/fgfr2b","display_name":"FGFR2b","score":0.996999979019165},{"id":"https://openalex.org/keywords/sonic-hedgehog","display_name":"Sonic hedgehog","score":0.8130000233650208},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-interactions","display_name":"epithelial-mesenchymal interactions","score":0.9909999966621399},{"id":"https://openalex.org/keywords/palate-development","display_name":"palate development","score":0.875},{"id":"https://openalex.org/keywords/fgf-signaling","display_name":"FGF signaling","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7110000252723694},{"id":"https://openalex.org/keywords/palatal-epithelium","display_name":"palatal epithelium","score":0.7919999957084656},{"id":"https://openalex.org/keywords/mesenchyme","display_name":"mesenchyme","score":0.6779999732971191},{"id":"https://openalex.org/keywords/apical-ectodermal-ridge","display_name":"apical ectodermal ridge","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C2776340970","wikidata":"https://www.wikidata.org/wiki/Q32838","display_name":"Mesenchyme","level":3,"score":0.9619874954223633},{"id":"https://openalex.org/C146759223","wikidata":"https://www.wikidata.org/wiki/Q17927902","display_name":"FGF10","level":4,"score":0.8548917174339294},{"id":"https://openalex.org/C2776637008","wikidata":"https://www.wikidata.org/wiki/Q14860072","display_name":"Sonic hedgehog","level":3,"score":0.7503377199172974},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.737929105758667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6177912354469299},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.5641763210296631},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5360496640205383},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.41281214356422424},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3551104664802551},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.34068119525909424},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11302962899208069}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002972","descriptor_name":"Cleft Palate","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002972","descriptor_name":"Cleft Palate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010159","descriptor_name":"Palate","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010159","descriptor_name":"Palate","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017468","descriptor_name":"Receptors, Fibroblast Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017468","descriptor_name":"Receptors, Fibroblast Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051497","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051523","descriptor_name":"Fibroblast Growth Factor 7","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051526","descriptor_name":"Fibroblast Growth Factor 10","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1172/jci200420384","doi":"https://doi.org/10.1172/jci200420384","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci200420384","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"doi:10.1172/jci20384","doi":"https://doi.org/10.1172/jci20384","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci20384","pdf_url":"http://www.jci.org/articles/view/20384/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1314937","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC420504","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:420504","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/420504","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:15199404","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15199404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/87c39566-07dd-4d55-9f46-1f74fbd9fb78","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/87c39566-07dd-4d55-9f46-1f74fbd9fb78","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rice, R, Spencer-Dene, B, Connor, E C, Gritli-Linde, A, McMahon, A P, Dickson, C, Thesleff, I & Rice, D P C 2004, 'Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate', Journal of Clinical Investigation, vol. 113, no. 12, pp. 1692 - 1700. https://doi.org/10.1172/JCI200420384","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1172/jci20384","doi":"https://doi.org/10.1172/jci20384","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci20384","pdf_url":"http://www.jci.org/articles/view/20384/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2521744835","display_name":null,"funder_award_id":"NS33462","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320321726","display_name":"Suomen Kulttuurirahasto","ror":"https://ror.org/027xav248"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1989699495.pdf","grobid_xml":"https://content.openalex.org/works/W1989699495.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1496559392","https://openalex.org/W1511607328","https://openalex.org/W1520653771","https://openalex.org/W1572873372","https://openalex.org/W1575984269","https://openalex.org/W1581259286","https://openalex.org/W1595393599","https://openalex.org/W1673380704","https://openalex.org/W1874138313","https://openalex.org/W1889850148","https://openalex.org/W1918585971","https://openalex.org/W1930773806","https://openalex.org/W1954982245","https://openalex.org/W1970686467","https://openalex.org/W1970750249","https://openalex.org/W1976520395","https://openalex.org/W1978596841","https://openalex.org/W1982990560","https://openalex.org/W1994132006","https://openalex.org/W2018474375","https://openalex.org/W2022809398","https://openalex.org/W2048474990","https://openalex.org/W2059614045","https://openalex.org/W2065295496","https://openalex.org/W2066479550","https://openalex.org/W2076060035","https://openalex.org/W2086397031","https://openalex.org/W2093377754","https://openalex.org/W2093831365","https://openalex.org/W2099002558","https://openalex.org/W2101469591","https://openalex.org/W2108698814","https://openalex.org/W2108707301","https://openalex.org/W2110042849","https://openalex.org/W2113198452","https://openalex.org/W2128588450","https://openalex.org/W2131986778","https://openalex.org/W2133228373","https://openalex.org/W2138800234","https://openalex.org/W2141541691","https://openalex.org/W2144192475","https://openalex.org/W2145083672","https://openalex.org/W2149879796","https://openalex.org/W2155343233","https://openalex.org/W2157666800","https://openalex.org/W2159072111","https://openalex.org/W2172122920","https://openalex.org/W2188125436","https://openalex.org/W2411134914","https://openalex.org/W4212811418","https://openalex.org/W4248888895","https://openalex.org/W4249711948"],"related_works":["https://openalex.org/W2151885701","https://openalex.org/W7095222050","https://openalex.org/W1851483244","https://openalex.org/W2138051521","https://openalex.org/W2232166712","https://openalex.org/W2137876744","https://openalex.org/W2789842992","https://openalex.org/W1990851216","https://openalex.org/W2062501938","https://openalex.org/W2072064870"],"abstract_inverted_index":{"Classical":[0],"research":[1],"has":[2],"suggested":[3],"that":[4,44,55,76,108],"early":[5],"palate":[6,105,119],"formation":[7],"develops":[8],"via":[9],"epithelial-mesenchymal":[10,110],"interactions,":[11],"and":[12,31,121],"in":[13,65,83,89,103],"this":[14,21],"study":[15],"we":[16,42],"reveal":[17,96],"which":[18,37,64],"signals":[19,67],"control":[20],"process.Using":[22],"Fgf10":[23,57],"-/-,":[24],"FGF":[25,140],"receptor":[26,141],"2b":[27],"-/-":[28],"(Fgfr2b":[29],"-/-),":[30],"Sonic":[32,162],"hedgehog":[33,163],"(Shh)":[34],"mutant":[35],"mice,":[36],"all":[38],"exhibit":[39],"cleft":[40],"palate,":[41],"show":[43,107],"Shh":[45],"is":[46,79],"a":[47,97],"downstream":[48],"target":[49],"of":[50,62,92,118],"Fgf10/Fgfr2b":[51],"signaling.Our":[52],"results":[53,95],"demonstrate":[54],"mesenchymal":[56],"regulates":[58],"the":[59,70,84,90,115],"epithelial":[60,150],"expression":[61],"Shh,":[63],"turn":[66],"back":[68],"to":[69],"mesenchyme.This":[71],"was":[72],"confirmed":[73],"by":[74],"demonstrating":[75],"cell":[77],"proliferation":[78],"decreased":[80],"not":[81],"only":[82],"palatal":[85],"epithelium":[86],"but":[87],"also":[88],"mesenchyme":[91],"Fgfr2b":[93],"-/-mice.These":[94],"new":[98],"role":[99],"for":[100],"Fgf":[101],"signaling":[102,125],"mammalian":[104],"development.We":[106],"coordinated":[109],"interactions":[111],"are":[112],"essential":[113],"during":[114],"initial":[116],"stages":[117],"development":[120],"require":[122],"an":[123],"Fgf-Shh":[124],"network.Nonstandard":[126],"abbreviations":[127],"used:":[128],"apical":[129],"ectodermal":[130],"ridge":[131],"(AER);":[132],"bone":[133],"morphogenetic":[134],"protein":[135],"(Bmp);":[136],"embryonic":[137],"day":[138],"(E);":[139],"2":[142],"(Fgfr2);":[143],"heterozygote":[144],"(Het);":[145],"Keratin":[146],"14":[147],"(K-14);":[148],"medial":[149],"edge":[151],"(MEE);":[152],"newborn":[153],"(NB);":[154],"paraformaldehyde":[155],"(PFA);":[156],"Patched":[157],"1":[158],"(Ptc1);":[159],"Smoothened":[160],"(Smo);":[161],"(Shh).":[164]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}