{"id":"https://openalex.org/W1989672017","doi":"https://doi.org/10.1016/0026-0495(89)90136-4","title":"Metabolism of glutamine in lymphocytes","display_name":"Metabolism of glutamine in lymphocytes","publication_year":1989,"publication_date":"1989-08-01","ids":{"openalex":"https://openalex.org/W1989672017","doi":"https://doi.org/10.1016/0026-0495(89)90136-4","mag":"1989672017","pmid":"https://pubmed.ncbi.nlm.nih.gov/2569663"},"language":"en","primary_location":{"id":"doi:10.1016/0026-0495(89)90136-4","doi":"https://doi.org/10.1016/0026-0495(89)90136-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0026-0495(89)90136-4","pdf_url":null,"source":{"id":"https://openalex.org/S119661813","display_name":"Metabolism","issn_l":"0026-0495","issn":["0026-0495","1532-8600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008517069","display_name":"Karl Brand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Karl Brand","raw_affiliation_strings":["Institute of Biochemistry, Medical Faculty, University of Erlangen-Nuremberg, FRG","the Research Institute for Experimental Nutrition eV, Erlangen, FRG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Medical Faculty, University of Erlangen-Nuremberg, FRG","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"the Research Institute for Experimental Nutrition eV, Erlangen, FRG","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111364708","display_name":"Werner Lothar Fekl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Werner Fekl","raw_affiliation_strings":["Institute of Biochemistry, Medical Faculty, University of Erlangen-Nuremberg, FRG","the Research Institute for Experimental Nutrition eV, Erlangen, FRG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Medical Faculty, University of Erlangen-Nuremberg, FRG","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"the Research Institute for Experimental Nutrition eV, Erlangen, FRG","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029601733","display_name":"Jutta v. Hintzenstern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jutta von Hintzenstern","raw_affiliation_strings":["Institute of Biochemistry, Medical Faculty, University of Erlangen-Nuremberg, FRG","the Research Institute for Experimental Nutrition eV, Erlangen, FRG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Medical Faculty, University of Erlangen-Nuremberg, FRG","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"the Research Institute for Experimental Nutrition eV, Erlangen, FRG","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029985164","display_name":"Klaus Langer","orcid":"https://orcid.org/0000-0002-0203-7478","observed_orcids":["https://orcid.org/0000-0002-0203-7478"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Klaus Langer","raw_affiliation_strings":["Institute of Biochemistry, Medical Faculty, University of Erlangen-Nuremberg, FRG","the Research Institute for Experimental Nutrition eV, Erlangen, FRG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Medical Faculty, University of Erlangen-Nuremberg, FRG","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"the Research Institute for Experimental Nutrition eV, Erlangen, FRG","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063830479","display_name":"Peter B. Luppa","orcid":"https://orcid.org/0000-0002-3648-0793","observed_orcids":["https://orcid.org/0000-0002-3648-0793"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Luppa","raw_affiliation_strings":["Institute of Biochemistry, Medical Faculty, University of Erlangen-Nuremberg, FRG","the Research Institute for Experimental Nutrition eV, Erlangen, FRG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Medical Faculty, University of Erlangen-Nuremberg, FRG","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"the Research Institute for Experimental Nutrition eV, Erlangen, FRG","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072103595","display_name":"Christoph Schoerner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Schoerner","raw_affiliation_strings":["Institute of Biochemistry, Medical Faculty, University of Erlangen-Nuremberg, FRG","the Research Institute for Experimental Nutrition eV, Erlangen, FRG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Medical Faculty, University of Erlangen-Nuremberg, FRG","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"the Research Institute for Experimental Nutrition eV, Erlangen, FRG","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008517069"],"corresponding_institution_ids":["https://openalex.org/I181369854"],"apc_list":{"value":5340,"currency":"USD","value_usd":5340},"apc_paid":null,"fwci":3.3013,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.93349703,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"38","issue":"8","first_page":"29","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.029200000688433647,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutamine-metabolism","display_name":"glutamine metabolism","score":1.0},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.9480000138282776},{"id":"https://openalex.org/keywords/thymocytes","display_name":"thymocytes","score":0.9919999837875366},{"id":"https://openalex.org/keywords/t-cell-lines","display_name":"T cell lines","score":0.6320000290870667},{"id":"https://openalex.org/keywords/b-cell-lines","display_name":"B-cell lines","score":0.9890000224113464},{"id":"https://openalex.org/keywords/alpha-ketoglutarate","display_name":"alpha-ketoglutarate","score":0.9330000281333923},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.9399999976158142},{"id":"https://openalex.org/keywords/aspartate","display_name":"aspartic acid","score":0.8510000109672546},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.8939999938011169},{"id":"https://openalex.org/keywords/glutamate-dehydrogenase","display_name":"glutamate dehydrogenase","score":0.9509999752044678},{"id":"https://openalex.org/keywords/transamination","display_name":"transamination","score":0.6610000133514404},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.6439999938011169},{"id":"https://openalex.org/keywords/pyruvate","display_name":"pyruvate","score":0.9070000052452087},{"id":"https://openalex.org/keywords/alanine","display_name":"alanine","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.9498819708824158},{"id":"https://openalex.org/C165135838","wikidata":"https://www.wikidata.org/wiki/Q133895","display_name":"Citric acid cycle","level":3,"score":0.7743951678276062},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6872425079345703},{"id":"https://openalex.org/C68793091","wikidata":"https://www.wikidata.org/wiki/Q603891","display_name":"Transamination","level":3,"score":0.6523149609565735},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.6315215229988098},{"id":"https://openalex.org/C111133373","wikidata":"https://www.wikidata.org/wiki/Q21132608","display_name":"Citrate synthase","level":3,"score":0.5811700820922852},{"id":"https://openalex.org/C197974221","wikidata":"https://www.wikidata.org/wiki/Q2526373","display_name":"Oxidative deamination","level":3,"score":0.5810872316360474},{"id":"https://openalex.org/C2777202666","wikidata":"https://www.wikidata.org/wiki/Q417383","display_name":"Glutamate dehydrogenase","level":4,"score":0.560609757900238},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5126985311508179},{"id":"https://openalex.org/C2777150147","wikidata":"https://www.wikidata.org/wiki/Q261968","display_name":"Isocitrate dehydrogenase","level":3,"score":0.4952329695224762},{"id":"https://openalex.org/C2775895851","wikidata":"https://www.wikidata.org/wiki/Q185906","display_name":"Asparagine","level":3,"score":0.48104169964790344},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.4534797668457031},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.3780291676521301},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3734140396118164},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19546210765838623},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000641","descriptor_name":"Ammonia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002952","descriptor_name":"Citric Acid Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005969","descriptor_name":"Glutamate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005971","descriptor_name":"Glutamates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007656","descriptor_name":"Ketoglutaric Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0026-0495(89)90136-4","doi":"https://doi.org/10.1016/0026-0495(89)90136-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0026-0495(89)90136-4","pdf_url":null,"source":{"id":"https://openalex.org/S119661813","display_name":"Metabolism","issn_l":"0026-0495","issn":["0026-0495","1532-8600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolism","raw_type":"journal-article"},{"id":"pmid:2569663","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2569663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolism: clinical and experimental","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1483212110","https://openalex.org/W1596308403","https://openalex.org/W1836071808","https://openalex.org/W1940949702","https://openalex.org/W1980284913","https://openalex.org/W1997712956","https://openalex.org/W2000628687","https://openalex.org/W2006195504","https://openalex.org/W2053387982","https://openalex.org/W2075636558","https://openalex.org/W2103912593","https://openalex.org/W2149459224","https://openalex.org/W4400553934"],"related_works":["https://openalex.org/W2126753151","https://openalex.org/W1836071808","https://openalex.org/W2000628687","https://openalex.org/W2053940626","https://openalex.org/W2338890205","https://openalex.org/W1940949702","https://openalex.org/W2126549654","https://openalex.org/W1978714928","https://openalex.org/W2061770363","https://openalex.org/W2031848854"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}