{"id":"https://openalex.org/W1989670405","doi":"https://doi.org/10.1111/j.1600-065x.1999.tb01282.x","title":"The downregulation of CD4 and MHC\u2010I by primate lentiviruses: a paradigm for the modulation of cell surface receptors","display_name":"The downregulation of CD4 and MHC\u2010I by primate lentiviruses: a paradigm for the modulation of cell surface receptors","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W1989670405","doi":"https://doi.org/10.1111/j.1600-065x.1999.tb01282.x","mag":"1989670405","pmid":"https://pubmed.ncbi.nlm.nih.gov/10399064"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-065x.1999.tb01282.x","doi":"https://doi.org/10.1111/j.1600-065x.1999.tb01282.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-065x.1999.tb01282.x","pdf_url":null,"source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://infoscience.epfl.ch/record/53716","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059190475","display_name":"Vincent Piguet","orcid":"https://orcid.org/0000-0001-6079-4517","observed_orcids":["https://orcid.org/0000-0001-6079-4517"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Vincent Piguet","raw_affiliation_strings":["Department of Genetics and Microbiology, University of Geneva, Switzerland","Department of Genetics and Microbiology, University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Microbiology, University of Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"Department of Genetics and Microbiology, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055664477","display_name":"Olivier Schwartz","orcid":"https://orcid.org/0000-0002-0729-1475","observed_orcids":["https://orcid.org/0000-0002-0729-1475"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Schwartz","raw_affiliation_strings":["Laboratoire Re\u0301trovirus a Transfert Ge\u0301ne\u0301tique, Pasteur Institute, Paris, France","Laboratoire R\u00e9trovirus a Transfert G\u00e9n\u00e9tique, Pasteur Institute, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Re\u0301trovirus a Transfert Ge\u0301ne\u0301tique, Pasteur Institute, Paris, France","institution_ids":["https://openalex.org/I157536573"]},{"raw_affiliation_string":"Laboratoire R\u00e9trovirus a Transfert G\u00e9n\u00e9tique, Pasteur Institute, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069929676","display_name":"Sylvie Le Gall","orcid":"https://orcid.org/0000-0003-0385-926X","observed_orcids":["https://orcid.org/0000-0003-0385-926X"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sylvie Le Gall","raw_affiliation_strings":["Laboratoire Re\u0301trovirus a Transfert Ge\u0301ne\u0301tique, Pasteur Institute, Paris, France","Laboratoire R\u00e9trovirus a Transfert G\u00e9n\u00e9tique, Pasteur Institute, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Re\u0301trovirus a Transfert Ge\u0301ne\u0301tique, Pasteur Institute, Paris, France","institution_ids":["https://openalex.org/I157536573"]},{"raw_affiliation_string":"Laboratoire R\u00e9trovirus a Transfert G\u00e9n\u00e9tique, Pasteur Institute, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082365845","display_name":"Didier Trono","orcid":"https://orcid.org/0000-0002-3383-0401","observed_orcids":["https://orcid.org/0000-0002-3383-0401"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Didier Trono","raw_affiliation_strings":["Department of Genetics and Microbiology, University of Geneva, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Microbiology, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082365845"],"corresponding_institution_ids":["https://openalex.org/I114457229"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":2.4424,"has_fulltext":false,"cited_by_count":204,"citation_normalized_percentile":{"value":0.93243243,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"168","issue":"1","first_page":"51","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd4-downregulation","display_name":"CD4 downregulation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/mhc-class-i-downregulation","display_name":"MHC class I downregulation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/primate-lentiviruses","display_name":"primate lentiviruses","score":0.9129999876022339},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.871999979019165},{"id":"https://openalex.org/keywords/simian-immunodeficiency-virus","display_name":"simian immunodeficiency virus","score":0.8809999823570251},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.6869999766349792},{"id":"https://openalex.org/keywords/nef","display_name":"NEF","score":0.7670000195503235},{"id":"https://openalex.org/keywords/vpu","display_name":"Vpu","score":0.9710000157356262},{"id":"https://openalex.org/keywords/env","display_name":"Env","score":0.6110000014305115},{"id":"https://openalex.org/keywords/clathrin-adaptor-complexes","display_name":"clathrin adaptor complexes","score":0.7059999704360962},{"id":"https://openalex.org/keywords/receptor-trafficking","display_name":"receptor trafficking","score":0.4779999852180481},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.875}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.771552324295044},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7404000759124756},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6821190118789673},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5807094573974609},{"id":"https://openalex.org/C2776855506","wikidata":"https://www.wikidata.org/wiki/Q21100505","display_name":"Tetherin","level":4,"score":0.5686576962471008},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.4863889515399933},{"id":"https://openalex.org/C63162447","wikidata":"https://www.wikidata.org/wiki/Q21100804","display_name":"Clathrin","level":4,"score":0.4543761610984802},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4467697739601135},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.434611976146698},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.39798229932785034},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.33345574140548706},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2695484161376953},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.23543456196784973},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.2162301242351532},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.17011934518814087},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12227123975753784},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000086082","descriptor_name":"Viroporin Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007424","descriptor_name":"Intracellular Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011323","descriptor_name":"Primates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011991","descriptor_name":"Receptors, Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015693","descriptor_name":"Gene Products, nef","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016086","descriptor_name":"Lentivirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D033942","descriptor_name":"Adaptor Proteins, Vesicular Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033965","descriptor_name":"Adaptor Protein Complex alpha Subunits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054298","descriptor_name":"Human Immunodeficiency Virus Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054311","descriptor_name":"nef Gene Products, Human Immunodeficiency Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054334","descriptor_name":"Viral Regulatory and Accessory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1111/j.1600-065x.1999.tb01282.x","doi":"https://doi.org/10.1111/j.1600-065x.1999.tb01282.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-065x.1999.tb01282.x","pdf_url":null,"source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},{"id":"pmid:10399064","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10399064","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological reviews","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:pasteur-01372749v1","doi":null,"is_oa":false,"landing_page_url":"https://pasteur.hal.science/pasteur-01372749","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Immunological Reviews, 1999, 168, pp.51-63. &#x27E8;10.1111/j.1600-065X.1999.tb01282.x&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:infoscience.epfl.ch:53716","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/53716","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:infoscience.tind.io:53716","doi":null,"is_oa":true,"landing_page_url":"https://infoscience.epfl.ch/handle/20.500.14299/215849","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"}],"best_oa_location":{"id":"pmh:oai:infoscience.epfl.ch:53716","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/53716","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":112,"referenced_works":["https://openalex.org/W14905039","https://openalex.org/W119567604","https://openalex.org/W1489814243","https://openalex.org/W1498574963","https://openalex.org/W1510952600","https://openalex.org/W1527219367","https://openalex.org/W1532805548","https://openalex.org/W1545558337","https://openalex.org/W1560893038","https://openalex.org/W1564649778","https://openalex.org/W1574834137","https://openalex.org/W1579711827","https://openalex.org/W1599781349","https://openalex.org/W1674854702","https://openalex.org/W1715327714","https://openalex.org/W1793297159","https://openalex.org/W1810523920","https://openalex.org/W1812353966","https://openalex.org/W1897759055","https://openalex.org/W1923801572","https://openalex.org/W1963569988","https://openalex.org/W1969436018","https://openalex.org/W1971057735","https://openalex.org/W1971065575","https://openalex.org/W1973398091","https://openalex.org/W1975209033","https://openalex.org/W1979815209","https://openalex.org/W1981164507","https://openalex.org/W1981951679","https://openalex.org/W1982180580","https://openalex.org/W1984125372","https://openalex.org/W1986384364","https://openalex.org/W1987672004","https://openalex.org/W1990719919","https://openalex.org/W1990949150","https://openalex.org/W1992438598","https://openalex.org/W1996047038","https://openalex.org/W1996164387","https://openalex.org/W2002683198","https://openalex.org/W2002904708","https://openalex.org/W2007845379","https://openalex.org/W2011630381","https://openalex.org/W2014818809","https://openalex.org/W2017669430","https://openalex.org/W2019007714","https://openalex.org/W2020107050","https://openalex.org/W2020700449","https://openalex.org/W2022098233","https://openalex.org/W2026668380","https://openalex.org/W2027738518","https://openalex.org/W2028834214","https://openalex.org/W2030039293","https://openalex.org/W2030608812","https://openalex.org/W2033240631","https://openalex.org/W2036270340","https://openalex.org/W2037152735","https://openalex.org/W2037343680","https://openalex.org/W2037881900","https://openalex.org/W2040087470","https://openalex.org/W2042471874","https://openalex.org/W2044907066","https://openalex.org/W2045684019","https://openalex.org/W2048869016","https://openalex.org/W2049652225","https://openalex.org/W2050475877","https://openalex.org/W2056723350","https://openalex.org/W2057481548","https://openalex.org/W2057567758","https://openalex.org/W2061060052","https://openalex.org/W2064863056","https://openalex.org/W2067599049","https://openalex.org/W2069318071","https://openalex.org/W2070615094","https://openalex.org/W2072070715","https://openalex.org/W2072947383","https://openalex.org/W2078338501","https://openalex.org/W2083556128","https://openalex.org/W2085279345","https://openalex.org/W2085340755","https://openalex.org/W2086264258","https://openalex.org/W2088564222","https://openalex.org/W2090646713","https://openalex.org/W2093250120","https://openalex.org/W2094442995","https://openalex.org/W2097213667","https://openalex.org/W2097508364","https://openalex.org/W2099637744","https://openalex.org/W2103731776","https://openalex.org/W2108277395","https://openalex.org/W2113282092","https://openalex.org/W2117093009","https://openalex.org/W2122334399","https://openalex.org/W2123030732","https://openalex.org/W2126169302","https://openalex.org/W2129667323","https://openalex.org/W2132959169","https://openalex.org/W2134618183","https://openalex.org/W2135319033","https://openalex.org/W2139250164","https://openalex.org/W2144935474","https://openalex.org/W2148426299","https://openalex.org/W2150341199","https://openalex.org/W2151024978","https://openalex.org/W2152115437","https://openalex.org/W2154005890","https://openalex.org/W2158177598","https://openalex.org/W2167567978","https://openalex.org/W2170830738","https://openalex.org/W2178812731","https://openalex.org/W2181940400","https://openalex.org/W2333926065","https://openalex.org/W6600623834"],"related_works":["https://openalex.org/W2094068975","https://openalex.org/W1812353966","https://openalex.org/W2061104960","https://openalex.org/W1976560794","https://openalex.org/W2417769741","https://openalex.org/W2026133847","https://openalex.org/W1987495778","https://openalex.org/W2304578264","https://openalex.org/W2110447839","https://openalex.org/W2133715451"],"abstract_inverted_index":{"The":[0,164],"human":[1],"and":[2,7,19,55,79,90,103,122,136,188],"simian":[3],"immunodeficiency":[4],"viruses":[5],"(HIV":[6],"SIV)":[8],"downregulate":[9,59],"the":[10,33,44,68,73,82,96,101,104,109,113,124,130,137,147,162,179],"cell":[11],"surface":[12],"expression":[13],"of":[14,20,29,35,108,112,127,133,149,155,166,196],"CD4,":[15,60],"their":[16],"primary":[17],"receptor,":[18,157],"class":[21],"I":[22],"histocompatibility":[23],"complex":[24,64,126],"(MHC-I),":[25],"a":[26,63,153,194],"critical":[27],"mediator":[28],"immune":[30,48],"recognition.":[31],"While":[32],"first":[34],"these":[36,117],"effects":[37],"seems":[38],"important":[39],"to":[40,58,185],"preserve":[41],"viral":[42,114],"infectivity,":[43],"second":[45],"likely":[46],"promotes":[47],"evasion.":[49],"Three":[50],"HIV-1":[51],"proteins,":[52],"Nef,":[53,150],"Env":[54,61],"Vpu,":[56,80],"contribute":[57],"forms":[62],"with":[65,158],"CD4":[66,89,187],"in":[67,75,100,116,161],"endoplasmic":[69],"reticulum,":[70],"thereby":[71],"retaining":[72],"receptor":[74,97],"this":[76,156,167],"compartment.":[77],"Nef":[78],"on":[81],"other":[83],"hand,":[84],"act":[85],"as":[86,171],"connectors":[87],"between":[88],"specific":[91],"intracellular":[92],"trafficking":[93],"pathways,":[94],"targeting":[95],"for":[98],"degradation":[99],"lysosome":[102],"proteasome,":[105],"respectively.":[106],"Some":[107],"downstream":[110],"partners":[111],"proteins":[115],"events":[118],"have":[119],"been":[120],"identified,":[121],"include":[123],"adaptor":[125],"clathrin-coated":[128],"pits,":[129],"beta":[131],"subunit":[132],"COP-I":[134],"coatomer,":[135],"ubiquitin":[138],"pathway-related":[139],"h-beta":[140],"TrCP":[141],"protein.":[142],"HIV-induced":[143],"MHC-I":[144,189],"downregulation,":[145],"mostly":[146],"effect":[148],"also":[151,191],"reflects":[152],"redistribution":[154],"its":[159],"accumulation":[160],"Golgi.":[163],"modalities":[165],"process,":[168],"however,":[169],"are":[170,190],"yet":[172],"imperfectly":[173],"understood.":[174],"New":[175],"evidence":[176],"indicates":[177],"that":[178],"mechanisms":[180],"employed":[181],"by":[182,193],"primate":[183],"lentiviruses":[184],"downmodulate":[186],"exploited":[192],"number":[195],"cellular":[197],"regulatory":[198],"processes.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
