{"id":"https://openalex.org/W1989659809","doi":"https://doi.org/10.1073/pnas.2035254100","title":"Establishment of memory for IL-10 expression in developing T helper 2 cells requires repetitive IL-4 costimulation and does not impair proliferation","display_name":"Establishment of memory for IL-10 expression in developing T helper 2 cells requires repetitive IL-4 costimulation and does not impair proliferation","publication_year":2003,"publication_date":"2003-09-26","ids":{"openalex":"https://openalex.org/W1989659809","doi":"https://doi.org/10.1073/pnas.2035254100","mag":"1989659809","pmid":"https://pubmed.ncbi.nlm.nih.gov/14514890","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/218754"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2035254100","doi":"https://doi.org/10.1073/pnas.2035254100","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.2035254100","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC218754","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009054700","display_name":"Max L\u00f6hning","orcid":"https://orcid.org/0000-0001-6382-7281","observed_orcids":["https://orcid.org/0000-0001-6382-7281"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095248","display_name":"German Rheumatism Research Centre","ror":"https://ror.org/00shv0x82","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210095248"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Max L\u00f6hning","raw_affiliation_strings":["Deutsches Rheumaforschungszentrum, Schumannstrasse 21/22, D-10117 Berlin, Germany; Miltenyi Biotec, Friedrich-Ebert-Strasse 68, D-51429 Bergisch Gladbach, Germany; and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deutsches Rheumaforschungszentrum, Schumannstrasse 21/22, D-10117 Berlin, Germany; Miltenyi Biotec, Friedrich-Ebert-Strasse 68, D-51429 Bergisch Gladbach, Germany; and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095248","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063209804","display_name":"Anne Richter","orcid":"https://orcid.org/0000-0003-4943-9447","observed_orcids":["https://orcid.org/0000-0003-4943-9447"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095248","display_name":"German Rheumatism Research Centre","ror":"https://ror.org/00shv0x82","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210095248"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Anne Richter","raw_affiliation_strings":["Deutsches Rheumaforschungszentrum, Schumannstrasse 21/22, D-10117 Berlin, Germany; Miltenyi Biotec, Friedrich-Ebert-Strasse 68, D-51429 Bergisch Gladbach, Germany; and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deutsches Rheumaforschungszentrum, Schumannstrasse 21/22, D-10117 Berlin, Germany; Miltenyi Biotec, Friedrich-Ebert-Strasse 68, D-51429 Bergisch Gladbach, Germany; and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095248","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054571057","display_name":"Torsten Stamm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095248","display_name":"German Rheumatism Research Centre","ror":"https://ror.org/00shv0x82","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210095248"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Torsten Stamm","raw_affiliation_strings":["Deutsches Rheumaforschungszentrum, Schumannstrasse 21/22, D-10117 Berlin, Germany; Miltenyi Biotec, Friedrich-Ebert-Strasse 68, D-51429 Bergisch Gladbach, Germany; and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deutsches Rheumaforschungszentrum, Schumannstrasse 21/22, D-10117 Berlin, Germany; Miltenyi Biotec, Friedrich-Ebert-Strasse 68, D-51429 Bergisch Gladbach, Germany; and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095248","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075061364","display_name":"Jane Hu\u2010Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095248","display_name":"German Rheumatism Research Centre","ror":"https://ror.org/00shv0x82","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210095248"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Jane Hu-Li","raw_affiliation_strings":["Deutsches Rheumaforschungszentrum, Schumannstrasse 21/22, D-10117 Berlin, Germany; Miltenyi Biotec, Friedrich-Ebert-Strasse 68, D-51429 Bergisch Gladbach, Germany; and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deutsches Rheumaforschungszentrum, Schumannstrasse 21/22, D-10117 Berlin, Germany; Miltenyi Biotec, Friedrich-Ebert-Strasse 68, D-51429 Bergisch Gladbach, Germany; and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095248","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070609648","display_name":"Mario Assenmacher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095248","display_name":"German Rheumatism Research Centre","ror":"https://ror.org/00shv0x82","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210095248"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Mario Assenmacher","raw_affiliation_strings":["Deutsches Rheumaforschungszentrum, Schumannstrasse 21/22, D-10117 Berlin, Germany; Miltenyi Biotec, Friedrich-Ebert-Strasse 68, D-51429 Bergisch Gladbach, Germany; and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deutsches Rheumaforschungszentrum, Schumannstrasse 21/22, D-10117 Berlin, Germany; Miltenyi Biotec, Friedrich-Ebert-Strasse 68, D-51429 Bergisch Gladbach, Germany; and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095248","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110180932","display_name":"William E. Paul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095248","display_name":"German Rheumatism Research Centre","ror":"https://ror.org/00shv0x82","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210095248"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"William E. Paul","raw_affiliation_strings":["Deutsches Rheumaforschungszentrum, Schumannstrasse 21/22, D-10117 Berlin, Germany; Miltenyi Biotec, Friedrich-Ebert-Strasse 68, D-51429 Bergisch Gladbach, Germany; and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deutsches Rheumaforschungszentrum, Schumannstrasse 21/22, D-10117 Berlin, Germany; Miltenyi Biotec, Friedrich-Ebert-Strasse 68, D-51429 Bergisch Gladbach, Germany; and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095248","https://openalex.org/I4210134534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006949032","display_name":"Andreas Radbruch","orcid":"https://orcid.org/0000-0001-5753-0000","observed_orcids":["https://orcid.org/0000-0001-5753-0000"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095248","display_name":"German Rheumatism Research Centre","ror":"https://ror.org/00shv0x82","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210095248"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Andreas Radbruch","raw_affiliation_strings":["Deutsches Rheumaforschungszentrum, Schumannstrasse 21/22, D-10117 Berlin, Germany; Miltenyi Biotec, Friedrich-Ebert-Strasse 68, D-51429 Bergisch Gladbach, Germany; and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deutsches Rheumaforschungszentrum, Schumannstrasse 21/22, D-10117 Berlin, Germany; Miltenyi Biotec, Friedrich-Ebert-Strasse 68, D-51429 Bergisch Gladbach, Germany; and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095248","https://openalex.org/I4210134534"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7084,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.66565542,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"100","issue":"21","first_page":"12307","last_page":"12312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.7760000228881836},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.984000027179718},{"id":"https://openalex.org/keywords/th2-cells","display_name":"Th2 cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/effector-memory-t-cells","display_name":"effector memory T cells","score":0.7870000004768372},{"id":"https://openalex.org/keywords/t-cell-receptor-activation","display_name":"T cell receptor stimulation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/th2-differentiation","display_name":"Th2 differentiation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.6769999861717224},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8230000138282776},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.6039999723434448},{"id":"https://openalex.org/keywords/immunological-memory","display_name":"immunological memory","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C2777367678","wikidata":"https://www.wikidata.org/wiki/Q2304808","display_name":"Memory T cell","level":4,"score":0.5903046131134033},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5615341663360596},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5474501252174377},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.49805116653442383},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.47521835565567017},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45119237899780273},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.4429197907447815},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.4372212886810303},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1891191601753235}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.2035254100","doi":"https://doi.org/10.1073/pnas.2035254100","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.2035254100","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:277499","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC218754","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:218754","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/218754","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:14514890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14514890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:277499","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC218754","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1494102420","https://openalex.org/W1509968819","https://openalex.org/W1510381594","https://openalex.org/W1515586509","https://openalex.org/W1515615230","https://openalex.org/W1517658874","https://openalex.org/W1526621387","https://openalex.org/W1562527353","https://openalex.org/W1573470869","https://openalex.org/W1602470456","https://openalex.org/W1981480494","https://openalex.org/W1985621901","https://openalex.org/W2017390755","https://openalex.org/W2021165722","https://openalex.org/W2025484368","https://openalex.org/W2027699993","https://openalex.org/W2029819700","https://openalex.org/W2038271225","https://openalex.org/W2040635819","https://openalex.org/W2045008512","https://openalex.org/W2045720698","https://openalex.org/W2054109196","https://openalex.org/W2054517109","https://openalex.org/W2059317525","https://openalex.org/W2065655094","https://openalex.org/W2066131688","https://openalex.org/W2067049479","https://openalex.org/W2091301099","https://openalex.org/W2101771134","https://openalex.org/W2124621398","https://openalex.org/W2127755180","https://openalex.org/W2130183546","https://openalex.org/W2136245823","https://openalex.org/W2138656295","https://openalex.org/W2138961639","https://openalex.org/W2161074777","https://openalex.org/W2172466148","https://openalex.org/W2886978647","https://openalex.org/W4313348037"],"related_works":["https://openalex.org/W3125413000","https://openalex.org/W1575237888","https://openalex.org/W1514297997","https://openalex.org/W2128680250","https://openalex.org/W2052100845","https://openalex.org/W2102770312","https://openalex.org/W2004285416","https://openalex.org/W2202483530","https://openalex.org/W2094902648","https://openalex.org/W2060409300"],"abstract_inverted_index":{"T":[0,35,79],"helper":[1],"(Th)":[2],"lymphocytes":[3,203],"can":[4,145,220],"develop":[5],"memory":[6,53,68,135,163,201,205,228],"for":[7,119,206],"the":[8,26,44,64,73,88,112,128,142],"expression":[9,181,210],"of":[10,20,25,46,59,66,72,90,130,141,171,182],"particular":[11],"cytokines,":[12],"like":[13],"IL-4":[14,30,52,77,92,132,160,183,207],"or":[15,161,184,208],"IL-10,":[16],"in":[17,43,50,87,96,102,151,167,190,215,225],"that":[18,42],"reexpression":[19,140],"those":[21],"cytokines":[22],"is":[23,54],"independent":[24],"original":[27],"costimulatory":[28],"signal":[29],"and":[31,78,108,133,219,229],"depends":[32,196],"only":[33],"on":[34,197],"cell":[36,48,75,80,148,155],"receptor":[37],"stimulation.":[38],"Here,":[39],"we":[40],"show":[41],"course":[45],"Th2":[47,154,177],"differentiation":[49],"vitro,":[51],"established":[55,83],"during":[56],"primary":[57,126],"activation":[58],"na\u00efve":[60,122],"Th":[61,74,106,123,157,172,202],"cells,":[62],"whereas":[63],"establishment":[65],"IL-10":[67,84,134,162,185,209],"requires":[69,136],"repetitive":[70],"stimulation":[71],"with":[76,159,204],"receptor.":[81],"Likewise,":[82],"memory,":[85],"maintained":[86],"absence":[89],"further":[91],"signals,":[93],"was":[94],"observed":[95],"individual":[97],"IL-10-producing":[98],"cells":[99,107,124,158,173],"generated":[100],"from":[101,175],"vivo":[103],"antigen-experienced":[104],"CD62L(low)":[105],"isolated":[109,174],"by":[110],"using":[111],"newly":[113],"developed":[114],"cytometric":[115],"cytokine":[116,143],"secretion":[117],"assay":[118],"IL-10.":[120],"In":[121,150],"undergoing":[125],"activation,":[127],"induction":[129],"both":[131],"DNA":[137],"synthesis,":[138],"but":[139],"genes":[144],"occur":[146],"throughout":[147],"cycle.":[149],"vitro":[152],"polarized":[153,176],"populations,":[156],"do":[164,187],"not":[165,188,212],"differ":[166,189],"proliferative":[168,191,217],"behavior.":[169,192],"Populations":[170],"cultures":[178],"according":[179],"to":[180],"also":[186],"Their":[193],"proliferation":[194],"mainly":[195],"IL-2.":[198],"Thus,":[199],"effector":[200],"are":[211],"intrinsically":[213],"impaired":[214],"their":[216],"potential":[218],"play":[221],"an":[222],"essential":[223],"role":[224],"reactive":[226],"immunological":[227],"its":[230],"regulation.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}