{"id":"https://openalex.org/W1989600081","doi":"https://doi.org/10.1111/jre.12066","title":"Role of salivary epithelial toll\u2010like receptors 2 and 4 in modulating innate immune responses in chronic periodontitis","display_name":"Role of salivary epithelial toll\u2010like receptors 2 and 4 in modulating innate immune responses in chronic periodontitis","publication_year":2013,"publication_date":"2013-05-17","ids":{"openalex":"https://openalex.org/W1989600081","doi":"https://doi.org/10.1111/jre.12066","mag":"1989600081","pmid":"https://pubmed.ncbi.nlm.nih.gov/23679005"},"language":"en","primary_location":{"id":"doi:10.1111/jre.12066","doi":"https://doi.org/10.1111/jre.12066","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jre.12066","pdf_url":null,"source":{"id":"https://openalex.org/S195000414","display_name":"Journal of Periodontal Research","issn_l":"0022-3484","issn":["0022-3484","1600-0765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Periodontal Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"V. Swaminathan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Swaminathan","raw_affiliation_strings":["Department of Periodontics and Allied Health, School of Dentistry, Indiana University Purdue, University at Indianapolis, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics and Allied Health, School of Dentistry, Indiana University Purdue, University at Indianapolis, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I55769427","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025229383","display_name":"Sivaraman Prakasam","orcid":"https://orcid.org/0000-0001-6751-6835","observed_orcids":["https://orcid.org/0000-0001-6751-6835"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Prakasam","raw_affiliation_strings":["Department of Periodontics and Allied Health, School of Dentistry, Indiana University Purdue, University at Indianapolis, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics and Allied Health, School of Dentistry, Indiana University Purdue, University at Indianapolis, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I55769427","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":null,"display_name":"V. Puri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Puri","raw_affiliation_strings":["Department of Periodontics and Allied Health, School of Dentistry, Indiana University Purdue, University at Indianapolis, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics and Allied Health, School of Dentistry, Indiana University Purdue, University at Indianapolis, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I55769427","https://openalex.org/I592451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069148100","display_name":"Mythily Srinivasan","orcid":"https://orcid.org/0000-0003-1431-8215","observed_orcids":["https://orcid.org/0000-0003-1431-8215"]},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M. Srinivasan","raw_affiliation_strings":["Oral Pathology, Medicine and Radiology, School of Dentistry, The Indiana University, Purdue University, Indianapolis, IN, USA","Mythily Srinivasan, MDS, PhD, Immunology Laboratory, 1121, West Michigan Street, Indianapolis, IN 46202, USA","Tel: +317 278 9686"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oral Pathology, Medicine and Radiology, School of Dentistry, The Indiana University, Purdue University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"Mythily Srinivasan, MDS, PhD, Immunology Laboratory, 1121, West Michigan Street, Indianapolis, IN 46202, USA","institution_ids":[]},{"raw_affiliation_string":"Tel: +317 278 9686","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5069148100"],"corresponding_institution_ids":["https://openalex.org/I55769427"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":2.4279,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.86593349,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"48","issue":"6","first_page":"757","last_page":"765"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-periodontitis","display_name":"chronic periodontitis","score":0.996999979019165},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.8629999756813049},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":1.0},{"id":"https://openalex.org/keywords/salivary-epithelial-cells","display_name":"salivary epithelial cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6919999718666077},{"id":"https://openalex.org/keywords/peptidoglycan-recognition-proteins","display_name":"peptidoglycan recognition proteins","score":0.9020000100135803},{"id":"https://openalex.org/keywords/whole-saliva","display_name":"whole saliva","score":0.6389999985694885},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.8109999895095825},{"id":"https://openalex.org/keywords/periodontal-pathogens","display_name":"periodontal pathogens","score":0.9190000295639038},{"id":"https://openalex.org/keywords/generalized-periodontitis","display_name":"generalized periodontitis","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.7521581649780273},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.7373191118240356},{"id":"https://openalex.org/C2779337755","wikidata":"https://www.wikidata.org/wiki/Q5113988","display_name":"Chronic periodontitis","level":3,"score":0.7114240527153015},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6632660627365112},{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.6550475358963013},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.6505019664764404},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6494554877281189},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.6276793479919434},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6095663905143738},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.5773557424545288},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5600042939186096},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5453006029129028},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5435017347335815},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.430184543132782},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24264422059059143},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11492329835891724},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.054716676473617554},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003774","descriptor_name":"Dental Plaque Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010512","descriptor_name":"Periodontal Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010514","descriptor_name":"Periodontal Pocket","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017622","descriptor_name":"Periodontal Attachment Loss","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053535","descriptor_name":"Keratin-13","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D055113","descriptor_name":"Chronic Periodontitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D055113","descriptor_name":"Chronic Periodontitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/jre.12066","doi":"https://doi.org/10.1111/jre.12066","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jre.12066","pdf_url":null,"source":{"id":"https://openalex.org/S195000414","display_name":"Journal of Periodontal Research","issn_l":"0022-3484","issn":["0022-3484","1600-0765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Periodontal Research","raw_type":"journal-article"},{"id":"pmid:23679005","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23679005","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of periodontal research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6600000262260437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W63738649","https://openalex.org/W104371847","https://openalex.org/W1489842152","https://openalex.org/W1491001272","https://openalex.org/W1568222576","https://openalex.org/W1852871843","https://openalex.org/W1860612338","https://openalex.org/W1895649975","https://openalex.org/W1923306256","https://openalex.org/W1934857244","https://openalex.org/W1984877185","https://openalex.org/W1988216048","https://openalex.org/W1993442297","https://openalex.org/W1993644920","https://openalex.org/W1994152080","https://openalex.org/W1994246205","https://openalex.org/W1997019819","https://openalex.org/W1999883443","https://openalex.org/W2005970466","https://openalex.org/W2012738222","https://openalex.org/W2016754754","https://openalex.org/W2018358963","https://openalex.org/W2020713278","https://openalex.org/W2024149378","https://openalex.org/W2026550982","https://openalex.org/W2027740390","https://openalex.org/W2037674532","https://openalex.org/W2038113413","https://openalex.org/W2044097621","https://openalex.org/W2044785246","https://openalex.org/W2045264957","https://openalex.org/W2046141546","https://openalex.org/W2053344942","https://openalex.org/W2054181973","https://openalex.org/W2057544744","https://openalex.org/W2061514799","https://openalex.org/W2061898374","https://openalex.org/W2062004035","https://openalex.org/W2063845786","https://openalex.org/W2076136819","https://openalex.org/W2080841094","https://openalex.org/W2082004773","https://openalex.org/W2095566926","https://openalex.org/W2104345414","https://openalex.org/W2111633168","https://openalex.org/W2111648905","https://openalex.org/W2115804775","https://openalex.org/W2117842866","https://openalex.org/W2120015194","https://openalex.org/W2124182404","https://openalex.org/W2131621671","https://openalex.org/W2142513160","https://openalex.org/W2143901448","https://openalex.org/W2144259342","https://openalex.org/W2145510982","https://openalex.org/W2146131845","https://openalex.org/W2148501086","https://openalex.org/W2149846571","https://openalex.org/W2150826665","https://openalex.org/W2155178900","https://openalex.org/W2155287847","https://openalex.org/W2161731510","https://openalex.org/W2162497876","https://openalex.org/W2164926125","https://openalex.org/W2168877147","https://openalex.org/W2170000318","https://openalex.org/W4210376357"],"related_works":["https://openalex.org/W2935693909","https://openalex.org/W2416137625","https://openalex.org/W4410128044","https://openalex.org/W2159464000","https://openalex.org/W2138188253","https://openalex.org/W3091789566","https://openalex.org/W2077986257","https://openalex.org/W6893595131","https://openalex.org/W2077735124","https://openalex.org/W1996466245"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,108],"OBJECTIVE:":[2],"Chronic":[3],"periodontitis":[4,121,212,235],"is":[5,17,31,74],"initiated":[6],"by":[7,19,34,148,175],"sequential":[8],"colonization":[9],"with":[10,40,53,103,118,160,179,187,203,211,222,233],"a":[11,75],"broad":[12],"array":[13],"of":[14,29,70,78,93,199,231,255],"bacteria":[15],"and":[16,50,99,122,146,190,193,216,239,258],"perpetuated":[18],"an":[20],"immune-inflammatory":[21],"response":[22],"to":[23,67,165,249],"the":[24,62,68,91,154,207,219,229,246,253],"changing":[25],"biofilm.":[26],"Host":[27],"recognition":[28,143],"microbes":[30],"largely":[32],"mediated":[33],"toll-like":[35],"receptors":[36],"(TLRs),":[37],"which":[38],"interact":[39,52],"conserved":[41],"pathogen-associated":[42],"molecular":[43],"patterns.":[44],"Based":[45],"on":[46],"ligand":[47],"recognition,":[48],"TLR-2":[49,98],"TLR-4":[51,100],"most":[54],"periodontal":[55,250],"pathogens.":[56],"Extracrevicular":[57],"bacterial":[58],"reservoirs,":[59],"such":[60],"as":[61],"oral":[63,79],"epithelial":[64,80,95,247],"cells,":[65],"contribute":[66],"persistence":[69],"periodontitis.":[71,106,204],"Human":[72],"saliva":[73,112],"rich":[76],"source":[77],"cells":[81,131],"that":[82],"express":[83],"functional":[84],"TLRs.":[85],"In":[86,152,205],"this":[87],"study":[88],"we":[89],"investigated":[90],"role":[92],"salivary":[94],"cell":[96],"(SEC)":[97],"in":[101,158,197,252],"patients":[102,117,202,210,232],"generalized":[104,119],"chronic":[105,120,234],"MATERIAL":[107],"METHODS:":[109],"Unstimulated":[110],"whole":[111],"(UWS)":[113],"was":[114,171],"collected":[115],"from":[116,123,133,201,209,228],"healthy":[124],"individuals":[125],"after":[126],"obtaining":[127],"informed":[128],"consent.":[129],"Epithelial":[130],"isolated":[132],"each":[134],"UWS":[135,230],"sample":[136],"were":[137,156],"assessed":[138,172],"for":[139,163,173,244],"TLR-2,":[140],"TLR-4,":[141],"peptidoglycan":[142],"protein":[144],"(PGRP)-3":[145],"PGRP-4":[147],"quantitative":[149],"real-time":[150],"PCR.":[151],"addition,":[153,206],"SECs":[155,200,208,226],"stimulated":[157],"vitro":[159],"microbial":[161],"products":[162],"up":[164],"24":[166],"h.":[167],"The":[168],"culture":[169],"supernatant":[170],"cytokines":[174],"ELISA.":[176],"RESULTS:":[177],"Stimulation":[178],"TLR-2-":[180],"or":[181],"TLR-4-specific":[182],"ligands":[183],"induced":[184],"cytokine":[185],"secretion":[186],"differential":[188],"kinetics":[189],"up-regulated":[191],"TLR2":[192],"TLR4":[194],"mRNAs,":[195,218],"respectively,":[196],"cultures":[198],"exhibited":[213],"reduced":[214],"PGRP3":[215],"PGRP4":[217],"TLR-responsive":[220],"genes":[221],"antibacterial":[223],"properties.":[224],"CONCLUSION:":[225],"derived":[227],"are":[236],"phenotypically":[237],"distinct":[238],"could":[240],"represent":[241],"potential":[242],"resources":[243],"assessing":[245],"responses":[248],"pathogens":[251],"course":[254],"disease":[256],"progression":[257],"persistence.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
