{"id":"https://openalex.org/W1989582016","doi":"https://doi.org/10.1038/sj.leu.2400605","title":"Antisense src expression inhibits tyrosine phosphorylation of Shc and its association with Grb2 and Sos which leads to MAP kinase activation in U937 human leukemia cells","display_name":"Antisense src expression inhibits tyrosine phosphorylation of Shc and its association with Grb2 and Sos which leads to MAP kinase activation in U937 human leukemia cells","publication_year":1997,"publication_date":"1997-04-01","ids":{"openalex":"https://openalex.org/W1989582016","doi":"https://doi.org/10.1038/sj.leu.2400605","mag":"1989582016","pmid":"https://pubmed.ncbi.nlm.nih.gov/9096689"},"language":"en","primary_location":{"id":"doi:10.1038/sj.leu.2400605","doi":"https://doi.org/10.1038/sj.leu.2400605","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.leu.2400605","pdf_url":null,"source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017990584","display_name":"Masamitsu Yamaguchi","orcid":"https://orcid.org/0000-0002-6321-9750","observed_orcids":["https://orcid.org/0000-0002-6321-9750"]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]},{"id":"https://openalex.org/I4210135297","display_name":"Kagawa University Hospital","ror":"https://ror.org/033sspj46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I201933988","https://openalex.org/I4210135297"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Yamaguchi","raw_affiliation_strings":["First Department of Internal Medicine, Kagawa Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Kagawa Medical School, Japan","institution_ids":["https://openalex.org/I201933988","https://openalex.org/I4210135297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090835480","display_name":"Takashi Tanaka","orcid":"https://orcid.org/0000-0001-7762-7432","observed_orcids":["https://orcid.org/0000-0001-7762-7432"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Tanaka","raw_affiliation_strings":["First Department of Internal Medicine, Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Kagawa, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058625239","display_name":"Masato Waki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Waki","raw_affiliation_strings":["First Department of Internal Medicine, Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Kagawa, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091145269","display_name":"Akira Kitanaka","orcid":"https://orcid.org/0000-0002-2659-8405","observed_orcids":["https://orcid.org/0000-0002-2659-8405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Kitanaka","raw_affiliation_strings":["First Department of Internal Medicine, Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Kagawa, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078931436","display_name":"Hiroshi Kamano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Kamano","raw_affiliation_strings":["First Department of Internal Medicine, Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Kagawa, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106080124","display_name":"Yoshitsugu Kubota","orcid":"https://orcid.org/0000-0003-4303-2195","observed_orcids":["https://orcid.org/0000-0003-4303-2195"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Kubota","raw_affiliation_strings":["Clinical Laboratory Medicine, Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory Medicine, Kagawa, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"H Ohnishi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Ohnishi","raw_affiliation_strings":["First Department of Internal Medicine, Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Kagawa, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109529531","display_name":"J Takahara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Takahara","raw_affiliation_strings":["First Department of Internal Medicine, Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Kagawa, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002584862","display_name":"Shozo Irino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]},{"id":"https://openalex.org/I4210135297","display_name":"Kagawa University Hospital","ror":"https://ror.org/033sspj46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I201933988","https://openalex.org/I4210135297"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Irino","raw_affiliation_strings":["Kagawa Medical School, Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kagawa Medical School, Kagawa, Japan","institution_ids":["https://openalex.org/I201933988","https://openalex.org/I4210135297"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":0.1984,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.412284,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"11","issue":"4","first_page":"497","last_page":"503"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7602999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7602999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.2257000058889389,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.9430000185966492},{"id":"https://openalex.org/keywords/antisense-rna","display_name":"antisense RNA","score":0.847000002861023},{"id":"https://openalex.org/keywords/shc","display_name":"Shc","score":0.7509999871253967},{"id":"https://openalex.org/keywords/grb2","display_name":"Grb2","score":0.9279999732971191},{"id":"https://openalex.org/keywords/so","display_name":"SO","score":0.996999979019165},{"id":"https://openalex.org/keywords/mapk-activation","display_name":"MAPK activation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.6240000128746033},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.8880000114440918},{"id":"https://openalex.org/keywords/u937-cells","display_name":"U937 cells","score":0.7770000100135803},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.7622488737106323},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.7310317754745483},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6215294599533081},{"id":"https://openalex.org/C177917778","wikidata":"https://www.wikidata.org/wiki/Q14905188","display_name":"GRB2","level":4,"score":0.6156314015388489},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5531541109085083},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5364831686019897},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.49155697226524353},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4801723062992096},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.438135027885437},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.43476149439811707},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.40328043699264526},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40222427248954773},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33051976561546326},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24202781915664673},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016372","descriptor_name":"RNA, Antisense","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051380","descriptor_name":"GRB2 Adaptor Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.leu.2400605","doi":"https://doi.org/10.1038/sj.leu.2400605","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.leu.2400605","pdf_url":null,"source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},{"id":"pmid:9096689","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9096689","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320316791","display_name":"Advanced Storage Research Consortium","ror":"https://ror.org/0300pft78"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2022991000","https://openalex.org/W2062241862","https://openalex.org/W1971613560","https://openalex.org/W2061452540","https://openalex.org/W2008812258","https://openalex.org/W2411955162","https://openalex.org/W2000269495","https://openalex.org/W2034949322","https://openalex.org/W2005167514","https://openalex.org/W2085760543"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
