{"id":"https://openalex.org/W1989554121","doi":"https://doi.org/10.1371/journal.pone.0026466","title":"High-Dose siRNAs Upregulate Mouse Eri-1 at both Transcription and Posttranscription Levels","display_name":"High-Dose siRNAs Upregulate Mouse Eri-1 at both Transcription and Posttranscription Levels","publication_year":2011,"publication_date":"2011-10-19","ids":{"openalex":"https://openalex.org/W1989554121","doi":"https://doi.org/10.1371/journal.pone.0026466","mag":"1989554121","pmid":"https://pubmed.ncbi.nlm.nih.gov/22039495","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3198429"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0026466","doi":"https://doi.org/10.1371/journal.pone.0026466","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0026466","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0026466&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0026466&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102936149","display_name":"Yingnan Bian","orcid":"https://orcid.org/0000-0002-8651-8737","observed_orcids":["https://orcid.org/0000-0002-8651-8737"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingnan Bian","raw_affiliation_strings":["Department of Biochemistry, School of Life Science, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Life Science, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076651715","display_name":"Wei Lan Zhou","orcid":"https://orcid.org/0000-0003-3742-2592","observed_orcids":["https://orcid.org/0000-0003-3742-2592"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhou","raw_affiliation_strings":["Department of Biochemistry, School of Life Science, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Life Science, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007947547","display_name":"Yingchun Zhao","orcid":"https://orcid.org/0000-0002-8958-4406","observed_orcids":["https://orcid.org/0000-0002-8958-4406"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingchun Zhao","raw_affiliation_strings":["Department of Biochemistry, School of Life Science, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Life Science, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100397119","display_name":"Xiaoping Li","orcid":"https://orcid.org/0000-0002-5057-0226","observed_orcids":["https://orcid.org/0000-0002-5057-0226"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoping Li","raw_affiliation_strings":["Department of Biochemistry, School of Life Science, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Life Science, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Geng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Geng","raw_affiliation_strings":["Department of Biochemistry, School of Life Science, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Life Science, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059159387","display_name":"Ruixin Hao","orcid":"https://orcid.org/0000-0001-8757-0871","observed_orcids":["https://orcid.org/0000-0001-8757-0871"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruixin Hao","raw_affiliation_strings":["Department of Biochemistry, School of Life Science, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Life Science, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100417913","display_name":"Qing Kun Yang","orcid":"https://orcid.org/0000-0001-8623-7532","observed_orcids":["https://orcid.org/0000-0001-8623-7532","https://orcid.org/0000-0001-5550-9275","https://orcid.org/0000-0001-5803-5343"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Yang","raw_affiliation_strings":["Department of Biochemistry, School of Life Science, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Life Science, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101784396","display_name":"Weida Huang","orcid":"https://orcid.org/0000-0003-4126-3045","observed_orcids":["https://orcid.org/0000-0003-4126-3045"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210111959","display_name":"Shanghai Advanced Research Institute","ror":"https://ror.org/02br7py06","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210111959"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weida Huang","raw_affiliation_strings":["Department of Biochemistry, School of Life Science, Fudan University, Shanghai, China","Laboratory for Synthetic Biology, Centers for Nano-Medicine, Shanghai Advanced Research Institute, Chinese Academy Sciences, Pudong, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Life Science, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Laboratory for Synthetic Biology, Centers for Nano-Medicine, Shanghai Advanced Research Institute, Chinese Academy Sciences, Pudong, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210111959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101784396"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I24943067","https://openalex.org/I4210111959"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.535,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.59893411,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"6","issue":"10","first_page":"e26466","last_page":"e26466"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.8169999718666077},{"id":"https://openalex.org/keywords/sirna-degradation","display_name":"siRNA degradation","score":0.6570000052452087},{"id":"https://openalex.org/keywords/3-exonuclease","display_name":"3' exonuclease","score":0.8330000042915344},{"id":"https://openalex.org/keywords/sp1","display_name":"Sp1","score":0.8389999866485596},{"id":"https://openalex.org/keywords/ets1","display_name":"ETS1","score":0.996999979019165},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.8569999933242798},{"id":"https://openalex.org/keywords/promoter-complex","display_name":"promoter complex","score":0.3880000114440918},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.9098829030990601},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.7392906546592712},{"id":"https://openalex.org/C60723119","wikidata":"https://www.wikidata.org/wiki/Q7833577","display_name":"Trans-acting siRNA","level":5,"score":0.5701179504394531},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5203037858009338},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5058314800262451},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.48087814450263977},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4684322774410248},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.416321724653244},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3914109468460083},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3003474175930023},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2664657533168793},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23221251368522644},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005092","descriptor_name":"Exonucleases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005092","descriptor_name":"Exonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005095","descriptor_name":"Exoribonucleases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0026466","doi":"https://doi.org/10.1371/journal.pone.0026466","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0026466","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0026466&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2203692","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3198429","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22039495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22039495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3198429","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3198429/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.774.5424","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.774.5424","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ac/d3/pone.0026466.PMC3198429.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:95a3167c43d0439a89b784b58646c9e8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/95a3167c43d0439a89b784b58646c9e8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 6, Iss 10, p e26466 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0026466","doi":"https://doi.org/10.1371/journal.pone.0026466","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0026466","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0026466&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G195310570","display_name":null,"funder_award_id":"50533010","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321851","display_name":"Fudan University","ror":"https://ror.org/013q1eq08"},{"id":"https://openalex.org/F4320335766","display_name":"Shanghai Leading Academic Discipline Project","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1989554121.pdf","grobid_xml":"https://content.openalex.org/works/W1989554121.grobid-xml"},"referenced_works_count":105,"referenced_works":["https://openalex.org/W32135351","https://openalex.org/W138718701","https://openalex.org/W590561559","https://openalex.org/W752290014","https://openalex.org/W1495457417","https://openalex.org/W1496109170","https://openalex.org/W1499500424","https://openalex.org/W1513739797","https://openalex.org/W1515466910","https://openalex.org/W1563624749","https://openalex.org/W1767847062","https://openalex.org/W1922521877","https://openalex.org/W1965349246","https://openalex.org/W1966543080","https://openalex.org/W1967302239","https://openalex.org/W1969499006","https://openalex.org/W1975247881","https://openalex.org/W1975437957","https://openalex.org/W1976840413","https://openalex.org/W1977056281","https://openalex.org/W1977159737","https://openalex.org/W1978966509","https://openalex.org/W1979840572","https://openalex.org/W1983158440","https://openalex.org/W1987027200","https://openalex.org/W1989454102","https://openalex.org/W1991440608","https://openalex.org/W1992170226","https://openalex.org/W1993180746","https://openalex.org/W1995197740","https://openalex.org/W1995866851","https://openalex.org/W1999507084","https://openalex.org/W2002256692","https://openalex.org/W2003681585","https://openalex.org/W2006648085","https://openalex.org/W2007591776","https://openalex.org/W2008588438","https://openalex.org/W2012362284","https://openalex.org/W2014916765","https://openalex.org/W2015298114","https://openalex.org/W2016112105","https://openalex.org/W2017034172","https://openalex.org/W2017184218","https://openalex.org/W2017642141","https://openalex.org/W2017716833","https://openalex.org/W2018308587","https://openalex.org/W2020427232","https://openalex.org/W2028513543","https://openalex.org/W2030120875","https://openalex.org/W2036370282","https://openalex.org/W2041237942","https://openalex.org/W2041594569","https://openalex.org/W2044209397","https://openalex.org/W2044227662","https://openalex.org/W2050423438","https://openalex.org/W2050601734","https://openalex.org/W2056917849","https://openalex.org/W2058426917","https://openalex.org/W2067065456","https://openalex.org/W2070297535","https://openalex.org/W2072699494","https://openalex.org/W2074183834","https://openalex.org/W2080011157","https://openalex.org/W2081452698","https://openalex.org/W2083381199","https://openalex.org/W2084324934","https://openalex.org/W2089046374","https://openalex.org/W2092337132","https://openalex.org/W2094105923","https://openalex.org/W2098355479","https://openalex.org/W2098963694","https://openalex.org/W2107398189","https://openalex.org/W2111843532","https://openalex.org/W2113261653","https://openalex.org/W2113934040","https://openalex.org/W2118611175","https://openalex.org/W2122472408","https://openalex.org/W2125818518","https://openalex.org/W2127344145","https://openalex.org/W2128674168","https://openalex.org/W2130042720","https://openalex.org/W2131472300","https://openalex.org/W2142305165","https://openalex.org/W2148759751","https://openalex.org/W2152041515","https://openalex.org/W2152327676","https://openalex.org/W2152949199","https://openalex.org/W2153175562","https://openalex.org/W2156852055","https://openalex.org/W2158010566","https://openalex.org/W2159042861","https://openalex.org/W2159479890","https://openalex.org/W2162075091","https://openalex.org/W2167999293","https://openalex.org/W2168249156","https://openalex.org/W2170023901","https://openalex.org/W2253277805","https://openalex.org/W2398350456","https://openalex.org/W2417470032","https://openalex.org/W2795830831","https://openalex.org/W4205246014","https://openalex.org/W4241398143","https://openalex.org/W4285719527","https://openalex.org/W6885532501","https://openalex.org/W7097514665"],"related_works":["https://openalex.org/W2012362284","https://openalex.org/W2054687025","https://openalex.org/W1992170226","https://openalex.org/W7095291200","https://openalex.org/W1707771787","https://openalex.org/W19455920","https://openalex.org/W2122338377","https://openalex.org/W2051316894","https://openalex.org/W2053606985","https://openalex.org/W2554530408"],"abstract_inverted_index":{"The":[0],"eri-1":[1],"gene":[2],"encodes":[3],"a":[4],"3'":[5,68],"exonuclease":[6],"that":[7,36],"can":[8,19],"negatively":[9],"regulate":[10],"RNA":[11],"interference":[12],"via":[13],"siRNase":[14],"activity.":[15],"High-dose":[16],"siRNAs":[17,27],"(hd-siRNAs)":[18],"enhance":[20],"Eri-1":[21,40],"expression,":[22],"which":[23],"in":[24],"return":[25],"degrade":[26],"and":[28,49,55],"greatly":[29],"reduces":[30],"RNAi":[31],"efficiency.":[32],"Here":[33],"we":[34],"report":[35],"hd-siRNAs":[37,64],"induce":[38],"mouse":[39],"(meri-1)":[41],"expression":[42],"through":[43],"the":[44,52,56,67,80,84],"recruitment":[45],"of":[46,58,75,86],"Sp1,":[47],"Ets-1,":[48],"STAT3":[50],"to":[51],"meri-1":[53,87],"promoter":[54],"formation":[57],"an":[59],"Sp1-Ets-1-STAT3":[60],"complex.":[61],"In":[62],"addition,":[63],"also":[65],"abolish":[66],"untranslated":[69],"region":[70],"(UTR)":[71],"mediated":[72],"posttranscriptional":[73],"repression":[74],"meri-1.":[76],"Our":[77],"findings":[78],"demonstrate":[79],"molecular":[81],"mechanism":[82],"underlying":[83],"upregulation":[85],"by":[88],"hd-siRNA.":[89]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}