{"id":"https://openalex.org/W1989521090","doi":"https://doi.org/10.1016/0026-0495(88)90122-9","title":"Development of a new radioimmunoassay for human osteocalcin: Evidence for a midmolecule epitope","display_name":"Development of a new radioimmunoassay for human osteocalcin: Evidence for a midmolecule epitope","publication_year":1988,"publication_date":"1988-09-01","ids":{"openalex":"https://openalex.org/W1989521090","doi":"https://doi.org/10.1016/0026-0495(88)90122-9","mag":"1989521090","pmid":"https://pubmed.ncbi.nlm.nih.gov/2458519"},"language":"en","primary_location":{"id":"doi:10.1016/0026-0495(88)90122-9","doi":"https://doi.org/10.1016/0026-0495(88)90122-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0026-0495(88)90122-9","pdf_url":null,"source":{"id":"https://openalex.org/S119661813","display_name":"Metabolism","issn_l":"0026-0495","issn":["0026-0495","1532-8600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087241181","display_name":"A. Taylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arch K. Taylor","raw_affiliation_strings":["Jerry Pettis VA Hospital, Department of Biochemistry, CA, Loma Linda, CA 92357","Department of Biochemistry, Loma Linda University, Loma Linda, CA, USA","Department of Medicine, Loma Linda University, Loma Linda, CA, USA","Department of Physiology, Loma Linda University, Loma Linda, CA, USA","Jerry Pettis VA Hospital Loma Linda, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jerry Pettis VA Hospital, Department of Biochemistry, CA, Loma Linda, CA 92357","institution_ids":["https://openalex.org/I4210116750"]},{"raw_affiliation_string":"Department of Biochemistry, Loma Linda University, Loma Linda, CA, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Department of Medicine, Loma Linda University, Loma Linda, CA, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Department of Physiology, Loma Linda University, Loma Linda, CA, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Jerry Pettis VA Hospital Loma Linda, CA, USA","institution_ids":["https://openalex.org/I4210116750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066137671","display_name":"Susan G. Linkhart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan G. Linkhart","raw_affiliation_strings":["Department of Biochemistry, Loma Linda University, Loma Linda, CA, USA","Department of Medicine, Loma Linda University, Loma Linda, CA, USA","Department of Physiology, Loma Linda University, Loma Linda, CA, USA","Jerry Pettis VA Hospital Loma Linda, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Loma Linda University, Loma Linda, CA, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Department of Medicine, Loma Linda University, Loma Linda, CA, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Department of Physiology, Loma Linda University, Loma Linda, CA, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Jerry Pettis VA Hospital Loma Linda, CA, USA","institution_ids":["https://openalex.org/I4210116750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054497725","display_name":"Subburaman Mohan","orcid":"https://orcid.org/0000-0003-0063-986X","observed_orcids":["https://orcid.org/0000-0003-0063-986X"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Subburaman Mohan","raw_affiliation_strings":["Department of Biochemistry, Loma Linda University, Loma Linda, CA, USA","Department of Medicine, Loma Linda University, Loma Linda, CA, USA","Department of Physiology, Loma Linda University, Loma Linda, CA, USA","Jerry Pettis VA Hospital Loma Linda, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Loma Linda University, Loma Linda, CA, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Department of Medicine, Loma Linda University, Loma Linda, CA, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Department of Physiology, Loma Linda University, Loma Linda, CA, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Jerry Pettis VA Hospital Loma Linda, CA, USA","institution_ids":["https://openalex.org/I4210116750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102858874","display_name":"David J. Baylink","orcid":"https://orcid.org/0000-0001-9526-7995","observed_orcids":["https://orcid.org/0000-0001-9526-7995"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Baylink","raw_affiliation_strings":["Department of Biochemistry, Loma Linda University, Loma Linda, CA, USA","Department of Medicine, Loma Linda University, Loma Linda, CA, USA","Department of Physiology, Loma Linda University, Loma Linda, CA, USA","Jerry Pettis VA Hospital Loma Linda, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Loma Linda University, Loma Linda, CA, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Department of Medicine, Loma Linda University, Loma Linda, CA, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Department of Physiology, Loma Linda University, Loma Linda, CA, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Jerry Pettis VA Hospital Loma Linda, CA, USA","institution_ids":["https://openalex.org/I4210116750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087241181"],"corresponding_institution_ids":["https://openalex.org/I26347476","https://openalex.org/I4210116750"],"apc_list":{"value":5340,"currency":"USD","value_usd":5340},"apc_paid":null,"fwci":11.6193,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.98436945,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"37","issue":"9","first_page":"872","last_page":"877"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.6244999766349792,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.6244999766349792,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.14560000598430634,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.12399999797344208,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/radioimmunoassay","display_name":"radioimmunoassay","score":0.9760000109672546},{"id":"https://openalex.org/keywords/antibody-specificity","display_name":"antibody specificity","score":0.746999979019165},{"id":"https://openalex.org/keywords/bone-turnover-markers","display_name":"bone turnover markers","score":0.8349999785423279},{"id":"https://openalex.org/keywords/serum-alkaline-phosphatase","display_name":"serum alkaline phosphatase","score":0.9039999842643738},{"id":"https://openalex.org/keywords/paget-s-disease","display_name":"Paget's disease","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hyperparathyroidism","display_name":"hyperparathyroidism","score":0.9959999918937683},{"id":"https://openalex.org/keywords/newborns","display_name":"neonates","score":0.5170000195503235},{"id":"https://openalex.org/keywords/bone-specific-protein","display_name":"bone-specific protein","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.9719277024269104},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.82713383436203},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.6678950190544128},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6555849313735962},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5909405946731567},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.5676440596580505},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5607802867889404},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5337019562721252},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5007719993591309},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.4680677652359009},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3042336106300354},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2547082304954529},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19432199001312256},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15950241684913635},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12261644005775452}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0026-0495(88)90122-9","doi":"https://doi.org/10.1016/0026-0495(88)90122-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0026-0495(88)90122-9","pdf_url":null,"source":{"id":"https://openalex.org/S119661813","display_name":"Metabolism","issn_l":"0026-0495","issn":["0026-0495","1532-8600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolism","raw_type":"journal-article"},{"id":"pmid:2458519","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2458519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolism: clinical and experimental","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2494010510","display_name":"Endosteal Bone Volume Regulation and Osteoporosis","funder_award_id":"R01AR031062","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1258321623","https://openalex.org/W1534710385","https://openalex.org/W1586874013","https://openalex.org/W1597802619","https://openalex.org/W1760484467","https://openalex.org/W1799755547","https://openalex.org/W1893651774","https://openalex.org/W1979777342","https://openalex.org/W1986593290","https://openalex.org/W1989061452","https://openalex.org/W1989534548","https://openalex.org/W2014684409","https://openalex.org/W2021188024","https://openalex.org/W2024303975","https://openalex.org/W2041633275","https://openalex.org/W2054747204","https://openalex.org/W2075721622","https://openalex.org/W2081825162","https://openalex.org/W2109152949","https://openalex.org/W2143005633","https://openalex.org/W4301311184"],"related_works":["https://openalex.org/W1918454276","https://openalex.org/W2163592625","https://openalex.org/W2261093661","https://openalex.org/W1972641924","https://openalex.org/W2474221799","https://openalex.org/W2269166654","https://openalex.org/W2102046797","https://openalex.org/W2327274273","https://openalex.org/W1989421212","https://openalex.org/W2054747204"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}