{"id":"https://openalex.org/W1989469585","doi":"https://doi.org/10.1016/s1071-9164(03)00489-5","title":"Cardiac-specific expression of GSK-3 impairs cardiac growth and calcium handling, leading to systolic and diastolic dysfunction, heart failure, and premature death","display_name":"Cardiac-specific expression of GSK-3 impairs cardiac growth and calcium handling, leading to systolic and diastolic dysfunction, heart failure, and premature death","publication_year":2003,"publication_date":"2003-09-12","ids":{"openalex":"https://openalex.org/W1989469585","doi":"https://doi.org/10.1016/s1071-9164(03)00489-5","mag":"1989469585"},"language":"en","primary_location":{"id":"doi:10.1016/s1071-9164(03)00489-5","doi":"https://doi.org/10.1016/s1071-9164(03)00489-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1071-9164(03)00489-5","pdf_url":"http://www.onlinejcf.com/article/S1071916403004895/pdf","source":{"id":"https://openalex.org/S67869649","display_name":"Journal of Cardiac Failure","issn_l":"1071-9164","issn":["1071-9164","1532-8414"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiac Failure","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.onlinejcf.com/article/S1071916403004895/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103435482","display_name":"Ashour Michael","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashour Michael","raw_affiliation_strings":["Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, MA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, MA USA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021026182","display_name":"Syed Haq","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Syed Haq","raw_affiliation_strings":["Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, MA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, MA USA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019462939","display_name":"Heiko Kilter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heiko Kilter","raw_affiliation_strings":["Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, MA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, MA USA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100363093","display_name":"Xin Chen","orcid":"https://orcid.org/0000-0002-7970-6991","observed_orcids":["https://orcid.org/0000-0002-7970-6991"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Chen","raw_affiliation_strings":["Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, MA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, MA USA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052626419","display_name":"Ronglih Liao","orcid":"https://orcid.org/0000-0002-9598-9020","observed_orcids":["https://orcid.org/0000-0002-9598-9020"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronglih Liao","raw_affiliation_strings":["Boston University Medical Center, Boston, MA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University Medical Center, Boston, MA USA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038739378","display_name":"Lei Cui","orcid":"https://orcid.org/0000-0002-7221-3609","observed_orcids":["https://orcid.org/0000-0002-7221-3609"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Cui","raw_affiliation_strings":["Boston University Medical Center, Boston, MA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University Medical Center, Boston, MA USA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056099500","display_name":"Richard D. Patten","orcid":"https://orcid.org/0000-0002-2535-2569","observed_orcids":["https://orcid.org/0000-0002-2535-2569"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Patten","raw_affiliation_strings":["Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, MA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, MA USA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075550603","display_name":"Jeffery D. Molkentin","orcid":"https://orcid.org/0000-0002-3558-6529","observed_orcids":["https://orcid.org/0000-0002-3558-6529"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffery Molkentin","raw_affiliation_strings":["Department of Pediatrics, Children\u2019s Hospital Medical Center, Cincinnati, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Children\u2019s Hospital Medical Center, Cincinnati, OH, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004831598","display_name":"Kausik Battacharya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kausik Battacharya","raw_affiliation_strings":["Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, MA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, MA USA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017332459","display_name":"Thomas L. Force","orcid":"https://orcid.org/0000-0002-0450-8659","observed_orcids":["https://orcid.org/0000-0002-0450-8659"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Force","raw_affiliation_strings":["Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, MA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, MA USA","institution_ids":["https://openalex.org/I1290900354"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3970,"currency":"USD","value_usd":3970},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0855381,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"5","first_page":"S39","last_page":"S39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.10589999705553055,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.060600001364946365,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gsk-3beta","display_name":"GSK3\u03b2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cardiac-growth","display_name":"cardiac growth","score":0.9240000247955322},{"id":"https://openalex.org/keywords/calcium-handling","display_name":"calcium handling","score":0.7360000014305115},{"id":"https://openalex.org/keywords/serca2a","display_name":"SERCA2a","score":0.8539999723434448},{"id":"https://openalex.org/keywords/diastolic-dysfunction","display_name":"diastolic dysfunction","score":0.9340000152587891},{"id":"https://openalex.org/keywords/systolic-dysfunction","display_name":"systolic dysfunction","score":0.9779999852180481},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9890000224113464},{"id":"https://openalex.org/keywords/diastolic-relaxation","display_name":"diastolic relaxation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/left-ventricular-filling-pressure","display_name":"left ventricular filling pressure","score":0.7770000100135803},{"id":"https://openalex.org/keywords/atrial-enlargement","display_name":"atrial enlargement","score":0.949999988079071},{"id":"https://openalex.org/keywords/gsk-3-inhibition","display_name":"GSK3 inhibition","score":0.6259999871253967},{"id":"https://openalex.org/keywords/cardiomyocyte-contractility","display_name":"cardiomyocyte contractility","score":0.6629999876022339},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7516654133796692},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.7426727414131165},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.7382612824440002},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7138492465019226},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7105447053909302},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.6013795733451843},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.5559287667274475},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5299989581108093},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.49178412556648254},{"id":"https://openalex.org/C17137333","wikidata":"https://www.wikidata.org/wiki/Q410105","display_name":"Phospholamban","level":3,"score":0.4364158511161804},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.43119049072265625},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.4183603823184967},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.352183073759079},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.20925623178482056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12637725472450256},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s1071-9164(03)00489-5","doi":"https://doi.org/10.1016/s1071-9164(03)00489-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1071-9164(03)00489-5","pdf_url":"http://www.onlinejcf.com/article/S1071916403004895/pdf","source":{"id":"https://openalex.org/S67869649","display_name":"Journal of Cardiac Failure","issn_l":"1071-9164","issn":["1071-9164","1532-8414"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiac Failure","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/s1071-9164(03)00489-5","doi":"https://doi.org/10.1016/s1071-9164(03)00489-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1071-9164(03)00489-5","pdf_url":"http://www.onlinejcf.com/article/S1071916403004895/pdf","source":{"id":"https://openalex.org/S67869649","display_name":"Journal of Cardiac Failure","issn_l":"1071-9164","issn":["1071-9164","1532-8414"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiac Failure","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8500000238418579}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1989469585.pdf","grobid_xml":"https://content.openalex.org/works/W1989469585.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2139855640","https://openalex.org/W2013880106","https://openalex.org/W7018511797","https://openalex.org/W1983066278","https://openalex.org/W2057994513","https://openalex.org/W2954381097","https://openalex.org/W2105014609","https://openalex.org/W2170208738","https://openalex.org/W3133820541","https://openalex.org/W2726953330"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}