{"id":"https://openalex.org/W1989429554","doi":"https://doi.org/10.2307/3283051","title":"Detection of Circulating Immune Complexes by the Enzyme-Linked Immunosorbent Assay in Sera from Cattle Infected with Fasciola hepatica","display_name":"Detection of Circulating Immune Complexes by the Enzyme-Linked Immunosorbent Assay in Sera from Cattle Infected with Fasciola hepatica","publication_year":1989,"publication_date":"1989-10-01","ids":{"openalex":"https://openalex.org/W1989429554","doi":"https://doi.org/10.2307/3283051","mag":"1989429554","pmid":"https://pubmed.ncbi.nlm.nih.gov/2795372"},"language":"en","primary_location":{"id":"doi:10.2307/3283051","doi":"https://doi.org/10.2307/3283051","is_oa":false,"landing_page_url":"https://doi.org/10.2307/3283051","pdf_url":null,"source":{"id":"https://openalex.org/S31573680","display_name":"Journal of Parasitology","issn_l":"0022-3395","issn":["0022-3395","1937-2345"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310316431","host_organization_name":"American Society of Parasitologists","host_organization_lineage":["https://openalex.org/P4310316431"],"host_organization_lineage_names":["American Society of Parasitologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Parasitology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038143566","display_name":"Raymond J. Langley","orcid":"https://orcid.org/0000-0001-8849-9325","observed_orcids":["https://orcid.org/0000-0001-8849-9325"]},"institutions":[{"id":"https://openalex.org/I158818660","display_name":"University of Puerto Rico, Medical Sciences Campus","ror":"https://ror.org/00h25w961","country_code":"PR","type":"education","lineage":["https://openalex.org/I158818660","https://openalex.org/I200399037"]},{"id":"https://openalex.org/I200399037","display_name":"University of Puerto Rico System","ror":"https://ror.org/02yg0nm07","country_code":"PR","type":"education","lineage":["https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Raymond J. Langley","raw_affiliation_strings":["Laboratory of Parasite Immunology and Pathology, University of Puerto Rico School of Medicine, San Juan 00936-5067"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Parasite Immunology and Pathology, University of Puerto Rico School of Medicine, San Juan 00936-5067","institution_ids":["https://openalex.org/I158818660","https://openalex.org/I200399037"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037032030","display_name":"George V. Hillyer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George V. Hillyer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9311,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.69819588,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"75","issue":"5","first_page":"690","last_page":"690"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12234","display_name":"Mollusks and Parasites Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fasciola-hepatica","display_name":"Fasciola hepatica","score":0.9900000095367432},{"id":"https://openalex.org/keywords/fascioliasis","display_name":"fascioliasis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/circulating-immune-complexes","display_name":"circulating immune complexes","score":0.9800000190734863},{"id":"https://openalex.org/keywords/polyethylene-glycol-precipitation","display_name":"polyethylene glycol precipitation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/excretory-secretory-antigens","display_name":"excretory-secretory antigens","score":0.9760000109672546},{"id":"https://openalex.org/keywords/antibody-detection","display_name":"antibody detection","score":0.4320000112056732},{"id":"https://openalex.org/keywords/immunodiagnosis","display_name":"immunodiagnosis","score":0.6589999794960022},{"id":"https://openalex.org/keywords/cattle","display_name":"cattle","score":0.6919999718666077},{"id":"https://openalex.org/keywords/worm-burden","display_name":"worm burden","score":0.7990000247955322},{"id":"https://openalex.org/keywords/elisa-development","display_name":"ELISA development","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C2777856171","wikidata":"https://www.wikidata.org/wiki/Q334149","display_name":"Fasciola hepatica","level":3,"score":0.8974045515060425},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.8158110976219177},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7627842426300049},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7598496675491333},{"id":"https://openalex.org/C2777228834","wikidata":"https://www.wikidata.org/wiki/Q157505","display_name":"Hepatica","level":4,"score":0.6687647104263306},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6298546195030212},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5749926567077637},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3935636878013611},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3280547857284546},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.22724586725234985}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000909","descriptor_name":"Antibodies, Helminth","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000947","descriptor_name":"Antigens, Helminth","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002418","descriptor_name":"Cattle Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005210","descriptor_name":"Fasciola hepatica","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005211","descriptor_name":"Fascioliasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005211","descriptor_name":"Fascioliasis","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2307/3283051","doi":"https://doi.org/10.2307/3283051","is_oa":false,"landing_page_url":"https://doi.org/10.2307/3283051","pdf_url":null,"source":{"id":"https://openalex.org/S31573680","display_name":"Journal of Parasitology","issn_l":"0022-3395","issn":["0022-3395","1937-2345"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310316431","host_organization_name":"American Society of Parasitologists","host_organization_lineage":["https://openalex.org/P4310316431"],"host_organization_lineage_names":["American Society of Parasitologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Parasitology","raw_type":"journal-article"},{"id":"pmid:2795372","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2795372","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of parasitology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1984029921","display_name":null,"funder_award_id":"AI-22906","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1505139144","https://openalex.org/W1662156426","https://openalex.org/W1900170447","https://openalex.org/W1970330386","https://openalex.org/W2001667072","https://openalex.org/W2002747742","https://openalex.org/W2006541840","https://openalex.org/W2093190943","https://openalex.org/W2128635872","https://openalex.org/W2148343215","https://openalex.org/W2331718633","https://openalex.org/W2395990819","https://openalex.org/W2396244349","https://openalex.org/W2408067182","https://openalex.org/W2408115843","https://openalex.org/W2464396489","https://openalex.org/W4299318019","https://openalex.org/W4407210094"],"related_works":["https://openalex.org/W4407202130","https://openalex.org/W1938623251","https://openalex.org/W6911171226","https://openalex.org/W2112840492","https://openalex.org/W2002747742","https://openalex.org/W1994742079","https://openalex.org/W2039007164","https://openalex.org/W1505139144","https://openalex.org/W1935996925","https://openalex.org/W1983420254"],"abstract_inverted_index":{"Polyethylene":[0],"glycol-precipitated":[1],"immune":[2,130,158],"complexes":[3,109,120],"(PIC)":[4],"from":[5],"the":[6,40,94,104,114,157,165,185,201,206],"sera":[7,176],"of":[8,68,156,175,195,231],"5":[9],"calves":[10],"with":[11,142,164,200],"Fasciola":[12],"hepatica":[13,219],"worm":[14,55,203],"burdens":[15],"ranging":[16],"between":[17],"27":[18],"and":[19,34,78,89,180,188],"70":[20],"flukes":[21],"were":[22,47,80,110],"examined":[23],"for":[24,154],"parasite":[25,64],"antigen":[26,65,99,171,220],"content":[27],"at":[28,135,178],"2,":[29],"4,":[30],"6,":[31],"8,":[32],"10,":[33],"16":[35],"wk":[36,137,182],"postinfection":[37],"(PI)":[38],"by":[39,66,113],"enzyme-linked":[41],"immunosorbent":[42],"assay":[43,62,92,191,209],"(ELISA).":[44],"Three":[45],"assays":[46,127,162],"devised":[48],"using":[49,82],"an":[50,98],"affinity-processed":[51],"rabbit":[52],"antibody":[53,70,101,146],"to":[54,71,103,147,227],"excretory/secretory":[56],"(FhES)":[57],"antigens.":[58,149],"The":[59,86,107,150],"PIC":[60,72,90,166,189,207],"plate":[61,208],"detected":[63,112,170,192],"adherence":[67],"anti-FhES":[69,95],"incubated":[73],"overnight":[74],"on":[75],"ELISA":[76],"plates,":[77],"tests":[79],"visualized":[81],"anti-rabbit":[83],"peroxidase-linked":[84],"antibody.":[85],"serum":[87,122,186],"complex":[88,131,159,187],"capture":[91,100,167,190],"utilized":[93],"immunoglobulin":[96],"as":[97,124],"linked":[102],"solid":[105],"phase.":[106],"attached":[108],"then":[111],"adhering":[115],"bovine":[116],"antibody,":[117],"either":[118],"soluble":[119],"in":[121,172,197,222],"or":[123],"PIC.":[125],"All":[126],"showed":[128,210],"circulating":[129,145],"(CIC)":[132],"values":[133],"elevated":[134],"6-8":[136],"PI,":[138],"which":[139],"generally":[140],"coincided":[141],"increased":[143],"host":[144],"FhES":[148],"greatest":[151,193],"detection":[152,161,221],"rate":[153],"all":[155],"(IC)":[160],"occurred":[163],"assay.":[168],"It":[169],"almost":[173],"90%":[174],"tested":[177],"6":[179],"8":[181],"PI.":[183],"Both":[184],"amounts":[194],"CIC":[196,223],"those":[198],"animals":[199],"largest":[202],"burdens,":[204],"whereas":[205],"no":[211],"such":[212],"trend.":[213],"This":[214],"study":[215],"shows":[216],"that":[217],"F.":[218],"can":[224],"be":[225],"used":[226],"aid":[228],"immunologic":[229],"diagnosis":[230],"fascioliasis.":[232]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
