{"id":"https://openalex.org/W1989290448","doi":"https://doi.org/10.1093/infdis/151.6.1037","title":"The Interaction of Chlamydia trachomatis with Host Cells: Ultrastructural Studies of the Mechanism of Release of a Biovar II Strain from HeLa 229 Cells","display_name":"The Interaction of Chlamydia trachomatis with Host Cells: Ultrastructural Studies of the Mechanism of Release of a Biovar II Strain from HeLa 229 Cells","publication_year":1985,"publication_date":"1985-06-01","ids":{"openalex":"https://openalex.org/W1989290448","doi":"https://doi.org/10.1093/infdis/151.6.1037","mag":"1989290448","pmid":"https://pubmed.ncbi.nlm.nih.gov/3889172"},"language":"en","primary_location":{"id":"doi:10.1093/infdis/151.6.1037","doi":"https://doi.org/10.1093/infdis/151.6.1037","is_oa":false,"landing_page_url":"https://doi.org/10.1093/infdis/151.6.1037","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014931114","display_name":"William J. Todd","orcid":"https://orcid.org/0000-0003-4015-6125","observed_orcids":["https://orcid.org/0000-0003-4015-6125"]},"institutions":[{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405287673","display_name":"Rocky Mountain Laboratories","ror":"https://ror.org/05v7g7w67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. J. Todd","raw_affiliation_strings":["Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, Electron Microscopy Section and Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, Hamilton, Montana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, Electron Microscopy Section and Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, Hamilton, Montana","institution_ids":["https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078176047","display_name":"Harlan D. Caldwell","orcid":"https://orcid.org/0000-0002-2018-8106","observed_orcids":["https://orcid.org/0000-0002-2018-8106"]},"institutions":[{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405287673","display_name":"Rocky Mountain Laboratories","ror":"https://ror.org/05v7g7w67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. D. Caldwell","raw_affiliation_strings":["Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, Electron Microscopy Section and Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, Hamilton, Montana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, Electron Microscopy Section and Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, Hamilton, Montana","institution_ids":["https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":2.1727,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.85093168,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"151","issue":"6","first_page":"1037","last_page":"1044"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chlamydia-trachomatis","display_name":"Chlamydia trachomatis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hela-229-cells","display_name":"HeLa 229 cells","score":0.8659999966621399},{"id":"https://openalex.org/keywords/host-cell-interactions","display_name":"host cell interactions","score":0.5360000133514404},{"id":"https://openalex.org/keywords/chlamydial-inclusions","display_name":"chlamydial inclusions","score":0.7630000114440918},{"id":"https://openalex.org/keywords/exocytosis","display_name":"exocytosis","score":0.7110000252723694},{"id":"https://openalex.org/keywords/host-cell-survival","display_name":"host cell survival","score":0.503000020980835},{"id":"https://openalex.org/keywords/ultrastructure","display_name":"ultrastructure","score":0.7979999780654907},{"id":"https://openalex.org/keywords/latent-infection","display_name":"latent infection","score":0.7070000171661377},{"id":"https://openalex.org/keywords/asymptomatic-infection","display_name":"asymptomatic infection","score":0.7910000085830688},{"id":"https://openalex.org/keywords/serotype-d","display_name":"serotype D","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2777391075","wikidata":"https://www.wikidata.org/wiki/Q131065","display_name":"Chlamydia trachomatis","level":2,"score":0.8016397953033447},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.7584300637245178},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.7318201065063477},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.6667934656143188},{"id":"https://openalex.org/C2777038808","wikidata":"https://www.wikidata.org/wiki/Q13474598","display_name":"Chlamydiaceae","level":3,"score":0.6126390099525452},{"id":"https://openalex.org/C2778967756","wikidata":"https://www.wikidata.org/wiki/Q1972080","display_name":"Biovar","level":3,"score":0.6036003232002258},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5701838731765747},{"id":"https://openalex.org/C2778651837","wikidata":"https://www.wikidata.org/wiki/Q5102716","display_name":"Chlamydiales","level":3,"score":0.48140478134155273},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.45684775710105896},{"id":"https://openalex.org/C2780122209","wikidata":"https://www.wikidata.org/wiki/Q153356","display_name":"Chlamydia","level":2,"score":0.45563995838165283},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41590142250061035},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38676774501800537},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3663036823272705},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.35042983293533325},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3259555995464325},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20012348890304565},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1391301453113556},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.13729718327522278},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.10764962434768677},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09328168630599976},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002690","descriptor_name":"Chlamydia Infections","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D002690","descriptor_name":"Chlamydia Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002692","descriptor_name":"Chlamydia trachomatis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/infdis/151.6.1037","doi":"https://doi.org/10.1093/infdis/151.6.1037","is_oa":false,"landing_page_url":"https://doi.org/10.1093/infdis/151.6.1037","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:3889172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3889172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.852.9595","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.852.9595","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jid.oxfordjournals.org/content/151/6/1037.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W93044663","https://openalex.org/W432872340","https://openalex.org/W1556883718","https://openalex.org/W1556894117","https://openalex.org/W1598777213","https://openalex.org/W1884592484","https://openalex.org/W1918393180","https://openalex.org/W1926994191","https://openalex.org/W1937410808","https://openalex.org/W1972589193","https://openalex.org/W2112677757","https://openalex.org/W2144485754","https://openalex.org/W2154734366","https://openalex.org/W2168591865","https://openalex.org/W2309032196","https://openalex.org/W2329093465"],"related_works":["https://openalex.org/W2747082597","https://openalex.org/W7036830711","https://openalex.org/W2585727310","https://openalex.org/W2329206336","https://openalex.org/W2092667396","https://openalex.org/W7164545710","https://openalex.org/W2901125732","https://openalex.org/W2590210181","https://openalex.org/W4284895880","https://openalex.org/W2518772581"],"abstract_inverted_index":{"Serotypes":[0],"of":[1,39,54,56,63,74,83,131],"Chlamydia":[2],"trachomatis":[3,41,76,135],"classified":[4],"as":[5,17],"biovar":[6],"II":[7],"strains":[8],"(immunotypes":[9],"A,":[10],"Ba,":[11],"and":[12,100,116,136],"B-K)":[13],"are":[14],"currently":[15],"recognized":[16],"important":[18],"human":[19],"pathogens":[20],"that":[21,71,107],"produce":[22,152,159],"disease":[23],"characterized":[24],"by":[25,89,98,123],"a":[26,124],"rather":[27],"complex":[28,148],"pathogenesis.":[29],"We":[30],"have":[31],"studied":[32,97],"some":[33],"morphological":[34],"phenomena":[35],"in":[36,140,153],"the":[37,52,84,108,119,137,147],"interaction":[38],"C.":[40,75,134],"(strain":[42],"UW3/Cx,":[43],"serotype":[44],"D)":[45],"with":[46,68],"HeLa":[47,65],"229":[48],"cells":[49,66,79,95],"to":[50,118,127,158],"define":[51],"mechanisms":[53,88],"release":[55],"these":[57,150],"obligate":[58],"intracellular":[59],"parasites.":[60],"Fluorescent-antibody":[61],"staining":[62],"unfixed":[64],"infected":[67],"chlamydiae":[69,91],"suggested":[70],"this":[72],"biotype":[73],"can":[77],"exit":[78],"without":[80],"concomitant":[81],"death":[82],"host":[85,114,120,138],"cell.":[86],"The":[87],"which":[90],"were":[92,96],"released":[93],"from":[94,113],"scanning":[99],"transmission":[101],"electron":[102],"microscopy.":[103],"Ultrastructural":[104],"observations":[105,130],"indicated":[106],"chlamydial":[109],"inclusion":[110],"was":[111],"segregated":[112],"cytoplasm":[115],"transported":[117],"cell":[121,139],"surface":[122],"process":[125],"similar":[126],"exocytosis.":[128],"These":[129],"interactions":[132],"between":[133],"vitro":[141],"may":[142],"be":[143],"relevant":[144],"for":[145],"understanding":[146],"pathogenesis":[149],"organisms":[151],"vivo,":[154],"specifically":[155],"their":[156],"ability":[157],"asymptomatic":[160],"or":[161],"latent":[162],"infections.":[163]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
