{"id":"https://openalex.org/W1989282155","doi":"https://doi.org/10.3892/mmr.2012.771","title":"Reduced levels of p15INK4b, p16INK4a, p21cip1 and p27kip1 in pancreatic carcinoma","display_name":"Reduced levels of p15INK4b, p16INK4a, p21cip1 and p27kip1 in pancreatic carcinoma","publication_year":2012,"publication_date":"2012-01-30","ids":{"openalex":"https://openalex.org/W1989282155","doi":"https://doi.org/10.3892/mmr.2012.771","mag":"1989282155","pmid":"https://pubmed.ncbi.nlm.nih.gov/22293850","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3493078"},"language":"en","primary_location":{"id":"doi:10.3892/mmr.2012.771","doi":"https://doi.org/10.3892/mmr.2012.771","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2012.771","pdf_url":"https://www.spandidos-publications.com/10.3892/mmr.2012.771/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.spandidos-publications.com/10.3892/mmr.2012.771/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100438635","display_name":"Gang Li","orcid":"https://orcid.org/0000-0001-7787-9330","observed_orcids":["https://orcid.org/0000-0001-7787-9330","https://orcid.org/0000-0003-3184-1032"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"GANG LI","raw_affiliation_strings":["The Third General Surgery Department, Zhanghai Hospital, Second Military Medical University, Shanghai, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third General Surgery Department, Zhanghai Hospital, Second Military Medical University, Shanghai, PR China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102011950","display_name":"Yuan Ji","orcid":"https://orcid.org/0000-0002-2631-9082","observed_orcids":["https://orcid.org/0000-0002-2631-9082"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"YUAN JI","raw_affiliation_strings":["Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, P.R. China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100322216","display_name":"Chen Liu","orcid":"https://orcid.org/0009-0003-0430-6146","observed_orcids":["https://orcid.org/0009-0003-0430-6146","https://orcid.org/0009-0008-6552-1719"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"CHEN LIU","raw_affiliation_strings":["Laboratory of Cancer Research, Tongji University School of Medicine, Shanghai, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Research, Tongji University School of Medicine, Shanghai, P.R. China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069288074","display_name":"Jingqi Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"JINGQI LI","raw_affiliation_strings":["Laboratory of Cancer Research, Tongji University School of Medicine, Shanghai, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Research, Tongji University School of Medicine, Shanghai, P.R. China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101079570","display_name":"Yingqi Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"YINGQI ZHOU","raw_affiliation_strings":["The Third General Surgery Department, Zhanghai Hospital, Second Military Medical University, Shanghai, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third General Surgery Department, Zhanghai Hospital, Second Military Medical University, Shanghai, P.R. China","institution_ids":["https://openalex.org/I177933477"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101079570"],"corresponding_institution_ids":["https://openalex.org/I177933477"],"apc_list":null,"apc_paid":null,"fwci":0.2569,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.52696681,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"5","issue":"4","first_page":"1106","last_page":"1110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.7925000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.7925000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.16599999368190765,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":1.0},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibitors","display_name":"cyclin-dependent kinase inhibitors","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cdkn2b","display_name":"CDKN2B","score":0.9810000061988831},{"id":"https://openalex.org/keywords/p16ink4a","display_name":"p16INK4a","score":1.0},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9990000128746033},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":1.0},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.8600000143051147},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.9010000228881836},{"id":"https://openalex.org/keywords/gene-downregulation","display_name":"gene downregulation","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6615841388702393},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6603875756263733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6321965456008911},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5729211568832397},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5367321968078613},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.4915059506893158},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.4860294461250305},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4713563323020935},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.46093717217445374},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4379495680332184},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4286136031150818},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37628936767578125},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.35245728492736816},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15227925777435303}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050762","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p15","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050762","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p15","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3892/mmr.2012.771","doi":"https://doi.org/10.3892/mmr.2012.771","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2012.771","pdf_url":"https://www.spandidos-publications.com/10.3892/mmr.2012.771/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2609701","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3493078","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3493078","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3493078","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Med Rep","raw_type":"Text"},{"id":"pmid:22293850","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22293850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular medicine reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/mmr.2012.771","doi":"https://doi.org/10.3892/mmr.2012.771","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2012.771","pdf_url":"https://www.spandidos-publications.com/10.3892/mmr.2012.771/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8252014856","display_name":null,"funder_award_id":"81071740","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1989282155.pdf","grobid_xml":"https://content.openalex.org/works/W1989282155.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1569698611","https://openalex.org/W1972860810","https://openalex.org/W1976284083","https://openalex.org/W1994465394","https://openalex.org/W2028313848","https://openalex.org/W2038318576","https://openalex.org/W2043103956","https://openalex.org/W2048655016","https://openalex.org/W2066848701","https://openalex.org/W2071622021","https://openalex.org/W2080024180","https://openalex.org/W2083663096","https://openalex.org/W2089218510","https://openalex.org/W2089673328","https://openalex.org/W2090705477","https://openalex.org/W2092536750","https://openalex.org/W2098911357","https://openalex.org/W2099023480","https://openalex.org/W2121619780","https://openalex.org/W2122574275","https://openalex.org/W2140158655","https://openalex.org/W2144140851","https://openalex.org/W2172206677","https://openalex.org/W6678372251"],"related_works":["https://openalex.org/W2031839147","https://openalex.org/W70642674","https://openalex.org/W1977624574","https://openalex.org/W1966639069","https://openalex.org/W2357993890","https://openalex.org/W2144140851","https://openalex.org/W2370059759","https://openalex.org/W1222822579","https://openalex.org/W3176982902","https://openalex.org/W1537913293"],"abstract_inverted_index":{"Pancreatic":[0],"carcinoma":[1,65,117,170,205],"is":[2],"one":[3],"of":[4,8,16,24,32,44,56,88,91,102,115,122,130,132,138,140,146,176,183,198,221],"the":[5,13,30,38,42,50,53,85,89,103,123,133,141,147,163,219],"leading":[6],"causes":[7],"cancer":[9],"mortality":[10],"worldwide,":[11],"although":[12],"molecular":[14],"mechanisms":[15],"this":[17,25,95,189],"disease":[18],"are":[19,111],"poorly":[20],"understood.":[21],"The":[22,119],"aim":[23],"study":[26],"was":[27,80,125,160],"to":[28,74,83],"examine":[29,84],"expression":[31,175],"cyclin-dependent":[33],"kinase":[34],"inhibitors":[35],"(CDKIs)":[36],"and":[37,59,69,109,144],"epigenetic":[39,210],"modifications":[40],"in":[41,62,127,162,167,185,202,224],"promoters":[43,90],"these":[45,186],"genes.":[46,93],"We":[47,207],"also":[48],"evaluated":[49],"correlation":[51],"between":[52],"methylation":[54,86,197],"status":[55,87],"CDKI":[57,76,92,104,200,222],"genes":[58,143,201,223],"smoking":[60,194],"habit":[61,195],"clinical":[63],"pancreatic":[64,116,169,204,225],"specimens.":[66,206],"Western":[67],"blotting":[68],"real-time":[70],"PCR":[71,79],"were":[72],"performed":[73],"assess":[75],"expression.":[77,157],"Methylation-specific":[78],"carried":[81],"out":[82],"In":[94,188],"study,":[96,190],"we":[97],"revealed":[98],"that":[99,209],"reduced":[100],"levels":[101],"proteins,":[105],"p15INK4b,":[106],"p16INK4a,":[107],"p21cip1":[108,148],"p27kip1,":[110],"a":[112,193,215],"prominent":[113],"feature":[114],"patients.":[118,187],"DNA":[120],"hypermethylation":[121,159,213],"promoter":[124,166],"observed":[126],"40%":[128],"(2":[129],"5)":[131,139],"p15INK4b":[134],"genes,":[135,149],"60%":[136,145],"(3":[137],"p16INK4a":[142],"which":[150],"markedly":[151,173],"correlated":[152],"with":[153,172,192],"their":[154,203],"decreased":[155,174],"mRNA":[156],"No":[158],"detected":[161],"p27kip1":[164,177],"gene":[165],"5":[168],"patients":[171,191],"mRNA,":[178],"suggesting":[179],"an":[180],"alternative":[181],"mechanism":[182,217],"p27kip":[184],"displayed":[196],"2":[199],"concluded":[208],"modification":[211],"via":[212],"represents":[214],"critical":[216],"for":[218],"inactivation":[220],"carcinoma.":[226]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}