{"id":"https://openalex.org/W1989239108","doi":"https://doi.org/10.7164/antibiotics.54.340","title":"New Type II Manumycins Produced by Streptomyces nodosus ssp. asukaensis and Their Biosynthesis.","display_name":"New Type II Manumycins Produced by Streptomyces nodosus ssp. asukaensis and Their Biosynthesis.","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W1989239108","doi":"https://doi.org/10.7164/antibiotics.54.340","mag":"1989239108","pmid":"https://pubmed.ncbi.nlm.nih.gov/11426658"},"language":"en","primary_location":{"id":"doi:10.7164/antibiotics.54.340","doi":"https://doi.org/10.7164/antibiotics.54.340","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.54.340","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/54/4/54_4_340/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/54/4/54_4_340/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111820133","display_name":"Yiding Hu","orcid":"https://orcid.org/0009-0003-3009-9435","observed_orcids":["https://orcid.org/0009-0003-3009-9435"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"YIDING HU","raw_affiliation_strings":["Department of Chemistry, University of Washington, Seattle 98195-1700, USA","Department of Chemistry Box 351700, University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Washington, Seattle 98195-1700, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Chemistry Box 351700, University of Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027410094","display_name":"Heinz G. Floss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"HEINZ G. FLOSS","raw_affiliation_strings":["Department of Chemistry, Box 351700, University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Box 351700, University of Washington","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.4453,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.65432781,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"54","issue":"4","first_page":"340","last_page":"348"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biosynthetic-origin","display_name":"biosynthetic origin","score":0.6610000133514404},{"id":"https://openalex.org/keywords/13c-labeling","display_name":"13C labeling","score":0.6499999761581421},{"id":"https://openalex.org/keywords/natural-product-biosynthesis","display_name":"natural product biosynthesis","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.6784305572509766},{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.6455348134040833},{"id":"https://openalex.org/C2777915650","wikidata":"https://www.wikidata.org/wiki/Q1430556","display_name":"Streptomycetaceae","level":5,"score":0.5815497636795044},{"id":"https://openalex.org/C2776060363","wikidata":"https://www.wikidata.org/wiki/Q343452","display_name":"Actinomycetales","level":4,"score":0.4337043762207031},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42995569109916687},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.41822534799575806},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39232364296913147},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.38297179341316223},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26909875869750977},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.23743155598640442},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11455726623535156},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.047628551721572876}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002855","descriptor_name":"Chromatography, Thin Layer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005285","descriptor_name":"Fermentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011090","descriptor_name":"Polyenes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D011090","descriptor_name":"Polyenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053284","descriptor_name":"Polyunsaturated Alkamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.7164/antibiotics.54.340","doi":"https://doi.org/10.7164/antibiotics.54.340","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.54.340","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/54/4/54_4_340/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},{"id":"pmid:11426658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11426658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antibiotics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7164/antibiotics.54.340","doi":"https://doi.org/10.7164/antibiotics.54.340","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.54.340","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/54/4/54_4_340/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1287679552","display_name":null,"funder_award_id":"AI-20264","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4326945634","display_name":"BIOLOGICALLY ACTIVE MICROBIAL METABOLITES","funder_award_id":"R01AI020264","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1989239108.pdf","grobid_xml":"https://content.openalex.org/works/W1989239108.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W623820796","https://openalex.org/W1970080442","https://openalex.org/W1981223977","https://openalex.org/W1986731228","https://openalex.org/W2008319612","https://openalex.org/W2034545230","https://openalex.org/W2034678670","https://openalex.org/W2035392907","https://openalex.org/W2049220891","https://openalex.org/W2055097128","https://openalex.org/W2055674022","https://openalex.org/W2059279550","https://openalex.org/W2079495138","https://openalex.org/W2091104804","https://openalex.org/W2132029924","https://openalex.org/W2177830855","https://openalex.org/W2951640931","https://openalex.org/W2952461266"],"related_works":["https://openalex.org/W2952758042","https://openalex.org/W1569866767","https://openalex.org/W2052401996","https://openalex.org/W2055652254","https://openalex.org/W7135648052","https://openalex.org/W7132704569","https://openalex.org/W4281672206","https://openalex.org/W2331143633","https://openalex.org/W2951988530","https://openalex.org/W1999030013"],"abstract_inverted_index":{"Five":[0],"new":[1],"type":[2,30,35],"II":[3,31],"manumycins,":[4],"containing":[5,38],"the":[6,29,34,46],"hydroxyquinol":[7],"mC7N":[8,41],"unit,":[9,42],"asukamycins":[10],"A-II,":[11],"B-II,":[12],"C-II,":[13],"D-II,":[14],"E-II,":[15],"were":[16],"discovered":[17],"in":[18],"cultures":[19],"of":[20,28,49],"Streptomyces":[21],"nodosus":[22],"ssp.":[23],"asukaensis.":[24],"The":[25],"biosynthetic":[26],"origin":[27],"manumycins":[32],"from":[33,45],"I":[36],"compounds,":[37],"an":[39],"epoxyquinol":[40],"was":[43],"deduced":[44],"time":[47],"course":[48],"production":[50],"and":[51,57],"proven":[52],"by":[53],"preparing":[54],"[7'-13C]asukamycin":[55],"A":[56],"demonstrating":[58],"its":[59],"incorporation":[60],"into":[61],"asukamycin":[62],"A-II.":[63]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}