{"id":"https://openalex.org/W1989199880","doi":"https://doi.org/10.1139/o67-118","title":"RIBONUCLEASE ACTIVITY IN REGENERATING RAT LIVER","display_name":"RIBONUCLEASE ACTIVITY IN REGENERATING RAT LIVER","publication_year":1967,"publication_date":"1967-07-01","ids":{"openalex":"https://openalex.org/W1989199880","doi":"https://doi.org/10.1139/o67-118","mag":"1989199880"},"language":"en","primary_location":{"id":"doi:10.1139/o67-118","doi":"https://doi.org/10.1139/o67-118","is_oa":false,"landing_page_url":"https://doi.org/10.1139/o67-118","pdf_url":null,"source":{"id":"https://openalex.org/S4210188051","display_name":"Canadian Journal of Biochemistry","issn_l":"0008-4018","issn":["0008-4018"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071010327","display_name":"D. J. S. Arora","orcid":"https://orcid.org/0000-0002-1707-2284","observed_orcids":["https://orcid.org/0000-0002-1707-2284"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. J. S. Arora","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000837762","display_name":"Gaston de Lamirande","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. de Lamirande","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.1569,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.9694501,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"7","first_page":"1021","last_page":"1026"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rnase-activity","display_name":"ribonuclease activity","score":0.9200000166893005},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.9750000238418579},{"id":"https://openalex.org/keywords/partial-hepatectomy","display_name":"partial hepatectomy","score":0.996999979019165},{"id":"https://openalex.org/keywords/ribosome","display_name":"ribosome","score":0.8209999799728394},{"id":"https://openalex.org/keywords/ribonucleoprotein-particles","display_name":"ribonucleoprotein particles","score":0.9039999842643738},{"id":"https://openalex.org/keywords/ribosome-stability","display_name":"ribosome stability","score":0.8899999856948853},{"id":"https://openalex.org/keywords/rat-liver","display_name":"rat liver","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C2778976237","wikidata":"https://www.wikidata.org/wiki/Q422523","display_name":"Ribonuclease","level":4,"score":0.8776091933250427},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.672096312046051},{"id":"https://openalex.org/C2776795407","wikidata":"https://www.wikidata.org/wiki/Q19597761","display_name":"Liver regeneration","level":3,"score":0.6606788039207458},{"id":"https://openalex.org/C75934600","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Ribonucleoprotein","level":4,"score":0.6510446667671204},{"id":"https://openalex.org/C2776909242","wikidata":"https://www.wikidata.org/wiki/Q1514021","display_name":"Hepatectomy","level":3,"score":0.5755565762519836},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5064786672592163},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.5063108205795288},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4523147940635681},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4209354519844055},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4174092411994934},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4138121008872986},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.3966735303401947},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37283921241760254},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3520203232765198},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17214611172676086},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09459331631660461},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.08700981736183167},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.07547703385353088},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04865804314613342}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1139/o67-118","doi":"https://doi.org/10.1139/o67-118","is_oa":false,"landing_page_url":"https://doi.org/10.1139/o67-118","pdf_url":null,"source":{"id":"https://openalex.org/S4210188051","display_name":"Canadian Journal of Biochemistry","issn_l":"0008-4018","issn":["0008-4018"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Biochemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1850394361","https://openalex.org/W1923338484","https://openalex.org/W1991966999","https://openalex.org/W1993503888","https://openalex.org/W2010619084","https://openalex.org/W2019647756","https://openalex.org/W2027209957","https://openalex.org/W2030983033","https://openalex.org/W2040363109","https://openalex.org/W2066721283"],"related_works":["https://openalex.org/W2028356154","https://openalex.org/W1964883670","https://openalex.org/W1573168059","https://openalex.org/W1972682977","https://openalex.org/W2030980695","https://openalex.org/W22792978","https://openalex.org/W2021600712","https://openalex.org/W65576374","https://openalex.org/W2081711908","https://openalex.org/W2095194835"],"abstract_inverted_index":{"Ribonucleoprotein":[0],"particles":[1],"were":[2],"isolated":[3],"from":[4,114],"sham-hepatectomized":[5],"and":[6,15,38,91,120],"partially":[7],"hepatectomized":[8],"animals.":[9],"The":[10,44,83],"levels":[11],"of":[12,16,33,50,71,80,97,129],"ribonucleic":[13],"acid":[14],"proteins,":[17],"as":[18,20,59],"well":[19],"the":[21,48,62,77,98,104,112,121,127],"ribosomal":[22],"ribonuclease":[23,72,84],"activity,":[24],"have":[25],"been":[26],"studied":[27],"in":[28,52,65,76],"regenerating":[29,53,115],"liver":[30,55,81,116],"at":[31,89,103],"periods":[32],"4,":[34],"8,":[35],"16,":[36],"36,":[37],"72":[39],"hours":[40],"after":[41,107],"partial":[42,108],"hepatectomy.":[43],"results":[45],"showed":[46],"that":[47,111],"amount":[49],"ribosomes":[51,113],"rat":[54],"was":[56,74,86,101],"not":[57],"affected":[58],"compared":[60],"with":[61],"level":[63],"observed":[64],"sham-operated":[66],"rats.":[67],"However,":[68],"a":[69],"decrease":[70],"activity":[73,85,100],"noticed":[75],"early":[78],"stages":[79],"regeneration.":[82],"practically":[87],"negligible":[88],"16":[90],"36":[92],"hours.":[93],"Less":[94],"than":[95],"50%":[96],"enzymatic":[99],"regained":[102],"72-hour":[105],"period":[106],"hepatectomy.Results":[109],"show":[110],"are":[117],"more":[118],"stable":[119],"stabilizing":[122],"factor":[123],"seems":[124],"to":[125],"be":[126],"absence":[128],"ribonuclease.":[130]},"counts_by_year":[],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2016-06-24T00:00:00"}