{"id":"https://openalex.org/W1989180020","doi":"https://doi.org/10.5483/bmbrep.2007.40.5.690","title":"Alteration of The Quaternary Structure of Human UDP-Glucose Dehydrogenase by a Double Mutation","display_name":"Alteration of The Quaternary Structure of Human UDP-Glucose Dehydrogenase by a Double Mutation","publication_year":2007,"publication_date":"2007-09-30","ids":{"openalex":"https://openalex.org/W1989180020","doi":"https://doi.org/10.5483/bmbrep.2007.40.5.690","mag":"1989180020","pmid":"https://pubmed.ncbi.nlm.nih.gov/17927902"},"language":"en","primary_location":{"id":"doi:10.5483/bmbrep.2007.40.5.690","doi":"https://doi.org/10.5483/bmbrep.2007.40.5.690","is_oa":true,"landing_page_url":"https://doi.org/10.5483/bmbrep.2007.40.5.690","pdf_url":"http://koreascience.or.kr:80/article/JAKO200710103425919.pdf","source":{"id":"https://openalex.org/S58514918","display_name":"BMB Reports","issn_l":"1976-6696","issn":["1976-6696","1976-670X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","kci-registered","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319427","host_organization_name":"Korean Society for Biochemistry and Molecular Biology","host_organization_lineage":["https://openalex.org/P4310319427"],"host_organization_lineage_names":["Korean Society for Biochemistry and Molecular Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMB Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://koreascience.or.kr:80/article/JAKO200710103425919.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109988471","display_name":"Jae\u2010Wan Huh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae-Wan Huh","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Ulsan, College of Medicine, Seoul 138-736, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Ulsan, College of Medicine, Seoul 138-736, Korea","institution_ids":["https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069021637","display_name":"Seung-Ju Yang","orcid":"https://orcid.org/0000-0001-9261-2749","observed_orcids":["https://orcid.org/0000-0001-9261-2749"]},"institutions":[{"id":"https://openalex.org/I165028127","display_name":"Konyang University","ror":"https://ror.org/02v8yp068","country_code":"KR","type":"education","lineage":["https://openalex.org/I165028127"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung-Ju Yang","raw_affiliation_strings":["Department of Biomedical Laboratory Science, Konyang University, Daejeon 320-718, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Laboratory Science, Konyang University, Daejeon 320-718, Korea","institution_ids":["https://openalex.org/I165028127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061879160","display_name":"Eun Young Hwang","orcid":"https://orcid.org/0000-0003-1997-1352","observed_orcids":["https://orcid.org/0000-0003-1997-1352"]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun-Young Hwang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 138-736, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 138-736, Korea","institution_ids":["https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090961780","display_name":"Myung\u2010Min Choi","orcid":"https://orcid.org/0000-0002-7242-297X","observed_orcids":["https://orcid.org/0000-0002-7242-297X"]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Myung-Min Choi","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 138-736, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 138-736, Korea","institution_ids":["https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100355268","display_name":"Hyunju Lee","orcid":"https://orcid.org/0000-0003-2389-7183","observed_orcids":["https://orcid.org/0000-0003-2389-7183","https://orcid.org/0000-0002-4532-6448"]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun-Ju Lee","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 138-736, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 138-736, Korea","institution_ids":["https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043659616","display_name":"Eun-A L Kim","orcid":"https://orcid.org/0000-0002-8582-234X","observed_orcids":["https://orcid.org/0000-0002-8582-234X"]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun-A Kim","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 138-736, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 138-736, Korea","institution_ids":["https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101316719","display_name":"Soo-Young Choi","orcid":"https://orcid.org/0009-0001-5011-8918","observed_orcids":["https://orcid.org/0009-0001-5011-8918"]},"institutions":[{"id":"https://openalex.org/I146824383","display_name":"Hallym University","ror":"https://ror.org/03sbhge02","country_code":"KR","type":"education","lineage":["https://openalex.org/I146824383"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Soo-Young Choi","raw_affiliation_strings":["Department of Biomedical Sciences, Hallym University, Chunchon 200-702, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Hallym University, Chunchon 200-702, Korea","institution_ids":["https://openalex.org/I146824383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028940266","display_name":"Jene Choi","orcid":"https://orcid.org/0000-0001-7618-7519","observed_orcids":["https://orcid.org/0000-0001-7618-7519"]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jene Choi","raw_affiliation_strings":["Department of Pathology, University of Ulsan College of Medicine, Seoul 138-736, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Ulsan College of Medicine, Seoul 138-736, Korea","institution_ids":["https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102152877","display_name":"Hea\u2010Nam Hong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hea-Nam Hong","raw_affiliation_strings":["Department of Anatomy and Cell Biology, University of Ulsan College of Medicine, Seoul 138-736, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, University of Ulsan College of Medicine, Seoul 138-736, Korea","institution_ids":["https://openalex.org/I40542001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101543585","display_name":"Sung\u2010Woo Cho","orcid":"https://orcid.org/0000-0003-3786-6484","observed_orcids":["https://orcid.org/0000-0003-3786-6484"]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sung-Woo Cho","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 138-736, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 138-736, Korea","institution_ids":["https://openalex.org/I40542001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101543585"],"corresponding_institution_ids":["https://openalex.org/I40542001"],"apc_list":{"value":550,"currency":"USD","value_usd":550},"apc_paid":{"value":550,"currency":"USD","value_usd":550},"fwci":0.2368,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.57670562,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"40","issue":"5","first_page":"690","last_page":"696"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.042500000447034836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/udp-glucose-dehydrogenase","display_name":"UDP-glucose dehydrogenase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/quaternary-structure","display_name":"quaternary structure","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hexameric-structure","display_name":"hexameric structure","score":0.7580000162124634},{"id":"https://openalex.org/keywords/double-mutations","display_name":"double mutations","score":0.6759999990463257},{"id":"https://openalex.org/keywords/protein-dimerization","display_name":"protein dimerization","score":0.7300000190734863},{"id":"https://openalex.org/keywords/substrate-affinity","display_name":"substrate affinity","score":0.8190000057220459},{"id":"https://openalex.org/keywords/streptococcus-pyogenes","display_name":"Streptococcus pyogenes","score":0.8360000252723694},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C7927669","wikidata":"https://www.wikidata.org/wiki/Q898529","display_name":"Protein quaternary structure","level":4,"score":0.7360353469848633},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.7225262522697449},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.6562689542770386},{"id":"https://openalex.org/C2780283098","wikidata":"https://www.wikidata.org/wiki/Q4688960","display_name":"Affinities","level":2,"score":0.6021778583526611},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5945241451263428},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.5783405303955078},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5287786722183228},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45443645119667053},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4458011984825134},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.42448002099990845},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.38245877623558044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36749038100242615},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33949393033981323},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09010681509971619}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014533","descriptor_name":"Uridine Diphosphate Glucose Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014533","descriptor_name":"Uridine Diphosphate Glucose Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014533","descriptor_name":"Uridine Diphosphate Glucose Dehydrogenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.5483/bmbrep.2007.40.5.690","doi":"https://doi.org/10.5483/bmbrep.2007.40.5.690","is_oa":true,"landing_page_url":"https://doi.org/10.5483/bmbrep.2007.40.5.690","pdf_url":"http://koreascience.or.kr:80/article/JAKO200710103425919.pdf","source":{"id":"https://openalex.org/S58514918","display_name":"BMB Reports","issn_l":"1976-6696","issn":["1976-6696","1976-670X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","kci-registered","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319427","host_organization_name":"Korean Society for Biochemistry and Molecular Biology","host_organization_lineage":["https://openalex.org/P4310319427"],"host_organization_lineage_names":["Korean Society for Biochemistry and Molecular Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMB Reports","raw_type":"journal-article"},{"id":"pmid:17927902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17927902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemistry and molecular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.5483/bmbrep.2007.40.5.690","doi":"https://doi.org/10.5483/bmbrep.2007.40.5.690","is_oa":true,"landing_page_url":"https://doi.org/10.5483/bmbrep.2007.40.5.690","pdf_url":"http://koreascience.or.kr:80/article/JAKO200710103425919.pdf","source":{"id":"https://openalex.org/S58514918","display_name":"BMB Reports","issn_l":"1976-6696","issn":["1976-6696","1976-670X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","kci-registered","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319427","host_organization_name":"Korean Society for Biochemistry and Molecular Biology","host_organization_lineage":["https://openalex.org/P4310319427"],"host_organization_lineage_names":["Korean Society for Biochemistry and Molecular Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMB Reports","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1989180020.pdf","grobid_xml":"https://content.openalex.org/works/W1989180020.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W587997370","https://openalex.org/W1479759526","https://openalex.org/W1590379492","https://openalex.org/W1593567129","https://openalex.org/W1889077695","https://openalex.org/W1974541622","https://openalex.org/W1974629826","https://openalex.org/W1975993749","https://openalex.org/W1989364648","https://openalex.org/W1990938993","https://openalex.org/W1992277952","https://openalex.org/W1994051122","https://openalex.org/W1994158354","https://openalex.org/W1997124026","https://openalex.org/W2001242899","https://openalex.org/W2003199291","https://openalex.org/W2016003895","https://openalex.org/W2019204518","https://openalex.org/W2025853015","https://openalex.org/W2070001543","https://openalex.org/W2072906796","https://openalex.org/W2085595045","https://openalex.org/W2113780941","https://openalex.org/W2129138696","https://openalex.org/W2132417094","https://openalex.org/W2164704435","https://openalex.org/W2413758164","https://openalex.org/W2420913585","https://openalex.org/W4245537525"],"related_works":["https://openalex.org/W2076421632","https://openalex.org/W1994051122","https://openalex.org/W18314362","https://openalex.org/W2036552153","https://openalex.org/W2982587785","https://openalex.org/W1963713023","https://openalex.org/W2406590514","https://openalex.org/W2089547522","https://openalex.org/W2969614474","https://openalex.org/W2129138696"],"abstract_inverted_index":{"There":[0],"are":[1,88],"conflicting":[2],"views":[3],"for":[4,25,63,86,102],"the":[5,78,82],"polymerization":[6],"process":[7],"of":[8],"human":[9],"UDP-glucose":[10],"dehydrogenase":[11],"(UGDH)":[12],"and":[13,43,52,70,81],"no":[14,38],"clear":[15],"evidence":[16],"has":[17],"been":[18],"reported":[19],"yet.":[20],"Based":[21],"on":[22,40],"crystal":[23],"coordinates":[24],"Streptococcus":[26],"pyogenes":[27],"UGDH,":[28],"we":[29],"made":[30],"double":[31,35],"mutant":[32],"A222Q/S233G.":[33],"The":[34],"mutagenesis":[36],"had":[37],"effects":[39],"expression,":[41],"stability,":[42],"secondary":[44],"structure.":[45],"Interestingly,":[46],"A222Q/S233G":[47],"was":[48],"a":[49],"dimeric":[50],"form":[51],"showed":[53,59],"an":[54,73],"UGDH":[55],"activity,":[56],"although":[57,95],"it":[58],"increased":[60],"Km":[61],"values":[62],"substrates.":[64],"These":[65],"results":[66],"suggest":[67],"that":[68],"Ala222":[69],"Ser233":[71],"play":[72],"important":[74],"role":[75],"in":[76],"maintaining":[77],"hexameric":[79],"structure":[80,97],"reduced":[83],"binding":[84],"affinities":[85],"substrates":[87],"attributable":[89],"to":[90],"its":[91],"altered":[92],"subunit":[93],"communication":[94],"quaternary":[96],"may":[98],"not":[99],"be":[100],"critical":[101],"catalysis.":[103]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
