{"id":"https://openalex.org/W1989048765","doi":"https://doi.org/10.1074/jbc.m112.374058","title":"Modulation of Inositol 1,4,5-Trisphosphate Receptor Type 2 Channel Activity by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII)-mediated Phosphorylation","display_name":"Modulation of Inositol 1,4,5-Trisphosphate Receptor Type 2 Channel Activity by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII)-mediated Phosphorylation","publication_year":2012,"publication_date":"2012-09-30","ids":{"openalex":"https://openalex.org/W1989048765","doi":"https://doi.org/10.1074/jbc.m112.374058","mag":"1989048765","pmid":"https://pubmed.ncbi.nlm.nih.gov/23019322","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3501088"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m112.374058","doi":"https://doi.org/10.1074/jbc.m112.374058","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.374058","pdf_url":"http://www.jbc.org/article/S0021925820622402/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820622402/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035660348","display_name":"Joshua T. Maxwell","orcid":"https://orcid.org/0000-0001-7389-5245","observed_orcids":["https://orcid.org/0000-0001-7389-5245"]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua T. Maxwell","raw_affiliation_strings":["Department of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois 60153, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois 60153, USA","institution_ids":["https://openalex.org/I1925986","https://openalex.org/I4210159390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007991211","display_name":"Sankar Natesan","orcid":"https://orcid.org/0000-0003-0927-8853","observed_orcids":["https://orcid.org/0000-0003-0927-8853"]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sankar Natesan","raw_affiliation_strings":["Department of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois 60153","From the \u2021Department of Cell and Molecular Physiology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois 60153","institution_ids":["https://openalex.org/I1925986"]},{"raw_affiliation_string":"From the \u2021Department of Cell and Molecular Physiology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153;","institution_ids":["https://openalex.org/I1925986","https://openalex.org/I4210159390"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114067960","display_name":"Gregory A. Mignery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregory A. Mignery","raw_affiliation_strings":["Department of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois 60153","From the \u2021Department of Cell and Molecular Physiology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois 60153","institution_ids":["https://openalex.org/I1925986"]},{"raw_affiliation_string":"From the \u2021Department of Cell and Molecular Physiology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153;","institution_ids":["https://openalex.org/I1925986","https://openalex.org/I4210159390"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5114067960"],"corresponding_institution_ids":["https://openalex.org/I1925986","https://openalex.org/I4210159390"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.6422,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.64524402,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"287","issue":"47","first_page":"39419","last_page":"39428"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7289999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7289999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.20430000126361847,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/camkii","display_name":"CaMKII","score":0.9440000057220459},{"id":"https://openalex.org/keywords/camkiidelta","display_name":"CaMKII\u03b4","score":0.7820000052452087},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.6119999885559082},{"id":"https://openalex.org/keywords/open-probability","display_name":"open probability","score":0.8690000176429749},{"id":"https://openalex.org/keywords/calcium-release","display_name":"calcium release","score":0.6909999847412109},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8009999990463257},{"id":"https://openalex.org/keywords/phosphomimetic-mutations","display_name":"phosphomimetic mutations","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7569246292114258},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.6526739001274109},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5110608339309692},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5091843008995056},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4522944688796997},{"id":"https://openalex.org/C152624196","wikidata":"https://www.wikidata.org/wiki/Q418917","display_name":"Inositol trisphosphate receptor","level":4,"score":0.44100499153137207},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.43622493743896484},{"id":"https://openalex.org/C2781387506","wikidata":"https://www.wikidata.org/wiki/Q138145","display_name":"Inositol trisphosphate","level":4,"score":0.42656978964805603},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3640718162059784},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3560647964477539},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3381636142730713}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053496","descriptor_name":"Inositol 1,4,5-Trisphosphate Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053496","descriptor_name":"Inositol 1,4,5-Trisphosphate Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m112.374058","doi":"https://doi.org/10.1074/jbc.m112.374058","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.374058","pdf_url":"http://www.jbc.org/article/S0021925820622402/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2814976","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3501088","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3501088","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3501088","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:23019322","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23019322","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m112.374058","doi":"https://doi.org/10.1074/jbc.m112.374058","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.374058","pdf_url":"http://www.jbc.org/article/S0021925820622402/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1644961519","display_name":"CaMKII and InsP3-Mediated Signaling in Cardiac Myocytes","funder_award_id":"P01HL080101","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1989048765.pdf","grobid_xml":"https://content.openalex.org/works/W1989048765.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1490359669","https://openalex.org/W1519110908","https://openalex.org/W1536950013","https://openalex.org/W1594175255","https://openalex.org/W1599277155","https://openalex.org/W1729732610","https://openalex.org/W1964152667","https://openalex.org/W1972265168","https://openalex.org/W1996602476","https://openalex.org/W2001907971","https://openalex.org/W2002287591","https://openalex.org/W2008667203","https://openalex.org/W2008906006","https://openalex.org/W2014843536","https://openalex.org/W2028452724","https://openalex.org/W2039916525","https://openalex.org/W2041979699","https://openalex.org/W2044107405","https://openalex.org/W2060891098","https://openalex.org/W2067137426","https://openalex.org/W2070690670","https://openalex.org/W2087693277","https://openalex.org/W2099883571","https://openalex.org/W2113111385","https://openalex.org/W2115900546","https://openalex.org/W2116297568","https://openalex.org/W2118075049","https://openalex.org/W2147528853","https://openalex.org/W2155499648","https://openalex.org/W2168556429","https://openalex.org/W2172253369"],"related_works":["https://openalex.org/W2028261862","https://openalex.org/W1576873947","https://openalex.org/W2033628728","https://openalex.org/W2258812490","https://openalex.org/W1885337384","https://openalex.org/W2041979699","https://openalex.org/W2035786682","https://openalex.org/W1998828489","https://openalex.org/W2129774784","https://openalex.org/W2625960276"],"abstract_inverted_index":{"InsP(3)-mediated":[0],"calcium":[1],"release":[2],"through":[3],"the":[4,16,23,58,68,77,91,127,141,185,197],"type":[5],"2":[6],"inositol":[7],"1,4,5-trisphosphate":[8],"receptor":[9],"(InsP(3)R2)":[10],"in":[11,15,53,57,67,109,120,140,171,193,196],"cardiac":[12],"myocytes":[13],"results":[14,52,176,192],"activation":[17],"of":[18,98,143,177,184],"associated":[19],"CaMKII,":[20],"thus":[21],"enabling":[22],"kinase":[24],"to":[25],"act":[26],"on":[27],"downstream":[28],"targets,":[29],"such":[30],"as":[31,76],"histone":[32],"deacetylases":[33],"4":[34],"and":[35,38,51,103,148,152,191],"5":[36],"(HDAC4":[37],"HDAC5).":[39],"The":[40,113,175],"CaMKII":[41,92,144,190],"activity":[42,121],"also":[43],"feedback":[44],"modulates":[45],"InsP(3)R2":[46,69,114,167,186],"function":[47],"by":[48,83,161,173,189],"direct":[49],"phosphorylation":[50,93],"a":[54,132,154,194],"dramatic":[55],"decrease":[56,119,195],"receptor-channel":[59],"open":[60,199],"probability":[61],"(P(o)).":[62],"We":[63],"have":[64],"identified":[65],"S150":[66,89],"core":[70],"suppressor":[71],"domain":[72],"(amino":[73],"acids":[74],"1-225)":[75],"specific":[78],"residue":[79],"that":[80,88,157,166,181],"is":[81,90,169,187],"phosphorylated":[82,160,170,188],"CaMKII.":[84,125,162],"Site-directed":[85],"mutagenesis":[86],"reveals":[87],"site":[94],"responsible":[95],"for":[96],"modulation":[97],"channel":[99,116,130,156,198],"activity.":[100],"Nonphosphorylatable":[101],"(S150A)":[102],"phosphomimetic":[104,128],"(S150E)":[105,129],"mutations":[106],"were":[107],"studied":[108],"planar":[110],"lipid":[111],"bilayers.":[112],"S150A":[115],"showed":[117],"no":[118],"when":[122],"treated":[123],"with":[124],"Conversely,":[126],"displayed":[131],"very":[133],"low":[134],"P(o)":[135],"under":[136],"normal":[137],"recording":[138],"conditions":[139],"absence":[142],"(2":[145],"\u03bcM":[146],"InsP(3)":[147],"250":[149],"nM":[150],"[Ca(2+)](FREE))":[151],"mimicked":[153],"WT":[155],"has":[158],"been":[159],"Phopho-specific":[163],"antibodies":[164],"demonstrate":[165],"Ser-150":[168],"vivo":[172],"CaMKII\u03b4.":[174],"this":[178],"study":[179],"show":[180],"serine":[182],"150":[183],"probability.":[200]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
