{"id":"https://openalex.org/W1988968768","doi":"https://doi.org/10.1210/jcem-45-2-330","title":"Lack of a Simple Relationship Between Endogenous Growth Hormone and NSILA-s Related Peptides","display_name":"Lack of a Simple Relationship Between Endogenous Growth Hormone and NSILA-s Related Peptides","publication_year":1977,"publication_date":"1977-08-01","ids":{"openalex":"https://openalex.org/W1988968768","doi":"https://doi.org/10.1210/jcem-45-2-330","mag":"1988968768","pmid":"https://pubmed.ncbi.nlm.nih.gov/885996"},"language":"en","primary_location":{"id":"doi:10.1210/jcem-45-2-330","doi":"https://doi.org/10.1210/jcem-45-2-330","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-45-2-330","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109098989","display_name":"KLARA MEGYESI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"KLARA MEGYESI","raw_affiliation_strings":["Diabetes Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070064147","display_name":"Phillip G\u00f6rden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"PHILLIP GORDEN","raw_affiliation_strings":["Diabetes Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091362054","display_name":"C. RONALD KANN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. RONALD KANN","raw_affiliation_strings":["Diabetes Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.8496,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.88688362,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"45","issue":"2","first_page":"330","last_page":"338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.7300000190734863},{"id":"https://openalex.org/keywords/insulin-like-growth-factor","display_name":"insulin-like growth factor","score":0.8050000071525574},{"id":"https://openalex.org/keywords/growth-hormone-regulation","display_name":"growth hormone regulation","score":0.3880000114440918},{"id":"https://openalex.org/keywords/fasting","display_name":"fasting","score":0.6460000276565552},{"id":"https://openalex.org/keywords/hypopituitarism","display_name":"hypopituitarism","score":0.8270000219345093},{"id":"https://openalex.org/keywords/acromegaly","display_name":"acromegaly","score":0.9860000014305115},{"id":"https://openalex.org/keywords/oral-glucose","display_name":"oral glucose","score":0.5640000104904175},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.8259999752044678},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.9539999961853027},{"id":"https://openalex.org/keywords/l-dopa","display_name":"L-DOPA","score":0.9100000262260437},{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":0.9980000257492065},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7506471872329712},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7049742341041565},{"id":"https://openalex.org/C80862487","wikidata":"https://www.wikidata.org/wiki/Q415679","display_name":"Somatomedin","level":4,"score":0.6240729093551636},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5669850707054138},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.4992966651916504},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4830187261104584},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47966268658638},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2001740038394928}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004295","descriptor_name":"Dihydroxyphenylalanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011869","descriptor_name":"Radioligand Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013002","descriptor_name":"Somatomedins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013217","descriptor_name":"Starvation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/jcem-45-2-330","doi":"https://doi.org/10.1210/jcem-45-2-330","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-45-2-330","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:885996","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/885996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W3765645","https://openalex.org/W322812660","https://openalex.org/W1526566805","https://openalex.org/W1927531004","https://openalex.org/W1964239865","https://openalex.org/W1978850951","https://openalex.org/W1985234572","https://openalex.org/W1989370995","https://openalex.org/W1993671654","https://openalex.org/W1998411386","https://openalex.org/W2017343559","https://openalex.org/W2029885359","https://openalex.org/W2033728462","https://openalex.org/W2039242258","https://openalex.org/W2052797391","https://openalex.org/W2053134566","https://openalex.org/W2076027242","https://openalex.org/W2090532551","https://openalex.org/W2097551860","https://openalex.org/W2137902303","https://openalex.org/W2146188417","https://openalex.org/W2250113602","https://openalex.org/W2289622023","https://openalex.org/W2413805152","https://openalex.org/W2414658238"],"related_works":["https://openalex.org/W2103804905","https://openalex.org/W2146188417","https://openalex.org/W2049571285","https://openalex.org/W2020635408","https://openalex.org/W2138651184","https://openalex.org/W1977712461","https://openalex.org/W2085555886","https://openalex.org/W1413763750","https://openalex.org/W1976170865","https://openalex.org/W2033728462"],"abstract_inverted_index":{"Using":[0],"a":[1,70,85,102,146,155,161],"liver":[2],"membrane":[3],"radioreceptor":[4,211],"assay":[5],"that":[6,18],"is":[7,24,47],"specific":[8],"for":[9],"NSILA-s":[10,65,79,98,129,140,170,202,204],"and":[11,29,66,74,112,139,160,200],"related":[12,130,141,205],"compounds":[13,206],"we":[14],"have":[15],"previously":[16],"shown":[17],"plasma":[19,22,120,178,201],"NSILA-s,":[20,41],"like":[21],"somatomedin,":[23],"low":[25],"in":[26,44,50,119,128,157,164,167,177,195],"hypopituitary":[27],"patients":[28],"rises":[30,118],"acutely":[31],"after":[32,81,93],"iv":[33,94,113],"hGH.":[34],"In":[35,56,150],"contrast":[36],"to":[37,59],"the":[38,51,62,183],"somatomedins,":[39],"however,":[40],"as":[42,207],"measured":[43,208],"this":[45,210],"assay,":[46],"not":[48],"elevated":[49],"sera":[52],"of":[53,72,185],"acromegalic":[54],"patients.":[55],"an":[57,125],"attempt":[58],"understand":[60],"better":[61],"interrelationship":[63],"between":[64,136,193],"endogenous":[67,137,196],"growth":[68,121,158,179,197],"hormone,":[69],"variety":[71],"physiologic":[73],"pharmacologic":[75],"stimuli":[76],"were":[77,90,107],"studied.":[78],"rose":[80,171],"oral":[82,110],"glucose":[83],"at":[84,101],"time":[86,103],"when":[87,104],"hGH":[88,105,138],"levels":[89,99,106],"falling.":[91],"Conversely,":[92],"insulin":[95],"or":[96,203],"estrogen,":[97],"fell":[100],"rising.":[108],"Furthermore,":[109],"L-Dopa":[111],"glucagon":[114],"both":[115],"produced":[116,154],"substantial":[117],"hormone":[122,159,198],"without":[123],"causing":[124],"acute":[126],"change":[127,176],"peptides.":[131],"The":[132],"most":[133],"striking":[134],"dissociation":[135],"peptides":[142],"was":[143,189],"observed":[144],"during":[145,172],"48\u201372":[147],"h":[148],"fast.":[149],"normal":[151],"subjects":[152],"fasting":[153,173],"rise":[156],"dramatic":[162],"fall":[163],"NSILA-s;":[165],"whereas":[166],"obese":[168],"subjects,":[169],"despite":[174],"no":[175,190],"hormone.":[180],"Thus,":[181],"within":[182],"context":[184],"these":[186],"studies,":[187],"there":[188],"apparent":[191],"correlation":[192],"changes":[194],"concentration":[199],"by":[209],"assay.":[212]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
