{"id":"https://openalex.org/W1988882109","doi":"https://doi.org/10.1002/masy.201200133","title":"Hydrolytically Degradable Thiol\u2013ene Hydrogels for Protein Release","display_name":"Hydrolytically Degradable Thiol\u2013ene Hydrogels for Protein Release","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W1988882109","doi":"https://doi.org/10.1002/masy.201200133","mag":"1988882109","pmid":"https://pubmed.ncbi.nlm.nih.gov/25309103","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4193501"},"language":"en","primary_location":{"id":"doi:10.1002/masy.201200133","doi":"https://doi.org/10.1002/masy.201200133","is_oa":false,"landing_page_url":"https://doi.org/10.1002/masy.201200133","pdf_url":null,"source":{"id":"https://openalex.org/S7773033","display_name":"Macromolecular Symposia","issn_l":"1022-1360","issn":["1022-1360","1521-3900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecular Symposia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4193501","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075800034","display_name":"Matthew S. Rehmann","orcid":"https://orcid.org/0000-0002-0726-5672","observed_orcids":["https://orcid.org/0000-0002-0726-5672"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew S. Rehmann","raw_affiliation_strings":["Department of Chemical & Biomolecular Engineering University of Delaware 150 Academy Street, Colburn Laboratory Newark DE 19716 USA","Department of Chemical & Biomolecular Engineering, University of Delaware, 150 Academy Street, Colburn Laboratory, Newark, DE, 19716 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical & Biomolecular Engineering University of Delaware 150 Academy Street, Colburn Laboratory Newark DE 19716 USA","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Department of Chemical & Biomolecular Engineering, University of Delaware, 150 Academy Street, Colburn Laboratory, Newark, DE, 19716 USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013298147","display_name":"Andrew C. Garibian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew C. Garibian","raw_affiliation_strings":["Department of Chemical & Biomolecular Engineering University of Delaware 150 Academy Street, Colburn Laboratory Newark DE 19716 USA","Department of Chemical & Biomolecular Engineering, University of Delaware, 150 Academy Street, Colburn Laboratory, Newark, DE, 19716 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical & Biomolecular Engineering University of Delaware 150 Academy Street, Colburn Laboratory Newark DE 19716 USA","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Department of Chemical & Biomolecular Engineering, University of Delaware, 150 Academy Street, Colburn Laboratory, Newark, DE, 19716 USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030683908","display_name":"April M. Kloxin","orcid":"https://orcid.org/0000-0002-4594-2953","observed_orcids":["https://orcid.org/0000-0002-4594-2953"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"April M. Kloxin","raw_affiliation_strings":["Department of Chemical & Biomolecular Engineering University of Delaware 150 Academy Street, Colburn Laboratory Newark DE 19716 USA","Department of Materials Science & Engineering University of Delaware Newark DE 19716 USA","Department of Chemical & Biomolecular Engineering, University of Delaware, 150 Academy Street, Colburn Laboratory, Newark, DE, 19716 USA","Department of Materials Science & Engineering, University of Delaware, Newark, DE, 19716 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical & Biomolecular Engineering University of Delaware 150 Academy Street, Colburn Laboratory Newark DE 19716 USA","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Department of Materials Science & Engineering University of Delaware Newark DE 19716 USA","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Department of Chemical & Biomolecular Engineering, University of Delaware, 150 Academy Street, Colburn Laboratory, Newark, DE, 19716 USA","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Department of Materials Science & Engineering, University of Delaware, Newark, DE, 19716 USA","institution_ids":["https://openalex.org/I86501945"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030683908"],"corresponding_institution_ids":["https://openalex.org/I86501945"],"apc_list":{"value":4020,"currency":"USD","value_usd":4020},"apc_paid":null,"fwci":0.4606,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.59200806,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"329","issue":"1","first_page":"58","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12570","display_name":"Photopolymerization techniques and applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10405","display_name":"Advanced Polymer Synthesis and Characterization","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrolytic-degradation","display_name":"hydrolytic degradation","score":0.968999981880188},{"id":"https://openalex.org/keywords/protein-release","display_name":"protein release","score":0.9010000228881836},{"id":"https://openalex.org/keywords/bovine-serum-albumin-encapsulation","display_name":"bovine serum albumin encapsulation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/thiols","display_name":"thiols","score":0.4569999873638153},{"id":"https://openalex.org/keywords/uv-crosslinking","display_name":"UV crosslinking","score":0.7379999756813049},{"id":"https://openalex.org/keywords/biodegradable-hydrogels","display_name":"biodegradable hydrogels","score":0.7409999966621399},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C2781324293","wikidata":"https://www.wikidata.org/wiki/Q220410","display_name":"Thiol","level":2,"score":0.7522373199462891},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.6849826574325562},{"id":"https://openalex.org/C27777614","wikidata":"https://www.wikidata.org/wiki/Q26469","display_name":"Ene reaction","level":2,"score":0.6802012324333191},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.47128480672836304},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.38513052463531494},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38381993770599365},{"id":"https://openalex.org/C126348684","wikidata":"https://www.wikidata.org/wiki/Q3456979","display_name":"Polymer science","level":1,"score":0.3678959012031555},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.3300105333328247},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2575870156288147},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11658191680908203}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1002/masy.201200133","doi":"https://doi.org/10.1002/masy.201200133","is_oa":false,"landing_page_url":"https://doi.org/10.1002/masy.201200133","pdf_url":null,"source":{"id":"https://openalex.org/S7773033","display_name":"Macromolecular Symposia","issn_l":"1022-1360","issn":["1022-1360","1521-3900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecular Symposia","raw_type":"journal-article"},{"id":"pmid:25309103","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25309103","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecular symposia","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3162893","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4193501","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4193501","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4193501","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Macromol Symp","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3162893","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4193501","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4389218539","display_name":"Molecular Design of Advanced Biomaterials","funder_award_id":"P20RR017716","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5905849278","display_name":"Chemistry-Biology Interface (CBI) NIH T32 Training Grant","funder_award_id":"T32GM008550","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1592120214","https://openalex.org/W1966288407","https://openalex.org/W1967784078","https://openalex.org/W1975088956","https://openalex.org/W1991672292","https://openalex.org/W1994032158","https://openalex.org/W1997417575","https://openalex.org/W1998289682","https://openalex.org/W2004474026","https://openalex.org/W2005310275","https://openalex.org/W2005333067","https://openalex.org/W2021157858","https://openalex.org/W2024649205","https://openalex.org/W2031037339","https://openalex.org/W2032306620","https://openalex.org/W2042992678","https://openalex.org/W2046007813","https://openalex.org/W2054131714","https://openalex.org/W2058983924","https://openalex.org/W2060475101","https://openalex.org/W2070170630","https://openalex.org/W2082218425","https://openalex.org/W2082511674","https://openalex.org/W2087816485","https://openalex.org/W2102477778","https://openalex.org/W2132551021","https://openalex.org/W2155986661"],"related_works":["https://openalex.org/W2005333067","https://openalex.org/W7149875701","https://openalex.org/W2155986661","https://openalex.org/W2034947704","https://openalex.org/W2135376591","https://openalex.org/W2095431539","https://openalex.org/W2056035146","https://openalex.org/W4414400826","https://openalex.org/W2109993926","https://openalex.org/W6903647605"],"abstract_inverted_index":{"A":[0],"new":[1],"degradable":[2],"PEG-diester-dinorbornene/PEG-triester-trithiol":[3],"hydrogel":[4,11,35],"was":[5],"evaluated":[6],"for":[7,65,79],"protein":[8,80],"release.":[9,81],"The":[10],"polymerized":[12],"rapidly":[13],"with":[14,52],"seconds":[15],"of":[16,29,41,68],"UV":[17],"irradiation":[18],"and":[19,39,86,98],"subsequently":[20],"hydrolytically":[21,69],"degraded":[22],"in":[23,100],"aqueous":[24],"buffer":[25],"over":[26,49],"the":[27,34,37,66,94],"course":[28],"approximately":[30],"3":[31],"weeks.":[32],"Further,":[33],"enabled":[36],"encapsulation":[38],"release":[40,87],"a":[42,63,74],"model":[43],"protein,":[44],"bovine":[45],"serum":[46],"albumin":[47],"(BSA),":[48],"7":[50],"days":[51],"~":[53],"90%":[54],"released":[55],"at":[56],"48":[57],"h.":[58],"This":[59],"study":[60],"serves":[61],"as":[62],"proof-of-concept":[64],"creation":[67],"degradable,":[70],"PEG-ester-thiol-based":[71],"hydrogels":[72],"by":[73,92],"photoinitiated":[75],"step":[76],"growth":[77],"mechanism":[78],"With":[82],"this":[83],"approach,":[84],"degradation":[85],"rates":[88],"could":[89],"be":[90],"tuned":[91],"varying":[93],"monomer":[95],"molecular":[96],"weight":[97],"functionality":[99],"future":[101],"studies.":[102]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}