{"id":"https://openalex.org/W1988787232","doi":"https://doi.org/10.1271/bbb.50640","title":"Properties of a Trifluoroleucine-Resistant Mutant ofSaccharomyces cerevisiae","display_name":"Properties of a Trifluoroleucine-Resistant Mutant ofSaccharomyces cerevisiae","publication_year":2006,"publication_date":"2006-07-23","ids":{"openalex":"https://openalex.org/W1988787232","doi":"https://doi.org/10.1271/bbb.50640","mag":"1988787232","pmid":"https://pubmed.ncbi.nlm.nih.gov/16861814"},"language":"en","primary_location":{"id":"doi:10.1271/bbb.50640","doi":"https://doi.org/10.1271/bbb.50640","is_oa":false,"landing_page_url":"https://doi.org/10.1271/bbb.50640","pdf_url":null,"source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083529442","display_name":"Takahiro OBA","orcid":"https://orcid.org/0000-0002-9967-6881","observed_orcids":["https://orcid.org/0000-0002-9967-6881"]},"institutions":[{"id":"https://openalex.org/I4210143778","display_name":"Fukuoka Industrial Technology Center","ror":"https://ror.org/04v6bh038","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4210143778"]},{"id":"https://openalex.org/I4405286418","display_name":"Biotechnology and Food Research Institute, Fukuoka Industrial Technology Center","ror":"https://ror.org/0233s7249","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210143778","https://openalex.org/I4405286418"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro OBA","raw_affiliation_strings":["Biotechnology and Food Research Institute, Fukuoka Industrial Technology Center, Kurume, Fukuoka 839-0861, Japan. ooba@fitc.pref.fukuoka.jp","Biotechnology and Food Research Institute, Fukuoka Industrial Technology Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology and Food Research Institute, Fukuoka Industrial Technology Center, Kurume, Fukuoka 839-0861, Japan. ooba@fitc.pref.fukuoka.jp","institution_ids":["https://openalex.org/I4210143778","https://openalex.org/I4405286418"]},{"raw_affiliation_string":"Biotechnology and Food Research Institute, Fukuoka Industrial Technology Center","institution_ids":["https://openalex.org/I4405286418"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yoshitsugu YAMAMOTO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshitsugu YAMAMOTO","raw_affiliation_strings":["Graduate School of Genetic Resources Technology, Kyushu University","Graduate School of Genetic Resources Technology, Kyushu Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Genetic Resources Technology, Kyushu University","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Graduate School of Genetic Resources Technology, Kyushu Univ","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044183925","display_name":"Shuji Nomiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286418","display_name":"Biotechnology and Food Research Institute, Fukuoka Industrial Technology Center","ror":"https://ror.org/0233s7249","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210143778","https://openalex.org/I4405286418"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuji NOMIYAMA","raw_affiliation_strings":["Biotechnology and Food Research Institute, Fukuoka Industrial Technology Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology and Food Research Institute, Fukuoka Industrial Technology Center","institution_ids":["https://openalex.org/I4405286418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065051277","display_name":"Hikaru Suenaga","orcid":"https://orcid.org/0000-0003-2218-9273","observed_orcids":["https://orcid.org/0000-0003-2218-9273"]},"institutions":[{"id":"https://openalex.org/I4405286418","display_name":"Biotechnology and Food Research Institute, Fukuoka Industrial Technology Center","ror":"https://ror.org/0233s7249","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210143778","https://openalex.org/I4405286418"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hikaru SUENAGA","raw_affiliation_strings":["Biotechnology and Food Research Institute, Fukuoka Industrial Technology Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology and Food Research Institute, Fukuoka Industrial Technology Center","institution_ids":["https://openalex.org/I4405286418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025351395","display_name":"Shigeru Muta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru MUTA","raw_affiliation_strings":["Graduate School of Genetic Resources Technology, Kyushu University","Graduate School of Genetic Resources Technology, Kyushu Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Genetic Resources Technology, Kyushu University","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Graduate School of Genetic Resources Technology, Kyushu Univ","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056078040","display_name":"Kosuke Tashiro","orcid":"https://orcid.org/0000-0003-4980-2058","observed_orcids":["https://orcid.org/0000-0003-4980-2058"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kosuke TASHIRO","raw_affiliation_strings":["Graduate School of Genetic Resources Technology, Kyushu University","Graduate School of Genetic Resources Technology, Kyushu Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Genetic Resources Technology, Kyushu University","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Graduate School of Genetic Resources Technology, Kyushu Univ","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067172907","display_name":"Satoru Kuhara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru KUHARA","raw_affiliation_strings":["Graduate School of Genetic Resources Technology, Kyushu University","Graduate School of Genetic Resources Technology, Kyushu Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Genetic Resources Technology, Kyushu University","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Graduate School of Genetic Resources Technology, Kyushu Univ","institution_ids":["https://openalex.org/I135598925"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3272,"currency":"USD","value_usd":3272},"apc_paid":null,"fwci":0.5614,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.5732565,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"70","issue":"7","first_page":"1776","last_page":"1779"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.03590000048279762,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9089999794960022},{"id":"https://openalex.org/keywords/leucine-biosynthesis","display_name":"leucine biosynthesis","score":0.7229999899864197},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.671999990940094},{"id":"https://openalex.org/keywords/mutant-strain","display_name":"mutant strain","score":0.36399999260902405}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.8518416881561279},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.80110764503479},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5721009373664856},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5707122087478638},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5512401461601257},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49706366658210754},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4849288761615753},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.48185738921165466},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.47635793685913086},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.45974001288414},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3473513722419739},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000439","descriptor_name":"Pentanols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015079","descriptor_name":"2-Isopropylmalate Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015079","descriptor_name":"2-Isopropylmalate Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025141","descriptor_name":"Drug Resistance, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1271/bbb.50640","doi":"https://doi.org/10.1271/bbb.50640","is_oa":false,"landing_page_url":"https://doi.org/10.1271/bbb.50640","pdf_url":null,"source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},{"id":"pmid:16861814","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16861814","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, biotechnology, and biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W371388455","https://openalex.org/W1012963668","https://openalex.org/W1751931305","https://openalex.org/W1967841743","https://openalex.org/W1994876071","https://openalex.org/W1995977462","https://openalex.org/W1998522775","https://openalex.org/W2002206908","https://openalex.org/W2007945179","https://openalex.org/W2033495915","https://openalex.org/W2060367766","https://openalex.org/W2065976692","https://openalex.org/W2069953403","https://openalex.org/W2073810164","https://openalex.org/W2075178600","https://openalex.org/W2075590600","https://openalex.org/W2077715645","https://openalex.org/W2079633636","https://openalex.org/W2092652042","https://openalex.org/W2093647181","https://openalex.org/W2161769721","https://openalex.org/W2165011536","https://openalex.org/W2166574880","https://openalex.org/W2176691344","https://openalex.org/W2335769790"],"related_works":["https://openalex.org/W2033495915","https://openalex.org/W7099919596","https://openalex.org/W2093647181","https://openalex.org/W2051693511","https://openalex.org/W2919505700","https://openalex.org/W2092652042","https://openalex.org/W2065976692","https://openalex.org/W7033039438","https://openalex.org/W2092327901","https://openalex.org/W6987121893"],"abstract_inverted_index":{"We":[0,17,42],"characterized":[1],"a":[2,11],"trifluoroleucine-resistant":[3],"mutant":[4],"of":[5,21,32],"Saccharomyces":[6],"cerevisiae,":[7],"TFL20,":[8],"that":[9,44,58],"has":[10],"mutation":[12],"in":[13,35,53],"the":[14,19,30,38,45],"LEU4":[15],"gene.":[16],"monitored":[18],"concentration":[20],"extracellular":[22],"i-AmOH":[23,64],"and":[24,28,48,57,65],"intracellular":[25],"amino":[26],"acids,":[27],"compared":[29],"ratios":[31],"gene":[33],"expression":[34],"TFL20":[36,54,59],"with":[37],"wild-type":[39],"strain,":[40],"K30.":[41],"found":[43],"LEU1,":[46],"LEU2,":[47],"BAT1":[49],"genes":[50],"were":[51],"up-regulated":[52],"for":[55],"metabolism,":[56],"simultaneously":[60],"produced":[61],"as":[62,67],"much":[63],"leucine":[66],"K30":[68],"does.":[69]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
