{"id":"https://openalex.org/W1988761237","doi":"https://doi.org/10.1056/nejmoa1215740","title":"Glucose Levels and Risk of Dementia","display_name":"Glucose Levels and Risk of Dementia","publication_year":2013,"publication_date":"2013-08-07","ids":{"openalex":"https://openalex.org/W1988761237","doi":"https://doi.org/10.1056/nejmoa1215740","mag":"1988761237","pmid":"https://pubmed.ncbi.nlm.nih.gov/23924004"},"language":"en","primary_location":{"id":"doi:10.1056/nejmoa1215740","doi":"https://doi.org/10.1056/nejmoa1215740","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa1215740","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa1215740?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa1215740?articleTools=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050170858","display_name":"Paul K. Crane","orcid":"https://orcid.org/0000-0003-4278-7465","observed_orcids":["https://orcid.org/0000-0003-4278-7465"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul K. Crane","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle, WA, USA. pcrane@uw.edu","Departments of Medicine, University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, WA, USA. pcrane@uw.edu","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Departments of Medicine, University of Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002703252","display_name":"Rod L. Walker","orcid":"https://orcid.org/0000-0002-8464-9805","observed_orcids":["https://orcid.org/0000-0002-8464-9805"]},"institutions":[{"id":"https://openalex.org/I150117356","display_name":"Kaiser Permanente Washington Health Research Institute","ror":"https://ror.org/0027frf26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I150117356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rod Walker","raw_affiliation_strings":["Group Health Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Group Health Research Institute","institution_ids":["https://openalex.org/I150117356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008134033","display_name":"Rebecca A. Hubbard","orcid":"https://orcid.org/0000-0003-0879-0994","observed_orcids":["https://orcid.org/0000-0003-0879-0994"]},"institutions":[{"id":"https://openalex.org/I150117356","display_name":"Kaiser Permanente Washington Health Research Institute","ror":"https://ror.org/0027frf26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I150117356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca A. Hubbard","raw_affiliation_strings":["Group Health Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Group Health Research Institute","institution_ids":["https://openalex.org/I150117356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103666070","display_name":"Ge Li","orcid":"https://orcid.org/0000-0002-6575-8969","observed_orcids":["https://orcid.org/0000-0002-6575-8969"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ge Li","raw_affiliation_strings":["Psychiatry and Behavioral Sciences, University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatry and Behavioral Sciences, University of Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113797452","display_name":"David M. Nathan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Nathan","raw_affiliation_strings":["Diabetes Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103284164","display_name":"Hui Zheng","orcid":"https://orcid.org/0000-0001-6194-4564","observed_orcids":["https://orcid.org/0000-0001-6194-4564"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Zheng","raw_affiliation_strings":["Biostatistics Center, Massachusetts General Hospital and Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics Center, Massachusetts General Hospital and Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001697701","display_name":"Sebastien Haneuse","orcid":"https://orcid.org/0000-0003-4963-0655","observed_orcids":["https://orcid.org/0000-0003-4963-0655"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sebastien Haneuse","raw_affiliation_strings":["Department of Biostatistics, Harvard School of Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Harvard School of Public Health","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019308143","display_name":"Suzanne Craft","orcid":"https://orcid.org/0000-0003-0591-8657","observed_orcids":["https://orcid.org/0000-0003-0591-8657"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne Craft","raw_affiliation_strings":["Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067728043","display_name":"Thomas Jude Montine","orcid":"https://orcid.org/0000-0002-1346-2728","observed_orcids":["https://orcid.org/0000-0002-1346-2728"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. Montine","raw_affiliation_strings":["Pathology, University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, University of Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066700951","display_name":"Steven E. Kahn","orcid":"https://orcid.org/0000-0001-7307-9002","observed_orcids":["https://orcid.org/0000-0001-7307-9002"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210094549","display_name":"VA Puget Sound Health Care System","ror":"https://ror.org/00ky3az31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094549","https://openalex.org/I4210138024"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven E. Kahn","raw_affiliation_strings":["Department of Medicine, VA Puget Sound Health Care System and University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, VA Puget Sound Health Care System and University of Washington","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210094549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109175200","display_name":"Wayne C. McCormick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wayne McCormick","raw_affiliation_strings":["Departments of Medicine, University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, University of Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047598978","display_name":"Susan M. McCurry","orcid":"https://orcid.org/0000-0001-8624-3772","observed_orcids":["https://orcid.org/0000-0001-8624-3772"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan M. McCurry","raw_affiliation_strings":["Psychosocial and Community Health, University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychosocial and Community Health, University of Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050509909","display_name":"James D. Bowen","orcid":"https://orcid.org/0000-0002-4258-250X","observed_orcids":["https://orcid.org/0000-0002-4258-250X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James D. Bowen","raw_affiliation_strings":["Swedish Neuroscience Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swedish Neuroscience Institute","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035154676","display_name":"Eric B. Larson","orcid":"https://orcid.org/0000-0003-4782-5360","observed_orcids":["https://orcid.org/0000-0003-4782-5360"]},"institutions":[{"id":"https://openalex.org/I150117356","display_name":"Kaiser Permanente Washington Health Research Institute","ror":"https://ror.org/0027frf26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I150117356"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric B. Larson","raw_affiliation_strings":["Departments of Medicine, University of Washington","Group Health Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, University of Washington","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Group Health Research Institute","institution_ids":["https://openalex.org/I150117356"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":49.3339,"has_fulltext":false,"cited_by_count":918,"citation_normalized_percentile":{"value":0.99951701,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"369","issue":"6","first_page":"540","last_page":"548"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dementia-risk","display_name":"dementia risk","score":0.7329999804496765},{"id":"https://openalex.org/keywords/glucose-levels","display_name":"glucose concentration","score":0.7310000061988831},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8690000176429749},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.6600000262260437},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9089999794960022},{"id":"https://openalex.org/keywords/non-diabetic-individuals","display_name":"non-diabetic individuals","score":0.578000009059906},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.5699999928474426},{"id":"https://openalex.org/keywords/adult-changes-in-thought-study","display_name":"Adult Changes in Thought study","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9240880012512207},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.8570272326469421},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7889789938926697},{"id":"https://openalex.org/C2777538456","wikidata":"https://www.wikidata.org/wiki/Q311213","display_name":"Glycated hemoglobin","level":4,"score":0.6565251350402832},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.650179922580719},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6368049383163452},{"id":"https://openalex.org/C176674119","wikidata":"https://www.wikidata.org/wiki/Q11582","display_name":"Liter","level":2,"score":0.5614806413650513},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5483022332191467},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4592677354812622},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.44153356552124023},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4401966333389282},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.42077505588531494},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.3491848111152649},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2981865108013153},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.08387750387191772}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004522","descriptor_name":"Educational Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004522","descriptor_name":"Educational Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004522","descriptor_name":"Educational Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1056/nejmoa1215740","doi":"https://doi.org/10.1056/nejmoa1215740","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa1215740","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa1215740?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:23924004","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23924004","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2935598","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3955123","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3955123","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3955123","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"N Engl J Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1056/nejmoa1215740","doi":"https://doi.org/10.1056/nejmoa1215740","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa1215740","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa1215740?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5600000023841858,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2999798359","display_name":null,"funder_award_id":"U01-AG-06781","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3677674694","display_name":null,"funder_award_id":"U01 AG006781","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000881174","display_name":"Diabetes Research Center","funder_award_id":"P30DK017047","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1988761237.pdf"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1480376833","https://openalex.org/W1576709629","https://openalex.org/W1621291577","https://openalex.org/W1867011869","https://openalex.org/W1943585197","https://openalex.org/W1968551454","https://openalex.org/W1970457757","https://openalex.org/W2005474341","https://openalex.org/W2009088633","https://openalex.org/W2027987672","https://openalex.org/W2038003980","https://openalex.org/W2045014938","https://openalex.org/W2049992563","https://openalex.org/W2058116753","https://openalex.org/W2070675490","https://openalex.org/W2079819090","https://openalex.org/W2082162766","https://openalex.org/W2092109263","https://openalex.org/W2111774300","https://openalex.org/W2116698967","https://openalex.org/W2117343153","https://openalex.org/W2127360394","https://openalex.org/W2129415792","https://openalex.org/W2155210372","https://openalex.org/W2156220037","https://openalex.org/W2209976199","https://openalex.org/W2527609605","https://openalex.org/W2796700885"],"related_works":["https://openalex.org/W173701420","https://openalex.org/W1974062255","https://openalex.org/W1980265236","https://openalex.org/W2084734332","https://openalex.org/W2005973474","https://openalex.org/W2400721776","https://openalex.org/W2110742466","https://openalex.org/W2049684666","https://openalex.org/W2994686985","https://openalex.org/W4281722959"],"abstract_inverted_index":{"BACKGROUND:":[0],"Diabetes":[1],"is":[2,9],"a":[3,131,171,228,272],"risk":[4,17,54,166,223,273],"factor":[5,274],"for":[6,101,127,198,275],"dementia.":[7,56],"It":[8],"unknown":[10],"whether":[11],"higher":[12,152,213,267],"glucose":[13,31,50,154,172,215,229,268],"levels":[14,32,39,51,155,216,269],"increase":[15],"the":[16,47,53,60,157,194,251,284],"of":[18,30,36,55,109,134,167,174,224,231,287],"dementia":[19,44,137,168,199,225],"in":[20,63,139],"people":[21],"without":[22,43,150,280],"diabetes.":[23,281],"METHODS:":[24],"We":[25,89],"used":[26],"35,264":[27],"clinical":[28],"measurements":[29,35],"and":[33,52,66,70,85,99,113,119,125,145],"10,208":[34],"glycated":[37],"hemoglobin":[38],"from":[40,59],"2067":[41],"participants":[42,82,141,149,210],"to":[45,96,117,163,207,220,260],"examine":[46],"relationship":[48],"between":[49],"Participants":[57],"were":[58,161,217],"Adult":[61],"Changes":[62],"Thought":[64],"study":[65,104],"included":[67],"839":[68],"men":[69],"1228":[71],"women":[72],"whose":[73],"mean":[74],"age":[75],"at":[76],"baseline":[77],"was":[78,200,255],"76":[79],"years;":[80],"232":[81],"had":[83],"diabetes,":[84,151,212],"1835":[86],"did":[87],"not.":[88],"fit":[90],"Cox":[91],"regression":[92],"models,":[93],"stratified":[94],"according":[95],"diabetes":[97,144],"status":[98,114],"adjusted":[100,195,252],"age,":[102],"sex,":[103],"cohort,":[105],"educational":[106],"level,":[107],"level":[108,173,230],"exercise,":[110],"blood":[111],"pressure,":[112],"with":[115,143,170,185,211,227,242],"respect":[116],"coronary":[118],"cerebrovascular":[120],"diseases,":[121],"atrial":[122],"fibrillation,":[123],"smoking,":[124],"treatment":[126],"hypertension.":[128],"RESULTS:":[129],"During":[130],"median":[132],"follow-up":[133],"6.8":[135],"years,":[136],"developed":[138],"524":[140],"(74":[142],"450":[146],"without).":[147],"Among":[148,209],"average":[153,214],"within":[156],"preceding":[158],"5":[159],"years":[160],"related":[162,219],"an":[164,221],"increased":[165,222],"(P=0.01);":[169],"115":[175],"mg":[176,187,233,244],"per":[177,181,188,192,234,238,245,249],"deciliter":[178,189,235,246],"(6.4":[179],"mmol":[180,191,237,248],"liter)":[182,239],"as":[183,240],"compared":[184,241],"100":[186],"(5.5":[190],"liter),":[193,250],"hazard":[196,253],"ratio":[197,254],"1.18":[201],"(95%":[202,257],"confidence":[203],"interval":[204],"[CI],":[205],"1.04":[206],"1.33).":[208],"also":[218],"(P=0.002);":[226],"190":[232],"(10.5":[236],"160":[243],"(8.9":[247],"1.40":[256],"CI,":[258],"1.12":[259],"1.76).":[261],"CONCLUSIONS:":[262],"Our":[263],"results":[264],"suggest":[265],"that":[266],"may":[270],"be":[271],"dementia,":[276],"even":[277],"among":[278],"persons":[279],"(Funded":[282],"by":[283],"National":[285],"Institutes":[286],"Health.)":[288]},"counts_by_year":[{"year":2026,"cited_by_count":41},{"year":2025,"cited_by_count":71},{"year":2024,"cited_by_count":77},{"year":2023,"cited_by_count":61},{"year":2022,"cited_by_count":90},{"year":2021,"cited_by_count":72},{"year":2020,"cited_by_count":51},{"year":2019,"cited_by_count":77},{"year":2018,"cited_by_count":69},{"year":2017,"cited_by_count":74},{"year":2016,"cited_by_count":68},{"year":2015,"cited_by_count":73},{"year":2014,"cited_by_count":67},{"year":2013,"cited_by_count":24}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2016-06-24T00:00:00"}