{"id":"https://openalex.org/W1988757263","doi":"https://doi.org/10.1371/journal.pone.0094075","title":"Dysregulation in microRNA Expression Is Associated with Alterations in Immune Functions in Combat Veterans with Post-Traumatic Stress Disorder","display_name":"Dysregulation in microRNA Expression Is Associated with Alterations in Immune Functions in Combat Veterans with Post-Traumatic Stress Disorder","publication_year":2014,"publication_date":"2014-04-23","ids":{"openalex":"https://openalex.org/W1988757263","doi":"https://doi.org/10.1371/journal.pone.0094075","mag":"1988757263","pmid":"https://pubmed.ncbi.nlm.nih.gov/24759737","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3997344"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0094075","doi":"https://doi.org/10.1371/journal.pone.0094075","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0094075","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0094075&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0094075&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018707155","display_name":"Juhua Zhou","orcid":"https://orcid.org/0000-0001-7925-0448","observed_orcids":["https://orcid.org/0000-0001-7925-0448"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juhua Zhou","raw_affiliation_strings":["Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, United States of America","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046315471","display_name":"Prakash S. Nagarkatti","orcid":"https://orcid.org/0000-0003-2663-0759","observed_orcids":["https://orcid.org/0000-0003-2663-0759"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prakash Nagarkatti","raw_affiliation_strings":["Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, United States of America","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100840411","display_name":"Zhong Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yin Zhong","raw_affiliation_strings":["Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, United States of America","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025976119","display_name":"Jay P. Ginsberg","orcid":"https://orcid.org/0000-0002-8375-2288","observed_orcids":["https://orcid.org/0000-0002-8375-2288"]},"institutions":[{"id":"https://openalex.org/I2801500240","display_name":"Wm. Jennings Bryan Dorn VA Medical Center","ror":"https://ror.org/04b7web15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801500240","https://openalex.org/I4210092080","https://openalex.org/I4210131075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay P. Ginsberg","raw_affiliation_strings":["William Jennings Bryan Dorn Veterans Medical Center, Columbia, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William Jennings Bryan Dorn Veterans Medical Center, Columbia, South Carolina, United States of America","institution_ids":["https://openalex.org/I2801500240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036897140","display_name":"Narendra Prasad Singh","orcid":"https://orcid.org/0000-0002-2443-7157","observed_orcids":["https://orcid.org/0000-0002-2443-7157"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Narendra P. Singh","raw_affiliation_strings":["Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, United States of America","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100417649","display_name":"Jiajia Zhang","orcid":"https://orcid.org/0000-0003-4566-0822","observed_orcids":["https://orcid.org/0000-0003-4566-0822","https://orcid.org/0009-0002-3012-5050","https://orcid.org/0009-0007-6884-0638","https://orcid.org/0009-0007-0626-898X"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiajia Zhang","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, United States of America","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061239650","display_name":"Mitzi Nagarkatti","orcid":"https://orcid.org/0000-0002-5977-5615","observed_orcids":["https://orcid.org/0000-0002-5977-5615"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]},{"id":"https://openalex.org/I2801500240","display_name":"Wm. Jennings Bryan Dorn VA Medical Center","ror":"https://ror.org/04b7web15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801500240","https://openalex.org/I4210092080","https://openalex.org/I4210131075"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mitzi Nagarkatti","raw_affiliation_strings":["Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, United States of America; William Jennings Bryan Dorn Veterans Medical Center, Columbia, South Carolina, United States of America","Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, United States of America","William Jennings Bryan Dorn Veterans Medical Center, Columbia, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, United States of America; William Jennings Bryan Dorn Veterans Medical Center, Columbia, South Carolina, United States of America","institution_ids":["https://openalex.org/I155781252","https://openalex.org/I2801500240"]},{"raw_affiliation_string":"Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, United States of America","institution_ids":["https://openalex.org/I155781252"]},{"raw_affiliation_string":"William Jennings Bryan Dorn Veterans Medical Center, Columbia, South Carolina, United States of America","institution_ids":["https://openalex.org/I2801500240"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061239650"],"corresponding_institution_ids":["https://openalex.org/I155781252","https://openalex.org/I2801500240"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":13.0009,"has_fulltext":true,"cited_by_count":174,"citation_normalized_percentile":{"value":0.98989917,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"9","issue":"4","first_page":"e94075","last_page":"e94075"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.08389999717473984,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/posttraumatic-stress-disorder","display_name":"post-traumatic stress disorder","score":0.9959999918937683},{"id":"https://openalex.org/keywords/combat-veterans","display_name":"combat veterans","score":0.8069999814033508},{"id":"https://openalex.org/keywords/microrna-expression","display_name":"microRNA expression","score":0.8149999976158142},{"id":"https://openalex.org/keywords/immune-dysregulation","display_name":"immune dysregulation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.8270000219345093},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":1.0},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/th2-cells","display_name":"Th2 cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8420000076293945},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":1.0},{"id":"https://openalex.org/keywords/mir-125a","display_name":"miR-125a","score":0.9300000071525574},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9570000171661377},{"id":"https://openalex.org/keywords/epigenetic-biomarkers","display_name":"epigenetic biomarkers","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.7709648013114929},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6615548133850098},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6447185277938843},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5740121603012085},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.49253377318382263},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4910271167755127},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.47008562088012695},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4551447033882141},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30635374784469604},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21563932299613953},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07739585638046265},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077214","descriptor_name":"Becaplermin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013313","descriptor_name":"Stress Disorders, Post-Traumatic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013313","descriptor_name":"Stress Disorders, Post-Traumatic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014728","descriptor_name":"Veterans","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018946","descriptor_name":"Chemokine CCL5","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020574","descriptor_name":"Proto-Oncogene Proteins c-sis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0094075","doi":"https://doi.org/10.1371/journal.pone.0094075","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0094075","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0094075&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2979181","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3997344","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3997344","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3997344","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24759737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24759737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.663.2967","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.663.2967","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997344/pdf/pone.0094075.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:621a8d33c4c445f985b67b040afe8581","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/621a8d33c4c445f985b67b040afe8581","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 4, p e94075 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0094075","doi":"https://doi.org/10.1371/journal.pone.0094075","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0094075","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0094075&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1352269040","display_name":null,"funder_award_id":"BX001357","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1744797454","display_name":"CAM Center for Epigenetic Regulation of Inflammation","funder_award_id":"P01AT003961","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G3076921915","display_name":"Immunopathological basis of PTSD","funder_award_id":"R01MH094755","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3552863514","display_name":"Role of natural indoles in experimental autoimmune encephalomyelitis","funder_award_id":"R01AT006888","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G4703803806","display_name":null,"funder_award_id":"I01 BX001357","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G4790470846","display_name":"Dietary Supplements and Inflammation Phase-2","funder_award_id":"P20GM103641","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8110899584","display_name":"Estrogen-T cell Interactions","funder_award_id":"R01ES019313","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1988757263.pdf","grobid_xml":"https://content.openalex.org/works/W1988757263.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W66236966","https://openalex.org/W385380125","https://openalex.org/W1705421561","https://openalex.org/W1973367937","https://openalex.org/W1975823070","https://openalex.org/W1976507701","https://openalex.org/W1978620450","https://openalex.org/W1995515625","https://openalex.org/W1995747779","https://openalex.org/W2001866502","https://openalex.org/W2004763680","https://openalex.org/W2005553679","https://openalex.org/W2008222388","https://openalex.org/W2012121005","https://openalex.org/W2013555477","https://openalex.org/W2016391660","https://openalex.org/W2022768282","https://openalex.org/W2023687307","https://openalex.org/W2027685151","https://openalex.org/W2031646626","https://openalex.org/W2042180443","https://openalex.org/W2052550272","https://openalex.org/W2054344840","https://openalex.org/W2055238656","https://openalex.org/W2060835067","https://openalex.org/W2063080163","https://openalex.org/W2064514539","https://openalex.org/W2067111782","https://openalex.org/W2071404781","https://openalex.org/W2074530163","https://openalex.org/W2079705951","https://openalex.org/W2083675778","https://openalex.org/W2084608645","https://openalex.org/W2091975706","https://openalex.org/W2093982682","https://openalex.org/W2094767740","https://openalex.org/W2110065044","https://openalex.org/W2114418219","https://openalex.org/W2121233376","https://openalex.org/W2138043812","https://openalex.org/W2159300071","https://openalex.org/W2163143776","https://openalex.org/W2339480733","https://openalex.org/W4238079920","https://openalex.org/W4241715325","https://openalex.org/W4244472623"],"related_works":["https://openalex.org/W7098768183","https://openalex.org/W140089174","https://openalex.org/W4313384810","https://openalex.org/W4206277095","https://openalex.org/W2750909308","https://openalex.org/W2511886302","https://openalex.org/W2580091278","https://openalex.org/W3208857916","https://openalex.org/W2953485060","https://openalex.org/W2551311303"],"abstract_inverted_index":{"While":[0],"the":[1,16,25,60,80,133,145,184,194,206,211],"immunological":[2,31,179,185],"dysfunction":[3,32],"in":[4,30,48,71,98,120,128,155,164,178,188,198,221],"combat":[5],"Veterans":[6],"with":[7,34,104,132,183,218],"post-traumatic":[8],"stress":[9],"disorder":[10],"(PTSD)":[11],"has":[12],"been":[13],"well":[14],"documented,":[15],"precise":[17],"mechanisms":[18],"remain":[19],"unclear.":[20],"The":[21,36,118],"current":[22,207],"study":[23,208],"evaluated":[24],"role":[26,177],"of":[27,38,62,82,108,138,147,151,160,196,245],"microRNA":[28],"(miR)":[29],"associated":[33,217],"PTSD.":[35,246],"presence":[37],"peripheral":[39],"blood":[40,49],"mononuclear":[41],"cells":[42,76,84,87,95,126],"(PBMC)":[43],"and":[44,65,85,110,124,172,242],"various":[45,66],"lymphocyte":[46,67],"subsets":[47,68],"collected":[50],"from":[51],"PTSD":[52,72,99,129,156,165,215],"patients":[53,130,166],"were":[54,77],"analyzed.":[55],"Our":[56],"studies":[57],"demonstrated":[58],"that":[59,144,174,214],"numbers":[61],"both":[63],"PBMC":[64,121],"increased":[69,105],"significantly":[70],"patients.":[73,100,157,190],"When":[74],"T":[75,90],"further":[78],"analyzed,":[79],"percentage":[81],"Th1":[83,123],"Th17":[86,125],"increased,":[88],"regulatory":[89],"cells(Tregs)":[91],"decreased,":[92],"while":[93,112],"Th2":[94],"remained":[96],"unaltered":[97],"These":[101],"data":[102],"correlated":[103,131],"plasma":[106],"levels":[107],"IFN-\u03b3":[109,203],"IL-17":[111],"IL-4":[113],"showed":[114,143,175],"no":[115],"significant":[116,149,219],"change.":[117],"increase":[119],"counts,":[122],"seen":[127,163,187],"clinical":[134],"scores.":[135],"High-throughput":[136],"analysis":[137,159],"PBMCs":[139],"for":[140,210,240],"1163":[141],"miRs":[142,152,162],"expression":[146],"a":[148],"number":[150],"was":[153,193,216],"altered":[154],"Pathway":[158],"dysregulated":[161],"revealed":[167],"relationship":[168],"between":[169],"selected":[170],"miRNAs":[171],"genes":[173],"direct/indirect":[176],"signaling":[180],"pathways":[181],"consistent":[182],"changes":[186],"these":[189],"Of":[191],"interest":[192],"down-regulation":[195],"miR-125a":[197],"PTSD,":[199],"which":[200,223],"specifically":[201],"targeted":[202],"production.":[204],"Together,":[205],"demonstrates":[209],"first":[212],"time":[213],"alterations":[220],"miRNAs,":[222],"may":[224,232],"promote":[225],"pro-inflammatory":[226],"cytokine":[227],"profile.":[228],"Such":[229],"epigenetic":[230],"events":[231],"provide":[233],"useful":[234],"tools":[235],"to":[236],"identify":[237],"potential":[238],"biomarkers":[239],"diagnosis,":[241],"facilitate":[243],"therapy":[244]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}