{"id":"https://openalex.org/W1988650452","doi":"https://doi.org/10.1093/emboj/18.3.501","title":"Leukocyte polarization in cell migration and immune interactions","display_name":"Leukocyte polarization in cell migration and immune interactions","publication_year":1999,"publication_date":"1999-02-01","ids":{"openalex":"https://openalex.org/W1988650452","doi":"https://doi.org/10.1093/emboj/18.3.501","mag":"1988650452","pmid":"https://pubmed.ncbi.nlm.nih.gov/9927410","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1171143"},"language":"en","primary_location":{"id":"doi:10.1093/emboj/18.3.501","doi":"https://doi.org/10.1093/emboj/18.3.501","is_oa":false,"landing_page_url":"https://doi.org/10.1093/emboj/18.3.501","pdf_url":null,"source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1988650452"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1171143","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006841984","display_name":"Francisco S\u00e1nchez\u2010Madrid","orcid":"https://orcid.org/0000-0001-5303-0762","observed_orcids":["https://orcid.org/0000-0001-5303-0762"]},"institutions":[{"id":"https://openalex.org/I4210130498","display_name":"Hospital Universitario de La Princesa","ror":"https://ror.org/03cg5md32","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130498","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Francisco S\u00e1nchez\u2010Madrid","raw_affiliation_strings":["Servicio de Inmunolog\u00eda, Hospital de la Princesa, Universidad Aut\u00f3noma Madrid, Diego de Le\u00f3n, 62, E-28006, Madrid, Spain. fsmadrid/princesa@hup.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Inmunolog\u00eda, Hospital de la Princesa, Universidad Aut\u00f3noma Madrid, Diego de Le\u00f3n, 62, E-28006, Madrid, Spain. fsmadrid/princesa@hup.es","institution_ids":["https://openalex.org/I4210130498","https://openalex.org/I63634437"]}]},{"author_position":"last","author":{"id":null,"display_name":"Miguel Angel del Pozo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miguel Angel del Pozo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006841984"],"corresponding_institution_ids":["https://openalex.org/I4210130498","https://openalex.org/I63634437"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":null,"fwci":3.8174,"has_fulltext":false,"cited_by_count":619,"citation_normalized_percentile":{"value":0.96096096,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"18","issue":"3","first_page":"501","last_page":"511"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.3621000051498413,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.3621000051498413,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.2915000021457672,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.2011999934911728,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9390000104904175},{"id":"https://openalex.org/keywords/lamellipodia","display_name":"lamellipodia","score":0.9409999847412109},{"id":"https://openalex.org/keywords/uropod","display_name":"uropod","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.9100000262260437},{"id":"https://openalex.org/keywords/chemoattractant-receptors","display_name":"chemoattractant receptors","score":0.8500000238418579},{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cytoskeletal-rearrangement","display_name":"cytoskeletal rearrangement","score":0.7900000214576721},{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":0.8889999985694885},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.953000009059906},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.8360000252723694},{"id":"https://openalex.org/keywords/lipid-kinase","display_name":"lipid kinase","score":0.9290000200271606},{"id":"https://openalex.org/keywords/second-messengers","display_name":"second messengers","score":0.9599999785423279},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6140000224113464},{"id":"https://openalex.org/keywords/immune-cell-motility","display_name":"immune cell motility","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.823470413684845},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7964062690734863},{"id":"https://openalex.org/C49353375","wikidata":"https://www.wikidata.org/wiki/Q189100","display_name":"Cell polarity","level":3,"score":0.752373456954956},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.6910465359687805},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.6715187430381775},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.6504737138748169},{"id":"https://openalex.org/C109185818","wikidata":"https://www.wikidata.org/wiki/Q3092607","display_name":"Lamellipodium","level":4,"score":0.5694711208343506},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5341358184814453},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.5069001317024231},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.5018935203552246},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.46226680278778076},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.4533613622188568},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.43317461013793945},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.4222128689289093},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4199710786342621},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.4121144413948059},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.32807856798171997},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23333454132080078},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09882867336273193}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/emboj/18.3.501","doi":"https://doi.org/10.1093/emboj/18.3.501","is_oa":false,"landing_page_url":"https://doi.org/10.1093/emboj/18.3.501","pdf_url":null,"source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:216006","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1171143","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:9927410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9927410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1171143","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1171143/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO J","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:216006","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1171143","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313831","display_name":"Comunidad de Madrid","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":131,"referenced_works":["https://openalex.org/W77948366","https://openalex.org/W93284168","https://openalex.org/W125282385","https://openalex.org/W1236053900","https://openalex.org/W1508695192","https://openalex.org/W1513643699","https://openalex.org/W1524475817","https://openalex.org/W1550035003","https://openalex.org/W1557956840","https://openalex.org/W1562441478","https://openalex.org/W1586680544","https://openalex.org/W1597402402","https://openalex.org/W1602835962","https://openalex.org/W1606615500","https://openalex.org/W1761948583","https://openalex.org/W1825153199","https://openalex.org/W1876503166","https://openalex.org/W1902051780","https://openalex.org/W1906447044","https://openalex.org/W1931472297","https://openalex.org/W1964441922","https://openalex.org/W1964484264","https://openalex.org/W1967265143","https://openalex.org/W1969563780","https://openalex.org/W1970866345","https://openalex.org/W1975981720","https://openalex.org/W1979713589","https://openalex.org/W1981462495","https://openalex.org/W1982092413","https://openalex.org/W1983879962","https://openalex.org/W1984164971","https://openalex.org/W1984625688","https://openalex.org/W1986639792","https://openalex.org/W1989342624","https://openalex.org/W1991811424","https://openalex.org/W1992277590","https://openalex.org/W1992304653","https://openalex.org/W1993312924","https://openalex.org/W1995811820","https://openalex.org/W1996047038","https://openalex.org/W2005216911","https://openalex.org/W2005395047","https://openalex.org/W2005659566","https://openalex.org/W2008207415","https://openalex.org/W2008791808","https://openalex.org/W2011936885","https://openalex.org/W2017415762","https://openalex.org/W2019125570","https://openalex.org/W2019286212","https://openalex.org/W2020993672","https://openalex.org/W2021266075","https://openalex.org/W2024367381","https://openalex.org/W2024957425","https://openalex.org/W2027810531","https://openalex.org/W2030463167","https://openalex.org/W2032295238","https://openalex.org/W2033133245","https://openalex.org/W2036145275","https://openalex.org/W2039247434","https://openalex.org/W2041247573","https://openalex.org/W2041463169","https://openalex.org/W2042263478","https://openalex.org/W2042578530","https://openalex.org/W2042626190","https://openalex.org/W2043290332","https://openalex.org/W2046425717","https://openalex.org/W2047886675","https://openalex.org/W2050277545","https://openalex.org/W2050865455","https://openalex.org/W2054613918","https://openalex.org/W2056491819","https://openalex.org/W2059797694","https://openalex.org/W2060006253","https://openalex.org/W2066497238","https://openalex.org/W2072128091","https://openalex.org/W2073447384","https://openalex.org/W2073891485","https://openalex.org/W2074751330","https://openalex.org/W2074937633","https://openalex.org/W2075569239","https://openalex.org/W2076171916","https://openalex.org/W2078384542","https://openalex.org/W2079450072","https://openalex.org/W2084939944","https://openalex.org/W2086037471","https://openalex.org/W2093082265","https://openalex.org/W2095359507","https://openalex.org/W2095773895","https://openalex.org/W2096791952","https://openalex.org/W2099253537","https://openalex.org/W2099675490","https://openalex.org/W2102416981","https://openalex.org/W2105164715","https://openalex.org/W2106488950","https://openalex.org/W2108824104","https://openalex.org/W2112093320","https://openalex.org/W2112600997","https://openalex.org/W2112630320","https://openalex.org/W2114559914","https://openalex.org/W2114934533","https://openalex.org/W2114955841","https://openalex.org/W2114964393","https://openalex.org/W2122218045","https://openalex.org/W2125898471","https://openalex.org/W2128407839","https://openalex.org/W2128511563","https://openalex.org/W2129558898","https://openalex.org/W2131315329","https://openalex.org/W2133931936","https://openalex.org/W2134185495","https://openalex.org/W2134360487","https://openalex.org/W2137736246","https://openalex.org/W2138198341","https://openalex.org/W2144476583","https://openalex.org/W2144518949","https://openalex.org/W2145393717","https://openalex.org/W2148849095","https://openalex.org/W2152108405","https://openalex.org/W2156819631","https://openalex.org/W2160272188","https://openalex.org/W2163295981","https://openalex.org/W2170765019","https://openalex.org/W2171303172","https://openalex.org/W2176220887","https://openalex.org/W2177733342","https://openalex.org/W2183079276","https://openalex.org/W2429606061","https://openalex.org/W3021509188","https://openalex.org/W4211128585","https://openalex.org/W4313379465","https://openalex.org/W6979047482"],"related_works":["https://openalex.org/W2145393717","https://openalex.org/W1567901499","https://openalex.org/W2015175611","https://openalex.org/W2120106378","https://openalex.org/W1963743570","https://openalex.org/W2169787574","https://openalex.org/W1992794497","https://openalex.org/W2041123950","https://openalex.org/W2011402559"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":25},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":20}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
