{"id":"https://openalex.org/W1988549151","doi":"https://doi.org/10.1002/jcb.240580212","title":"Effects of c\u2010Jun and a negative dominant mutation of c\u2010Jun on differentiation and gene expression in lens epithelial cells","display_name":"Effects of c\u2010Jun and a negative dominant mutation of c\u2010Jun on differentiation and gene expression in lens epithelial cells","publication_year":1995,"publication_date":"1995-06-01","ids":{"openalex":"https://openalex.org/W1988549151","doi":"https://doi.org/10.1002/jcb.240580212","mag":"1988549151","pmid":"https://pubmed.ncbi.nlm.nih.gov/7673330"},"language":"en","primary_location":{"id":"doi:10.1002/jcb.240580212","doi":"https://doi.org/10.1002/jcb.240580212","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.240580212","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112136821","display_name":"Jo Ann Rinaudo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jo Ann Rinaudo","raw_affiliation_strings":["Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-2730, USA","Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892\u20102730"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-2730, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]},{"raw_affiliation_string":"Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892\u20102730","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077525720","display_name":"EMANUEL J. VACCHIANO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emanuel Vacchiano","raw_affiliation_strings":["Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-2730"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-2730","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108453115","display_name":"Peggy S. Zelenka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peggy S. Zelenka","raw_affiliation_strings":["Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-2730"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-2730","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108453115"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"],"apc_list":{"value":5110,"currency":"USD","value_usd":5110},"apc_paid":null,"fwci":0.2478,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.46752512,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"58","issue":"2","first_page":"237","last_page":"247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.47290000319480896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.47290000319480896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.3474000096321106,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":0.08739999681711197,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lens-epithelial-cells","display_name":"lens epithelial cells","score":0.8840000033378601},{"id":"https://openalex.org/keywords/lens-differentiation","display_name":"lens differentiation","score":0.656000018119812},{"id":"https://openalex.org/keywords/lens-fiber-cells","display_name":"lens fiber cells","score":0.6209999918937683},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/alphaa-crystallin","display_name":"alphaA-crystallin","score":0.8700000047683716},{"id":"https://openalex.org/keywords/negative-regulation","display_name":"negative regulation","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C2779087070","wikidata":"https://www.wikidata.org/wiki/Q5005943","display_name":"c-jun","level":4,"score":0.796532154083252},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6442581415176392},{"id":"https://openalex.org/C2909221355","wikidata":"https://www.wikidata.org/wiki/Q146701","display_name":"Lens Fiber","level":3,"score":0.616692841053009},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5973938703536987},{"id":"https://openalex.org/C7263354","wikidata":"https://www.wikidata.org/wiki/Q2992167","display_name":"Crystallin","level":2,"score":0.5669916272163391},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5467192530632019},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5246491432189941},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4921233057975769},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4708169102668762},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.44334954023361206},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43536248803138733},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.42625489830970764},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4244697690010071},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40874984860420227},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.24076151847839355},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13089382648468018},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005799","descriptor_name":"Genes, Dominant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016758","descriptor_name":"Genes, jun","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcb.240580212","doi":"https://doi.org/10.1002/jcb.240580212","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.240580212","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:7673330","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7673330","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W29175536","https://openalex.org/W126627744","https://openalex.org/W1489145497","https://openalex.org/W1516457342","https://openalex.org/W1517480469","https://openalex.org/W1527082041","https://openalex.org/W1532686067","https://openalex.org/W1579393067","https://openalex.org/W1594840269","https://openalex.org/W1784478130","https://openalex.org/W1884284628","https://openalex.org/W1967778139","https://openalex.org/W1979655386","https://openalex.org/W1979837932","https://openalex.org/W1987557547","https://openalex.org/W1989403340","https://openalex.org/W1991369017","https://openalex.org/W1993418718","https://openalex.org/W1998835611","https://openalex.org/W2002609010","https://openalex.org/W2004002827","https://openalex.org/W2021246941","https://openalex.org/W2021253208","https://openalex.org/W2023666553","https://openalex.org/W2032118018","https://openalex.org/W2042715351","https://openalex.org/W2045925233","https://openalex.org/W2046460054","https://openalex.org/W2059605176","https://openalex.org/W2060913542","https://openalex.org/W2068055791","https://openalex.org/W2075556833","https://openalex.org/W2077676304","https://openalex.org/W2080532845","https://openalex.org/W2086501414","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2119725374","https://openalex.org/W2281631575","https://openalex.org/W2399911287","https://openalex.org/W2408408246","https://openalex.org/W2414070944","https://openalex.org/W2418691345","https://openalex.org/W2465565396","https://openalex.org/W2473472230","https://openalex.org/W6651336719"],"related_works":["https://openalex.org/W2042715351","https://openalex.org/W2039231830","https://openalex.org/W2005763122","https://openalex.org/W1784478130","https://openalex.org/W2057285474","https://openalex.org/W1980841124","https://openalex.org/W1807235381","https://openalex.org/W2741909194","https://openalex.org/W2092803294","https://openalex.org/W4230193263"],"abstract_inverted_index":{"We":[0],"have":[1],"used":[2],"a":[3,13],"retroviral":[4],"vector":[5],"(RCAS)":[6],"to":[7,27],"overexpress":[8],"wild-type":[9],"chicken":[10,17,51],"c-Jun":[11,18,33,57,82,130],"or":[12,111,131],"deletion":[14],"mutant":[15],"of":[16,32,49,56,61,69,89,118,138],"(Jun":[19],"delta":[20,104],"7)":[21],"lacking":[22],"the":[23,29,59,67,87,100,116],"DNA":[24],"binding":[25],"region":[26],"investigate":[28],"possible":[30],"role":[31],"in":[34,46,122,145],"lens":[35,52,147],"epithelial":[36,53],"cell":[37,62,79,124],"proliferation":[38,63,110],"and":[39,64,141],"differentiation.":[40],"Both":[41],"constructs":[42],"were":[43],"efficiently":[44],"expressed":[45],"primary":[47],"cultures":[48],"embryonic":[50],"cells.":[54,148],"Overexpression":[55],"increased":[58,115],"rate":[60],"greatly":[65],"delayed":[66],"appearance":[68],"\"lentoid":[70],"bodies,\"":[71],"structures":[72],"which":[73],"contain":[74],"differentiated":[75],"cells":[76],"expressing":[77],"fiber":[78],"markers.":[80],"Excess":[81],"expression":[83],"also":[84],"significantly":[85],"decreased":[86],"level":[88,117],"beta":[90,142],"A3/A1-crystallin":[91,143],"mRNA,":[92],"without":[93],"affecting":[94],"alpha":[95,119,139],"A-crystallin":[96,120],"mRNA.":[97],"In":[98],"contrast,":[99],"mutated":[101],"protein,":[102],"Jun":[103],"7,":[105],"had":[106],"no":[107],"effect":[108],"on":[109],"differentiation":[112],"but":[113],"markedly":[114],"mRNA":[121],"proliferating":[123,146],"cultures.":[125],"These":[126],"results":[127],"suggest":[128],"that":[129],"Jun-related":[132],"proteins":[133],"may":[134],"be":[135],"negative":[136],"regulators":[137],"A-":[140],"genes":[144]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}