{"id":"https://openalex.org/W1988499671","doi":"https://doi.org/10.1111/j.1444-0903.2004.00658.x","title":"Modern management of pancreatic carcinoma","display_name":"Modern management of pancreatic carcinoma","publication_year":2004,"publication_date":"2004-08-01","ids":{"openalex":"https://openalex.org/W1988499671","doi":"https://doi.org/10.1111/j.1444-0903.2004.00658.x","mag":"1988499671","pmid":"https://pubmed.ncbi.nlm.nih.gov/15317546"},"language":"en","primary_location":{"id":"doi:10.1111/j.1444-0903.2004.00658.x","doi":"https://doi.org/10.1111/j.1444-0903.2004.00658.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1444-0903.2004.00658.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1444-0903.2004.00658.x","source":{"id":"https://openalex.org/S60716783","display_name":"Internal Medicine Journal","issn_l":"1444-0903","issn":["1444-0903","1445-5994"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine Journal","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1444-0903.2004.00658.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011795261","display_name":"David Goldstein","orcid":"https://orcid.org/0000-0001-6142-3291","observed_orcids":["https://orcid.org/0000-0001-6142-3291"]},"institutions":[{"id":"https://openalex.org/I4210108821","display_name":"Prince of Wales Hospital","ror":"https://ror.org/022arq532","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210108821"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"D. Goldstein","raw_affiliation_strings":["Department of Medical Oncology, Prince of Wales Hospital, New South Wales, Australia. d.goldstein@unsw.edu.au","Departments of Medical Oncology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Prince of Wales Hospital, New South Wales, Australia. d.goldstein@unsw.edu.au","institution_ids":["https://openalex.org/I4210108821"]},{"raw_affiliation_string":"Departments of Medical Oncology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086586885","display_name":"Susan L. Carroll","orcid":"https://orcid.org/0000-0003-4959-0315","observed_orcids":["https://orcid.org/0000-0003-4959-0315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Carroll","raw_affiliation_strings":["Radiation Oncology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079752841","display_name":"Minoti Vivek Apte","orcid":"https://orcid.org/0000-0003-0194-8939","observed_orcids":["https://orcid.org/0000-0003-0194-8939"]},"institutions":[{"id":"https://openalex.org/I2800681009","display_name":"Bankstown Lidcombe Hospital","ror":"https://ror.org/00qrpt643","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1311436738","https://openalex.org/I2800681009","https://openalex.org/I2801351115","https://openalex.org/I4210163551"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"M. Apte","raw_affiliation_strings":["Department of Gastroenterology, Bankstown-Lidcombe and Liverpool Hospitals and The University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Bankstown-Lidcombe and Liverpool Hospitals and The University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I2800681009","https://openalex.org/I31746571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109319890","display_name":"G. Keogh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108821","display_name":"Prince of Wales Hospital","ror":"https://ror.org/022arq532","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210108821"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["AU","CN"],"is_corresponding":false,"raw_author_name":"G. Keogh","raw_affiliation_strings":["Surgery, Prince of Wales Hospital, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Prince of Wales Hospital, and","institution_ids":["https://openalex.org/I4210108821","https://openalex.org/I4210114914"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5011795261"],"corresponding_institution_ids":["https://openalex.org/I4210108821"],"apc_list":{"value":3570,"currency":"USD","value_usd":3570},"apc_paid":null,"fwci":0.47,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.46409432,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"34","issue":"8","first_page":"475","last_page":"481"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.953000009059906},{"id":"https://openalex.org/keywords/pancreatic-cancer-management","display_name":"pancreatic cancer management","score":0.7820000052452087},{"id":"https://openalex.org/keywords/molecular-pathogenesis","display_name":"molecular pathogenesis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/surgical-resection","display_name":"surgical resection","score":0.8389999866485596},{"id":"https://openalex.org/keywords/laparoscopic-surgery","display_name":"laparoscopic surgery","score":0.921999990940094},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/unresectable-disease","display_name":"unresectable disease","score":0.7450000047683716},{"id":"https://openalex.org/keywords/metastatic-disease","display_name":"metastatic disease","score":0.9419999718666077},{"id":"https://openalex.org/keywords/palliative-care","display_name":"palliative care","score":0.8500000238418579},{"id":"https://openalex.org/keywords/biliary-obstruction","display_name":"biliary obstruction","score":0.8420000076293945},{"id":"https://openalex.org/keywords/duodenal-obstruction","display_name":"duodenal obstruction","score":0.9739999771118164},{"id":"https://openalex.org/keywords/pain-management","display_name":"pain management","score":0.6039999723434448},{"id":"https://openalex.org/keywords/celiac-plexus-block","display_name":"celiac plexus block","score":0.8029999732971191},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.7680000066757202},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9768213033676147},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5472745895385742},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5407533645629883},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.49566376209259033},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.4759606719017029},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4419117271900177},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4143243432044983},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3665749132633209},{"id":"https://openalex.org/C61434518","wikidata":"https://www.wikidata.org/wiki/Q932510","display_name":"General surgery","level":1,"score":0.33480435609817505},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32517749071121216},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2870427966117859},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2635183334350586}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010180","descriptor_name":"Pancreatectomy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018714","descriptor_name":"Radiotherapy, Adjuvant","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1444-0903.2004.00658.x","doi":"https://doi.org/10.1111/j.1444-0903.2004.00658.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1444-0903.2004.00658.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1444-0903.2004.00658.x","source":{"id":"https://openalex.org/S60716783","display_name":"Internal Medicine Journal","issn_l":"1444-0903","issn":["1444-0903","1445-5994"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine Journal","raw_type":"journal-article"},{"id":"pmid:15317546","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15317546","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal medicine journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1444-0903.2004.00658.x","doi":"https://doi.org/10.1111/j.1444-0903.2004.00658.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1444-0903.2004.00658.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1444-0903.2004.00658.x","source":{"id":"https://openalex.org/S60716783","display_name":"Internal Medicine Journal","issn_l":"1444-0903","issn":["1444-0903","1445-5994"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1988499671.pdf","grobid_xml":"https://content.openalex.org/works/W1988499671.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W5805428","https://openalex.org/W156810664","https://openalex.org/W242933480","https://openalex.org/W1539297447","https://openalex.org/W1544807320","https://openalex.org/W1546667874","https://openalex.org/W1854099548","https://openalex.org/W1894182878","https://openalex.org/W1927512257","https://openalex.org/W1930757563","https://openalex.org/W1931508686","https://openalex.org/W1966489616","https://openalex.org/W1972373303","https://openalex.org/W1974219858","https://openalex.org/W1975004250","https://openalex.org/W1983585865","https://openalex.org/W1990923591","https://openalex.org/W2010833449","https://openalex.org/W2015172086","https://openalex.org/W2024970269","https://openalex.org/W2027119506","https://openalex.org/W2027451548","https://openalex.org/W2043168293","https://openalex.org/W2044313019","https://openalex.org/W2044573147","https://openalex.org/W2046133119","https://openalex.org/W2047318784","https://openalex.org/W2062035346","https://openalex.org/W2080483063","https://openalex.org/W2081536801","https://openalex.org/W2081740630","https://openalex.org/W2091820305","https://openalex.org/W2103607678","https://openalex.org/W2108089177","https://openalex.org/W2109935462","https://openalex.org/W2115812130","https://openalex.org/W2117954462","https://openalex.org/W2119429437","https://openalex.org/W2121120744","https://openalex.org/W2123344367","https://openalex.org/W2129857462","https://openalex.org/W2133654949","https://openalex.org/W2135352785","https://openalex.org/W2137300622","https://openalex.org/W2145615263","https://openalex.org/W2150881991","https://openalex.org/W2155805287","https://openalex.org/W2160702758","https://openalex.org/W2161604049","https://openalex.org/W2162651519","https://openalex.org/W2170294270","https://openalex.org/W2172206677","https://openalex.org/W2318156113","https://openalex.org/W2413513425","https://openalex.org/W3025531565","https://openalex.org/W4241578751","https://openalex.org/W4253769310","https://openalex.org/W4297819854"],"related_works":["https://openalex.org/W310596826","https://openalex.org/W2072238083","https://openalex.org/W106427042","https://openalex.org/W3192601136","https://openalex.org/W2461747934","https://openalex.org/W1940051907","https://openalex.org/W4210986789","https://openalex.org/W3208433328","https://openalex.org/W2064485158","https://openalex.org/W2406989148"],"abstract_inverted_index":{"Pancreatic":[0],"cancer":[1],"remains":[2,58],"a":[3],"fearsome":[4],"disease.":[5],"New":[6],"insights":[7],"into":[8],"the":[9,28,59,77,101],"molecular":[10],"pathogenesis":[11],"may":[12,75,105,123],"influence":[13],"choice":[14],"of":[15,33,38,79,84,110],"treatment":[16,49,61],"modalities":[17],"and":[18,42,50,63,92,97],"provide":[19],"avenues":[20],"for":[21,25,48],"novel":[22],"therapeutic":[23],"strategies":[24],"testing":[26],"in":[27,66],"clinic.":[29],"The":[30,82],"survival":[31],"rate":[32,78],"patients":[34,104],"with":[35,90,119,126,128,133,142],"all":[36],"stages":[37],"disease":[39,94],"is":[40,87,100],"poor":[41],"clinical":[43],"trials":[44],"are":[45,95],"appropriate":[46],"alternatives":[47],"should":[51],"be":[52,124],"considered.":[53],"Surgical":[54],"resection,":[55],"when":[56],"possible,":[57],"primary":[60],"modality":[62],"can":[64],"result":[65],"long-term":[67],"cure.":[68],"Less":[69],"invasive":[70],"techniques":[71],"such":[72],"as":[73],"laparoscopy":[74],"reduce":[76],"unnecessary":[80],"laparotomies.":[81],"role":[83],"adjuvant":[85],"therapy":[86],"re-emerging.":[88],"Patients":[89],"unresectable":[91],"metastatic":[93],"incurable":[96],"optimal":[98],"palliation":[99],"goal.":[102],"These":[103],"benefit":[106],"from":[107],"palliative":[108],"bypass":[109],"biliary":[111],"or":[112,129,132,137],"duodenal":[113],"obstruction":[114],"if":[115],"symptomatic.":[116],"Pain":[117],"associated":[118],"local":[120,138],"tumour":[121],"infiltration":[122],"palliated":[125],"radiation,":[127],"without":[130],"chemotherapy,":[131],"coeliac":[134],"nerve":[135],"blocks":[136],"neurosurgical":[139],"procedures.":[140],"Chemotherapy":[141],"gemcitabine":[143],"has":[144,150],"modest":[145],"objective":[146],"response":[147],"rates":[148],"but":[149],"been":[151],"shown":[152],"to":[153],"improve":[154],"symptoms.":[155]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}