{"id":"https://openalex.org/W1988313382","doi":"https://doi.org/10.1034/j.1399-302x.2001.160103.x","title":"Differentiation of Streptococcus mutans and Streptococcus sobrinus via genotypic and phenotypic profiles from three different populations","display_name":"Differentiation of Streptococcus mutans and Streptococcus sobrinus via genotypic and phenotypic profiles from three different populations","publication_year":2001,"publication_date":"2001-02-01","ids":{"openalex":"https://openalex.org/W1988313382","doi":"https://doi.org/10.1034/j.1399-302x.2001.160103.x","mag":"1988313382","pmid":"https://pubmed.ncbi.nlm.nih.gov/11169134"},"language":"en","primary_location":{"id":"doi:10.1034/j.1399-302x.2001.160103.x","doi":"https://doi.org/10.1034/j.1399-302x.2001.160103.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1399-302x.2001.160103.x","pdf_url":null,"source":{"id":"https://openalex.org/S96830227","display_name":"Oral Microbiology and Immunology","issn_l":"0902-0055","issn":["0902-0055","1399-302X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oral Microbiology and Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100709211","display_name":"Yihong Li","orcid":"https://orcid.org/0000-0002-5476-1943","observed_orcids":["https://orcid.org/0000-0002-5476-1943"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Y. Li","raw_affiliation_strings":["Department of Oral Biology, School of Dentistry, University of Alabama at Birmingham, 35294-0007, USA","Department of Oral Biology, School of Dentistry, University of Alabama at Birmingham, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology, School of Dentistry, University of Alabama at Birmingham, 35294-0007, USA","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Department of Oral Biology, School of Dentistry, University of Alabama at Birmingham, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109550132","display_name":"P.W. Caufield","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. W. Caufield","raw_affiliation_strings":["Department of Oral Biology, School of Dentistry, University of Alabama at Birmingham, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology, School of Dentistry, University of Alabama at Birmingham, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040612210","display_name":"Ing\u2010Mari Redmo Emanuelsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183111857","display_name":"Malm\u00f6 University","ror":"https://ror.org/05wp7an13","country_code":"SE","type":"education","lineage":["https://openalex.org/I183111857"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"I. Redmo Emanuelsson","raw_affiliation_strings":["Department of Cariology, Faculty of Odontology, University of Malmo\u0308, Sweden","Department of Cariology, Faculty of Odontology, University of Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cariology, Faculty of Odontology, University of Malmo\u0308, Sweden","institution_ids":["https://openalex.org/I183111857"]},{"raw_affiliation_string":"Department of Cariology, Faculty of Odontology, University of Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I183111857"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004374932","display_name":"Elisabeth Thornqvist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183111857","display_name":"Malm\u00f6 University","ror":"https://ror.org/05wp7an13","country_code":"SE","type":"education","lineage":["https://openalex.org/I183111857"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"E. Thornqvist","raw_affiliation_strings":["Department of Cariology, Faculty of Odontology, University of Malmo\u0308, Sweden","Department of Cariology, Faculty of Odontology, University of Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cariology, Faculty of Odontology, University of Malmo\u0308, Sweden","institution_ids":["https://openalex.org/I183111857"]},{"raw_affiliation_string":"Department of Cariology, Faculty of Odontology, University of Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I183111857"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100709211"],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":null,"apc_paid":null,"fwci":4.84,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.93728895,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":"1","first_page":"16","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.7759000062942505,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.7759000062942505,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.19249999523162842,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptococcus-mutans","display_name":"Streptococcus mutans","score":1.0},{"id":"https://openalex.org/keywords/streptococcus-sobrinus","display_name":"Streptococcus sobrinus","score":1.0},{"id":"https://openalex.org/keywords/mutans-streptococci","display_name":"mutans streptococci","score":0.9919999837875366},{"id":"https://openalex.org/keywords/bacterial-species-differentiation","display_name":"bacterial species differentiation","score":0.7059999704360962},{"id":"https://openalex.org/keywords/arbitrarily-primed-pcr","display_name":"arbitrarily primed PCR","score":0.9049999713897705},{"id":"https://openalex.org/keywords/serotyping","display_name":"serotyping","score":0.7789999842643738},{"id":"https://openalex.org/keywords/biotyping","display_name":"biotyping","score":0.9940000176429749},{"id":"https://openalex.org/keywords/gc-content","display_name":"GC content","score":0.7829999923706055},{"id":"https://openalex.org/keywords/clinical-isolates","display_name":"clinical isolates","score":0.6660000085830688},{"id":"https://openalex.org/keywords/cariogenic-bacteria","display_name":"cariogenic bacteria","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C2779958046","wikidata":"https://www.wikidata.org/wiki/Q603315","display_name":"Streptococcus sobrinus","level":4,"score":0.9437123537063599},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8390448093414307},{"id":"https://openalex.org/C2776906770","wikidata":"https://www.wikidata.org/wiki/Q936454","display_name":"HaeIII","level":5,"score":0.7845126986503601},{"id":"https://openalex.org/C2778430296","wikidata":"https://www.wikidata.org/wiki/Q131452","display_name":"Streptococcus mutans","level":3,"score":0.7217094898223877},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6845241785049438},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5971656441688538},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.5898653864860535},{"id":"https://openalex.org/C10389963","wikidata":"https://www.wikidata.org/wiki/Q848328","display_name":"Serotype","level":2,"score":0.5583246350288391},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34117189049720764},{"id":"https://openalex.org/C168007829","wikidata":"https://www.wikidata.org/wiki/Q857299","display_name":"Restriction fragment length polymorphism","level":4,"score":0.25325220823287964},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23610973358154297},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2274802327156067},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10699674487113953}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002876","descriptor_name":"Chromosomes, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012703","descriptor_name":"Serotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013295","descriptor_name":"Streptococcus mutans","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D013295","descriptor_name":"Streptococcus mutans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015183","descriptor_name":"Restriction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015252","descriptor_name":"Deoxyribonucleases, Type II Site-Specific","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015373","descriptor_name":"Bacterial Typing Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016172","descriptor_name":"DNA Fingerprinting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016986","descriptor_name":"Streptococcus sobrinus","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D016986","descriptor_name":"Streptococcus sobrinus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1034/j.1399-302x.2001.160103.x","doi":"https://doi.org/10.1034/j.1399-302x.2001.160103.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1399-302x.2001.160103.x","pdf_url":null,"source":{"id":"https://openalex.org/S96830227","display_name":"Oral Microbiology and Immunology","issn_l":"0902-0055","issn":["0902-0055","1399-302X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oral Microbiology and Immunology","raw_type":"journal-article"},{"id":"pmid:11169134","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11169134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oral microbiology and immunology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1282619311","display_name":null,"funder_award_id":"DE 11147","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G1409713527","display_name":"SPECIALIZED CARIES RESEARCH CENTER","funder_award_id":"P50DE011147","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G575303998","display_name":null,"funder_award_id":"DE 09082","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G6504167746","display_name":"S MUTANS--CHARACTERIZATION OF ITS MUTACIN ANTIBIOTIC","funder_award_id":"R01DE009082","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W102083873","https://openalex.org/W752333882","https://openalex.org/W1584241544","https://openalex.org/W1738849700","https://openalex.org/W1920839896","https://openalex.org/W1987486717","https://openalex.org/W1988753748","https://openalex.org/W1989830117","https://openalex.org/W1990605957","https://openalex.org/W1991431761","https://openalex.org/W2005287624","https://openalex.org/W2014613624","https://openalex.org/W2016084764","https://openalex.org/W2035860799","https://openalex.org/W2060123690","https://openalex.org/W2068925644","https://openalex.org/W2096621506","https://openalex.org/W2118900956","https://openalex.org/W2137554528","https://openalex.org/W2147188244","https://openalex.org/W2147724119","https://openalex.org/W2148337956","https://openalex.org/W2155098443","https://openalex.org/W2156607603","https://openalex.org/W2418385324","https://openalex.org/W2419027922","https://openalex.org/W3146406052","https://openalex.org/W4206702770"],"related_works":["https://openalex.org/W1971286821","https://openalex.org/W2330480480","https://openalex.org/W2139947941","https://openalex.org/W1987486717","https://openalex.org/W2623405865","https://openalex.org/W2034756882","https://openalex.org/W1998977230","https://openalex.org/W2372628405","https://openalex.org/W2183846902","https://openalex.org/W2107578304"],"abstract_inverted_index":{"Routine":[0],"identification":[1],"of":[2,26,34,63,130,143,152,165,177,209,213,228,245],"Streptococcus":[3,6],"mutans":[4,64,146,215],"and":[5,19,44,57,69,128,138,189,233],"sobrinus":[7,149,218],"is":[8],"generally":[9],"based":[10,75],"upon":[11],"growth":[12],"on":[13,76],"various":[14,24],"selective":[15],"media,":[16],"colony":[17],"morphology":[18],"biochemical":[20],"characteristics.":[21],"We":[22],"examined":[23,124],"approaches":[25,231],"differentiating":[27],"these":[28,229],"two":[29,72,230],"species":[30],"through":[31],"a":[32,162,174,237],"combination":[33],"the":[35,80,101,117,141,170,193,199,204,222],"conventional":[36],"phenotypic":[37],"methodology":[38],"with":[39,88,107,192],"chromosomal":[40],"DNA":[41,131],"fingerprint":[42],"(CDF)":[43],"arbitrarily":[45],"primed":[46],"polymerase":[47],"chain":[48],"reaction":[49],"(AP-PCR)":[50],"methods.":[51],"Initially,":[52],"ten":[53],"ATCC":[54],"type":[55],"strains":[56,159,172],"20":[58],"randomly":[59],"selected":[60],"clinical":[61],"isolates":[62],"streptococci":[65],"(MS)":[66],"were":[67,98,114,122],"characterized":[68],"grouped":[70],"into":[71],"major":[73],"types":[74],"patterns":[77,87,106],"generated":[78],"by":[79],"CDF":[81,223],"using":[82],"HaeIII":[83],"digestion.":[84],"The":[85,104,181,195,207],"CDF's":[86,105],"restriction":[89,108],"fragments":[90,109],"equal":[91],"to":[92,167,179,221,241],"or":[93,243],"greater":[94],"than":[95,111],"6.6":[96,112],"kb":[97,113],"defined":[99,115],"as":[100,116,236],"CDF-1":[102,158],"group.":[103,119],"less":[110],"CDF-2":[118,171],"Both":[120],"groups":[121],"then":[123],"for":[125,140],"biotype,":[126],"serotype,":[127],"composition":[129],"via":[132],"thermal":[133],"denaturation.":[134],"AP-PCR":[135,210],"was":[136,219],"applied":[137],"evaluated":[139],"capability":[142,208],"delineating":[144],"S.":[145,148,214,217],"from":[147,216],"strains.":[150],"Results":[151],"this":[153],"study":[154],"showed":[155],"that":[156,226],"all":[157],"fit":[160],"within":[161],"G+C":[163,175],"range":[164,176],"36.2%":[166],"42.2%,":[168],"whereas":[169],"had":[173],"45.8%":[178],"47.0%.":[180],"serotyping":[182,242],"assay":[183,197],"exhibited":[184],"100%":[185],"sensitivity,":[186],"90%":[187],"specificity":[188,201],"86.7%":[190],"agreement":[191],"CDF.":[194],"biotyping":[196,244],"presented":[198],"poorest":[200],"(38.5%),":[202],"indicating":[203],"highest":[205],"variability.":[206],"in":[211],"differentiation":[212],"comparable":[220],"method,":[224],"suggesting":[225],"either":[227],"can":[232],"may":[234],"serve":[235],"viable":[238],"alternative":[239],"method":[240],"MS.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}