{"id":"https://openalex.org/W1988222534","doi":"https://doi.org/10.1097/01.ju.0000133655.71782.14","title":"MOLECULAR AND CELLULAR PATHOGENESIS OF BENIGN PROSTATIC HYPERPLASIA","display_name":"MOLECULAR AND CELLULAR PATHOGENESIS OF BENIGN PROSTATIC HYPERPLASIA","publication_year":2004,"publication_date":"2004-10-08","ids":{"openalex":"https://openalex.org/W1988222534","doi":"https://doi.org/10.1097/01.ju.0000133655.71782.14","mag":"1988222534","pmid":"https://pubmed.ncbi.nlm.nih.gov/15540721"},"language":"en","primary_location":{"id":"doi:10.1097/01.ju.0000133655.71782.14","doi":"https://doi.org/10.1097/01.ju.0000133655.71782.14","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.ju.0000133655.71782.14","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069614467","display_name":"Keith L. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"KEITH L. LEE","raw_affiliation_strings":["From the Department of Urology, Stanford University School of Medicine, Stanford, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, Stanford University School of Medicine, Stanford, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109552590","display_name":"Donna M. Peehl","orcid":"https://orcid.org/0009-0003-8592-7242","observed_orcids":["https://orcid.org/0009-0003-8592-7242"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DONNA M. PEEHL","raw_affiliation_strings":["From the Department of Urology, Stanford University School of Medicine, Stanford, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, Stanford University School of Medicine, Stanford, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":1.3254,"has_fulltext":false,"cited_by_count":188,"citation_normalized_percentile":{"value":0.77272727,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"172","issue":"5","first_page":"1784","last_page":"1791"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12866","display_name":"Urologic and reproductive health conditions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":1.0},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/prostatic-epithelium","display_name":"prostate epithelium","score":0.7979999780654907},{"id":"https://openalex.org/keywords/prostatic-stroma","display_name":"prostate stroma","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6909999847412109},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9739999771118164},{"id":"https://openalex.org/keywords/candidate-genes","display_name":"candidate genes","score":0.718999981880188},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9010000228881836},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/growth-regulation","display_name":"growth regulation","score":0.5770000219345093},{"id":"https://openalex.org/keywords/cell-culture-model","display_name":"cell culture model","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9371509552001953},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7810359001159668},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.7555193305015564},{"id":"https://openalex.org/C2994223898","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate disease","level":4,"score":0.4648664593696594},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.3630984425544739},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36000245809555054},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.33854764699935913},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22771713137626648},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.09866812825202942}],"mesh":[{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.ju.0000133655.71782.14","doi":"https://doi.org/10.1097/01.ju.0000133655.71782.14","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.ju.0000133655.71782.14","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:15540721","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15540721","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7799999713897705}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W155326310","https://openalex.org/W158180555","https://openalex.org/W1531175687","https://openalex.org/W1538847424","https://openalex.org/W1558144205","https://openalex.org/W1580316843","https://openalex.org/W1722430236","https://openalex.org/W1964621103","https://openalex.org/W1965831940","https://openalex.org/W1973609567","https://openalex.org/W1974557172","https://openalex.org/W1975410250","https://openalex.org/W1977315608","https://openalex.org/W1981831159","https://openalex.org/W1986146441","https://openalex.org/W1987143696","https://openalex.org/W1987165109","https://openalex.org/W1988516136","https://openalex.org/W1990773600","https://openalex.org/W1995064793","https://openalex.org/W1996663128","https://openalex.org/W2003062516","https://openalex.org/W2005010706","https://openalex.org/W2009490070","https://openalex.org/W2009978907","https://openalex.org/W2013608315","https://openalex.org/W2015198241","https://openalex.org/W2015247714","https://openalex.org/W2016002890","https://openalex.org/W2017682357","https://openalex.org/W2021731226","https://openalex.org/W2024227612","https://openalex.org/W2025694032","https://openalex.org/W2039818194","https://openalex.org/W2042070210","https://openalex.org/W2053831799","https://openalex.org/W2055651270","https://openalex.org/W2058712340","https://openalex.org/W2059767485","https://openalex.org/W2061485338","https://openalex.org/W2064157149","https://openalex.org/W2064531218","https://openalex.org/W2065366305","https://openalex.org/W2065579733","https://openalex.org/W2068879625","https://openalex.org/W2069029149","https://openalex.org/W2069375457","https://openalex.org/W2074757081","https://openalex.org/W2075600855","https://openalex.org/W2077010673","https://openalex.org/W2080913546","https://openalex.org/W2082612334","https://openalex.org/W2083184460","https://openalex.org/W2084562061","https://openalex.org/W2086251495","https://openalex.org/W2086342587","https://openalex.org/W2087546949","https://openalex.org/W2090575954","https://openalex.org/W2090788158","https://openalex.org/W2099449161","https://openalex.org/W2100566420","https://openalex.org/W2103384793","https://openalex.org/W2104536025","https://openalex.org/W2104681526","https://openalex.org/W2107152318","https://openalex.org/W2124662269","https://openalex.org/W2132728194","https://openalex.org/W2144881249","https://openalex.org/W2145212251","https://openalex.org/W2145817734","https://openalex.org/W2156264356","https://openalex.org/W2158335066","https://openalex.org/W2159280763","https://openalex.org/W2163470211","https://openalex.org/W2165151843","https://openalex.org/W2169900020","https://openalex.org/W2398704715","https://openalex.org/W2464152831","https://openalex.org/W4244642218","https://openalex.org/W4255510824","https://openalex.org/W4292291331","https://openalex.org/W6681621528"],"related_works":["https://openalex.org/W4406806945","https://openalex.org/W4237563896","https://openalex.org/W2785500990","https://openalex.org/W3211129037","https://openalex.org/W2412161808","https://openalex.org/W2744349428","https://openalex.org/W3084261092","https://openalex.org/W2027820660","https://openalex.org/W2338168020","https://openalex.org/W1979111679"],"abstract_inverted_index":{"PURPOSE:":[0],"Symptomatic":[1],"benign":[2],"prostatic":[3],"hyperplasia":[4],"(BPH)":[5],"is":[6,41,168],"one":[7],"of":[8,30,33,55,57,63,114,131,139,159,186],"the":[9,15,28,31,37,52,58,92,129,135],"most":[10],"common":[11,184],"ailments":[12],"seen":[13],"by":[14],"urologist.":[16],"Significant":[17],"advances":[18],"have":[19,103],"occurred":[20],"in":[21,27,85,91,98,109,119,142,153,156],"medical":[22],"and":[23,26,44,60,70,89,94,116,126,164,173,179],"surgical":[24],"therapy,":[25],"understanding":[29,158],"biology":[32],"this":[34,183],"disease.":[35],"However,":[36],"basic":[38,72,171],"science":[39,73,172],"literature":[40],"often":[42],"conflicting":[43],"confusing,":[45],"without":[46],"a":[47,162],"unified":[48],"voice.":[49],"We":[50,68],"report":[51],"current":[53],"state":[54],"knowledge":[56],"molecular":[59,163],"cellular":[61,165],"basis":[62],"BPH.":[64],"MATERIALS":[65],"AND":[66],"METHODS:":[67],"compiled":[69],"interpreted":[71],"studies":[74],"relevant":[75],"to":[76],"BPH":[77,99,120,143,160],"pathogenesis.":[78,100],"RESULTS:":[79],"Cellular":[80],"alterations":[81],"that":[82,170],"include":[83],"changes":[84],"proliferation,":[86],"differentiation,":[87],"apoptosis":[88],"senescence":[90],"epithelium":[93],"stroma":[95],"are":[96,144],"implicated":[97],"Molecular":[101],"analyses":[102],"yielded":[104],"numerous":[105],"candidate":[106],"genes":[107],"important":[108],"disease":[110,185],"progression.":[111],"Differential":[112],"expression":[113],"cytokines":[115],"growth":[117,140],"factors":[118],"tissue":[121],"suggests":[122],"roles":[123],"for":[124,182],"inflammation":[125],"hypoxia.":[127],"Through":[128],"use":[130],"cell":[132],"culture":[133],"models":[134],"complex":[136],"regulatory":[137],"mechanisms":[138],"control":[141],"becoming":[145],"defined.":[146],"CONCLUSIONS:":[147],"The":[148],"scientific":[149],"endeavor":[150],"has":[151],"resulted":[152],"great":[154],"strides":[155],"our":[157],"on":[161],"level.":[166],"It":[167],"hopeful":[169],"translational":[174],"research":[175],"will":[176],"improve":[177],"treatment":[178],"prevention":[180],"strategies":[181],"elderly":[187],"men.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":13}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
