{"id":"https://openalex.org/W1988116237","doi":"https://doi.org/10.1128/jvi.78.23.12996-13006.2004","title":"Inhibition of Human Immunodeficiency Virus Replication by a Dual CCR5/CXCR4 Antagonist","display_name":"Inhibition of Human Immunodeficiency Virus Replication by a Dual CCR5/CXCR4 Antagonist","publication_year":2004,"publication_date":"2004-11-12","ids":{"openalex":"https://openalex.org/W1988116237","doi":"https://doi.org/10.1128/jvi.78.23.12996-13006.2004","mag":"1988116237","pmid":"https://pubmed.ncbi.nlm.nih.gov/15542651"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.78.23.12996-13006.2004","doi":"https://doi.org/10.1128/jvi.78.23.12996-13006.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.78.23.12996-13006.2004","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lirias.kuleuven.be/retrieve/765606a7-2eac-4a2b-ae70-671e9fb77001","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009622930","display_name":"Katrien Princen","orcid":"https://orcid.org/0000-0002-7209-6422","observed_orcids":["https://orcid.org/0000-0002-7209-6422"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Katrien Princen","raw_affiliation_strings":["Rega Institute for Medical Research, Leuven, Belgium","Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275"]},{"raw_affiliation_string":"Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088923965","display_name":"Sigrid Hatse","orcid":"https://orcid.org/0000-0002-6764-2628","observed_orcids":["https://orcid.org/0000-0002-6764-2628"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Sigrid Hatse","raw_affiliation_strings":["Rega Institute for Medical Research, Leuven, Belgium","Rega Institute for Medical Research , Leuven , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275"]},{"raw_affiliation_string":"Rega Institute for Medical Research , Leuven , Belgium","institution_ids":["https://openalex.org/I24156275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027298107","display_name":"Kurt Vermeire","orcid":"https://orcid.org/0000-0003-1123-1907","observed_orcids":["https://orcid.org/0000-0003-1123-1907"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Kurt Vermeire","raw_affiliation_strings":["Rega Institute for Medical Research, Leuven, Belgium","Rega Institute for Medical Research , Leuven , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275"]},{"raw_affiliation_string":"Rega Institute for Medical Research , Leuven , Belgium","institution_ids":["https://openalex.org/I24156275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006689393","display_name":"Stefano Aquaro","orcid":"https://orcid.org/0000-0002-8417-2103","observed_orcids":["https://orcid.org/0000-0002-8417-2103"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Stefano Aquaro","raw_affiliation_strings":["Rega Institute for Medical Research, Leuven, Belgium","Rega Institute for Medical Research , Leuven , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275"]},{"raw_affiliation_string":"Rega Institute for Medical Research , Leuven , Belgium","institution_ids":["https://openalex.org/I24156275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040662398","display_name":"Erik De Clercq","orcid":"https://orcid.org/0000-0002-2985-8890","observed_orcids":["https://orcid.org/0000-0002-2985-8890"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Erik De Clercq","raw_affiliation_strings":["Rega Institute for Medical Research, Leuven, Belgium","Rega Institute for Medical Research , Leuven , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275"]},{"raw_affiliation_string":"Rega Institute for Medical Research , Leuven , Belgium","institution_ids":["https://openalex.org/I24156275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018498114","display_name":"Lars\u2010Ole Gerlach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lars-Ole Gerlach","raw_affiliation_strings":["The Panum Institute, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Panum Institute, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035872776","display_name":"METTE MARIE ROSENKILDE","orcid":"https://orcid.org/0000-0001-9600-3254","observed_orcids":["https://orcid.org/0000-0001-9600-3254"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Mette Rosenkilde","raw_affiliation_strings":["The Panum Institute, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Panum Institute, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021396103","display_name":"Thue Walter Schwartz","orcid":"https://orcid.org/0000-0002-0261-6904","observed_orcids":["https://orcid.org/0000-0002-0261-6904"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Thue W. Schwartz","raw_affiliation_strings":["The Panum Institute, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Panum Institute, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086331947","display_name":"Renato T. Skerlj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Renato Skerlj","raw_affiliation_strings":["AnorMED, Langley, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AnorMED, Langley, British Columbia, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075997430","display_name":"Gary J Bridger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary Bridger","raw_affiliation_strings":["AnorMED, Langley, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AnorMED, Langley, British Columbia, Canada","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023796496","display_name":"Dominique Schols","orcid":"https://orcid.org/0000-0003-3256-5850","observed_orcids":["https://orcid.org/0000-0003-3256-5850"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Dominique Schols","raw_affiliation_strings":["Rega Institute for Medical Research, Leuven, Belgium","Rega Institute for Medical Research , Leuven , Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275"]},{"raw_affiliation_string":"Rega Institute for Medical Research , Leuven , Belgium","institution_ids":["https://openalex.org/I24156275"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5023796496"],"corresponding_institution_ids":["https://openalex.org/I24156275"],"apc_list":null,"apc_paid":null,"fwci":4.6594,"has_fulltext":true,"cited_by_count":86,"citation_normalized_percentile":{"value":0.94258536,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"78","issue":"23","first_page":"12996","last_page":"13006"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.5449000000953674,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.5449000000953674,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.24060000479221344,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.19750000536441803,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maraviroc","display_name":"maraviroc","score":0.7369999885559082},{"id":"https://openalex.org/keywords/ccr5-antagonist","display_name":"CCR5 antagonist","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cxcr4-antagonist","display_name":"CXCR4 antagonist","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.6470000147819519},{"id":"https://openalex.org/keywords/hiv-2","display_name":"HIV-2","score":0.9760000109672546},{"id":"https://openalex.org/keywords/virus-entry-inhibition","display_name":"viral entry inhibition","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cxcl12","display_name":"CXCL12","score":0.9620000123977661},{"id":"https://openalex.org/keywords/ccl3","display_name":"CCL3","score":0.8019999861717224},{"id":"https://openalex.org/keywords/carbon-tetrachloride","display_name":"carbon tetrachloride","score":0.6809999942779541},{"id":"https://openalex.org/keywords/monocyte-chemotaxis","display_name":"monocyte chemotaxis","score":0.7210000157356262},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/chemokine-receptor-binding","display_name":"chemokine receptor binding","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7055356502532959},{"id":"https://openalex.org/C116484652","wikidata":"https://www.wikidata.org/wiki/Q3492926","display_name":"CCL5","level":5,"score":0.5791789293289185},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.5727829933166504},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5328090190887451},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5029866099357605},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.49089914560317993},{"id":"https://openalex.org/C37044404","wikidata":"https://www.wikidata.org/wiki/Q5009692","display_name":"CCR5 receptor antagonist","level":5,"score":0.4890974164009094},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.46617889404296875},{"id":"https://openalex.org/C128879288","wikidata":"https://www.wikidata.org/wiki/Q5009764","display_name":"CC chemokine receptors","level":5,"score":0.4257952570915222},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35001665353775024},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3348005414009094},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2858904004096985},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2334595024585724},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19237911701202393},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18794235587120056},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.15125009417533875},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14837828278541565},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.06882816553115845},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006571","descriptor_name":"Heterocyclic Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006571","descriptor_name":"Heterocyclic Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006571","descriptor_name":"Heterocyclic Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019742","descriptor_name":"Chemokines, CC","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019742","descriptor_name":"Chemokines, CC","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019742","descriptor_name":"Chemokines, CC","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019743","descriptor_name":"Chemokines, CXC","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019743","descriptor_name":"Chemokines, CXC","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019743","descriptor_name":"Chemokines, CXC","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D054377","descriptor_name":"Chemokine CXCL12","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054377","descriptor_name":"Chemokine CXCL12","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054377","descriptor_name":"Chemokine CXCL12","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065100","descriptor_name":"CCR5 Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065100","descriptor_name":"CCR5 Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065100","descriptor_name":"CCR5 Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1128/jvi.78.23.12996-13006.2004","doi":"https://doi.org/10.1128/jvi.78.23.12996-13006.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.78.23.12996-13006.2004","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmid:15542651","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15542651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/35655","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/35655","pdf_url":"https://lirias.kuleuven.be/retrieve/765606a7-2eac-4a2b-ae70-671e9fb77001","source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Virology, vol. 78 (23), (12996-3006)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:142213","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC524989","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:524989","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/524989","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/c195a5c0-9d2e-11de-bc73-000ea68e967b","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/c195a5c0-9d2e-11de-bc73-000ea68e967b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Princen , K , Hatse , S , Vermeire , K , Aquaro , S , De Clercq , E , Gerlach , L-O , Rosenkilde , M , Schwartz , T W , Skerlj , R , Bridger , G & Schols , D 2004 , ' Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist ' , Journal of Virology , vol. 78 , no. 23 , pp. 12996-3006 . https://doi.org/10.1128/JVI.78.23.12996-13006.2004","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/35655","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/35655","pdf_url":"https://lirias.kuleuven.be/retrieve/765606a7-2eac-4a2b-ae70-671e9fb77001","source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Virology, vol. 78 (23), (12996-3006)","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310483","display_name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","ror":"https://ror.org/03ge1nb22"},{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1988116237.pdf","grobid_xml":"https://content.openalex.org/works/W1988116237.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W82820957","https://openalex.org/W1501974099","https://openalex.org/W1602460865","https://openalex.org/W1723922714","https://openalex.org/W1884075248","https://openalex.org/W1885192584","https://openalex.org/W1927934418","https://openalex.org/W1963984954","https://openalex.org/W1964083898","https://openalex.org/W1965019797","https://openalex.org/W1980430937","https://openalex.org/W1981258449","https://openalex.org/W1981440980","https://openalex.org/W1981644527","https://openalex.org/W1984811742","https://openalex.org/W1985510414","https://openalex.org/W1996183144","https://openalex.org/W2003239995","https://openalex.org/W2007021820","https://openalex.org/W2015326137","https://openalex.org/W2026444780","https://openalex.org/W2027856522","https://openalex.org/W2028309086","https://openalex.org/W2030017358","https://openalex.org/W2032023518","https://openalex.org/W2034053987","https://openalex.org/W2043855995","https://openalex.org/W2057633014","https://openalex.org/W2058252938","https://openalex.org/W2062148688","https://openalex.org/W2066759271","https://openalex.org/W2067964854","https://openalex.org/W2071564876","https://openalex.org/W2090630729","https://openalex.org/W2092788945","https://openalex.org/W2097125607","https://openalex.org/W2097842164","https://openalex.org/W2099277404","https://openalex.org/W2102780335","https://openalex.org/W2103292929","https://openalex.org/W2108256128","https://openalex.org/W2114668630","https://openalex.org/W2117394497","https://openalex.org/W2120831807","https://openalex.org/W2121138614","https://openalex.org/W2125413693","https://openalex.org/W2131376910","https://openalex.org/W2135739941","https://openalex.org/W2140478082","https://openalex.org/W2142655367","https://openalex.org/W2144172655","https://openalex.org/W2147169218","https://openalex.org/W2150833007","https://openalex.org/W2150898533","https://openalex.org/W2152834564","https://openalex.org/W2154552023","https://openalex.org/W2158049812","https://openalex.org/W2158850631","https://openalex.org/W2165244186","https://openalex.org/W2165431186","https://openalex.org/W2165690748","https://openalex.org/W2171248814","https://openalex.org/W2340606985","https://openalex.org/W4299418965"],"related_works":["https://openalex.org/W3039069304","https://openalex.org/W158306923","https://openalex.org/W1535487569","https://openalex.org/W3034998481","https://openalex.org/W2082737563","https://openalex.org/W2054851724","https://openalex.org/W2090681997","https://openalex.org/W2002510880","https://openalex.org/W2519261321","https://openalex.org/W2008130406"],"abstract_inverted_index":{"Here":[0],"we":[1],"report":[2],"that":[3,80,180],"the":[4,89,96,102,116,121,170,215,225,237,249],"N-pyridinylmethyl":[5],"cyclam":[6],"analog":[7],"AMD3451":[8,56,81,93,168,200,247],"has":[9],"antiviral":[10],"activity":[11],"against":[12],"a":[13,242],"wide":[14],"variety":[15],"of":[16,22,227],"R5,":[17,59],"R5/X4,":[18,60],"and":[19,29,54,61,84,109,126,149,176,186,190,203,208,259],"X4":[20,62,85],"strains":[21],"human":[23],"immunodeficiency":[24],"virus":[25,90],"type":[26],"1":[27],"(HIV-1)":[28],"HIV-2":[30],"(50%":[31],"inhibitory":[32],"concentration":[33],"[IC(50)]":[34],"ranging":[35],"from":[36],"1.2":[37],"to":[38,71,161,214,241],"26.5":[39],"microM)":[40],"in":[41,67,106,110,128,206,212],"various":[42],"T-cell":[43],"lines,":[44],"CCR5-":[45],"or":[46,147],"CXCR4-transfected":[47,111],"cells,":[48,112],"peripheral":[49],"blood":[50],"mononuclear":[51],"cells":[52,108],"(PBMCs),":[53],"monocytes/macrophages.":[55],"also":[57,194],"inhibited":[58,95,169,196,201],"HIV-1":[63,86],"primary":[64],"clinical":[65],"isolates":[66],"PBMCs":[68],"(IC(50),":[69],"1.8":[70],"7.3":[72],"microM).":[73],"A":[74],"PCR-based":[75],"viral":[76],"entry":[77,91],"assay":[78],"revealed":[79],"blocks":[82],"R5":[83],"infection":[87],"at":[88,158,236],"stage.":[92],"dose-dependently":[94,195],"intracellular":[97,153],"Ca(2+)":[98,117,138,154,171],"signaling":[99,139,155],"induced":[100,119,173,181],"by":[101,120,156,174,182,197],"CXCR4":[103,217],"ligand":[104],"CXCL12":[105,175],"T-lymphocytic":[107],"as":[113,115,233],"well":[114],"flux":[118,172],"CCR5":[122,258],"ligands":[123],"CCL5,":[124,185],"CCL3,":[125,184],"CCL4":[127,177],"CCR5-transfected":[129,209],"cells.":[130,210],"The":[131,188],"compound":[132],"did":[133,150,220],"not":[134,151,179,221],"interfere":[135],"with":[136,245,254],"chemokine-induced":[137],"through":[140],"CCR1,":[141],"CCR2,":[142],"CCR3,":[143],"CCR4,":[144],"CCR6,":[145],"CCR9,":[146],"CXCR3":[148],"induce":[152],"itself":[157],"concentrations":[159],"up":[160],"400":[162],"microM.":[163],"In":[164],"freshly":[165],"isolated":[166],"monocytes,":[167],"but":[178,223],"CCL2,":[183],"CCL7.":[187],"CXCL12-":[189,202],"CCL3-induced":[191],"chemotaxis":[192],"was":[193],"AMD3451.":[198],"Furthermore,":[199],"CCL3L1-induced":[204],"endocytosis":[205],"CXCR4-":[207],"AMD3451,":[211],"contrast":[213],"specific":[216],"antagonist":[218],"AMD3100,":[219],"inhibit":[222],"enhanced":[224],"binding":[226],"several":[228],"anti-CXCR4":[229],"monoclonal":[230],"antibodies":[231],"(such":[232],"clone":[234],"12G5)":[235],"cell":[238],"surface,":[239],"pointing":[240],"different":[243],"interaction":[244],"CXCR4.":[246],"is":[248],"first":[250],"low-molecular-weight":[251],"anti-HIV":[252],"agent":[253],"selective":[255],"HIV":[256],"coreceptor,":[257],"CXCR4,":[260],"interaction.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
