{"id":"https://openalex.org/W1988094065","doi":"https://doi.org/10.1046/j.1471-4159.1999.0732278.x","title":"Staurosporine\u2010Induced Activation of Caspase\u20103 Is Potentiated by Presenilin 1 Familial Alzheimer's Disease Mutations in Human Neuroglioma Cells","display_name":"Staurosporine\u2010Induced Activation of Caspase\u20103 Is Potentiated by Presenilin 1 Familial Alzheimer's Disease Mutations in Human Neuroglioma Cells","publication_year":1999,"publication_date":"1999-12-01","ids":{"openalex":"https://openalex.org/W1988094065","doi":"https://doi.org/10.1046/j.1471-4159.1999.0732278.x","mag":"1988094065","pmid":"https://pubmed.ncbi.nlm.nih.gov/10582585"},"language":"en","primary_location":{"id":"doi:10.1046/j.1471-4159.1999.0732278.x","doi":"https://doi.org/10.1046/j.1471-4159.1999.0732278.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1471-4159.1999.0732278.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090395755","display_name":"Dora M. Kovacs","orcid":"https://orcid.org/0000-0003-1785-3248","observed_orcids":["https://orcid.org/0000-0003-1785-3248"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dora M. Kovacs","raw_affiliation_strings":["Department of Neurology, Massachusetts General Hospital East, Harvard Medical School, Charlestown 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Massachusetts General Hospital East, Harvard Medical School, Charlestown 02129, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043578488","display_name":"Ronald Mancini","orcid":"https://orcid.org/0000-0002-6454-7238","observed_orcids":["https://orcid.org/0000-0002-6454-7238"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Mancini","raw_affiliation_strings":["Genetics and Aging Unit and Department of Neurology, Massachusetts General Hospital East, Harvard Medical School, Charlestown, Massachusetts, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Aging Unit and Department of Neurology, Massachusetts General Hospital East, Harvard Medical School, Charlestown, Massachusetts, U.S.A","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John Henderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Henderson","raw_affiliation_strings":["Genetics and Aging Unit and Department of Neurology, Massachusetts General Hospital East, Harvard Medical School, Charlestown, Massachusetts, U.S.A","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Aging Unit and Department of Neurology, Massachusetts General Hospital East, Harvard Medical School, Charlestown, Massachusetts, U.S.A","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109966976","display_name":"S Na","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sang J. Na","raw_affiliation_strings":["Genetics and Aging Unit and Department of Neurology, Massachusetts General Hospital East, Harvard Medical School, Charlestown, Massachusetts, U.S.A","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Aging Unit and Department of Neurology, Massachusetts General Hospital East, Harvard Medical School, Charlestown, Massachusetts, U.S.A","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112503285","display_name":"Stephen D. Schmidt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen D. Schmidt","raw_affiliation_strings":["Genetics and Aging Unit and Department of Neurology, Massachusetts General Hospital East, Harvard Medical School, Charlestown, Massachusetts, U.S.A","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Aging Unit and Department of Neurology, Massachusetts General Hospital East, Harvard Medical School, Charlestown, Massachusetts, U.S.A","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tae\u2010Wan Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tae\u2010Wan Kim","raw_affiliation_strings":["Genetics and Aging Unit and Department of Neurology, Massachusetts General Hospital East, Harvard Medical School, Charlestown, Massachusetts, U.S.A","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Aging Unit and Department of Neurology, Massachusetts General Hospital East, Harvard Medical School, Charlestown, Massachusetts, U.S.A","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050004777","display_name":"Rudolph E. Tanzi","orcid":"https://orcid.org/0000-0002-7032-1454","observed_orcids":["https://orcid.org/0000-0002-7032-1454"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rudolph E. Tanzi","raw_affiliation_strings":["Genetics and Aging Unit and Department of Neurology, Massachusetts General Hospital East, Harvard Medical School, Charlestown, Massachusetts, U.S.A","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Aging Unit and Department of Neurology, Massachusetts General Hospital East, Harvard Medical School, Charlestown, Massachusetts, U.S.A","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":2.2658,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.87453006,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"73","issue":"6","first_page":"2278","last_page":"2285"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/presenilin-1","display_name":"presenilin 1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/familial-alzheimer-s-disease","display_name":"familial Alzheimer's disease","score":0.906000018119812},{"id":"https://openalex.org/keywords/caspase-3-activation","display_name":"caspase-3 activation","score":0.949999988079071},{"id":"https://openalex.org/keywords/staurosporine","display_name":"staurosporine","score":0.9710000157356262},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8130000233650208},{"id":"https://openalex.org/keywords/c-terminal-fragment","display_name":"C-terminal fragment","score":0.6830000281333923},{"id":"https://openalex.org/keywords/presenilin-1-mutations","display_name":"presenilin 1 mutations","score":0.7590000033378601},{"id":"https://openalex.org/keywords/neuroglioma-cells","display_name":"neuroglioma cells","score":0.7850000262260437},{"id":"https://openalex.org/keywords/proapoptotic-effects","display_name":"proapoptotic effects","score":0.671999990940094},{"id":"https://openalex.org/keywords/anti-apoptotic-effects","display_name":"anti-apoptotic effects","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2779084600","wikidata":"https://www.wikidata.org/wiki/Q5957181","display_name":"Staurosporine","level":4,"score":0.9214772582054138},{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.8914334774017334},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7947489023208618},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6694013476371765},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.6572310328483582},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.610069215297699},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5358980894088745},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5295541882514954},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4974816143512726},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45433738827705383},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.41975805163383484},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4140769839286804},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.3596404194831848},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3294545114040375},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21307367086410522},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15069159865379333},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.14079925417900085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11766514182090759},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11450809240341187},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.07413920760154724},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.07333189249038696},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06576785445213318}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004792","descriptor_name":"Enzyme Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011065","descriptor_name":"Poly(ADP-ribose) Polymerases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1471-4159.1999.0732278.x","doi":"https://doi.org/10.1046/j.1471-4159.1999.0732278.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1471-4159.1999.0732278.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:10582585","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10582585","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.800000011920929,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1611341694","https://openalex.org/W1905311838","https://openalex.org/W1942214720","https://openalex.org/W1949477754","https://openalex.org/W1963923664","https://openalex.org/W1973614276","https://openalex.org/W1981845572","https://openalex.org/W1982825693","https://openalex.org/W1988110501","https://openalex.org/W1997280654","https://openalex.org/W2012840355","https://openalex.org/W2024461005","https://openalex.org/W2025242397","https://openalex.org/W2027982321","https://openalex.org/W2030190314","https://openalex.org/W2032374711","https://openalex.org/W2038681771","https://openalex.org/W2041037585","https://openalex.org/W2045153164","https://openalex.org/W2046209489","https://openalex.org/W2053156705","https://openalex.org/W2054499580","https://openalex.org/W2058876174","https://openalex.org/W2060579161","https://openalex.org/W2068137765","https://openalex.org/W2070068402","https://openalex.org/W2070654470","https://openalex.org/W2071677771","https://openalex.org/W2075175573","https://openalex.org/W2082040667","https://openalex.org/W2083594148","https://openalex.org/W2083633251","https://openalex.org/W2087458270","https://openalex.org/W2088152552","https://openalex.org/W2098938948","https://openalex.org/W2127110045","https://openalex.org/W2132357350","https://openalex.org/W2136781825","https://openalex.org/W2150970420","https://openalex.org/W2157999078","https://openalex.org/W4300457050"],"related_works":["https://openalex.org/W2585603607","https://openalex.org/W63654367","https://openalex.org/W2009342209","https://openalex.org/W2133872757","https://openalex.org/W2058876174","https://openalex.org/W7038574858","https://openalex.org/W2020063328","https://openalex.org/W1953874250","https://openalex.org/W1989288748","https://openalex.org/W2081926478"],"abstract_inverted_index":{"Familial":[0],"Alzheimer's":[1],"disease":[2],"(FAD)":[3],"mutant":[4,29,53,74,118,140,153,165,170],"forms":[5,30],"of":[6,27,31,47,67,90,96,100,127,151,158,164,169,175],"presenilin":[7],"1":[8],"(PS1)":[9],"and":[10,71,108,148],"2":[11],"have":[12],"been":[13],"shown":[14],"to":[15,18,44,56,86,94,110,135],"sensitize":[16],"cells":[17,83,102],"apoptotic":[19],"cell":[20,106,122],"death.":[21],"Here":[22],"we":[23],"explore":[24],"the":[25,138,156],"effects":[26,174],"FAD":[28,73,139,152],"PS1":[32,75,129,143,154,166,171],"on":[33],"caspase":[34,41,146,149],"activation":[35,42,116,147],"during":[36],"apoptosis.":[37],"We":[38],"show":[39],"that":[40],"leads":[43],"increased":[45,105,132],"generation":[46],"alternative":[48],"C-terminal":[49],"fragments":[50],"(CTFs)":[51],"from":[52],"as":[54],"compared":[55],"wild-type":[57],"(wt)":[58],"PS1.":[59,97,177],"For":[60],"this":[61],"purpose,":[62],"very":[63],"low":[64],"expression":[65],"levels":[66,126],"wt,":[68],"A246E,":[69],"L286V,":[70],"deltaE10":[72],"proteins":[76],"in":[77,104,114,117,137],"stably":[78],"transfected":[79],"human":[80],"H4":[81],"neuroglioma":[82],"were":[84,131],"used":[85],"avoid":[87],"artifactual":[88],"induction":[89],"spontaneous":[91],"apoptosis":[92],"due":[93],"overexpression":[95],"Staurosporine":[98],"treatment":[99],"these":[101],"resulted":[103],"death":[107],"up":[109],"a":[111,160],"10-fold":[112],"increase":[113],"caspase-3":[115],"versus":[119,141],"wt":[120,142,176],"PS1-expressing":[121],"lines.":[123],"Correspondingly,":[124],"relative":[125],"caspase-cleaved":[128],"CTFs":[130],"by":[133],"five-":[134],"sixfold":[136],"cells.":[144],"Elevated":[145],"cleavage":[150],"suggest":[155],"possibility":[157],"either":[159],"direct":[161],"proapoptotic":[162],"effect":[163],"or":[167],"interference":[168],"with":[172],"antiapoptotic":[173]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
