{"id":"https://openalex.org/W1988092128","doi":"https://doi.org/10.1007/bf00427766","title":"Treatment schedule as a determinant of the development of tolerance to haloperidol","display_name":"Treatment schedule as a determinant of the development of tolerance to haloperidol","publication_year":1984,"publication_date":"1984-09-01","ids":{"openalex":"https://openalex.org/W1988092128","doi":"https://doi.org/10.1007/bf00427766","mag":"1988092128","pmid":"https://pubmed.ncbi.nlm.nih.gov/6425895"},"language":"en","primary_location":{"id":"doi:10.1007/bf00427766","doi":"https://doi.org/10.1007/bf00427766","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00427766","pdf_url":null,"source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105351777","display_name":"Robert J. Carey","orcid":"https://orcid.org/0000-0003-4566-1438","observed_orcids":["https://orcid.org/0000-0003-4566-1438"]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]},{"id":"https://openalex.org/I4210114695","display_name":"Syracuse VA Medical Center","ror":"https://ror.org/0332k3m42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210114695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Carey","raw_affiliation_strings":["Department of Psychiatry, SUNY Upstate Medical Center, 13210, Syracuse, NY, USA","Syracuse Veterans Administration Medical Center, 13210, Syracuse, NY, USA","Department of Psychiatry, SUNY Upstate Medical Center, Syracuse, USA","Syracuse Veterans Administration Medical Center, Syracuse, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, SUNY Upstate Medical Center, 13210, Syracuse, NY, USA","institution_ids":["https://openalex.org/I20388574"]},{"raw_affiliation_string":"Syracuse Veterans Administration Medical Center, 13210, Syracuse, NY, USA","institution_ids":["https://openalex.org/I4210114695"]},{"raw_affiliation_string":"Department of Psychiatry, SUNY Upstate Medical Center, Syracuse, USA","institution_ids":["https://openalex.org/I20388574"]},{"raw_affiliation_string":"Syracuse Veterans Administration Medical Center, Syracuse, USA","institution_ids":["https://openalex.org/I4210114695"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110317031","display_name":"Joseph DeVeaugh-Geiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]},{"id":"https://openalex.org/I4210114695","display_name":"Syracuse VA Medical Center","ror":"https://ror.org/0332k3m42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210114695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph De Veaugh-Geiss","raw_affiliation_strings":["Department of Psychiatry, SUNY Upstate Medical Center, 13210, Syracuse, NY, USA","Syracuse Veterans Administration Medical Center, 13210, Syracuse, NY, USA","Department of Psychiatry, SUNY Upstate Medical Center, Syracuse, USA","Syracuse Veterans Administration Medical Center, Syracuse, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, SUNY Upstate Medical Center, 13210, Syracuse, NY, USA","institution_ids":["https://openalex.org/I20388574"]},{"raw_affiliation_string":"Syracuse Veterans Administration Medical Center, 13210, Syracuse, NY, USA","institution_ids":["https://openalex.org/I4210114695"]},{"raw_affiliation_string":"Department of Psychiatry, SUNY Upstate Medical Center, Syracuse, USA","institution_ids":["https://openalex.org/I20388574"]},{"raw_affiliation_string":"Syracuse Veterans Administration Medical Center, Syracuse, USA","institution_ids":["https://openalex.org/I4210114695"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.6543,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.57879066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"82","issue":"3","first_page":"164","last_page":"167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.7851999998092651,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.7851999998092651,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.18619999289512634,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haloperidol","display_name":"haloperidol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/drug-tolerance","display_name":"drug tolerance","score":0.9399999976158142},{"id":"https://openalex.org/keywords/treatment-schedule","display_name":"treatment schedule","score":0.9549999833106995},{"id":"https://openalex.org/keywords/dosing-frequency","display_name":"dosing frequency","score":0.8199999928474426},{"id":"https://openalex.org/keywords/homovanillic-acid","display_name":"homovanillic acid","score":0.7910000085830688},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.6110000014305115},{"id":"https://openalex.org/keywords/limbic-system","display_name":"limbic system","score":0.9100000262260437},{"id":"https://openalex.org/keywords/spontaneous-locomotor-activity","display_name":"spontaneous motor activity","score":0.9279999732971191},{"id":"https://openalex.org/keywords/antipsychotic-side-effects","display_name":"antipsychotic adverse effects","score":0.7760000228881836},{"id":"https://openalex.org/keywords/tardive-dyskinesia","display_name":"tardive dyskinesia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/drug-holidays","display_name":"drug holidays","score":0.9279999732971191},{"id":"https://openalex.org/keywords/chronic-neuroleptic-treatment","display_name":"chronic neuroleptic treatment","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C2780948584","wikidata":"https://www.wikidata.org/wiki/Q251347","display_name":"Haloperidol","level":3,"score":0.9675589799880981},{"id":"https://openalex.org/C2775841634","wikidata":"https://www.wikidata.org/wiki/Q903566","display_name":"Homovanillic acid","level":4,"score":0.6238263249397278},{"id":"https://openalex.org/C2779158372","wikidata":"https://www.wikidata.org/wiki/Q1546328","display_name":"Tardive dyskinesia","level":3,"score":0.5822706818580627},{"id":"https://openalex.org/C2779985140","wikidata":"https://www.wikidata.org/wiki/Q1425425","display_name":"Drug tolerance","level":2,"score":0.564665675163269},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5486330986022949},{"id":"https://openalex.org/C2781353949","wikidata":"https://www.wikidata.org/wiki/Q3271533","display_name":"Dopamine antagonist","level":4,"score":0.5283594727516174},{"id":"https://openalex.org/C2780405171","wikidata":"https://www.wikidata.org/wiki/Q629444","display_name":"Dyskinesia","level":4,"score":0.5059434771537781},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.45760393142700195},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3953986167907715},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3773544430732727},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3528023362159729},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3444281816482544},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19328397512435913},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.09196898341178894},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.07459869980812073},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.0},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006220","descriptor_name":"Haloperidol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006220","descriptor_name":"Haloperidol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006719","descriptor_name":"Homovanillic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00427766","doi":"https://doi.org/10.1007/bf00427766","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00427766","pdf_url":null,"source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},{"id":"pmid:6425895","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6425895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1975216040","https://openalex.org/W1984144069","https://openalex.org/W1995671765","https://openalex.org/W2010924124","https://openalex.org/W2011415448","https://openalex.org/W2020845741","https://openalex.org/W2047787119","https://openalex.org/W2054098272","https://openalex.org/W2055366180","https://openalex.org/W2057859596","https://openalex.org/W2061900068","https://openalex.org/W2084352899","https://openalex.org/W2151872428","https://openalex.org/W2158005602","https://openalex.org/W2313395536","https://openalex.org/W2410341745","https://openalex.org/W2426496751","https://openalex.org/W2427120669","https://openalex.org/W2475266370","https://openalex.org/W4239309065","https://openalex.org/W4247139476"],"related_works":["https://openalex.org/W1975305355","https://openalex.org/W1972603531","https://openalex.org/W1976035941","https://openalex.org/W2033379203","https://openalex.org/W2038286000","https://openalex.org/W2022622356","https://openalex.org/W2025946941","https://openalex.org/W18644361","https://openalex.org/W1968068318","https://openalex.org/W2090843709"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}