{"id":"https://openalex.org/W198808642","doi":null,"title":"Effect of vitamin E deficiency and selenium deficiency on insulin secretory reserve and free radical scavenging systems in islets: decrease of islet manganosuperoxide dismutase.","display_name":"Effect of vitamin E deficiency and selenium deficiency on insulin secretory reserve and free radical scavenging systems in islets: decrease of islet manganosuperoxide dismutase.","publication_year":1986,"publication_date":"1986-05-01","ids":{"openalex":"https://openalex.org/W198808642","mag":"198808642","pmid":"https://pubmed.ncbi.nlm.nih.gov/3517203"},"language":"en","primary_location":{"id":"pmid:3517203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3517203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086215826","display_name":"Kei Asayama","orcid":"https://orcid.org/0000-0003-3365-0547","observed_orcids":["https://orcid.org/0000-0003-3365-0547"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Asayama","raw_affiliation_strings":["Vanderbilt University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108490437","display_name":"Neil W. Kooy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N W Kooy","raw_affiliation_strings":["Pediatrics - Pediatric Critical Care"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics - Pediatric Critical Care","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008819992","display_name":"Ian M. Burr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I M Burr","raw_affiliation_strings":["Vanderbilt University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1676,"has_fulltext":false,"cited_by_count":124,"citation_normalized_percentile":{"value":0.91941876,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"107","issue":"5","first_page":"459","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.5282999873161316,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.5282999873161316,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.32010000944137573,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.10480000078678131,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-e-deficiency","display_name":"vitamin E deficiency","score":1.0},{"id":"https://openalex.org/keywords/selenium-deficiency","display_name":"selenium deficiency","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.8730000257492065},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9890000224113464},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.996999979019165},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.8820000290870667},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7630000114440918},{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.8569999933242798},{"id":"https://openalex.org/keywords/pathogenesis-of-diabetes","display_name":"diabetes pathogenesis","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8390285968780518},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.836184024810791},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.8030898571014404},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.7998595833778381},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.7484180331230164},{"id":"https://openalex.org/C2779135701","wikidata":"https://www.wikidata.org/wiki/Q1322302","display_name":"Selenium deficiency","level":5,"score":0.6512601971626282},{"id":"https://openalex.org/C2777551382","wikidata":"https://www.wikidata.org/wiki/Q141180","display_name":"Vitamin E","level":3,"score":0.5582321882247925},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.5247276425361633},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5056483745574951},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4803275167942047},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4749208390712738},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4531280994415283},{"id":"https://openalex.org/C2778248901","wikidata":"https://www.wikidata.org/wiki/Q5282371","display_name":"Dismutase","level":4,"score":0.446475625038147},{"id":"https://openalex.org/C2778387500","wikidata":"https://www.wikidata.org/wiki/Q7936965","display_name":"Vitamin E deficiency","level":4,"score":0.44097277522087097},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.36902302503585815},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3015606701374054},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22994142770767212},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14324188232421875}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012643","descriptor_name":"Selenium","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014811","descriptor_name":"Vitamin E Deficiency","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D014811","descriptor_name":"Vitamin E Deficiency","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014811","descriptor_name":"Vitamin E Deficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3517203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3517203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},{"id":"mag:198808642","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3517203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2979875969","https://openalex.org/W2378771947","https://openalex.org/W2385248598","https://openalex.org/W2038649471","https://openalex.org/W1976880476","https://openalex.org/W2419210909","https://openalex.org/W2043769217","https://openalex.org/W2133775279","https://openalex.org/W2073598814","https://openalex.org/W988783826"],"abstract_inverted_index":{"There":[0],"is":[1],"increasing":[2],"evidence":[3],"that":[4,15],"islet":[5,43],"beta":[6],"cells":[7],"may":[8,18],"be":[9],"susceptible":[10],"to":[11,20,123,133],"redox":[12],"insult,":[13],"and":[14,39,45,57,70,76,95,127,212,214],"this":[16],"susceptibility":[17],"contribute":[19],"the":[21,31,102,109,149,163,176,208],"pathogenesis":[22],"of":[23,26,33,53,66,101,162],"experimental":[24],"models":[25],"diabetes":[27],"mellitus.":[28],"We":[29],"investigated":[30],"effect":[32],"vitamin":[34,73,124],"E":[35],"deficiency,":[36,38],"selenium":[37],"combined":[40,77,128,179],"deficiency":[41,131],"on":[42],"function":[44],"free":[46],"radical":[47],"scavenging":[48],"systems.":[49],"The":[50],"tissue":[51,204],"levels":[52,104,120,218],"glutathione":[54,210],"peroxidase,":[55],"catalase,":[56],"immunoreactive":[58],"superoxide":[59,141,216],"dismutases":[60],"were":[61,82,98,115],"measured":[62],"in":[63,92,105,113,121,144,148,153,160,175,187,190,202],"four":[64],"groups":[65,151,201],"rats":[67],"(i.e.,":[68],"controls":[69],"those":[71],"with":[72,178],"E,":[74,125],"selenium,":[75,126],"deficiency).":[78],"Glucose":[79],"tolerance":[80],"tests":[81],"performed":[83],"for":[84],"each":[85,161],"animal":[86],"before":[87],"sacrifice.":[88],"Superoxide":[89],"dismutase":[90,111,142,217],"concentrations":[91,112],"liver,":[93],"heart,":[94],"skeletal":[96],"muscle":[97],"within":[99],"20%":[100],"control":[103,119],"all":[106,191],"groups.":[107,166],"However,":[108],"manganosuperoxide":[110],"islets":[114,145],"significantly":[116,199],"lower":[117],"than":[118,152],"response":[122],"deficiency.":[129,180],"Combined":[130],"appeared":[132],"have":[134],"an":[135],"additive":[136],"effect.":[137],"In":[138],"contrast,":[139],"cuprozinc":[140,213],"concentration":[143],"was":[146,158,169,184],"higher":[147],"deficient":[150,165],"controls.":[154],"Insulin":[155],"secretory":[156],"reserve":[157],"decreased":[159,186],"three":[164],"This":[167],"decrease":[168],"reflected":[170],"as":[171],"glucose":[172],"intolerance":[173],"only":[174],"group":[177],"Glutathione":[181],"peroxidase":[182,211],"activity":[183,195],"markedly":[185],"selenium-deficient":[188],"animals":[189],"tissues":[192,220],"studied.":[193,205,221],"Catalase":[194],"did":[196],"not":[197],"change":[198],"among":[200,219],"any":[203],"Islets":[206],"had":[207],"lowest":[209],"total":[215]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
