{"id":"https://openalex.org/W1988085367","doi":"https://doi.org/10.1039/c4md00095a","title":"Structure activity relationship study of mezzettiasides natural products and their four new disaccharide analogues for anticancer/antibacterial activity","display_name":"Structure activity relationship study of mezzettiasides natural products and their four new disaccharide analogues for anticancer/antibacterial activity","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W1988085367","doi":"https://doi.org/10.1039/c4md00095a","mag":"1988085367","pmid":"https://pubmed.ncbi.nlm.nih.gov/25729554","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4338990"},"language":"en","primary_location":{"id":"doi:10.1039/c4md00095a","doi":"https://doi.org/10.1039/c4md00095a","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c4md00095a","pdf_url":null,"source":{"id":"https://openalex.org/S191926780","display_name":"MedChemComm","issn_l":"2040-2503","issn":["2040-2503","2040-2511"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MedChemComm","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4338990","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057707366","display_name":"Sumit O. Bajaj","orcid":"https://orcid.org/0000-0003-4621-3055","observed_orcids":["https://orcid.org/0000-0003-4621-3055"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumit O. Bajaj","raw_affiliation_strings":["Boston","Department of Chemistry and Chemical Biology","Northeastern University","USA","Department of Chemistry & Chemical Biology, Northeastern University, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry and Chemical Biology","institution_ids":[]},{"raw_affiliation_string":"Northeastern University","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry & Chemical Biology, Northeastern University, Boston, USA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pei Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pei Shi","raw_affiliation_strings":["Boston","Department of Chemistry and Chemical Biology","Northeastern University","USA","Department of Chemistry & Chemical Biology, Northeastern University, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry and Chemical Biology","institution_ids":[]},{"raw_affiliation_string":"Northeastern University","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry & Chemical Biology, Northeastern University, Boston, USA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015910317","display_name":"Penny J. Beuning","orcid":"https://orcid.org/0000-0002-7770-022X","observed_orcids":["https://orcid.org/0000-0002-7770-022X"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Penny J. Beuning","raw_affiliation_strings":["Boston","Department of Chemistry and Chemical Biology","Northeastern University","USA","Department of Chemistry & Chemical Biology, Northeastern University, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry and Chemical Biology","institution_ids":[]},{"raw_affiliation_string":"Northeastern University","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry & Chemical Biology, Northeastern University, Boston, USA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008293667","display_name":"George Augustine O'Doherty","orcid":"https://orcid.org/0000-0002-1699-2249","observed_orcids":["https://orcid.org/0000-0002-1699-2249"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"George A. O'Doherty","raw_affiliation_strings":["Boston","Department of Chemistry and Chemical Biology","Northeastern University","USA","Department of Chemistry & Chemical Biology, Northeastern University, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry and Chemical Biology","institution_ids":[]},{"raw_affiliation_string":"Northeastern University","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry & Chemical Biology, Northeastern University, Boston, USA","institution_ids":["https://openalex.org/I12912129"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008293667","https://openalex.org/A5015910317"],"corresponding_institution_ids":["https://openalex.org/I12912129"],"apc_list":null,"apc_paid":null,"fwci":0.6829,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.66202851,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"5","issue":"8","first_page":"1138","last_page":"1142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.7943999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.7943999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.061400000005960464,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.02410000003874302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8460000157356262},{"id":"https://openalex.org/keywords/disaccharide-analogues","display_name":"disaccharide analogues","score":0.9639999866485596},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8790000081062317},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.9950000047683716},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C2777346074","wikidata":"https://www.wikidata.org/wiki/Q173600","display_name":"Disaccharide","level":2,"score":0.8876532316207886},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.714313805103302},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5850071310997009},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.48278677463531494},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4411432445049286},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19554081559181213},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1554403305053711},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.03996196389198303}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1039/c4md00095a","doi":"https://doi.org/10.1039/c4md00095a","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c4md00095a","pdf_url":null,"source":{"id":"https://openalex.org/S191926780","display_name":"MedChemComm","issn_l":"2040-2503","issn":["2040-2503","2040-2511"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MedChemComm","raw_type":"journal-article"},{"id":"pmid:25729554","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25729554","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MedChemComm","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4338990","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4338990","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Medchemcomm","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4338990","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4338990","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Medchemcomm","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4627179102","display_name":"De Novo Synthesis of Oligosaccharides","funder_award_id":"R01GM090259","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1578519026","https://openalex.org/W1904634031","https://openalex.org/W1964047167","https://openalex.org/W1964983631","https://openalex.org/W1979782237","https://openalex.org/W1995353363","https://openalex.org/W2012098976","https://openalex.org/W2018047005","https://openalex.org/W2027305651","https://openalex.org/W2029870060","https://openalex.org/W2067294869","https://openalex.org/W2070796344","https://openalex.org/W2081889709","https://openalex.org/W2085998013","https://openalex.org/W2087865186","https://openalex.org/W2090822821","https://openalex.org/W2092374973","https://openalex.org/W2108871577","https://openalex.org/W2122710851","https://openalex.org/W2132287305","https://openalex.org/W2135673226","https://openalex.org/W2137594582","https://openalex.org/W2145805088","https://openalex.org/W2163603671","https://openalex.org/W2950107886","https://openalex.org/W2951296715"],"related_works":["https://openalex.org/W2106170409","https://openalex.org/W1913284378","https://openalex.org/W2287303819","https://openalex.org/W2309379652","https://openalex.org/W2275682609","https://openalex.org/W4406814584","https://openalex.org/W2782082630","https://openalex.org/W7100487845","https://openalex.org/W4407126050","https://openalex.org/W4400871589"],"abstract_inverted_index":{")":[0],"activities":[1],"for":[2],"the":[3,15],"ten":[4],"natural":[5,21],"products":[6,22],"and":[7,17],"four":[8],"new":[9],"analogues":[10],"were":[11,23],"found.":[12],"Comparison":[13],"to":[14],"cleistrioside":[16],"cleistetroside":[18],"classes":[19],"of":[20],"made.":[24]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}