{"id":"https://openalex.org/W198804307","doi":null,"title":"Immunohistochemical localization of L-dopa and aromatic L-amino acid-decarboxylase in the rat retina.","display_name":"Immunohistochemical localization of L-dopa and aromatic L-amino acid-decarboxylase in the rat retina.","publication_year":1994,"publication_date":"1994-06-01","ids":{"openalex":"https://openalex.org/W198804307","mag":"198804307","pmid":"https://pubmed.ncbi.nlm.nih.gov/8206708"},"language":"en","primary_location":{"id":"pmid:8206708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8206708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110097930","display_name":"J Nguyen-Legros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J Nguyen-Legros","raw_affiliation_strings":["Laboratoire de Neurocytologie Oculaire, INSERM U-86, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Neurocytologie Oculaire, INSERM U-86, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058232999","display_name":"Monique Krieger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Krieger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111516359","display_name":"Axelle Simon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Simon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4477,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.87768318,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"35","issue":"7","first_page":"2906","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.6503999829292297,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.6503999829292297,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.1388999968767166,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.10419999808073044,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-dopa","display_name":"L-DOPA","score":0.9779999852180481},{"id":"https://openalex.org/keywords/aromatic-l-amino-acid-decarboxylase","display_name":"aromatic L-amino acid decarboxylase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.9610000252723694},{"id":"https://openalex.org/keywords/amacrine-cells","display_name":"amacrine cells","score":0.8349999785423279},{"id":"https://openalex.org/keywords/catecholaminergic-neurons","display_name":"catecholaminergic neurons","score":0.7419999837875366},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.41999998688697815},{"id":"https://openalex.org/keywords/tyramine","display_name":"tyramine","score":0.8169999718666077},{"id":"https://openalex.org/keywords/photoreceptor-inner-segment","display_name":"photoreceptor inner segment","score":0.8230000138282776},{"id":"https://openalex.org/keywords/melatonin-synthesis","display_name":"melatonin synthesis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/5-hydroxytryptophan","display_name":"5-hydroxytryptophan","score":0.9430000185966492},{"id":"https://openalex.org/keywords/retina","display_name":"retina","score":0.42399999499320984},{"id":"https://openalex.org/keywords/neurotransmitter-localization","display_name":"neurotransmitter localization","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.7771079540252686},{"id":"https://openalex.org/C159167319","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine hydroxylase","level":3,"score":0.7644268274307251},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.7213249206542969},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.6411604285240173},{"id":"https://openalex.org/C58824617","wikidata":"https://www.wikidata.org/wiki/Q421186","display_name":"Aromatic L-amino acid decarboxylase","level":3,"score":0.6005597114562988},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5940709114074707},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.5603731870651245},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.544198215007782},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5423563122749329},{"id":"https://openalex.org/C2776824294","wikidata":"https://www.wikidata.org/wiki/Q18344428","display_name":"Catecholaminergic","level":3,"score":0.47903528809547424},{"id":"https://openalex.org/C2775951788","wikidata":"https://www.wikidata.org/wiki/Q418293","display_name":"Tryptophan hydroxylase","level":5,"score":0.47279852628707886},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.3058406710624695},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2251664102077484},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1764313280582428},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.15612033009529114},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06555071473121643},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05161455273628235}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001142","descriptor_name":"Aromatic-L-Amino-Acid Decarboxylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007980","descriptor_name":"Levodopa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014439","descriptor_name":"Tyramine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8206708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8206708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:198804307","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8206708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1524216117","https://openalex.org/W1557250139","https://openalex.org/W1966463400","https://openalex.org/W1981264477","https://openalex.org/W1988773631","https://openalex.org/W1994705298","https://openalex.org/W1998084858","https://openalex.org/W1999557729","https://openalex.org/W2000062259","https://openalex.org/W2000994345","https://openalex.org/W2006444295","https://openalex.org/W2009262191","https://openalex.org/W2014569722","https://openalex.org/W2018402046","https://openalex.org/W2020616818","https://openalex.org/W2021895129","https://openalex.org/W2028485638","https://openalex.org/W2028773214","https://openalex.org/W2032337451","https://openalex.org/W2037352899","https://openalex.org/W2041914492","https://openalex.org/W2047629945","https://openalex.org/W2056870398","https://openalex.org/W2061240293","https://openalex.org/W2061381045","https://openalex.org/W2063220119","https://openalex.org/W2067488590","https://openalex.org/W2077031566","https://openalex.org/W2117584366","https://openalex.org/W2121334545","https://openalex.org/W2135753165","https://openalex.org/W2140532521","https://openalex.org/W2410407661","https://openalex.org/W2470831765","https://openalex.org/W2484382723","https://openalex.org/W2489746220","https://openalex.org/W2552318961"],"related_works":["https://openalex.org/W2009262191","https://openalex.org/W2435187744","https://openalex.org/W2094519131","https://openalex.org/W1983668293","https://openalex.org/W46696815","https://openalex.org/W1963966013","https://openalex.org/W2139673404","https://openalex.org/W2136697301","https://openalex.org/W2142943326","https://openalex.org/W2027589923"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,140,152,186,231],"purpose":[2],"of":[3,15,45,57,62,91,109,143,193,233,248],"this":[4],"study":[5],"was":[6],"threefold:":[7],"to":[8,32,37,39,53,154,189,210,244],"determine":[9],"if":[10],"some":[11],"catecholaminergic":[12],"amacrine":[13,113,179,196,225],"cells":[14,28,47,118,126,132,145,160,180,197,226],"the":[16,25,42,49,55,60,116,149,162,176,215,228,236,245],"rat":[17,50,83,163,216,229],"retina":[18],"use":[19],"L-DOPA":[20,134,166],"as":[21,170],"their":[22],"neurotransmitter,":[23],"especially":[24],"small":[26,177,191],"(2CA)":[27],"that":[29,181,220],"are":[30,222],"immunoreactive":[31],"tyrosine":[33,69],"hydroxylase":[34,70],"but":[35],"not":[36,102,157,183,200,208],"dopamine;":[38],"understand":[40],"better":[41],"possible":[43],"existence":[44],"serotoninergic":[46],"in":[48,59,82,107,161,214,227,235],"retina;":[51],"and":[52,80,88,111],"clarify":[54],"role":[56],"serotonin":[58],"metabolism":[61],"melatonin.":[63],"METHODS:":[64],"Immunohistochemistry":[65],"using":[66],"antibodies":[67,100],"against":[68],"(TH),":[71],"L-DOPA,":[72],"aromatic":[73],"L-amino":[74],"acid":[75],"decarboxylase":[76],"(AADC),":[77],"dopamine":[78],"(DA),":[79],"tyramine":[81,155],"retinal":[84],"wholemounts,":[85],"serial":[86],"sections,":[87],"various":[89],"combinations":[90],"double":[92],"labeling.":[93],"RESULTS:":[94],"Paired":[95],"wholemounts":[96],"immunoreacted":[97],"with":[98],"anti-TH/AADC":[99],"did":[101,156],"show":[103],"a":[104,171,190,212],"significant":[105],"difference":[106],"densities":[108],"TH+":[110,117,131,178,195],"AADC+":[112],"cells.":[114],"All":[115],"exhibited":[119,133],"AADC":[120],"immunoreactivity.":[121],"There":[122],"were":[123,146],"no":[124,223],"AADC-immunoreactive":[125],"lacking":[127],"TH.":[128],"A":[129],"few":[130],"immunoreactivity;":[135],"they":[136],"also":[137,206],"contained":[138],"AADC.":[139],"inner":[141,239],"segments":[142,240],"photoreceptor":[144,237],"labeled":[147],"by":[148],"anti-AADC":[150],"antibody.":[151],"antibody":[153],"label":[158],"any":[159],"retina.":[164,217,230],"CONCLUSIONS:":[165],"can":[167],"be":[168],"excluded":[169],"candidate":[172],"active":[173],"substance":[174],"for":[175],"do":[182],"exhibit":[184],"DA-immunoreactivity.":[185],"L-DOPA-immunoreactivity":[187],"restricted":[188],"number":[192],"large":[194],"probably":[198],"does":[199,207],"represent":[201],"an":[202],"end":[203],"product.":[204],"Tyramine":[205],"appear":[209],"constitute":[211],"neurotransmitter":[213],"We":[218],"confirm":[219],"there":[221],"serotonin-synthesizing":[224],"localization":[232],"AADC-immunoreactivity":[234],"cell":[238],"is":[241],"possibly":[242],"related":[243],"biosynthetic":[246],"pathway":[247],"melatonin":[249],"from":[250],"5-hydroxytryptophan.":[251]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
