{"id":"https://openalex.org/W1988024272","doi":"https://doi.org/10.1097/00000542-200001000-00021","title":"Stellate Ganglion Block Modifies the Distribution of Lymphocyte Subsets and Natural-killer Cell Activity","display_name":"Stellate Ganglion Block Modifies the Distribution of Lymphocyte Subsets and Natural-killer Cell Activity","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W1988024272","doi":"https://doi.org/10.1097/00000542-200001000-00021","mag":"1988024272","pmid":"https://pubmed.ncbi.nlm.nih.gov/10638906"},"language":"en","primary_location":{"id":"doi:10.1097/00000542-200001000-00021","doi":"https://doi.org/10.1097/00000542-200001000-00021","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000542-200001000-00021","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112312103","display_name":"Masataka Yokoyama","orcid":"https://orcid.org/0000-0003-1247-5866","observed_orcids":["https://orcid.org/0000-0003-1247-5866"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masataka Yokoyama","raw_affiliation_strings":["Assistant Professor","Department of Anesthesiology & Resuscitology, Okayama University Medical School, Okayama City, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor","institution_ids":[]},{"raw_affiliation_string":"Department of Anesthesiology & Resuscitology, Okayama University Medical School, Okayama City, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080820573","display_name":"Hideki Nakatsuka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hideki Nakatsuka","raw_affiliation_strings":["Staff Anesthesiologist"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Staff Anesthesiologist","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111591649","display_name":"Yoshitar\u014d Itano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshitaro Itano","raw_affiliation_strings":["Research Associate"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Associate","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074476733","display_name":"Masahisa Hirakawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masahisa Hirakawa","raw_affiliation_strings":["Professor and Chairman"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor and Chairman","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1655,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.77564665,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"92","issue":"1","first_page":"109","last_page":"109"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stellate-ganglion-block","display_name":"stellate ganglion block","score":0.996999979019165},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.8560000061988831},{"id":"https://openalex.org/keywords/lymphocyte-subsets","display_name":"lymphocyte subsets","score":0.8090000152587891},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9350000023841858},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.6110000014305115},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cd4-cd8-ratio","display_name":"CD4/CD8 ratio","score":0.9900000095367432},{"id":"https://openalex.org/keywords/t-helper-cells","display_name":"T helper cells","score":0.8450000286102295},{"id":"https://openalex.org/keywords/suppressor-inducer-t-cells","display_name":"suppressor-inducer T cells","score":0.8659999966621399},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9150000214576721},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":1.0},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.996999979019165},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7198021411895752},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7037588357925415},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6789616942405701},{"id":"https://openalex.org/C2775859304","wikidata":"https://www.wikidata.org/wiki/Q132621","display_name":"Epinephrine","level":2,"score":0.6229027509689331},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6157895922660828},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6095974445343018},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5799309015274048},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5564296841621399},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.5120030045509338},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.4997122287750244},{"id":"https://openalex.org/C2780546910","wikidata":"https://www.wikidata.org/wiki/Q185690","display_name":"Adrenocorticotropic hormone","level":3,"score":0.49553191661834717},{"id":"https://openalex.org/C139254425","wikidata":"https://www.wikidata.org/wiki/Q1332167","display_name":"Volume of distribution","level":3,"score":0.45864492654800415},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.4282425045967102},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.37990710139274597},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.3739722967147827},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3104265034198761},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21811005473136902},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.17330226302146912},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0794593095779419},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000779","descriptor_name":"Anesthetics, Local","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007273","descriptor_name":"Injections, Intramuscular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008012","descriptor_name":"Lidocaine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009407","descriptor_name":"Nerve Block","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013233","descriptor_name":"Stellate Ganglion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013233","descriptor_name":"Stellate Ganglion","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016131","descriptor_name":"Lymphocyte Subsets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016131","descriptor_name":"Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00000542-200001000-00021","doi":"https://doi.org/10.1097/00000542-200001000-00021","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000542-200001000-00021","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:10638906","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10638906","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W341404584","https://openalex.org/W1969382469","https://openalex.org/W1969388680","https://openalex.org/W1970092944","https://openalex.org/W1970846543","https://openalex.org/W1992094377","https://openalex.org/W1994594346","https://openalex.org/W1999492991","https://openalex.org/W2007264874","https://openalex.org/W2021971668","https://openalex.org/W2032626281","https://openalex.org/W2032979121","https://openalex.org/W2033636981","https://openalex.org/W2036013539","https://openalex.org/W2050399061","https://openalex.org/W2051918741","https://openalex.org/W2062558899","https://openalex.org/W2068610695","https://openalex.org/W2075071157","https://openalex.org/W2090334210"],"related_works":["https://openalex.org/W2059114243","https://openalex.org/W4415078915","https://openalex.org/W3035303805","https://openalex.org/W2058872318","https://openalex.org/W2267403518","https://openalex.org/W1997413131","https://openalex.org/W2389258098","https://openalex.org/W2338813527","https://openalex.org/W2388208323","https://openalex.org/W2054810022"],"abstract_inverted_index":{"BACKGROUND:":[0],"Recent":[1],"investigations":[2],"suggest":[3],"that":[4,216,225,247,289],"the":[5,10,22,26,66,119,131,155,188,226,296],"sympathetic":[6,291],"nervous":[7],"system":[8],"affects":[9,21],"immune":[11,23,297],"system.":[12],"This":[13],"study":[14],"examined":[15],"whether":[16],"stellate":[17],"ganglion":[18],"block":[19,293],"(SGB)":[20],"response,":[24],"specifically":[25],"distribution":[27,92],"of":[28,54,61,76,93,106,134,157,190,208,217,237,248],"lymphocyte":[29,94,279],"subsets":[30,95,280],"and":[31,71,86,98,111,122,136,146,171,215,281],"natural-killer":[32],"(NK)":[33],"cell":[34,100,229,257,284],"activity.":[35],"METHODS:":[36],"Ten":[37],"volunteers":[38],"received":[39],"three":[40],"different":[41],"treatments":[42,124],"in":[43,118,154,187,278,282],"random":[44],"order":[45],"at":[46,65],"7-day":[47],"intervals:":[48],"(1)":[49],"SGB":[50,287],"with":[51],"7":[52],"ml":[53],"1%":[55,77],"lidocaine;":[56],"(2)":[57],"an":[58,73],"identical":[59,74],"volume":[60,75],"normal":[62,120],"saline":[63,121],"injected":[64,79],"same":[67],"site":[68],"as":[69],"SGB;":[70],"(3)":[72],"lidocaine":[78],"intramuscularly.":[80],"Blood":[81],"samples":[82],"were":[83,113,149,152],"drawn":[84],"before":[85],"30":[87],"min":[88],"after":[89],"treatment.":[90],"The":[91,206,235],"was":[96,102,193],"analyzed,":[97],"NK":[99,191,256,283],"activity":[101,258,285],"measured.":[103,114],"Plasma":[104],"concentrations":[105,133],"epinephrine,":[107],"norepinephrine,":[108],"adrenocorticotropic":[109,144],"hormone,":[110],"cortisol":[112,147],"RESULTS:":[115],"Any":[116],"value":[117],"intramuscular":[123],"did":[125,253],"not":[126,254],"change":[127],"significantly.":[128],"After":[129],"SGB,":[130],"plasma":[132],"epinephrine":[135],"norepinephrine":[137],"decreased":[138,220,259],"significantly":[139,260],"(P":[140,212,221,232,243],"<":[141,169,183,204,213,222,233,244,270],"0.01),":[142,214,223],"but":[143,246,275],"hormone":[145],"values":[148],"unchanged.":[150],"Increases":[151],"observed":[153,194],"proportion":[156,189,207,236],"B":[158],"cells":[159,173,192,210,219,241,252],"(from":[160,174,195,261],"18.4":[161],"+/-":[162,166,176,180,197,201,263,267],"3.0%":[163],"to":[164,178,199,265],"20.0":[165],"3.8%;":[167],"P":[168,182,203,269],"0.01)":[170],"T":[172],"64.2":[175],"4.1%":[177],"67.1":[179],"4.2%;":[181],"0.01).":[184,205,234,271],"A":[185,273],"decrease":[186],"13.4":[196],"2.7%":[198],"9.8":[200],"2.2%;":[202],"CD4+":[209,227],"increased":[211,231,242],"CD8+":[218],"so":[224],"cell/CD8+":[228],"ratio":[230],"CD29+":[238],"(helper-inducer":[239],"T)":[240,251],"0.05),":[245],"CD45RA+":[249],"(suppressor-inducer":[250],"change.":[255],"33.6":[262],"8.3%":[264],"29.1":[266],"7.6%;":[268],"CONCLUSIONS:":[272],"small":[274],"significant":[276],"alteration":[277],"by":[286],"indicates":[288],"local":[290],"nerve":[292],"may":[294],"modulate":[295],"response.":[298]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
