{"id":"https://openalex.org/W1987982071","doi":"https://doi.org/10.1016/0163-7258(92)90037-z","title":"Rhythms and the pharmacology of lithium","display_name":"Rhythms and the pharmacology of lithium","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W1987982071","doi":"https://doi.org/10.1016/0163-7258(92)90037-z","mag":"1987982071","pmid":"https://pubmed.ncbi.nlm.nih.gov/1297145"},"language":"en","primary_location":{"id":"doi:10.1016/0163-7258(92)90037-z","doi":"https://doi.org/10.1016/0163-7258(92)90037-z","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0163-7258(92)90037-z","pdf_url":null,"source":{"id":"https://openalex.org/S83493678","display_name":"Pharmacology & Therapeutics","issn_l":"0163-7258","issn":["0163-7258","1879-016X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005099410","display_name":"Harry Klemfuss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Harry Klemfuss","raw_affiliation_strings":["Department of Psychiatry, University of California, San Diego","Department of Psychiatry, University of California, San Diego, USA","Veterans Affairs Medical Center, San Diego, CA 92161, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Psychiatry, University of California, San Diego, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Veterans Affairs Medical Center, San Diego, CA 92161, U.S.A","institution_ids":["https://openalex.org/I2799886695"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005099410"],"corresponding_institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I36258959"],"apc_list":{"value":5660,"currency":"USD","value_usd":5660},"apc_paid":null,"fwci":0.7767,"has_fulltext":false,"cited_by_count":135,"citation_normalized_percentile":{"value":0.58227848,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"56","issue":"1","first_page":"53","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.701200008392334,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.701200008392334,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.2919999957084656,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lithium","display_name":"lithium","score":0.9990000128746033},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.8190000057220459},{"id":"https://openalex.org/keywords/chronopharmacology","display_name":"chronopharmacology","score":0.9629999995231628},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.847000002861023},{"id":"https://openalex.org/keywords/biological-rhythms","display_name":"biological rhythms","score":0.5590000152587891},{"id":"https://openalex.org/keywords/light-exposure","display_name":"light exposure","score":0.4950000047683716},{"id":"https://openalex.org/keywords/retina","display_name":"retina","score":0.9440000057220459},{"id":"https://openalex.org/keywords/second-messenger-signaling","display_name":"second messenger signaling","score":0.6690000295639038},{"id":"https://openalex.org/keywords/phosphoinositides","display_name":"phosphoinositides","score":0.8579999804496765},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/neurotransmitters","display_name":"neurotransmitters","score":0.7009999752044678},{"id":"https://openalex.org/keywords/hormones","display_name":"hormones","score":0.38199999928474426},{"id":"https://openalex.org/keywords/mood-disorders","display_name":"mood disorders","score":0.3059999942779541}],"concepts":[{"id":"https://openalex.org/C2778541603","wikidata":"https://www.wikidata.org/wiki/Q152763","display_name":"Lithium (medication)","level":2,"score":0.857893705368042},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.7373633980751038},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.6170244216918945},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.5960423946380615},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.5807619094848633},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5328963994979858},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.4856818616390228},{"id":"https://openalex.org/C2781246090","wikidata":"https://www.wikidata.org/wiki/Q7836908","display_name":"Treatment of bipolar disorder","level":5,"score":0.47080695629119873},{"id":"https://openalex.org/C2781046926","wikidata":"https://www.wikidata.org/wiki/Q410174","display_name":"Lithium carbonate","level":4,"score":0.4627833962440491},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.46273598074913025},{"id":"https://openalex.org/C88160501","wikidata":"https://www.wikidata.org/wiki/Q5223563","display_name":"Dark therapy","level":3,"score":0.46131420135498047},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.45343366265296936},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4440310001373291},{"id":"https://openalex.org/C2781291010","wikidata":"https://www.wikidata.org/wiki/Q178580","display_name":"Period (music)","level":2,"score":0.4224804639816284},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4056117534637451},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38761407136917114},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34671950340270996},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.298175185918808},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2708716094493866},{"id":"https://openalex.org/C2776809841","wikidata":"https://www.wikidata.org/wiki/Q185935","display_name":"Mania","level":4,"score":0.1411556601524353},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13388586044311523},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.0},{"id":"https://openalex.org/C2182769","wikidata":"https://www.wikidata.org/wiki/Q62500","display_name":"Ionic bonding","level":3,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002909","descriptor_name":"Chronobiology Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008094","descriptor_name":"Lithium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008094","descriptor_name":"Lithium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0163-7258(92)90037-z","doi":"https://doi.org/10.1016/0163-7258(92)90037-z","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0163-7258(92)90037-z","pdf_url":null,"source":{"id":"https://openalex.org/S83493678","display_name":"Pharmacology & Therapeutics","issn_l":"0163-7258","issn":["0163-7258","1879-016X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology &amp; Therapeutics","raw_type":"journal-article"},{"id":"pmid:1297145","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1297145","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & therapeutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":229,"referenced_works":["https://openalex.org/W10772297","https://openalex.org/W14758024","https://openalex.org/W21495289","https://openalex.org/W70471278","https://openalex.org/W73040960","https://openalex.org/W76332899","https://openalex.org/W81176037","https://openalex.org/W87739736","https://openalex.org/W133622693","https://openalex.org/W135926648","https://openalex.org/W140345343","https://openalex.org/W193922767","https://openalex.org/W226115339","https://openalex.org/W591954920","https://openalex.org/W634244182","https://openalex.org/W1415228902","https://openalex.org/W1486793005","https://openalex.org/W1544120003","https://openalex.org/W1552151388","https://openalex.org/W1594088585","https://openalex.org/W1664153790","https://openalex.org/W1761390008","https://openalex.org/W1801000351","https://openalex.org/W1805771451","https://openalex.org/W1889236699","https://openalex.org/W1896895124","https://openalex.org/W1942495330","https://openalex.org/W1963564662","https://openalex.org/W1963741751","https://openalex.org/W1963785753","https://openalex.org/W1966515143","https://openalex.org/W1966808572","https://openalex.org/W1968278205","https://openalex.org/W1970284332","https://openalex.org/W1970916945","https://openalex.org/W1971666768","https://openalex.org/W1973131293","https://openalex.org/W1973373025","https://openalex.org/W1974103634","https://openalex.org/W1975052720","https://openalex.org/W1975393866","https://openalex.org/W1975867623","https://openalex.org/W1976507371","https://openalex.org/W1976786703","https://openalex.org/W1978679391","https://openalex.org/W1980214507","https://openalex.org/W1982897397","https://openalex.org/W1982943052","https://openalex.org/W1989360790","https://openalex.org/W1990396201","https://openalex.org/W1991978547","https://openalex.org/W1992621135","https://openalex.org/W1993155711","https://openalex.org/W1993597470","https://openalex.org/W1993828736","https://openalex.org/W1994084097","https://openalex.org/W1994124519","https://openalex.org/W1995752472","https://openalex.org/W1996057591","https://openalex.org/W1996246287","https://openalex.org/W1997309821","https://openalex.org/W1997411276","https://openalex.org/W1998152396","https://openalex.org/W2001394790","https://openalex.org/W2003659636","https://openalex.org/W2004336960","https://openalex.org/W2004985139","https://openalex.org/W2008581435","https://openalex.org/W2008751974","https://openalex.org/W2008986093","https://openalex.org/W2009546386","https://openalex.org/W2010710929","https://openalex.org/W2011104380","https://openalex.org/W2011345965","https://openalex.org/W2012425065","https://openalex.org/W2014304477","https://openalex.org/W2015694963","https://openalex.org/W2016708579","https://openalex.org/W2017228951","https://openalex.org/W2017314814","https://openalex.org/W2017468154","https://openalex.org/W2018803544","https://openalex.org/W2018853867","https://openalex.org/W2019171928","https://openalex.org/W2020506490","https://openalex.org/W2020951277","https://openalex.org/W2021436114","https://openalex.org/W2021720019","https://openalex.org/W2022241286","https://openalex.org/W2025203722","https://openalex.org/W2027606162","https://openalex.org/W2028294371","https://openalex.org/W2029018744","https://openalex.org/W2029227663","https://openalex.org/W2029305411","https://openalex.org/W2029354626","https://openalex.org/W2029738937","https://openalex.org/W2031458084","https://openalex.org/W2033885366","https://openalex.org/W2035160273","https://openalex.org/W2035753029","https://openalex.org/W2035785789","https://openalex.org/W2037210025","https://openalex.org/W2037474774","https://openalex.org/W2039078243","https://openalex.org/W2041650809","https://openalex.org/W2041962197","https://openalex.org/W2042098222","https://openalex.org/W2043069063","https://openalex.org/W2043135121","https://openalex.org/W2045777317","https://openalex.org/W2046618925","https://openalex.org/W2047179436","https://openalex.org/W2047280079","https://openalex.org/W2048437805","https://openalex.org/W2049191605","https://openalex.org/W2050083058","https://openalex.org/W2051363364","https://openalex.org/W2051708625","https://openalex.org/W2052024880","https://openalex.org/W2053689185","https://openalex.org/W2055335838","https://openalex.org/W2055731279","https://openalex.org/W2056425442","https://openalex.org/W2056683391","https://openalex.org/W2058080420","https://openalex.org/W2058282000","https://openalex.org/W2058814517","https://openalex.org/W2060395067","https://openalex.org/W2062474713","https://openalex.org/W2064924920","https://openalex.org/W2069513497","https://openalex.org/W2070783023","https://openalex.org/W2072018453","https://openalex.org/W2073808251","https://openalex.org/W2074269110","https://openalex.org/W2075084351","https://openalex.org/W2076637045","https://openalex.org/W2077095849","https://openalex.org/W2078430173","https://openalex.org/W2079452729","https://openalex.org/W2079581208","https://openalex.org/W2079906822","https://openalex.org/W2081433661","https://openalex.org/W2083307191","https://openalex.org/W2084861601","https://openalex.org/W2085156548","https://openalex.org/W2085833130","https://openalex.org/W2085872187","https://openalex.org/W2085968319","https://openalex.org/W2086122924","https://openalex.org/W2086278587","https://openalex.org/W2088065179","https://openalex.org/W2088295459","https://openalex.org/W2088641039","https://openalex.org/W2090937036","https://openalex.org/W2091067967","https://openalex.org/W2093946593","https://openalex.org/W2095247433","https://openalex.org/W2095932454","https://openalex.org/W2103779140","https://openalex.org/W2107827954","https://openalex.org/W2111824860","https://openalex.org/W2112381794","https://openalex.org/W2113323125","https://openalex.org/W2117484544","https://openalex.org/W2119715096","https://openalex.org/W2120941695","https://openalex.org/W2123524711","https://openalex.org/W2126176338","https://openalex.org/W2126996448","https://openalex.org/W2132673430","https://openalex.org/W2134761012","https://openalex.org/W2135809214","https://openalex.org/W2138488650","https://openalex.org/W2142600563","https://openalex.org/W2144164161","https://openalex.org/W2146828315","https://openalex.org/W2147819588","https://openalex.org/W2161609636","https://openalex.org/W2164518454","https://openalex.org/W2165095081","https://openalex.org/W2166231225","https://openalex.org/W2169065497","https://openalex.org/W2206384312","https://openalex.org/W2237171118","https://openalex.org/W2237405964","https://openalex.org/W2255646486","https://openalex.org/W2268987149","https://openalex.org/W2270970238","https://openalex.org/W2299437091","https://openalex.org/W2299536044","https://openalex.org/W2315825567","https://openalex.org/W2330970170","https://openalex.org/W2333121857","https://openalex.org/W2344403404","https://openalex.org/W2400144338","https://openalex.org/W2409052417","https://openalex.org/W2413625212","https://openalex.org/W2415521140","https://openalex.org/W2416367790","https://openalex.org/W2418166026","https://openalex.org/W2418479636","https://openalex.org/W2419028667","https://openalex.org/W2430678507","https://openalex.org/W2473237507","https://openalex.org/W2485956465","https://openalex.org/W2486569607","https://openalex.org/W2489037556","https://openalex.org/W2489278463","https://openalex.org/W2511012595","https://openalex.org/W2520080162","https://openalex.org/W2744039628","https://openalex.org/W2889255650","https://openalex.org/W2917881898","https://openalex.org/W2983445473","https://openalex.org/W2993860386","https://openalex.org/W3043693503","https://openalex.org/W3112761749","https://openalex.org/W3142424074","https://openalex.org/W3172829587","https://openalex.org/W3217417991","https://openalex.org/W4241287667","https://openalex.org/W4254914195","https://openalex.org/W4285719527","https://openalex.org/W4300179793","https://openalex.org/W4300784327","https://openalex.org/W4302316564","https://openalex.org/W6726836540"],"related_works":["https://openalex.org/W2556302996","https://openalex.org/W4283797729","https://openalex.org/W2020951277","https://openalex.org/W2303535716","https://openalex.org/W2900996428","https://openalex.org/W7165038456","https://openalex.org/W2971159528","https://openalex.org/W2782835056","https://openalex.org/W2607590755","https://openalex.org/W581430220"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
