{"id":"https://openalex.org/W1987975969","doi":"https://doi.org/10.1007/978-3-642-18930-2_20","title":"mTOR as a Target for Cancer Therapy","display_name":"mTOR as a Target for Cancer Therapy","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W1987975969","doi":"https://doi.org/10.1007/978-3-642-18930-2_20","mag":"1987975969","pmid":"https://pubmed.ncbi.nlm.nih.gov/14560967"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-642-18930-2_20","doi":"https://doi.org/10.1007/978-3-642-18930-2_20","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-18930-2_20","pdf_url":null,"source":{"id":"https://openalex.org/S192937065","display_name":"Current topics in microbiology and immunology","issn_l":"0070-217X","issn":["0070-217X","2196-9965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Topics in Microbiology and Immunology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2111328376","display_name":"TOR"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109173471","display_name":"Peter J. Houghton","orcid":"https://orcid.org/0000-0002-2400-8184","observed_orcids":["https://orcid.org/0000-0002-2400-8184"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"P. J. Houghton","raw_affiliation_strings":["Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105-2794, USA. peter.houghton@stjude.org","Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN, 38105-2794, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105-2794, USA. peter.houghton@stjude.org","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN, 38105-2794, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083421941","display_name":"Shile Huang","orcid":"https://orcid.org/0000-0002-3239-1072","observed_orcids":["https://orcid.org/0000-0002-3239-1072"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Huang","raw_affiliation_strings":["Department of Molecular Pharmacology, St. Jude Children\u2019s Research Hospital, 332 N. Lauderdale, Memphis, TN, 38105-2794, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology, St. Jude Children\u2019s Research Hospital, 332 N. Lauderdale, Memphis, TN, 38105-2794, USA","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109173471"],"corresponding_institution_ids":["https://openalex.org/I1313298211"],"apc_list":null,"apc_paid":null,"fwci":9.6247,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.98560209,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"279","issue":null,"first_page":"339","last_page":"359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.8289999961853027},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8029999732971191},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-receptor","display_name":"insulin-like growth factor receptor","score":0.8659999966621399},{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.7020000219345093},{"id":"https://openalex.org/keywords/mitogenic-signaling","display_name":"mitogenic signaling","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6910214424133301},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6159603595733643},{"id":"https://openalex.org/C183713625","wikidata":"https://www.wikidata.org/wiki/Q5282002","display_name":"Discovery and development of mTOR inhibitors","level":4,"score":0.5232476592063904},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38223421573638916},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3493642807006836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31318649649620056},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17009836435317993},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14632532000541687},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.08347636461257935}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018232","descriptor_name":"Rhabdomyosarcoma, Alveolar","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018232","descriptor_name":"Rhabdomyosarcoma, Alveolar","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-3-642-18930-2_20","doi":"https://doi.org/10.1007/978-3-642-18930-2_20","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-18930-2_20","pdf_url":null,"source":{"id":"https://openalex.org/S192937065","display_name":"Current topics in microbiology and immunology","issn_l":"0070-217X","issn":["0070-217X","2196-9965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Topics in Microbiology and Immunology","raw_type":"book-chapter"},{"id":"pmid:14560967","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14560967","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current topics in microbiology and immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1292651958","display_name":"MTOR as a Therapeutic Target in Childhood Cancer","funder_award_id":"R01CA096696","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5145123177","display_name":"Studies of Childhood Solid Tumors","funder_award_id":"P01CA023099","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5733301036","display_name":"Rapamycin-Induced Selective Apoptosis in Malignant Cells","funder_award_id":"R01CA077776","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000904664","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA021765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W149708184","https://openalex.org/W1231309445","https://openalex.org/W1592142762","https://openalex.org/W1599727238","https://openalex.org/W1827870815","https://openalex.org/W1906388559","https://openalex.org/W1924008417","https://openalex.org/W1926863270","https://openalex.org/W1939283405","https://openalex.org/W1949632792","https://openalex.org/W1954313480","https://openalex.org/W1966155043","https://openalex.org/W1969971113","https://openalex.org/W1970497539","https://openalex.org/W1981001162","https://openalex.org/W1985046929","https://openalex.org/W1987005832","https://openalex.org/W1988609792","https://openalex.org/W1993855694","https://openalex.org/W1997554027","https://openalex.org/W2001881651","https://openalex.org/W2002485919","https://openalex.org/W2008294451","https://openalex.org/W2011485783","https://openalex.org/W2014625042","https://openalex.org/W2015062933","https://openalex.org/W2015174638","https://openalex.org/W2015277956","https://openalex.org/W2024839583","https://openalex.org/W2024842574","https://openalex.org/W2027328554","https://openalex.org/W2037100222","https://openalex.org/W2037676225","https://openalex.org/W2038347115","https://openalex.org/W2049053107","https://openalex.org/W2053132428","https://openalex.org/W2056854271","https://openalex.org/W2057106513","https://openalex.org/W2057709162","https://openalex.org/W2063013559","https://openalex.org/W2069105509","https://openalex.org/W2069652470","https://openalex.org/W2073885879","https://openalex.org/W2074465644","https://openalex.org/W2080477342","https://openalex.org/W2083131818","https://openalex.org/W2089869923","https://openalex.org/W2094957750","https://openalex.org/W2097731453","https://openalex.org/W2102648794","https://openalex.org/W2104135564","https://openalex.org/W2114859236","https://openalex.org/W2115009664","https://openalex.org/W2115479382","https://openalex.org/W2116495852","https://openalex.org/W2120356140","https://openalex.org/W2123664371","https://openalex.org/W2124587511","https://openalex.org/W2128139378","https://openalex.org/W2135090837","https://openalex.org/W2135753091","https://openalex.org/W2141825683","https://openalex.org/W2142506125","https://openalex.org/W2144304119","https://openalex.org/W2151559596","https://openalex.org/W2158612356","https://openalex.org/W2167041446","https://openalex.org/W2171433167","https://openalex.org/W2289990245"],"related_works":["https://openalex.org/W2093604520","https://openalex.org/W121459652","https://openalex.org/W2954917865","https://openalex.org/W1980138637","https://openalex.org/W7099549144","https://openalex.org/W2029348880","https://openalex.org/W2110604215","https://openalex.org/W2088363975","https://openalex.org/W7096351785","https://openalex.org/W2791698913"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
