{"id":"https://openalex.org/W1987883102","doi":"https://doi.org/10.1242/jcs.106831","title":"Telomeres at a glance","display_name":"Telomeres at a glance","publication_year":2012,"publication_date":"2012-09-15","ids":{"openalex":"https://openalex.org/W1987883102","doi":"https://doi.org/10.1242/jcs.106831","mag":"1987883102","pmid":"https://pubmed.ncbi.nlm.nih.gov/23135002","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6518153"},"language":"en","primary_location":{"id":"doi:10.1242/jcs.106831","doi":"https://doi.org/10.1242/jcs.106831","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.106831","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6518153","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053124609","display_name":"Agnel J. Sfeir","orcid":"https://orcid.org/0000-0003-1633-8535","observed_orcids":["https://orcid.org/0000-0003-1633-8535"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Agnel Sfeir","raw_affiliation_strings":["The Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5053124609"],"corresponding_institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"],"apc_list":null,"apc_paid":null,"fwci":0.3429,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.30005018,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"125","issue":"18","first_page":"4173","last_page":"4178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomeres","display_name":"telomeres","score":0.878000020980835},{"id":"https://openalex.org/keywords/telomere-structure","display_name":"telomere structure","score":0.7269999980926514},{"id":"https://openalex.org/keywords/telomeric-dna","display_name":"telomeric DNA","score":0.6480000019073486},{"id":"https://openalex.org/keywords/telomeric-repeats","display_name":"telomeric repeats","score":0.49000000953674316},{"id":"https://openalex.org/keywords/telomere-protection","display_name":"telomere protection","score":0.4860000014305115},{"id":"https://openalex.org/keywords/end-replication-problem","display_name":"end-replication problem","score":0.824999988079071},{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":0.7120000123977661},{"id":"https://openalex.org/keywords/telomere-dysfunction","display_name":"telomere dysfunction","score":0.6710000038146973},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/telomere-length-control","display_name":"telomere length control","score":0.3880000114440918},{"id":"https://openalex.org/keywords/telomere-length-heterogeneity","display_name":"telomere length heterogeneity","score":0.35899999737739563}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.9417405128479004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8184084892272949},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.6869759559631348},{"id":"https://openalex.org/C80116771","wikidata":"https://www.wikidata.org/wiki/Q5408688","display_name":"Eukaryotic chromosome fine structure","level":4,"score":0.5391374826431274},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.48564282059669495},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4824700653553009},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.47650638222694397},{"id":"https://openalex.org/C60325843","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Nucleoprotein","level":3,"score":0.4668441712856293},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4482012391090393},{"id":"https://openalex.org/C27149982","wikidata":"https://www.wikidata.org/wiki/Q3456514","display_name":"Tandem repeat","level":4,"score":0.44631513953208923},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.438432514667511},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2206953763961792},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16547244787216187}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034501","descriptor_name":"Telomere-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1242/jcs.106831","doi":"https://doi.org/10.1242/jcs.106831","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.106831","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6518153","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6518153","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Sci","raw_type":"Text"},{"id":"pmid:23135002","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23135002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cell science","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6518153","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6518153","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Sci","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5769648056","display_name":"Deciphering the extra-telomeric function of Rap1, a metabolic regulator counterac","funder_award_id":"R01DK102562","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":102,"referenced_works":["https://openalex.org/W1483245334","https://openalex.org/W1520911672","https://openalex.org/W1533359580","https://openalex.org/W1676646253","https://openalex.org/W1829553711","https://openalex.org/W1943069336","https://openalex.org/W1965580483","https://openalex.org/W1965612858","https://openalex.org/W1970447674","https://openalex.org/W1970501424","https://openalex.org/W1970801073","https://openalex.org/W1981936717","https://openalex.org/W1982061874","https://openalex.org/W1982199027","https://openalex.org/W1984622067","https://openalex.org/W1985910275","https://openalex.org/W1985910710","https://openalex.org/W1988762563","https://openalex.org/W1990507848","https://openalex.org/W1996946708","https://openalex.org/W1998335196","https://openalex.org/W2000210729","https://openalex.org/W2000971601","https://openalex.org/W2001828972","https://openalex.org/W2003010415","https://openalex.org/W2003446723","https://openalex.org/W2003718497","https://openalex.org/W2004007316","https://openalex.org/W2010045481","https://openalex.org/W2011882274","https://openalex.org/W2013073993","https://openalex.org/W2014414194","https://openalex.org/W2017606844","https://openalex.org/W2019622456","https://openalex.org/W2021836517","https://openalex.org/W2022507419","https://openalex.org/W2028320710","https://openalex.org/W2032407757","https://openalex.org/W2033731825","https://openalex.org/W2035389897","https://openalex.org/W2040204581","https://openalex.org/W2043545239","https://openalex.org/W2044664714","https://openalex.org/W2049947939","https://openalex.org/W2050302428","https://openalex.org/W2053300345","https://openalex.org/W2054632884","https://openalex.org/W2058375396","https://openalex.org/W2058499120","https://openalex.org/W2059468683","https://openalex.org/W2062046532","https://openalex.org/W2073204556","https://openalex.org/W2077830374","https://openalex.org/W2078484854","https://openalex.org/W2078502421","https://openalex.org/W2084252557","https://openalex.org/W2084575716","https://openalex.org/W2085829147","https://openalex.org/W2086316954","https://openalex.org/W2086992094","https://openalex.org/W2087011288","https://openalex.org/W2088586185","https://openalex.org/W2090388015","https://openalex.org/W2090827678","https://openalex.org/W2106996266","https://openalex.org/W2110419228","https://openalex.org/W2113239996","https://openalex.org/W2114697209","https://openalex.org/W2116282320","https://openalex.org/W2120533799","https://openalex.org/W2122740168","https://openalex.org/W2123605670","https://openalex.org/W2124112426","https://openalex.org/W2124139300","https://openalex.org/W2124242199","https://openalex.org/W2124365042","https://openalex.org/W2126564248","https://openalex.org/W2127440297","https://openalex.org/W2128500969","https://openalex.org/W2129992844","https://openalex.org/W2131549919","https://openalex.org/W2134283983","https://openalex.org/W2136856258","https://openalex.org/W2137986693","https://openalex.org/W2138398263","https://openalex.org/W2139893790","https://openalex.org/W2142420543","https://openalex.org/W2145952889","https://openalex.org/W2147765162","https://openalex.org/W2148197898","https://openalex.org/W2149718327","https://openalex.org/W2150490516","https://openalex.org/W2153321182","https://openalex.org/W2153633026","https://openalex.org/W2155983703","https://openalex.org/W2156857490","https://openalex.org/W2161232591","https://openalex.org/W2161355984","https://openalex.org/W2168203939","https://openalex.org/W3187658540","https://openalex.org/W4295934140","https://openalex.org/W7095856360"],"related_works":["https://openalex.org/W2110499037","https://openalex.org/W2790491246","https://openalex.org/W2777737929","https://openalex.org/W1970801073","https://openalex.org/W2122303898","https://openalex.org/W4361013013","https://openalex.org/W181279290","https://openalex.org/W1996952541","https://openalex.org/W2079167507","https://openalex.org/W2228301362"],"abstract_inverted_index":{"The":[0,18,35,506,1212,1368,1534,1565,1605,1704,1724,1869,2176,2269,2624,2731,2964,2986,3007,3034,3155,3210,3336],"linearity":[1,1840],"of":[2,26,42,83,96,99,117,133,159,172,178,191,213,284,324,358,370,420,494,532,671,719,779,798,814,849,943,976,1070,1117,1130,1143,1189,1250,1264,1280,1299,1311,1319,1344,1352,1390,1413,1428,1455,1554,1577,1593,1607,1617,1645,1661,1671,1679,1683,1734,1785,1793,1805,1841,1849,1882,1908,1943,1953,1961,1969,1974,2023,2046,2180,2208,2259,2344,2403,2410,2454,2458,2466,2473,2540,2548,2611,2637,2642,2674,2695,2710,2737,2759,2780,2793,2860,2868,2903,2929,2951,2961,2994,3000,3009,3017,3032,3048,3053,3079,3090,3099,3107,3132,3173,3187,3207,3230,3245,3253,3268,3297,3303,3378,3423],"chromosomes":[3],"creates":[4],"two":[5,573,1696,2911],"major":[6,1045,1080,1323,1558],"problems":[7,55],"for":[8,733,917,1462,2102,2317,2398,2573,3162,3237,3264,3333,3404,3428],"eukaryotic":[9,983],"cells:":[10],"the":[11,15,23,27,40,60,69,78,89,115,123,129,134,143,147,156,214,282,285,289,294,321,330,366,371,379,500,514,529,533,550,664,681,734,763,812,846,850,870,888,899,931,964,989,1044,1108,1114,1128,1131,1141,1187,1237,1241,1248,1251,1260,1281,1285,1295,1300,1304,1309,1312,1321,1326,1341,1350,1353,1388,1391,1473,1504,1512,1561,1570,1575,1643,1658,1662,1669,1677,1707,1794,1803,1822,1839,1847,1851,1861,1883,1888,1905,1921,1940,1967,1975,2007,2058,2111,2209,2219,2234,2240,2342,2361,2375,2385,2401,2407,2411,2425,2428,2452,2462,2467,2486,2499,2506,2529,2536,2579,2607,2672,2708,2734,2738,2743,2778,2786,2841,2901,2904,2908,2927,2959,2970,2992,3015,3097,3108,3133,3143,3171,3208,3227,3231,3235,3238,3269,3301,3304,3317,3322,3331,3334,3345,3376,3424,3431,3436],"end-replication":[12,19,1852],"problem":[13,20,37,1796,1853],"and":[14,101,111,131,136,181,194,207,231,254,264,278,361,395,425,491,525,559,567,577,605,666,674,700,728,737,748,775,828,866,891,920,957,968,985,1013,1036,1040,1053,1055,1098,1135,1139,1154,1163,1168,1173,1193,1208,1220,1257,1262,1290,1335,1373,1416,1524,1540,1550,1586,1622,1688,1692,1719,1739,1775,1797,1833,1854,1866,1880,1893,1910,1927,1949,1984,1989,1999,2003,2011,2043,2074,2083,2090,2096,2212,2223,2227,2285,2330,2483,2524,2538,2562,2586,2621,2703,2715,2763,2783,2824,2835,2840,2849,2871,2899,2936,2966,3024,3028,3056,3119,3221,3280,3328,3341,3353,3366,3384,3421],"end-protection":[16,36,1067,1795],"problem.":[17],"stems":[21],"from":[22,288,869,950,1095,1394,1430,1584,1587,2185,2616,2733,3170,3202],"inherent":[24],"inability":[25],"replication":[28,750,1384,1563,1572],"machinery":[29,902,1573],"to":[30,39,46,74,149,319,364,373,513,528,653,656,685,785,794,939,945,1006,1091,1235,1331,1336,1348,1379,1382,1396,1426,1543,1560,1800,1820,1860,2016,2037,2060,2088,2163,2169,2218,2239,2275,2360,2372,2383,2393,2421,2424,2445,2478,2504,2558,2578,2594,2654,2665,2688,2726,2742,2753,2891,2922,3193,3315,3373,3387,3414,3435,3445],"fully":[31,2062,2484,2647,3374],"duplicate":[32],"linear":[33,43],"templates.":[34],"refers":[38],"propensity":[41,3089],"chromosome":[44,66,407,877,948,1019,1066,1093,1204,1842,2170],"ends":[45,408,878,949,975,1020,1094,2171],"be":[47,238,940,2355],"recognized":[48,1062],"as":[49,297,299,452,462,470,480,489,599,647,692,730,845,1469,1471,1761,1763,1877,2243,2245,2498,2755,2772,2954,3393,3395],"DNA":[50,173,189,413,516,534,657,743,749,760,952,1029,1046,1096,1144,1296,1408,1556,1562,1651,1710,1765,2386,2412,2426,2694,3323],"double-strand":[51],"breaks":[52],"(DSBs).":[53],"Both":[54],"are":[56,270,279,362,438,580,651,723,874,885,978,1021,1025,1111,1591,1751,1798,1817,1836,1950,2014,2116,2476,2635,2652,2663,2789,2814,2889,2980,3308,3326],"surmounted":[57],"by":[58,281,300,328,387,405,416,519,726,862,898,966,1028,1068,1214,1284,1370,1503,1522,1536,1612,1716,1758,1764,1773,1780,1838,1997,2006,2077,2140,2198,2279,2676,2797,3014,3039,3319],"telomeres,":[59,118,1200,1431,1448,2804,3261],"specific":[61,176,1650,2396],"nucleoprotein":[62,852],"complexes":[63],"that":[64,87,140,240,304,333,579,636,722,823,873,911,1004,1063,1110,1409,1457,1488,1590,1633,1699,1713,1835,2086,2115,2190,2193,2216,2340,2351,2417,2670,2997,3042,3074,3213,3242,3260,3281,3359],"adorn":[65],"ends.In":[67,1843],"2009,":[68],"Nobel":[70],"Prize":[71],"was":[72,385,792,960,1060],"awarded":[73],"pioneering":[75],"researchers":[76],"in":[77,81,200,217,248,258,353,783,963,999,1085,1127,1186,1203,1240,1268,1333,1338,1451,1494,1511,1518,1668,1737,1745,1753,1873,1916,1931,2029,2118,2172,2187,2262,2303,2319,2357,2400,2451,2495,2528,2542,2554,2601,2618,2630,2658,2682,2698,2751,2926,2946,2949,2958,2969,2977,2991,3050,3072,3165,3176,3180,3199,3226,3276,3294,3349,3390,3396],"telomere":[79,135,160,215,372,770,851,918,1238,1282,1463,1618,1702,1735,1856,2304,2362,2560,2564,2569,2584,2596,2612,2627,2656,2689,2699,2739,2787,2892,2919,2931,2952,3022,3080,3163,3174,3196,3214,3222,3347,3379],"field":[80],"recognition":[82],"their":[84,195,410,1071,1380,1811,2825,3286],"seminal":[85],"findings":[86,113],"set":[88,177,419],"stage":[90,3078,3236],"for,":[91],"so":[92,2605],"far,":[93,2606],"three":[94,167,521,3251],"decades":[95,3252],"vigorous":[97],"investigation":[98],"telomeres":[100,338,495,640,799,895,1064,1161,1493,1583,1682,1816,2204,2634,2724,2813,2869,2895,2968,3127,3299],"telomerase.":[102,2345,2677],"In":[103,186,434,631,1077,1808,1899,1991,2321,2566,2678,2800,2914],"this":[104,912,935,2194,2440,2589],"article,":[105],"I":[106,127,154,3411,3433],"review":[107],"our":[108,3295],"current":[109,2257],"knowledge":[110],"recent":[112,138,1078,2347,2496,3040],"regarding":[114,2777],"function":[116,426,813,921,937,1606,1670,2397,2537,3023,3279,3332,3383],"with":[119,509,552,602,645,790,796,826,988,1113,1810,2161,2277,2281,2802,2829,2865,2916,3130,3148,3218],"a":[120,175,182,221,350,355,375,417,596,693,753,1001,1452,1495,1519,1731,1754,1783,1790,1878,2061,2070,2173,2206,2214,2301,2314,2395,2455,2546,2667,2727,2756,3077,3160,3190,3273],"focus":[121],"on":[122,293,310,335,642,702,818,1106,2050,2066,2941,3381,3430],"mammalian":[124,435,1746,1815,1874,2263,2555,2631,2812],"system.":[125],"Specifically,":[126],"delineate":[128],"structure":[130,377,424,1306],"composition":[132],"highlight":[137],"discoveries":[139],"have":[141,245,317,349,427,686,714,821,1082,1403,1675,1694,1789,2026,2191,2324,2349,3075,3125,3139,3272,3313,3440],"elucidated":[142],"molecular":[144,322,932],"mechanisms":[145,933],"underlying":[146,934,2626],"solutions":[148],"both":[150,311,603,1749,2282],"\u2018end":[151],"problems\u2019.":[152],"Lastly,":[153],"describe":[155],"perilous":[157],"consequences":[158,1678],"dysfunction":[161,2932,2953,3094,3164,3283],"during":[162,887,1472,1477,1574,1904,3407],"tumorigenesis.The":[163],"telomeric":[164,188,359,515,788,1398,1407,1555,1579,2241,2693,2798],"architecture":[165],"incorporates":[166],"known":[168,451,461,469,479,488,684,810,2653,2664],"entities:":[169],"tandem":[170],"repeats":[171,193,2675],"sequence,":[174],"binding":[179,447,457,555,1157,1310,1395,1982,2902],"proteins":[180,721,2085,3340],"non-coding":[183,913],"RNA":[184,286,836,863,914,1890,2247,2459,2517],"transcript.":[185],"mammals,":[187],"consists":[190,1881],"TTAGGG":[192],"complementary":[196],"AATCCC":[197],"sequences":[198],"and,":[199,2604],"humans,":[201,1900],"its":[202,520,553,643,648,892,1806,1911,2051,2067,2106,2167,2550],"size":[203],"ranges":[204],"between":[205,2201,2328,3338],"5":[206,2850],"15":[208],"kb.":[209],"A":[210,1274,1386],"key":[211,2159],"feature":[212],"end":[216,337,1283,2363],"all":[218,1684,1845,2045,3321],"organisms":[219],"is":[220,414,517,663,680,809,860,867,896,915,955,1010,1089,1197,1222,1233,1294,1329,1347,1444,1490,1501,1515,1546,1609,1706,1714,1726,1730,1771,1778,1858,1902,1913,1963,1995,2004,2034,2075,2105,2138,2166,2196,2265,2381,2391,2427,2449,2545,2571,2588,2645,2740,2795,2827,2984,2988,3012,3070,3256,3288,3356],"3\u2032":[222,308],"single-stranded":[223,242,1354,1397,2220],"G-rich":[224,268,347,1549],"overhang":[225,551,830,1355,2221],"(Makarov":[226,2816],"et":[227,251,275,340,344,391,399,536,540,544,563,587,591,612,616,620,624,628,659,697,710,801,805,833,855,880,904,923,927,992,1254,1271,1357,1361,1365,1437,1441,1466,1481,1527,1531,1598,1602,1896,1936,1957,2054,2093,2122,2126,2130,2148,2152,2156,2249,2253,2288,2292,2307,2333,2337,2365,2436,2511,2521,2532,2720,2768,2809,2817,2821,2852,2856,2875,2879,3004,3060,3064,3111,3116,3122,3152,3248],"al.,":[228,252,276,341,345,392,400,537,541,545,564,588,592,613,617,621,625,629,660,698,711,802,806,834,856,881,905,924,928,993,1255,1272,1358,1362,1366,1438,1442,1467,1482,1528,1532,1599,1603,1897,1937,1958,2055,2094,2123,2127,2131,2149,2153,2157,2250,2254,2289,2293,2308,2334,2338,2366,2437,2512,2522,2533,2721,2769,2810,2818,2822,2853,2857,2876,2880,3005,3061,3065,3112,3117,3123,3153,3249],"1997;":[229,538,542],"McElligott":[230],"Wellinger,":[232],"1997).":[233,2706],"Although,":[234],"it":[235,600,655,679,689,1500,1516,2390,3255],"should":[236],"also":[237,450,460,468,478,487,690,2035,2354,3095,3360],"noted":[239,3225],"5\u2032":[241],"C-rich":[243],"overhangs":[244,269,348],"been":[246,843,909,1083,1103,1229,1404,1411,1742,2027,2273,2370,2419,2443,2502,2526,2749,3037,3140,3442],"observed":[247,1744],"worms":[249],"(Raices":[250],"2008)":[253],"can":[255,1258,1634,1700,2048],"occur":[256],"transiently":[257],"some":[259,2030,2650],"human":[260,819,1944,2024,2283,2684,3100,3270],"cancer":[261,1945,2031,2962,3055,3391],"cells":[262,820,944,984,1875,1929,1946,2264,2556,2884,2909,2915,3201],"(Oganesian":[263],"Karlseder,":[265],"2011).":[266],"Mammalian":[267],"30-500":[271],"nucleotides":[272],"long":[273],"(Chai":[274,2287],"2005)":[277,1138],"generated":[280],"removal":[283],"primer":[287],"terminal":[290],"Okazaki":[291],"fragment":[292],"lagging":[295],"strand,":[296],"well":[298,1470,1762,2244,3258,3394],"post-replicative":[301],"processing":[302,326],"events":[303,327],"involve":[305],"nucleases":[306],"performing":[307],"resection":[309],"newly":[312],"synthesized":[313],"strands.":[314],"Recent":[315,1484],"studies":[316,713,817,1638,2186,2323,2617],"started":[318],"unravel":[320,3316],"details":[323,2776],"such":[325,2480],"identifying":[329],"Apollo":[331],"nuclease":[332],"acts":[334],"leading":[336],"(Lam":[339],"2010;":[342,925,1439,2873],"Wu":[343,590,1364],"2010).":[346,661,882,1419,1533,2367],"central":[351],"role":[352,1343,2316,2553,3161,3275],"sustaining":[354],"diverse":[356],"array":[357],"functions":[360],"thought":[363],"invade":[365],"preceding":[367],"duplex":[368,530,2735],"region":[369,531,1977,2736],"form":[374,499],"lariat-like":[376],"called":[378],"t-loop.":[380,3335],"This":[381,1101,2368,2576,3185],"higher-order":[382],"architecture,":[383],"which":[384,406,497,510,758,954,1180,1201,1215,1293,1371,1424,1507,1537,1628,1729,2047,2237,2310,2747,2805,2974,3019,3085,3146,3262,3320,3343],"revealed":[386],"electron":[388],"microscopy":[389],"(Griffith":[390],"1999;":[393,2225],"Nikitina":[394],"Woodcock,":[396],"2004;":[397,2124,2718,2854],"Raices":[398],"2008),":[401],"provides":[402],"one":[403],"mechanism":[404,1213,1369,1535,2625],"maintain":[409,2563],"protective":[411,2905],"cap.Telomeric":[412],"bound":[415],"specialized":[418],"proteins,":[421],"whose":[422,2633,3438],"composition,":[423],"diverged":[428],"across":[429],"species":[430],"(de":[431,503,1074],"Lange,":[432,504,569,676,739,1075,1137,1165,1170,1175,1210,1418,1690,2705,2717,2765],"2009).":[433,807,1176,1273,1604,2623],"cells,":[436,1000,1919,2632],"there":[437,3307],"six":[439,1823],"bona":[440],"fide":[441],"telomere-specific":[442,1520],"proteins:":[443],"TRF1":[444,524,604,1568,1608,2681,2696],"(telomeric":[445,455],"repeat":[446,456],"factor":[448,458,476,704,2416],"1,":[449,2847],"TERF1),":[453],"TRF2":[454,526,606,1125,1216,1232,1245,2713],"2,":[459,477],"TERF2),":[463],"RAP1":[464,662,1523],"(TERF2":[465],"interacting":[466,474,2280],"protein,":[467],"TERF2IP),":[471],"TIN2":[472,594,2711],"(TRF1":[473],"nuclear":[475,703,2430],"TINF2),":[481],"TPP1":[482,610,827,1421,2329,2352,2380,2399],"(adrenocortical":[483],"dysplasia":[484],"protein":[485,1072,1158,1385,2144,2215,2432],"homolog,":[486],"ACD)":[490],"POT1":[492,548,574,637,1332,1372,1414,1429,1525,1539],"(protection":[493],"1),":[496,2205],"together":[498],"shelterin":[501,511,672,727,1088,1119,1566,1647,1672,1685,1759,1813,2661,2906],"complex":[502,735,755,772,853,1864,2073,2271],"2005).":[505,1076,1211,2294,2770],"exquisite":[507],"specificity":[508],"binds":[512,1246,2217,2238],"conferred":[518],"DNA-binding":[522],"modules.":[523],"bind":[527,2087],"(Bianchi":[535],"Broccoli":[539],"Bilaud":[543],"1997),":[546],"whereas":[547,1340,2691],"coats":[549],"oligonucleotide/oligosaccharide":[554],"(OB)":[556],"folds":[557,650],"(Baumann":[558],"Cech,":[560],"2001;":[561,2251],"Lei":[562,2767],"2002;":[565,2290],"Loayza":[566],"de":[568,675,738,1136,1164,1169,1174,1209,1417,1689,2704,2716,2764,3402,3425],"2003).":[570,677,2255],"Rodents":[571],"express":[572],"paralogs":[575],"(POT1a":[576],"POT1b)":[578],"structurally":[581],"similar,":[582],"yet":[583,930,3314],"functionally":[584],"divergent":[585],"(Hockemeyer":[586,1356],"2006;":[589,622,1166,1363,2128],"2006).":[593,1367,2858],"has":[595,634,842,908,1102,1228,1410,1486,1740,1978,2183,2272,2369,2418,2442,2490,2501,2525,2748,2944,3036,3168],"bridging":[597],"function,":[598],"interacts":[601,825],"while":[607],"simultaneously":[608],"recruiting":[609,1613,2358],"(Ye":[611,2714],"2004a;":[614],"Ye":[615],"2004b;":[618],"O'Connor":[619],"Takai":[623,1440,2719],"2011;":[626,2877],"Houghtaling":[627],"2004).":[630,3154],"vivo":[632,2947],"data":[633],"suggested":[635,822,2350,2420],"accumulation":[638,1142],"at":[639,894,1160,1199,1247,1406,1447,1492,1966,2723,2785,3142,3204],"relies":[641],"interaction":[644,2200,2327,2377],"TPP1,":[646],"OB":[649],"insufficient":[652],"tether":[654],"(Kibe":[658,1436],"sixth":[665],"most":[667,1917,2177,2608,2882,3156],"evolutionary":[668],"conserved":[669],"member":[670,1152],"(Li":[673],"Furthermore,":[678,995,1185,1939],"only":[682],"subunit":[683,1567],"non-telomeric":[687],"functions:":[688],"operates":[691],"transcriptional":[694,1981],"regulator":[695,1616,2758],"(Martinez":[696],"2010)":[699,2722],"impinges":[701],"kappa":[705],"B":[706,3200],"(NF-\u03baB)":[707],"signaling":[708,1002,2508],"(Teo":[709],"2010).Biochemical":[712],"uncovered":[715,1979],"an":[716,2199,2326,2515,2955,2989,3044,3087,3357],"increasing":[717,3088],"number":[718],"telomere-associated":[720,3339],"primarily":[724,1964],"recruited":[725],"act":[729,2754],"accessory":[731,765],"factors":[732,766,2651,2843],"(Palm":[736,1526],"2008).":[740],"They":[741],"include":[742],"damage":[744,1145,1297,1652,1766,2387,2413,3324],"factors,":[745,1146,1767,2079],"nucleases,":[746],"helicases":[747],"proteins.":[751],"Recently,":[752],"trimeric":[754],"termed":[756],"CST,":[757,815],"contains":[759],"polymerase":[761,864,1721,2518],"\u03b1,":[762],"primase":[764],"CTC1":[767],"(for":[768,777,787,839,1287],"CTS":[769],"maintenance":[771,919,1464,2305],"component":[773,1891,2207],"1)":[774,782,1159],"STN1":[776,824],"suppressor":[778,2001],"cdc":[780],"thirteen":[781],"addition":[784,2673],"TEN1":[786],"pathways":[789,1698,1750,2509,2544,3325],"STN1),":[791],"found":[793,875,1930,2503],"associate":[795,2276],"\u223c20%":[797],"(Miyake":[800],"2009;":[803,1529,1600,2154],"Surovtseva":[804],"Little":[808],"about":[811],"but":[816,1449],"limits":[829],"length":[831,1351,1619,2570,2585,2597,2613,2628,3197,3348],"(Wan":[832],"2009).An":[835],"component,":[837],"TERRA":[838,858,883],"telomeric-repeat-containing":[840],"RNA),":[841],"identified":[844,1695,2600],"third":[847],"entity":[848],"(Azzalin":[854,903],"2007).":[857,906,1483,1898,2132],"transcription":[859,1994],"mediated":[861,1715,2139,2197],"II":[865],"initiated":[868,1011],"sub-telomeric":[871],"regions":[872],"near":[876],"(Porro":[879],"levels":[884,2709],"regulated":[886,1996],"cell":[889,1007,1182,2574,2685,3354],"cycle,":[890],"localization":[893],"modulated":[897],"nonsense-mediated":[900],"decay":[901],"It":[907,1059],"postulated":[910],"important":[916,2100],"(Redon":[922],"Flynn":[926],"2011),":[929],"proposed":[936],"remain":[938],"uncovered.The":[941],"ability":[942,1381],"distinguish":[946],"native":[947],"broken":[951],"\u2013":[953,959],"unstable":[956,979],"fusogenic":[958],"first":[961,1705,2592],"documented":[962,3141],"1940s":[965],"McClintock":[967],"Muller":[969],"(Muller,":[970],"1938;":[971],"McClintock,":[972],"1941).":[973],"Linear":[974],"plasmids":[977],"when":[980,996,2982,3068,3128],"introduced":[981],"into":[982,2069,2492],"often":[986],"recombine":[987],"genome":[990],"(Orr-Weaver":[991],"1981).":[994],"DSBs":[997],"accumulate":[998],"cascade":[1003],"leads":[1005,1425,2577,2687,2725,2921],"cycle":[1008,1183],"arrest":[1009],"(Weinert":[1012],"Hartwell,":[1014],"1988).":[1015],"By":[1016,2924],"contrast,":[1017,2925],"natural":[1018,2463],"inherently":[1022],"stable:":[1023],"they":[1024,2888],"not":[1026,1042,1459,1547,1741,2299,2646,3441],"targeted":[1027],"repair":[1030,1038,1099,1196,1711],"pathways,":[1031],"namely":[1032],"non-homologous":[1033],"end-joining":[1034],"(NHEJ)":[1035],"homology-directed":[1037],"(HDR),":[1039],"do":[1041,1458,2298],"activate":[1043],"damage-induced":[1047],"kinases":[1048],"ataxia":[1049],"telangiectasia":[1050],"mutated":[1051],"(ATM)":[1052],"ATM":[1054,1133,1177,1219,1301],"Rad3":[1056],"related":[1057],"(ATR).":[1058],"later":[1061],"accomplish":[1065],"means":[1069],"elements":[1073],"years,":[1079,2497],"strides":[1081],"made":[1084],"understanding":[1086,2258,2610,3296,3375],"how":[1087,1642,2587,3298],"employed":[1090],"disguise":[1092],"damage-sensing":[1097],"pathways.":[1100],"predominantly":[1104],"based":[1105],"dissecting":[1107],"phenotypes":[1109],"associated":[1112],"functional":[1115],"impairment":[1116],"individual":[1118,1646],"subunits":[1120,1648,2662],"using":[1121],"conditional":[1122],"knockout":[1123],"mice.Deleting":[1124],"results":[1126,1202,2482,2697,3211],"activation":[1129,1377,1435,2409],"kinase":[1132,1327],"(Celli":[1134,1207,2306],"triggers":[1140],"including":[1147,1615,1987,2040,2080,2833,3105],"H2AX":[1148],"(H2A":[1149],"histone":[1150,2831],"family,":[1151],"X),":[1153],"53BP1":[1155],"(p53":[1156],"(Dimitrova":[1162],"Denchi":[1167],"2007;":[1171,2335],"Dimitrova":[1172,3420],"activates":[1178,1649],"p53,":[1179,2930],"induces":[1181],"arrest.":[1184],"absence":[1188,2928],"TRF2,":[1190],"ligase":[1191,1717],"4-":[1192],"Ku-mediated":[1194],"NHEJ":[1195,1221,1709,1770,1832],"activated":[1198,1925],"end-to-end":[1205],"fusions":[1206,3223],"normally":[1217],"represses":[1218],"currently":[1223],"under":[1224],"investigation.":[1225,3363],"One":[1226],"model":[1227],"proposed,":[1230],"whereby":[1231,1768],"able":[1234,1799],"sequester":[1236],"terminus":[1239,2744,2788],"t-loop":[1242,1252,1275,1305],"structure.":[1243],"Purified":[1244],"junction":[1249],"(Stansel":[1253],"2001)":[1256],"promote":[1259],"formation":[1261],"stabilization":[1263],"structures":[1265,1632],"resembling":[1266],"t-loops":[1267],"vitro":[1269,2322],"(Poulet":[1270],"configuration":[1276],"would":[1277,1307,3020],"prevent":[1278,1383],"detection":[1279,2475],"MRN":[1286],"MRE11,":[1288],"RAD50":[1289],"NBS1)":[1291],"complex,":[1292,1506,1814,2211,2236,2907],"sensor":[1298,1389],"pathway.":[1302],"Similarly,":[1303],"exclude":[1308],"Ku70\u2013Ku80":[1313,1505,1774,2270],"heterodimer,":[1314],"thereby":[1315,1581],"blocking":[1316],"NHEJ.The":[1317],"task":[1318,1848],"suppressing":[1320],"second":[1322,1725],"checkpoint":[1324],"activator,":[1325],"ATR,":[1328,1828],"ascribed":[1330],"humans":[1334],"POT1a":[1337,1374],"mice,":[1339,2973],"main":[1342],"mouse":[1345,3051],"POT1b":[1346],"regulate":[1349],"2005;":[1359],"Hockemeyer":[1360],"block":[1375,1544],"ATR":[1376,1392,1434],"pertains":[1378],"(RPA),":[1387],"pathway,":[1393],"DNA.":[1399],"Indeed,":[1400,3067],"RPA":[1401],"foci":[1402],"detected":[1405],"depleted":[1412],"(Gong":[1415],"Deleting":[1420],"or":[1422,2712],"TIN2,":[1423],"loss":[1427],"prompts":[1432],"similar":[1433,2728],"2011).HDR":[1443],"typically":[1445],"repressed":[1446,1491,1502,1517,1752,1915],"occurs":[1450],"small":[1453],"subset":[1454],"tumors":[1456,2996,3011],"use":[1460],"telomerase":[1461,1862,1871,1884,1889,1901,1962,2018,2064,2103,2141,2164,2181,2210,2246,2260,2278,2359,2404,2423,2468,2474,2487,2541,2760,2781,2886,3049,3069,3149],"(Bryan":[1465],"1997)":[1468],"early":[1474,1906,2956],"cleavage":[1475],"cycles":[1476],"embryonic":[1478],"development":[1479],"(Liu":[1480],"work":[1485,2940,3041],"indicated":[1487],"recombination":[1489,1545],"highly":[1496,1551,1755],"redundant":[1497,1756],"manner.":[1498,2175],"First,":[1499],"inhibits":[1508],"general":[1509],"HDR":[1510],"nucleus.":[1513],"Additionally,":[1514],"manner":[1521,1757],"Sfeir":[1530,1601],"Rap1,":[1538],"Ku":[1541,2235,2318],"cooperate":[1542],"understood.The":[1548],"repetitive":[1552],"nature":[1553,1804],"poses":[1557],"challenges":[1559,1825],"machinery.":[1564],"assists":[1569],"semi-conservative":[1571],"duplication":[1576],"bulk":[1578],"DNA,":[1580,2242],"protecting":[1582],"breakage":[1585],"acquiring":[1588],"features":[1589],"reminiscent":[1592],"common":[1594],"fragile":[1595],"sites":[1596,1983,2114],"(Mart\u00ednez":[1597],"mainly":[1610],"achieved":[1611],"helicases,":[1614],"1":[1620,1722,2145],"(RTEL1)":[1621],"Bloom":[1623],"syndrome,":[1624],"RecQ":[1625],"helicase-like":[1626],"(BLM),":[1627],"unwind":[1629],"spurious":[1630],"secondary":[1631],"hinder":[1635],"fork":[1636],"progression.The":[1637],"described":[1639],"above":[1640],"exemplify":[1641],"deletion":[1644],"response":[1653],"pathway(s)":[1654],"without":[1655,2406],"greatly":[1656],"destabilizing":[1657],"remaining":[1659],"components":[1660,1686],"complex.":[1663],"To":[1664],"uncover":[1665],"possible":[1666],"redundancies":[1667],"components,":[1673,1760],"we":[1674,1693,1787],"investigated":[1676],"completely":[1680],"depleting":[1681,2692],"(Sfeir":[1687],"2012),":[1691],"additional":[1697],"threaten":[1701],"integrity.":[1703],"alternative":[1708,1769,1831],"pathway":[1712,2232],"3":[1718,2848],"poly(ADP-ribose)":[1720],"(PARP1).":[1723],"nucleolytic":[1727,1776],"degradation,":[1728],"marked":[1732],"outcome":[1733,2987],"deprotection":[1736],"yeast":[1738,2803],"previously":[1743],"cells.":[1747,2032],"Interestingly,":[1748],"inhibited":[1772],"degradation":[1777],"blocked":[1779],"53BP1.After":[1781],"nearly":[1782],"decade":[1784],"investigation,":[1786],"now":[1788,3257],"clear":[1791],"definition":[1792],"better":[1801],"understand":[1802],"solution.":[1807],"summary,":[1809],"six-member":[1812],"properly":[1818],"armed":[1819],"face":[1821,2910],"different":[1824,3205,3350],"(namely":[1826],"ATM,":[1827],"NHEJ,":[1829],"HDR,":[1830],"resection)":[1834],"imposed":[1837],"almost":[1844],"eukaryotes,":[1846],"solving":[1850],"counteracting":[1855],"erosion":[1857,2561,2920],"assigned":[1859],"enzyme":[1863,2500],"(Greider":[1865],"Blackburn,":[1867],"1985).":[1868],"active":[1870,2063],"holoenzyme":[1872],"exists":[1876],"dimer":[1879],"reverse":[1885],"transcriptase":[1886],"(TERT),":[1887],"(TERC)":[1892],"dyskerin":[1894],"(Cohen":[1895],"expressed":[1903,3043],"stages":[1907,3206,3229,3352],"embryogenesis,":[1909],"expression":[1912],"subsequently":[1914],"somatic":[1918,2883],"except":[1920],"male":[1922],"germ":[1923],"line,":[1924],"lymphocytes":[1926],"stem":[1928],"certain":[1932,2660],"regenerative":[1933,3397],"tissues":[1934],"(Wright":[1935,2808],"1996).":[1938],"vast":[1941],"majority":[1942],"reactivate":[1947],"telomerase,":[1948,3018,3342],"thus":[1951],"capable":[1952],"proliferating":[1954],"indefinitely":[1955],"(Kim":[1956],"1994).":[1959],"Regulation":[1960],"exerted":[1965],"level":[1968],"TERT":[1970,1993,2025,2089,2284,2331,2376],"transcription.":[1971],"Extensive":[1972],"analysis":[1973],"promoter":[1976],"many":[1980,3309],"regulatory":[1985],"elements,":[1986],"GC-boxes":[1988],"E-boxes.":[1990],"addition,":[1992],"oncogenes":[1998],"tumor":[2000,2938,3166,3188],"genes,":[2002],"influenced":[2005,2076],"surrounding":[2008],"chromatin.":[2009,2799],"Post-transcriptional":[2010],"translational":[2012],"processes":[2013],"likely":[2015],"control":[2017],"activity.":[2019],"Alternative":[2020],"splice":[2021],"variants":[2022],"reported":[2028],"Telomerase":[2033,2133],"subject":[2036,2547],"post-translational":[2038],"modifications":[2039],"sumoylation,":[2041],"phosphorylation":[2042],"ubiquitylation,":[2044],"impact":[2049,2539,3377],"activity":[2052,2519,2761,2784],"(Cong":[2053],"2002).In":[2056],"vivo,":[2057,2752],"maturation":[2059,2104],"depends":[2065],"assembly":[2068],"ribonucleoprotein":[2071],"(RNP)":[2072],"several":[2078],"pontin,":[2081],"reptin":[2082],"others":[2084],"TERC":[2091,2286],"(Venteicher":[2092,2147],"2008":[2095],"see":[2097],"poster).":[2098],"Another":[2099,2230,2415],"step":[2101,2160],"trafficking":[2107],"through":[2108,2135],"Cajal":[2109,2136,2142],"bodies,":[2110],"dynamic":[2112],"subnuclear":[2113],"involved":[2117,2356,2450],"RNP":[2119,2431],"biogenesis":[2120,2453],"(Zhu":[2121],"Tomlinson":[2125],"Cristofari":[2129],"transit":[2134],"bodies":[2137],"body":[2143],"(TCAB1)":[2146],"2008;":[2150],"Venteicher":[2151],"Koo":[2155],"2011).A":[2158],"regards":[2162],"action":[2165],"recruitment":[2168,2182,2231,2261,2315,2405],"timely":[2174],"coherent":[2178],"picture":[2179],"emerged":[2184,3169],"Saccharomyces":[2188],"cerevisiae":[2189,2603],"shown":[2192,2274,2750],"process":[2195,2590],"EST1":[2202],"(ever-shorter":[2203],"Cdc13,":[2213],"(Evans":[2222],"Lundblad,":[2224],"Qi":[2226],"Zakian,":[2228],"2000).":[2229,3006],"involves":[2233],"(Peterson":[2248],"Stellwagen":[2252],"Our":[2256],"much":[2266],"more":[2267,2470,3029],"limited.":[2268],"Ting":[2291],"However,":[2295,2771,3290],"Ku70-deficient":[2296],"mice":[2297,2943,3073],"show":[2300],"defect":[2302],"2006),":[2309],"possibly":[2311],"argues":[2312],"against":[2313],"mammals.":[2320],"exposed":[2325],"(Wang":[2332],"Xin":[2336],"2007)":[2339],"enhances":[2341],"processivity":[2343],"More":[2346],"experiments":[2348],"might":[2353,3385],"(Abreu":[2364],"difficult":[2371,2392,2444],"prove,":[2373],"because":[2374,2447],"domain":[2378],"within":[2379],"required":[2382],"repress":[2384],"response.":[2388,2414],"Therefore,":[2389],"establish":[2394,2666],"context":[2402],"confounding":[2408,2481],"bridge":[2422],"heterogenous":[2429],"A1":[2433],"(hnRNPA1)":[2434],"(LaBranche":[2435],"1998).":[2438],"Again,":[2439],"observation":[2441],"confirm,":[2446],"hnRNPA1":[2448],"wide":[2456],"spectrum":[2457],"transcripts.":[2460],"Given":[2461],"low":[2464],"abundance":[2465],"enzyme,":[2469],"sophisticated":[2471],"methods":[2472],"needed":[2477],"resolve":[2479],"characterize":[2485],"pathway.Telomerase":[2488],"research":[2489],"moved":[2491],"extra":[2493],"dimensions":[2494],"modulate":[2505],"Wnt":[2507],"(Park":[2510],"2009),":[2513],"display":[2514,2998],"RNA-dependent":[2516],"(Maida":[2520],"2009)":[2523],"spotted":[2527],"mitochondria":[2530],"(Sharma":[2531],"2012).":[2534,3066],"Whereas":[2535],"these":[2543,2861,3010,3365],"debate,":[2549],"indisputable":[2551],"chief":[2552],"remains":[2557],"combat":[2559],"length.":[2565],"fact,":[2567],"appropriate":[2568,3346],"crucial":[2572],"survival.":[2575],"following":[2580],"question:":[2581],"what":[2582],"determines":[2583],"regulated?The":[2591],"genes":[2593],"influence":[2595,2655],"regulation":[2598,2614,2629,2779],"were":[2599,3224],"S.":[2602],"comprehensive":[2609],"comes":[2615],"fungi":[2619],"(Shore":[2620],"Bianchi,":[2622],"orders":[2636],"magnitude":[2638],"longer":[2639],"than":[2640,3266],"those":[2641,3106,3131],"budding":[2643],"yeast,":[2644],"understood.":[2648],"Nevertheless,":[2649],"length;":[2657],"particular,":[2659],"negative-feedback":[2668],"loop":[2669],"controls":[2671],"effect,":[2679],"overexpressing":[2680],"cancer-derived":[2683],"lines":[2686],"shortening,":[2690],"elongation":[2700,2867],"(van":[2701],"Steensel":[2702],"Reducing":[2707],"extension":[2729],"phenotype.":[2730],"message":[2732],"relayed":[2741],"via":[2745],"POT1,":[2746],"negative":[2757],"(Loayza":[2762],"2003;":[2766]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
