{"id":"https://openalex.org/W1987878428","doi":"https://doi.org/10.1097/00007890-199805131-00132","title":"FLT-3 LIGAND INCREASES MICROCHIMERISM BUT CAN PREVENT THE THERAPEUTIC EFFECT OF DONOR BONE MARROW IN TRANSIENTLY IMMUNOSUPPRESSED CARDIAC ALLOGRAFT RECIPIENTS","display_name":"FLT-3 LIGAND INCREASES MICROCHIMERISM BUT CAN PREVENT THE THERAPEUTIC EFFECT OF DONOR BONE MARROW IN TRANSIENTLY IMMUNOSUPPRESSED CARDIAC ALLOGRAFT RECIPIENTS","publication_year":1998,"publication_date":"1998-05-01","ids":{"openalex":"https://openalex.org/W1987878428","doi":"https://doi.org/10.1097/00007890-199805131-00132","mag":"1987878428"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-199805131-00132","doi":"https://doi.org/10.1097/00007890-199805131-00132","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199805131-00132","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069651723","display_name":"Angus W. Thomson","orcid":"https://orcid.org/0000-0001-6731-8871","observed_orcids":["https://orcid.org/0000-0001-6731-8871"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angus W. Thomson","raw_affiliation_strings":["","Thomas E. Starzl Transplantation Institute and Dept of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Thomas E. Starzl Transplantation Institute and Dept of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110238174","display_name":"Mary A. Antonysamy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary A. Antonysamy","raw_affiliation_strings":["","Thomas E. Starzl Transplantation Institute and Dept of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Thomas E. Starzl Transplantation Institute and Dept of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063324769","display_name":"Raymond John Steptoe","orcid":"https://orcid.org/0000-0002-6513-6406","observed_orcids":["https://orcid.org/0000-0002-6513-6406"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond J. Steptoe","raw_affiliation_strings":["","Thomas E. Starzl Transplantation Institute and Dept of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Thomas E. Starzl Transplantation Institute and Dept of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ajai Khanna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ajai Khanna","raw_affiliation_strings":["","Thomas E. Starzl Transplantation Institute and Dept of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Thomas E. Starzl Transplantation Institute and Dept of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109176212","display_name":"William A. Rudert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A. Rudert","raw_affiliation_strings":["","Thomas E. Starzl Transplantation Institute and Dept of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Thomas E. Starzl Transplantation Institute and Dept of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055497627","display_name":"Vladimir M. Subbotin","orcid":"https://orcid.org/0000-0001-9133-648X","observed_orcids":["https://orcid.org/0000-0001-9133-648X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vladimir M. Subbotin","raw_affiliation_strings":["","Thomas E. Starzl Transplantation Institute and Dept of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Thomas E. Starzl Transplantation Institute and Dept of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"65","issue":"Supplement","first_page":"111","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.02669999934732914,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flt3-ligand","display_name":"Flt3 ligand","score":0.8119999766349792},{"id":"https://openalex.org/keywords/microchimerism","display_name":"microchimerism","score":0.8840000033378601},{"id":"https://openalex.org/keywords/donor-bone-marrow","display_name":"donor bone marrow","score":0.6819999814033508},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/graft-survival","display_name":"graft survival","score":0.5870000123977661},{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.8069999814033508},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8299999833106995},{"id":"https://openalex.org/keywords/allograft-rejection","display_name":"allograft rejection","score":0.6790000200271606},{"id":"https://openalex.org/keywords/donor-specific-t-cells","display_name":"donor-specific T cells","score":0.37299999594688416},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.7990000247955322},{"id":"https://openalex.org/keywords/mixed-lymphocyte-reaction","display_name":"mixed lymphocyte reaction","score":0.8849999904632568},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.6029999852180481},{"id":"https://openalex.org/keywords/hematopoietic-growth-factors","display_name":"hematopoietic growth factors","score":0.7549999952316284},{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.4410000145435333},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.5270000100135803},{"id":"https://openalex.org/keywords/xenotransplantation","display_name":"xenotransplantation","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C162834538","wikidata":"https://www.wikidata.org/wiki/Q222580","display_name":"Microchimerism","level":4,"score":0.8909984827041626},{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.7022714614868164},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6485752463340759},{"id":"https://openalex.org/C2778740727","wikidata":"https://www.wikidata.org/wiki/Q12055129","display_name":"Mixed lymphocyte reaction","level":4,"score":0.567557692527771},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5391327142715454},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.517734706401825},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5087881684303284},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4499635398387909},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.4464958906173706},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.43241024017333984},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.42554181814193726},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41138243675231934},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.40751853585243225},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3485691547393799},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3155615031719208},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.275970995426178},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.26368603110313416},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2273901104927063},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2251196801662445},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.17593824863433838},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.1072697639465332},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/00007890-199805131-00132","doi":"https://doi.org/10.1097/00007890-199805131-00132","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199805131-00132","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1988053215","https://openalex.org/W1492984594","https://openalex.org/W2146650280","https://openalex.org/W2084454527","https://openalex.org/W2050984090","https://openalex.org/W2086161163","https://openalex.org/W2022203912","https://openalex.org/W1966392577","https://openalex.org/W2240817869","https://openalex.org/W2324317923"],"abstract_inverted_index":{"132":[0],"Purpose:":[1],"The":[2],"aim":[3],"of":[4,12,40,58,118,188,228,261,275,333,357],"this":[5,352],"study":[6],"was":[7,129,139,175,219],"to":[8,47,54,114,190,195,208,223,252,267],"examine":[9],"the":[10,13,38,115,165,182,209,272,308,320],"influence":[11],"recently":[14],"cloned":[15],"hematopoietic":[16],"growth":[17,325],"factor":[18],"flt3-ligand":[19],"(FL)":[20],"on":[21],"microchimerism":[22],"and":[23,50,53,100,147,168,203,236,304,310,342],"organ":[24],"allograft":[25],"survival":[26,128,246,345],"in":[27,62,95,106,164,179,181,200,216,288,307,319,328,338],"transiently":[28],"immunosuppressed":[29],"recipients":[30,120,227],"given":[31,232,254],"donor":[32,101,201,205,217,276],"bone":[33],"marrow":[34],"(BM)":[35],"cells":[36,52,61,73,92,161,202,218],"at":[37],"time":[39,247],"transplant.":[41],"FL":[42,78,171,189,262,286,313],"administration":[43],"has":[44],"been":[45],"shown":[46],"mobilise":[48],"stem":[49],"progenitor":[51],"strikingly":[55],"increase":[56,178,199,215],"numbers":[57],"functional":[59],"dendritic":[60,359],"vivo.Methods:":[63],"C3H":[64,119,226],"(H2k)":[65],"mice":[66],"received":[67],"50":[68],"\u00d7":[69],"106":[70],"B10(H2b)":[71],"BM":[72,108,166,169,183,191,210,224,235,268,277,281,284,309,311],"either":[74],"alone":[75,167,256,282],"or":[76,82,283],"with":[77,316],"(10":[79,263],"\u03bcg/day),":[80],"tacrolimus(2mg/kg/day)":[81],"both":[83],"agents":[84],"for":[85,134],"7":[86,265],"days.":[87],"Donor":[88,160],"MHC":[89],"class":[90,102],"II+(IAb+)":[91],"were":[93,121,162],"quantitated":[94,140],"spleens":[96],"by":[97,109,131,141,148],"immunohistochemical":[98],"analysis,":[99],"II":[103],"DNA":[104,206],"detected":[105],"recipient":[107],"PCR.":[110],"Heterotopic":[111],"heart":[112,230,291],"transplants":[113],"ear":[116],"pinnae":[117],"performed":[122],"using":[123],"neonatal":[124],"B10":[125,229,234],"donors.":[126],"Graft":[127],"monitored":[130],"daily":[132],"examination":[133],"contractile":[135],"activity.":[136],"Anti-donor":[137],"reactivity":[138,341],"3-day":[142],"mixed":[143],"leukocyte":[144],"reactions":[145],"(MLR)":[146],"cytotoxic":[149],"T":[150],"lymphocyte":[151],"(CTL)":[152],"assay":[153],"using51":[154],"Cr-":[155],"labelled":[156],"target":[157],"cells.":[158,360],"Results:":[159],"rare":[163],"+":[170,184,192,211,269,285,312],"groups,":[172,315],"whereas":[173],"there":[174],"a":[176,196,241],"substantial":[177],"chimerism":[180,329],"tacrolimus":[185,193,212,237,255,270],"group.":[186,213],"Addition":[187,260],"led":[194],"further":[197],"8-fold":[198],"enhanced":[204],"compared":[207,222,251],"This":[214],"almost":[220],"500-fold":[221],"alone.":[225],"allografts":[231],"perioperative":[233],"(days":[238],"0-13)":[239],"exhibited":[240],"markedly":[242],"extended":[243],"median":[244],"graft":[245,292,344],"(MST;":[248],"42":[249],"days)":[250,266],"those":[253],"(MST:":[257,278],"22":[258],"days).":[259,280,297],"\u03bcg/day;":[264],"prevented":[271],"beneficial":[273],"effect":[274],"18":[279],"resulted":[287],"uniform":[289],"early":[290],"failure":[293],"(MST":[294],"<":[295],"8":[296],"Functional":[298],"studies":[299],"revealed":[300],"maximal":[301],"anti-donor":[302,340],"MLR":[303],"CTL":[305],"activities":[306],"treated":[314],"minimal":[317],"activity":[318],"tacrolimus-treated":[321],"groups.Conclusion:":[322],"Thus,":[323],"dramatic":[324],"factor-induced":[326],"increases":[327],"achieved":[330],"under":[331],"cover":[332],"short-term":[334],"immunosuppression":[335],"may":[336,353],"result":[337],"augmented":[339],"reduced":[343],"after":[346],"immunosuppressive":[347],"drug":[348],"withdrawal.":[349],"With":[350],"FL,":[351],"reflect":[354],"striking":[355],"augmentation":[356],"immunostimulatory":[358]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}