{"id":"https://openalex.org/W1987700535","doi":"https://doi.org/10.1523/jneurosci.3277-07.2007","title":"Activity-Dependent Ubiquitination of GABAAReceptors Regulates Their Accumulation at Synaptic Sites","display_name":"Activity-Dependent Ubiquitination of GABAAReceptors Regulates Their Accumulation at Synaptic Sites","publication_year":2007,"publication_date":"2007-11-28","ids":{"openalex":"https://openalex.org/W1987700535","doi":"https://doi.org/10.1523/jneurosci.3277-07.2007","mag":"1987700535","pmid":"https://pubmed.ncbi.nlm.nih.gov/18045928","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6673389"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.3277-07.2007","doi":"https://doi.org/10.1523/jneurosci.3277-07.2007","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.3277-07.2007","pdf_url":"https://www.jneurosci.org/content/jneuro/27/48/13341.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/27/48/13341.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041424459","display_name":"Richard S. Saliba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard S. Saliba","raw_affiliation_strings":["Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110857818","display_name":"Guido Michels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Guido Michels","raw_affiliation_strings":["Department of Internal Medicine III, University of Cologne, 50937 Cologne, Germany, and","Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III, University of Cologne, 50937 Cologne, Germany, and","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104,","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080984230","display_name":"Tija C. Jacob","orcid":"https://orcid.org/0000-0002-8288-7885","observed_orcids":["https://orcid.org/0000-0002-8288-7885"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tija C. Jacob","raw_affiliation_strings":["Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104,","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010982846","display_name":"Menelas N. Pangalos","orcid":"https://orcid.org/0000-0001-9783-0956","observed_orcids":["https://orcid.org/0000-0001-9783-0956"]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Menelas N. Pangalos","raw_affiliation_strings":["Wyeth Research ,","Wyeth Research, Neuroscience Discovery, Princeton, New Jersey 08852"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wyeth Research ,","institution_ids":["https://openalex.org/I4403928396"]},{"raw_affiliation_string":"Wyeth Research, Neuroscience Discovery, Princeton, New Jersey 08852","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020338130","display_name":"Stephen J. Moss","orcid":"https://orcid.org/0000-0001-7459-3644","observed_orcids":["https://orcid.org/0000-0001-7459-3644"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Stephen J. Moss","raw_affiliation_strings":["Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104,","Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104,","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom,","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5020338130"],"corresponding_institution_ids":["https://openalex.org/I45129253","https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":3.6404,"has_fulltext":true,"cited_by_count":133,"citation_normalized_percentile":{"value":0.93778432,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"27","issue":"48","first_page":"13341","last_page":"13351"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.9520000219345093},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.7350000143051147},{"id":"https://openalex.org/keywords/synaptic-inhibition","display_name":"synaptic inhibition","score":0.7689999938011169},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.7450000047683716},{"id":"https://openalex.org/keywords/exocytosis","display_name":"exocytosis","score":0.7829999923706055},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.8190000057220459},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.5699999928474426},{"id":"https://openalex.org/keywords/neuronal-activity","display_name":"neuronal activity","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6355741620063782},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.6167924404144287},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5878342390060425},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5741823315620422},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4757382869720459},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40475624799728394},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35883936285972595},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19520682096481323},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07623007893562317}],"mesh":[{"descriptor_ui":"D000779","descriptor_name":"Anesthetics, Local","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013779","descriptor_name":"Tetrodotoxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018682","descriptor_name":"GABA Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018683","descriptor_name":"Excitatory Amino Acid Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053444","descriptor_name":"Inhibitory Postsynaptic Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053444","descriptor_name":"Inhibitory Postsynaptic Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053444","descriptor_name":"Inhibitory Postsynaptic Potentials","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1523/jneurosci.3277-07.2007","doi":"https://doi.org/10.1523/jneurosci.3277-07.2007","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.3277-07.2007","pdf_url":"https://www.jneurosci.org/content/jneuro/27/48/13341.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:18045928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18045928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6673389","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6673389/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"mag:2188313855","doi":null,"is_oa":false,"landing_page_url":"https://www.jneurosci.org/content/27/48/13341.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1523/jneurosci.3277-07.2007","doi":"https://doi.org/10.1523/jneurosci.3277-07.2007","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.3277-07.2007","pdf_url":"https://www.jneurosci.org/content/jneuro/27/48/13341.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4211522035","display_name":"Constructing inhibitory synapses","funder_award_id":"R01NS051195","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5527276199","display_name":"Modulation of GABAB receptor signaling","funder_award_id":"R01NS048045","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5747839961","display_name":"The role of ubiquitination in regulating GABA(A) receptor functional expression","funder_award_id":"R01NS056359","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8575350035","display_name":"Origin and Mechanism of Promiscuous Prion Strains","funder_award_id":"R01NS046478","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306684","display_name":"Epilepsy Foundation","ror":"https://ror.org/01pxre019"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320324811","display_name":"Universit\u00e4t zu K\u00f6ln","ror":"https://ror.org/00rcxh774"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1987700535.pdf","grobid_xml":"https://content.openalex.org/works/W1987700535.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1504868096","https://openalex.org/W1514853588","https://openalex.org/W1575801138","https://openalex.org/W1965334496","https://openalex.org/W1967391569","https://openalex.org/W1974146730","https://openalex.org/W1984624523","https://openalex.org/W1988139687","https://openalex.org/W1988749472","https://openalex.org/W1990567359","https://openalex.org/W1991211989","https://openalex.org/W2000087227","https://openalex.org/W2002335162","https://openalex.org/W2004821943","https://openalex.org/W2005722151","https://openalex.org/W2022378061","https://openalex.org/W2023951056","https://openalex.org/W2030159093","https://openalex.org/W2033602348","https://openalex.org/W2035504473","https://openalex.org/W2037873496","https://openalex.org/W2037921808","https://openalex.org/W2039738625","https://openalex.org/W2040956654","https://openalex.org/W2047103551","https://openalex.org/W2050243692","https://openalex.org/W2059067548","https://openalex.org/W2066781880","https://openalex.org/W2068107769","https://openalex.org/W2073536709","https://openalex.org/W2082803657","https://openalex.org/W2085955152","https://openalex.org/W2086269846","https://openalex.org/W2097643979","https://openalex.org/W2101235918","https://openalex.org/W2112444339","https://openalex.org/W2113971423","https://openalex.org/W2130464434","https://openalex.org/W2140869385","https://openalex.org/W2148939305","https://openalex.org/W2150123812","https://openalex.org/W2151538478","https://openalex.org/W2151711957","https://openalex.org/W2152236836","https://openalex.org/W2153982845","https://openalex.org/W2156087438","https://openalex.org/W2158524945","https://openalex.org/W2171862076","https://openalex.org/W2411914118","https://openalex.org/W4321429493"],"related_works":["https://openalex.org/W2086269846","https://openalex.org/W2157192646","https://openalex.org/W2008702542","https://openalex.org/W2033129564","https://openalex.org/W2087715700","https://openalex.org/W2079398298","https://openalex.org/W1986595101","https://openalex.org/W2062568722","https://openalex.org/W2104643900","https://openalex.org/W1990567359"],"abstract_inverted_index":{"GABA(A)":[0],"receptors":[1,17],"(GABA(A)Rs)":[2],"are":[3],"the":[4,12,35,44,52,58,73,76,89,92,107,118,130,142,150,176],"major":[5],"mediators":[6],"of":[7,21,37,55,68,75,91,98,111,120,162,178],"fast":[8],"synaptic":[9,32,38,114,157,179,187],"inhibition":[10,180],"in":[11,50],"brain.":[13],"In":[14],"neurons,":[15],"these":[16],"undergo":[18],"significant":[19],"rates":[20],"endocytosis":[22],"and":[23,34,61,109,153,164,181],"exocytosis,":[24],"processes":[25],"that":[26,46],"regulate":[27,175],"both":[28,106],"their":[29,62,80,127,147,165],"accumulation":[30,155],"at":[31,156],"sites":[33],"efficacy":[36,177],"inhibition.":[39],"Here":[40],"we":[41],"have":[42],"evaluated":[43],"role":[45],"neuronal":[47,69,121],"activity":[48,70,90,122],"plays":[49],"regulating":[51],"residence":[53],"time":[54],"GABA(A)Rs":[56,163],"on":[57,88,129],"plasma":[59,131,151],"membrane":[60,152],"targeting":[63],"to":[64,137,174,185],"synapses.":[65],"Chronic":[66],"blockade":[67],"dramatically":[71],"increases":[72],"level":[74,119],"GABA(A)R":[77,124,139],"ubiquitination,":[78],"decreasing":[79],"cell":[81,99],"surface":[82,100],"stability":[83,128,140],"via":[84],"a":[85,171],"mechanism":[86,173],"dependent":[87],"proteasome.":[93],"Coincident":[94],"with":[95],"this":[96],"loss":[97],"expression":[101],"levels,":[102],"TTX":[103],"treatment":[104],"reduced":[105],"amplitude":[108],"frequency":[110],"miniature":[112],"inhibitory":[113],"currents.":[115],"Conversely,":[116],"increasing":[117],"decreases":[123],"ubiquitination":[125,134,161],"enhancing":[126],"membrane.":[132],"Activity-dependent":[133],"primarily":[135],"acts":[136],"reduce":[138],"within":[141],"endoplasmic":[143],"reticulum":[144],"and,":[145],"thereby,":[146],"insertion":[148],"into":[149],"subsequent":[154,166],"sites.":[158],"Thus,":[159],"activity-dependent":[160],"proteasomal":[167],"degradation":[168],"may":[169,182],"represent":[170],"potent":[172],"also":[183],"contribute":[184],"homeostatic":[186],"plasticity.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}