{"id":"https://openalex.org/W1987690650","doi":"https://doi.org/10.1016/j.tibs.2004.09.002","title":"The biochemical response of the heart to hypertension and exercise","display_name":"The biochemical response of the heart to hypertension and exercise","publication_year":2004,"publication_date":"2004-09-21","ids":{"openalex":"https://openalex.org/W1987690650","doi":"https://doi.org/10.1016/j.tibs.2004.09.002","mag":"1987690650","pmid":"https://pubmed.ncbi.nlm.nih.gov/15501680"},"language":"en","primary_location":{"id":"doi:10.1016/j.tibs.2004.09.002","doi":"https://doi.org/10.1016/j.tibs.2004.09.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tibs.2004.09.002","pdf_url":null,"source":{"id":"https://openalex.org/S136233269","display_name":"Trends in Biochemical Sciences","issn_l":"0968-0004","issn":["0968-0004","1362-4326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Biochemical Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039100833","display_name":"Tetsuro Wakatsuki","orcid":"https://orcid.org/0000-0002-2175-1132","observed_orcids":["https://orcid.org/0000-0002-2175-1132"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210135078","display_name":"Washington University Medical Center","ror":"https://ror.org/036c27j91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210135078"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tetsuro Wakatsuki","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Washington University Medical Center, Campus Box 8231, 660 South Euclid Avenue, St Louis, MI 63110-1093, USA. wakatsuk@biochem.wustl.edu","Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Washington University Medical Center, Campus Box 8231, 660 South Euclid Avenue, St Louis, MI 63110-1093, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Washington University Medical Center, Campus Box 8231, 660 South Euclid Avenue, St Louis, MI 63110-1093, USA. wakatsuk@biochem.wustl.edu","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210135078"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Washington University Medical Center, Campus Box 8231, 660 South Euclid Avenue, St Louis, MI 63110-1093, USA","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210135078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067994300","display_name":"Joseph Schlessinger","orcid":"https://orcid.org/0000-0002-5085-5969","observed_orcids":["https://orcid.org/0000-0002-5085-5969"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Schlessinger","raw_affiliation_strings":["Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108823076","display_name":"Elliot L. Elson","orcid":"https://orcid.org/0000-0002-0810-5646","observed_orcids":["https://orcid.org/0000-0002-0810-5646"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210135078","display_name":"Washington University Medical Center","ror":"https://ror.org/036c27j91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210135078"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elliot L. Elson","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Washington University Medical Center, Campus Box 8231, 660 South Euclid Avenue, St Louis, MI 63110-1093, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Washington University Medical Center, Campus Box 8231, 660 South Euclid Avenue, St Louis, MI 63110-1093, USA","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210135078"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5039100833"],"corresponding_institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210135078"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":1.2858,"has_fulltext":false,"cited_by_count":117,"citation_normalized_percentile":{"value":0.7835689,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"29","issue":"11","first_page":"609","last_page":"617"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.8519999980926514},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.6919999718666077},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.8939999938011169},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.7049999833106995},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8299999833106995},{"id":"https://openalex.org/keywords/fibroblast-activation","display_name":"fibroblast activation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/cardiomyocyte-death","display_name":"cardiomyocyte death","score":0.8650000095367432},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.6029999852180481},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.7990000247955322},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9610000252723694},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.9359999895095825},{"id":"https://openalex.org/keywords/beta-adrenergic-signaling","display_name":"beta-adrenergic signaling","score":0.9020000100135803},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.7269999980926514},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.7100492119789124},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.6455093622207642},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6281980276107788},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6101218461990356},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5660131573677063},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5392293930053711},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5375193357467651},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5161207914352417},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5045162439346313},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5016231536865234},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4704802334308624},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4702039361000061},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4650503396987915},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.43377745151519775},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.333566814661026},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.3309457302093506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.298443466424942},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.11664634943008423}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010805","descriptor_name":"Physical Conditioning, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020257","descriptor_name":"Ventricular Remodeling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tibs.2004.09.002","doi":"https://doi.org/10.1016/j.tibs.2004.09.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tibs.2004.09.002","pdf_url":null,"source":{"id":"https://openalex.org/S136233269","display_name":"Trends in Biochemical Sciences","issn_l":"0968-0004","issn":["0968-0004","1362-4326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Biochemical Sciences","raw_type":"journal-article"},{"id":"pmid:15501680","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15501680","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in biochemical sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W163401016","https://openalex.org/W370902999","https://openalex.org/W1494886612","https://openalex.org/W1533702935","https://openalex.org/W1572205294","https://openalex.org/W1597640694","https://openalex.org/W1880366974","https://openalex.org/W1964436833","https://openalex.org/W1970102552","https://openalex.org/W1979064111","https://openalex.org/W1985326986","https://openalex.org/W1997271589","https://openalex.org/W2000007398","https://openalex.org/W2004775541","https://openalex.org/W2010690048","https://openalex.org/W2016193552","https://openalex.org/W2022880024","https://openalex.org/W2026182775","https://openalex.org/W2028415754","https://openalex.org/W2029593661","https://openalex.org/W2030968333","https://openalex.org/W2031217240","https://openalex.org/W2031267053","https://openalex.org/W2034341872","https://openalex.org/W2034813299","https://openalex.org/W2045369584","https://openalex.org/W2056550364","https://openalex.org/W2056982291","https://openalex.org/W2060072866","https://openalex.org/W2063198400","https://openalex.org/W2064839515","https://openalex.org/W2072962685","https://openalex.org/W2079156477","https://openalex.org/W2085250186","https://openalex.org/W2093801383","https://openalex.org/W2094138142","https://openalex.org/W2096984112","https://openalex.org/W2100347223","https://openalex.org/W2103051421","https://openalex.org/W2103447315","https://openalex.org/W2105014609","https://openalex.org/W2106741130","https://openalex.org/W2111340301","https://openalex.org/W2115013104","https://openalex.org/W2115157006","https://openalex.org/W2116041125","https://openalex.org/W2119370228","https://openalex.org/W2122074209","https://openalex.org/W2124961813","https://openalex.org/W2125586000","https://openalex.org/W2132136466","https://openalex.org/W2132907629","https://openalex.org/W2133463851","https://openalex.org/W2133905708","https://openalex.org/W2134686559","https://openalex.org/W2134922991","https://openalex.org/W2135674333","https://openalex.org/W2136070250","https://openalex.org/W2137477023","https://openalex.org/W2139186800","https://openalex.org/W2151168522","https://openalex.org/W2155591792","https://openalex.org/W2159505514","https://openalex.org/W2162681171","https://openalex.org/W2164313332","https://openalex.org/W2167135785","https://openalex.org/W2170208738","https://openalex.org/W2171313781","https://openalex.org/W2172011106","https://openalex.org/W2187014198","https://openalex.org/W2309492117","https://openalex.org/W4211075026","https://openalex.org/W4249341602"],"related_works":["https://openalex.org/W4388970873","https://openalex.org/W4294798550","https://openalex.org/W1991500169","https://openalex.org/W2085749059","https://openalex.org/W1977152294","https://openalex.org/W2322682955","https://openalex.org/W4281384601","https://openalex.org/W1967593612","https://openalex.org/W4415262857","https://openalex.org/W2021458745"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}