{"id":"https://openalex.org/W1987672004","doi":"https://doi.org/10.1126/science.282.5392.1327","title":"A Structural Explanation for the Recognition of Tyrosine-Based Endocytotic Signals","display_name":"A Structural Explanation for the Recognition of Tyrosine-Based Endocytotic Signals","publication_year":1998,"publication_date":"1998-11-13","ids":{"openalex":"https://openalex.org/W1987672004","doi":"https://doi.org/10.1126/science.282.5392.1327","mag":"1987672004","pmid":"https://pubmed.ncbi.nlm.nih.gov/9812899","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5600252"},"language":"en","primary_location":{"id":"doi:10.1126/science.282.5392.1327","doi":"https://doi.org/10.1126/science.282.5392.1327","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.282.5392.1327","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5600252/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010631231","display_name":"David J. Owen","orcid":"https://orcid.org/0000-0002-8351-6322","observed_orcids":["https://orcid.org/0000-0002-8351-6322"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David J. Owen","raw_affiliation_strings":["Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK","institution_ids":["https://openalex.org/I170203145","https://openalex.org/I90344618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103441204","display_name":"Philip R. Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Philip R. Evans","raw_affiliation_strings":["Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK","institution_ids":["https://openalex.org/I170203145","https://openalex.org/I90344618"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103441204"],"corresponding_institution_ids":["https://openalex.org/I170203145","https://openalex.org/I90344618"],"apc_list":null,"apc_paid":null,"fwci":8.1647,"has_fulltext":false,"cited_by_count":587,"citation_normalized_percentile":{"value":0.98847964,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"282","issue":"5392","first_page":"1327","last_page":"1332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ap2-adaptor-complex","display_name":"AP2 adaptor complex","score":0.8040000200271606},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.671999990940094},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tgn38","display_name":"TGN38","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hydrophobic-pocket","display_name":"hydrophobic pocket","score":0.7400000095367432},{"id":"https://openalex.org/keywords/peptide-conformation","display_name":"peptide conformation","score":0.6679999828338623},{"id":"https://openalex.org/keywords/protein-dimerization","display_name":"protein dimerization","score":0.8880000114440918},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.5}],"concepts":[{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.8812230825424194},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.719050407409668},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.6875365376472473},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.5225369930267334},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48141050338745117},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.4681565761566162},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4587562084197998},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4582286775112152},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4492081105709076},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.44725823402404785},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.44712480902671814},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4392314553260803},{"id":"https://openalex.org/C10858879","wikidata":"https://www.wikidata.org/wiki/Q899790","display_name":"Signal peptide","level":4,"score":0.43193936347961426},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4278262257575989},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.41059333086013794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37176164984703064},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.15048372745513916},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021382","descriptor_name":"Protein Sorting Signals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021382","descriptor_name":"Protein Sorting Signals","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D033942","descriptor_name":"Adaptor Proteins, Vesicular Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033961","descriptor_name":"Adaptor Protein Complex 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D033962","descriptor_name":"Adaptor Protein Complex 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033963","descriptor_name":"Adaptor Protein Complex 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D033965","descriptor_name":"Adaptor Protein Complex alpha Subunits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033983","descriptor_name":"Adaptor Protein Complex mu Subunits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1126/science.282.5392.1327","doi":"https://doi.org/10.1126/science.282.5392.1327","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.282.5392.1327","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:9812899","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9812899","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5600252","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5600252/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Science","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5600252","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5600252/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Science","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1275105234","https://openalex.org/W1591680814","https://openalex.org/W1972960760","https://openalex.org/W1975209033","https://openalex.org/W1978096114","https://openalex.org/W1979815209","https://openalex.org/W1980219322","https://openalex.org/W1980467950","https://openalex.org/W1992628345","https://openalex.org/W2001641653","https://openalex.org/W2013083986","https://openalex.org/W2030634945","https://openalex.org/W2033240631","https://openalex.org/W2038126024","https://openalex.org/W2038840577","https://openalex.org/W2039620693","https://openalex.org/W2040909391","https://openalex.org/W2042238592","https://openalex.org/W2061671663","https://openalex.org/W2067691363","https://openalex.org/W2070615094","https://openalex.org/W2071846646","https://openalex.org/W2085340755","https://openalex.org/W2101446086","https://openalex.org/W2106315897","https://openalex.org/W2131134035","https://openalex.org/W2136203552","https://openalex.org/W2142498139","https://openalex.org/W2164682544","https://openalex.org/W2166714339","https://openalex.org/W2169364535"],"related_works":["https://openalex.org/W2131134035","https://openalex.org/W2008478256","https://openalex.org/W2028175970","https://openalex.org/W1980219322","https://openalex.org/W2003319930","https://openalex.org/W2126269466","https://openalex.org/W2023132550","https://openalex.org/W2092307134","https://openalex.org/W7097543129","https://openalex.org/W2059031237"],"abstract_inverted_index":{"Many":[0],"cell":[1],"surface":[2],"proteins":[3],"are":[4],"marked":[5],"for":[6],"endocytosis":[7],"by":[8,18,75],"a":[9],"cytoplasmic":[10],"sequence":[11],"motif,":[12],"tyrosine-X-X-(hydrophobic":[13],"residue),":[14],"that":[15,78,94],"is":[16],"recognized":[17],"the":[19,28,37,47,68,80,85,88,90,97],"mu2":[20,34],"subunit":[21],"of":[22,27,33,41,101],"AP2":[23],"adaptors.":[24],"Crystal":[25],"structures":[26],"internalization":[29,38],"signal":[30,39,60],"binding":[31,102],"domain":[32],"complexed":[35],"with":[36],"peptides":[40,61],"epidermal":[42],"growth":[43],"factor":[44],"receptor":[45],"and":[46,82,99],"trans-Golgi":[48],"network":[49],"protein":[50,91],"TGN38":[51],"have":[52],"been":[53],"determined":[54],"at":[55],"2.7":[56],"angstrom":[57],"resolution.":[58],"The":[59],"adopted":[62],"an":[63],"extended":[64],"conformation":[65],"rather":[66],"than":[67],"expected":[69],"tight":[70],"turn.":[71],"Specificity":[72],"was":[73],"conferred":[74],"hydrophobic":[76],"pockets":[77],"bind":[79],"tyrosine":[81],"leucine":[83],"in":[84],"peptide.":[86],"In":[87],"crystal,":[89],"forms":[92],"dimers":[93],"could":[95],"increase":[96],"strength":[98],"specificity":[100],"to":[103],"dimeric":[104],"receptors.":[105]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":22}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}