{"id":"https://openalex.org/W1987648024","doi":"https://doi.org/10.1002/(sici)1097-0215(19970717)72:2<277::aid-ijc13>3.0.co;2-d","title":"Mutation analysis and loss of heterozygosity of PEDF in central nervous system primitive neuroectodermal tumors","display_name":"Mutation analysis and loss of heterozygosity of PEDF in central nervous system primitive neuroectodermal tumors","publication_year":1997,"publication_date":"1997-07-17","ids":{"openalex":"https://openalex.org/W1987648024","doi":"https://doi.org/10.1002/(sici)1097-0215(19970717)72:2<277::aid-ijc13>3.0.co;2-d","mag":"1987648024","pmid":"https://pubmed.ncbi.nlm.nih.gov/9219833"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-0215(19970717)72:2<277::aid-ijc13>3.0.co;2-d","doi":"https://doi.org/10.1002/(sici)1097-0215(19970717)72:2<277::aid-ijc13>3.0.co;2-d","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0215(19970717)72:2<277::aid-ijc13>3.0.co;2-d","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0215%2819970717%2972%3A2%3C277%3A%3AAID-IJC13%3E3.0.CO%3B2-D","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0215%2819970717%2972%3A2%3C277%3A%3AAID-IJC13%3E3.0.CO%3B2-D","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021461445","display_name":"Irene Slavc","orcid":"https://orcid.org/0000-0002-9419-6790","observed_orcids":["https://orcid.org/0000-0002-9419-6790"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Irene Slavc","raw_affiliation_strings":["Department of Pediatrics, University of Vienna, Austria","Department of Pediatrics, University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Department of Pediatrics, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021429317","display_name":"Ignacio R. Rodr\u00edguez","orcid":"https://orcid.org/0009-0004-7522-8947","observed_orcids":["https://orcid.org/0009-0004-7522-8947"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ignacio R. Rodriguez","raw_affiliation_strings":["National Eye Institute, NIH, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Eye Institute, NIH, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026553433","display_name":"Krzysztof Mazuruk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krzysztof Mazuruk","raw_affiliation_strings":["National Eye Institute, NIH, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Eye Institute, NIH, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111389306","display_name":"Gerald J. Chader","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald J. Chader","raw_affiliation_strings":["National Eye Institute, NIH, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Eye Institute, NIH, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023572421","display_name":"Jaclyn A. Biegel","orcid":"https://orcid.org/0000-0001-9270-6411","observed_orcids":["https://orcid.org/0000-0001-9270-6411"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaclyn A. Biegel","raw_affiliation_strings":["The Children's Hospital of Philadelphia, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Children's Hospital of Philadelphia, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I1335321130"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5021461445"],"corresponding_institution_ids":["https://openalex.org/I129774422"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":0.7167,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.71359728,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"72","issue":"2","first_page":"277","last_page":"282"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.4036000072956085,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.4036000072956085,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.09769999980926514,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.07739999890327454,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pigment-epithelium-derived-factor","display_name":"pigment epithelium-derived factor","score":0.968999981880188},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9599999785423279},{"id":"https://openalex.org/keywords/17p-deletion","display_name":"17p deletion","score":0.8830000162124634},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8730000257492065},{"id":"https://openalex.org/keywords/mutation","display_name":"genetic mutations","score":0.5120000243186951},{"id":"https://openalex.org/keywords/single-strand-conformation-polymorphism","display_name":"single-strand conformation polymorphism","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.8354336023330688},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8145439624786377},{"id":"https://openalex.org/C52237779","wikidata":"https://www.wikidata.org/wiki/Q18030441","display_name":"PEDF","level":3,"score":0.7786867618560791},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.5993940234184265},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.565079391002655},{"id":"https://openalex.org/C2778965386","wikidata":"https://www.wikidata.org/wiki/Q420068","display_name":"Serpin","level":3,"score":0.5379437208175659},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49776768684387207},{"id":"https://openalex.org/C129219603","wikidata":"https://www.wikidata.org/wiki/Q1788683","display_name":"Single-strand conformation polymorphism","level":4,"score":0.482134073972702},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4723549783229828},{"id":"https://openalex.org/C2777542201","wikidata":"https://www.wikidata.org/wiki/Q1336182","display_name":"Fluorescence in situ hybridization","level":4,"score":0.433212548494339},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4078066349029541},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.3605235815048218},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3495693802833557},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.16491979360580444},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.14386847615242004},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099174","descriptor_name":"Pigment Epithelium-Derived Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002886","descriptor_name":"Chromosomes, Human, Pair 17","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015843","descriptor_name":"Serpins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018242","descriptor_name":"Neuroectodermal Tumors, Primitive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1097-0215(19970717)72:2<277::aid-ijc13>3.0.co;2-d","doi":"https://doi.org/10.1002/(sici)1097-0215(19970717)72:2<277::aid-ijc13>3.0.co;2-d","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0215(19970717)72:2<277::aid-ijc13>3.0.co;2-d","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0215%2819970717%2972%3A2%3C277%3A%3AAID-IJC13%3E3.0.CO%3B2-D","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1097-0215(19970717)72:2<277::aid-ijc13>3.3.co;2-n","doi":"https://doi.org/10.1002/(sici)1097-0215(19970717)72:2<277::aid-ijc13>3.3.co;2-n","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0215(19970717)72:2<277::aid-ijc13>3.3.co;2-n","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:9219833","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9219833","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/(sici)1097-0215(19970717)72:2<277::aid-ijc13>3.0.co;2-d","doi":"https://doi.org/10.1002/(sici)1097-0215(19970717)72:2<277::aid-ijc13>3.0.co;2-d","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0215(19970717)72:2<277::aid-ijc13>3.0.co;2-d","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0215%2819970717%2972%3A2%3C277%3A%3AAID-IJC13%3E3.0.CO%3B2-D","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G7879044393","display_name":"Genetics of pediatric rhabdoid tumors","funder_award_id":"R01CA046274","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1987648024.pdf","grobid_xml":"https://content.openalex.org/works/W1987648024.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W74870324","https://openalex.org/W1546685691","https://openalex.org/W1966971933","https://openalex.org/W1977838939","https://openalex.org/W1981570640","https://openalex.org/W1983447138","https://openalex.org/W1984513377","https://openalex.org/W1990739064","https://openalex.org/W2023449786","https://openalex.org/W2037268137","https://openalex.org/W2043577803","https://openalex.org/W2048242881","https://openalex.org/W2075701227","https://openalex.org/W2075800108","https://openalex.org/W2080663056","https://openalex.org/W2083625623","https://openalex.org/W2085625230","https://openalex.org/W2094245793","https://openalex.org/W2094719911","https://openalex.org/W2096722608","https://openalex.org/W2097974266","https://openalex.org/W2110847375","https://openalex.org/W2119798255","https://openalex.org/W2131922441","https://openalex.org/W2159315829","https://openalex.org/W2177676738","https://openalex.org/W2287945620","https://openalex.org/W2416016623","https://openalex.org/W2474079320","https://openalex.org/W3147266715"],"related_works":["https://openalex.org/W2044633368","https://openalex.org/W2134825321","https://openalex.org/W2011246864","https://openalex.org/W1593929630","https://openalex.org/W3125615072","https://openalex.org/W2097974266","https://openalex.org/W1611487446","https://openalex.org/W2094245793","https://openalex.org/W4237748313","https://openalex.org/W2080142062"],"abstract_inverted_index":{"Deletion":[0],"of":[1,21,90,102,107,118,131,159,165],"17p":[2,119,162],"is":[3,63,174],"the":[4,19,47,66,99,103,108,115,132,136,178],"most":[5],"frequent":[6],"abnormality":[7],"observed":[8],"in":[9,65,125,144,163,182],"central":[10],"nervous":[11],"system":[12],"(CNS)":[13],"primitive":[14],"neuroectodermal":[15],"tumors":[16,110],"(PNETs),":[17],"implicating":[18],"presence":[20],"a":[22,157,175],"tumor":[23,69],"suppressor":[24,180],"gene":[25,31,52,181],"which":[26],"maps":[27],"to":[28,42,46,87,94],"17p.":[29],"The":[30,54],"for":[32,177],"pigment":[33],"epithelium-derived":[34],"factor":[35],"(PEDF)":[36],"has":[37,57],"been":[38],"cloned":[39],"and":[40,59,62,70,93,147],"mapped":[41],"17p13.":[43,183],"PEDF":[44,55,104,173],"belongs":[45],"serine":[48],"protease":[49],"inhibitor":[50],"(SERPIN)":[51],"family.":[53],"protein":[56],"neurotrophic":[58],"neuronal-survival":[60],"activities":[61],"expressed":[64],"CNS.":[67],"Twenty":[68],"matched":[71],"normal":[72],"DNA":[73,134],"samples":[74],"from":[75,135],"patients":[76],"with":[77,114,139,156],"PNETs":[78],"were":[79],"screened":[80],"by":[81,121],"single-strand":[82],"conformation":[83],"polymorphism":[84],"(SSCP)":[85],"analysis":[86,130],"determine":[88],"loss":[89,158],"heterozygosity":[91],"(LOH)":[92],"identify":[95],"potential":[96],"mutations":[97],"within":[98],"8":[100],"exons":[101,145],"gene.":[105],"Ten":[106],"20":[109],"demonstrated":[111,141],"LOH,":[112],"consistent":[113,155],"deletion":[116],"status":[117],"determined":[120],"cytogenetic":[122],"or":[123],"fluorescence":[124],"situ":[126],"hybridization":[127],"studies.":[128],"SSCP":[129],"genomic":[133],"10":[137],"cases":[138],"LOH":[140],"several":[142],"polymorphisms":[143],"4":[146],"7,":[148],"but":[149,168],"no":[150],"mutations.":[151],"Our":[152],"results":[153],"are":[154],"alleles":[160],"on":[161],"50%":[164],"CNS":[166],"PNETs,":[167],"do":[169],"not":[170],"suggest":[171],"that":[172],"candidate":[176],"PNET":[179]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}