{"id":"https://openalex.org/W1987516241","doi":"https://doi.org/10.1158/1078-0432.ccr-14-1421","title":"Phase I Hepatic Immunotherapy for Metastases Study of Intra-Arterial Chimeric Antigen Receptor\u2013Modified T-cell Therapy for CEA+ Liver Metastases","display_name":"Phase I Hepatic Immunotherapy for Metastases Study of Intra-Arterial Chimeric Antigen Receptor\u2013Modified T-cell Therapy for CEA+ Liver Metastases","publication_year":2015,"publication_date":"2015-04-08","ids":{"openalex":"https://openalex.org/W1987516241","doi":"https://doi.org/10.1158/1078-0432.ccr-14-1421","mag":"1987516241","pmid":"https://pubmed.ncbi.nlm.nih.gov/25850950","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4506253"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-14-1421","doi":"https://doi.org/10.1158/1078-0432.ccr-14-1421","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-14-1421","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4506253","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040099847","display_name":"Steven C. Katz","orcid":"https://orcid.org/0000-0002-6030-9312","observed_orcids":["https://orcid.org/0000-0002-6030-9312"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven C. Katz","raw_affiliation_strings":["1Department of Surgery, Roger Williams Medical Center, Providence, Rhode Island/Boston University School of Medicine, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Surgery, Roger Williams Medical Center, Providence, Rhode Island/Boston University School of Medicine, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003003191","display_name":"Rachel A. Burga","orcid":"https://orcid.org/0000-0002-0204-8986","observed_orcids":["https://orcid.org/0000-0002-0204-8986"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel A. Burga","raw_affiliation_strings":["1Department of Surgery, Roger Williams Medical Center, Providence, Rhode Island/Boston University School of Medicine, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Surgery, Roger Williams Medical Center, Providence, Rhode Island/Boston University School of Medicine, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029757559","display_name":"Elise M. McCormack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elise McCormack","raw_affiliation_strings":["2Department of Medicine, Roger Williams Medical Center, Providence, Rhode Island/Boston University School of Medicine, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Medicine, Roger Williams Medical Center, Providence, Rhode Island/Boston University School of Medicine, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046047064","display_name":"Lijuan Wang","orcid":"https://orcid.org/0000-0002-5439-8988","observed_orcids":["https://orcid.org/0000-0002-5439-8988"]},"institutions":[{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Juan Wang","raw_affiliation_strings":["3Department of Pathology, Roger Williams Medical Center, Providence, Rhode Island"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Pathology, Roger Williams Medical Center, Providence, Rhode Island","institution_ids":["https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085614603","display_name":"Wesley Mooring","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wesley Mooring","raw_affiliation_strings":["3Department of Pathology, Roger Williams Medical Center, Providence, Rhode Island"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Pathology, Roger Williams Medical Center, Providence, Rhode Island","institution_ids":["https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069399653","display_name":"Gary R. Point","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary R. Point","raw_affiliation_strings":["1Department of Surgery, Roger Williams Medical Center, Providence, Rhode Island/Boston University School of Medicine, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Surgery, Roger Williams Medical Center, Providence, Rhode Island/Boston University School of Medicine, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076500518","display_name":"Pranay D. Khare","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pranay D. Khare","raw_affiliation_strings":["4Roger Williams Medical Center, GMP Core Facility and Clinical Protocol Office, Providence, Rhode Island"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Roger Williams Medical Center, GMP Core Facility and Clinical Protocol Office, Providence, Rhode Island","institution_ids":["https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089574971","display_name":"Mitchell Thorn","orcid":"https://orcid.org/0009-0009-5100-6289","observed_orcids":["https://orcid.org/0009-0009-5100-6289"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell Thorn","raw_affiliation_strings":["1Department of Surgery, Roger Williams Medical Center, Providence, Rhode Island/Boston University School of Medicine, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Surgery, Roger Williams Medical Center, Providence, Rhode Island/Boston University School of Medicine, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967103","display_name":"Qiangzhong Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiangzhong Ma","raw_affiliation_strings":["2Department of Medicine, Roger Williams Medical Center, Providence, Rhode Island/Boston University School of Medicine, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Medicine, Roger Williams Medical Center, Providence, Rhode Island/Boston University School of Medicine, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033923741","display_name":"Brian F. Stainken","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian F. Stainken","raw_affiliation_strings":["5Department of Radiology, Roger Williams Medical Center, Providence, Rhode Island/Boston University School of Medicine, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Radiology, Roger Williams Medical Center, Providence, Rhode Island/Boston University School of Medicine, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019297227","display_name":"Earle O. Assanah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Earle O. Assanah","raw_affiliation_strings":["5Department of Radiology, Roger Williams Medical Center, Providence, Rhode Island/Boston University School of Medicine, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Radiology, Roger Williams Medical Center, Providence, Rhode Island/Boston University School of Medicine, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112185274","display_name":"Robin Davies","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robin Davies","raw_affiliation_strings":["4Roger Williams Medical Center, GMP Core Facility and Clinical Protocol Office, Providence, Rhode Island"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Roger Williams Medical Center, GMP Core Facility and Clinical Protocol Office, Providence, Rhode Island","institution_ids":["https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112759390","display_name":"N. Joseph Espat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Joseph Espat","raw_affiliation_strings":["1Department of Surgery, Roger Williams Medical Center, Providence, Rhode Island/Boston University School of Medicine, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Surgery, Roger Williams Medical Center, Providence, Rhode Island/Boston University School of Medicine, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113527586","display_name":"Richard Paul Junghans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard P. Junghans","raw_affiliation_strings":["2Department of Medicine, Roger Williams Medical Center, Providence, Rhode Island/Boston University School of Medicine, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Medicine, Roger Williams Medical Center, Providence, Rhode Island/Boston University School of Medicine, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":15.7215,"has_fulltext":false,"cited_by_count":397,"citation_normalized_percentile":{"value":0.9950015,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"21","issue":"14","first_page":"3149","last_page":"3159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.9480000138282776},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"carcinoembryonic antigen","score":0.7990000247955322},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.972000002861023},{"id":"https://openalex.org/keywords/hepatic-arterial-infusion","display_name":"hepatic artery infusion","score":0.9100000262260437},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tumor-necrosis","display_name":"tumor necrosis","score":0.6069999933242798},{"id":"https://openalex.org/keywords/gastrointestinal-cancer","display_name":"gastrointestinal cancer","score":0.41100001335144043},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.6349999904632568},{"id":"https://openalex.org/keywords/safety","display_name":"safety","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9115843772888184},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.5773124694824219},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5276257395744324},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5203344821929932},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5032820105552673},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4983844757080078},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4519582986831665},{"id":"https://openalex.org/C2777387746","wikidata":"https://www.wikidata.org/wiki/Q769706","display_name":"Carcinoembryonic antigen","level":3,"score":0.4159294366836548},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33158332109451294},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31220290064811707}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010478","descriptor_name":"Chemotherapy, Cancer, Regional Perfusion","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1158/1078-0432.ccr-14-1421","doi":"https://doi.org/10.1158/1078-0432.ccr-14-1421","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-14-1421","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:25850950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25850950","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Clinical Trial, Phase I"},{"id":"pmh:oai:europepmc.org:3910480","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4506253","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4506253","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4506253","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3910480","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4506253","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G8684304693","display_name":"Reversing genetically modified T cell suppression in a model of liver metastases","funder_award_id":"K08CA160662","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306091","display_name":"American Association for Cancer Research","ror":"https://ror.org/02fnpv153"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W137108379","https://openalex.org/W1487353108","https://openalex.org/W1577562406","https://openalex.org/W1643040145","https://openalex.org/W1840130277","https://openalex.org/W1924680600","https://openalex.org/W1952738420","https://openalex.org/W1972372578","https://openalex.org/W1977431234","https://openalex.org/W1979816704","https://openalex.org/W1981709767","https://openalex.org/W1982146826","https://openalex.org/W1983143892","https://openalex.org/W1986372945","https://openalex.org/W1987192484","https://openalex.org/W1988382766","https://openalex.org/W2004604773","https://openalex.org/W2017596953","https://openalex.org/W2017851655","https://openalex.org/W2033255923","https://openalex.org/W2035285625","https://openalex.org/W2041811840","https://openalex.org/W2044709564","https://openalex.org/W2057183283","https://openalex.org/W2060802019","https://openalex.org/W2061202126","https://openalex.org/W2082118645","https://openalex.org/W2088763689","https://openalex.org/W2093654081","https://openalex.org/W2094695058","https://openalex.org/W2099657378","https://openalex.org/W2100158834","https://openalex.org/W2100515276","https://openalex.org/W2101653483","https://openalex.org/W2105400883","https://openalex.org/W2105700807","https://openalex.org/W2110929565","https://openalex.org/W2113989224","https://openalex.org/W2117370635","https://openalex.org/W2124515527","https://openalex.org/W2127734125","https://openalex.org/W2130011407","https://openalex.org/W2131239494","https://openalex.org/W2150065276","https://openalex.org/W2160834915","https://openalex.org/W2560367415","https://openalex.org/W4256034449","https://openalex.org/W6617516232"],"related_works":["https://openalex.org/W2947877311","https://openalex.org/W2741580363","https://openalex.org/W4410804665","https://openalex.org/W3080292686","https://openalex.org/W2554682179","https://openalex.org/W1986701354","https://openalex.org/W7131784367","https://openalex.org/W2072041272","https://openalex.org/W2597946622","https://openalex.org/W4399346726"],"abstract_inverted_index":{"PURPOSE:":[0],"Chimeric":[1],"antigen":[2],"receptor-modified":[3],"T":[4],"cells":[5,108],"(CAR-T)":[6],"have":[7,221],"demonstrated":[8,194,222],"encouraging":[9,230],"results":[10],"in":[11,30,68,86,177,197,203,235],"early-phase":[12],"clinical":[13,233,245],"trials.":[14],"Successful":[15],"adaptation":[16],"of":[17,28,46,66,130,133,171,205,225,232,247],"CAR-T":[18,48,67,83,104,152,165,227,248],"technology":[19],"for":[20,250],"CEA-expressing":[21],"adenocarcinoma":[22],"liver":[23,72,123,198,251],"metastases,":[24,124],"a":[25,59,128,142,236],"major":[26],"cause":[27],"death":[29],"patients":[31,69,75,99,118,126,169,176],"with":[32,70,100,112,158,213,229,240],"gastrointestinal":[33],"cancers,":[34],"has":[35],"yet":[36],"to":[37,42,63,150],"be":[38],"achieved.":[39],"We":[40,57,94,220],"sought":[41],"test":[43,64],"intrahepatic":[44],"delivery":[45],"anti-CEA":[47,82,226],"through":[49],"percutaneous":[50],"hepatic":[51],"artery":[52],"infusions":[53],"(HAIs).":[54],"EXPERIMENTAL":[55],"DESIGN:":[56],"conducted":[58],"phase":[60],"I":[61],"trial":[62],"HAI":[65,105],"CEA(+)":[71],"metastases.":[73],"Six":[74],"completed":[76],"the":[77,101,151,175,178,223],"protocol,":[78],"and":[79,91,125,167,216],"3":[80,98,144],"received":[81,127,181],"HAIs":[84,228,249],"alone":[85],"dose-escalation":[87],"fashion":[88],"(10(8),":[89],"10(9),":[90],"10(10)":[92],"cells).":[93],"treated":[95],"an":[96,195],"additional":[97],"maximum":[102],"planned":[103],"dose":[106],"(10(10)":[107],"\u00d7":[109],"3)":[110],"along":[111],"systemic":[113,135,182],"IL2":[114,183,214],"support.":[115],"RESULTS:":[116],"Four":[117],"had":[119],"more":[120],"than":[121],"10":[122],"mean":[129],"2.5":[131],"lines":[132],"conventional":[134],"therapy":[136],"before":[137],"enrollment.":[138],"No":[139],"patient":[140,155],"suffered":[141],"grade":[143],"or":[145,201],"4":[146,204],"adverse":[147],"event":[148],"related":[149],"HAIs.":[153],"One":[154],"remains":[156],"alive":[157],"stable":[159],"disease":[160],"at":[161],"23":[162],"months":[163],"following":[164],"HAI,":[166],"5":[168],"died":[170],"progressive":[172],"disease.":[173],"Among":[174],"cohort":[179],"that":[180],"support,":[184],"CEA":[185,217],"levels":[186,211],"decreased":[187],"37%":[188],"(range,":[189],"19%-48%)":[190],"from":[191],"baseline.":[192],"Biopsies":[193],"increase":[196],"metastasis":[199],"necrosis":[200],"fibrosis":[202],"6":[206],"patients.":[207],"Elevated":[208],"serum":[209],"IFN\u03b3":[210],"correlated":[212],"administration":[215],"decreases.":[218],"CONCLUSIONS:":[219],"safety":[224],"signals":[231],"activity":[234],"heavily":[237],"pretreated":[238],"population":[239],"large":[241],"tumor":[242],"burdens.":[243],"Further":[244],"testing":[246],"metastases":[252],"is":[253],"warranted.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":26},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":38},{"year":2022,"cited_by_count":45},{"year":2021,"cited_by_count":42},{"year":2020,"cited_by_count":48},{"year":2019,"cited_by_count":46},{"year":2018,"cited_by_count":39},{"year":2017,"cited_by_count":45},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}