{"id":"https://openalex.org/W1987508761","doi":"https://doi.org/10.4161/cbt.9.5.10926","title":"Estrogen receptor-alpha-interacting cytokeratins potentiate the antiestrogenic activity of fulvestrant","display_name":"Estrogen receptor-alpha-interacting cytokeratins potentiate the antiestrogenic activity of fulvestrant","publication_year":2010,"publication_date":"2010-03-01","ids":{"openalex":"https://openalex.org/W1987508761","doi":"https://doi.org/10.4161/cbt.9.5.10926","mag":"1987508761","pmid":"https://pubmed.ncbi.nlm.nih.gov/20061804"},"language":"en","primary_location":{"id":"doi:10.4161/cbt.9.5.10926","doi":"https://doi.org/10.4161/cbt.9.5.10926","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.9.5.10926","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.9.5.10926?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology &amp; Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.9.5.10926?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062806638","display_name":"Xinghua Long","orcid":"https://orcid.org/0000-0001-8948-650X","observed_orcids":["https://orcid.org/0000-0001-8948-650X","https://orcid.org/0000-0001-9761-7506"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinghua Long","raw_affiliation_strings":["Medical Sciences, Indiana University School of Medicine, Bloomington, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Sciences, Indiana University School of Medicine, Bloomington, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090420512","display_name":"Meiyun Fan","orcid":"https://orcid.org/0000-0002-0185-5065","observed_orcids":["https://orcid.org/0000-0002-0185-5065"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meiyun Fan","raw_affiliation_strings":["Department of pathology and Laboratory Medicine ; and the Center for Cancer Research ; University of Tennessee health science Center ; Memphis , TN Usa;","University of Tennessee Health Science Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of pathology and Laboratory Medicine ; and the Center for Cancer Research ; University of Tennessee health science Center ; Memphis , TN Usa;","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"University of Tennessee Health Science Center","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061888144","display_name":"Kenneth P. Nephew","orcid":"https://orcid.org/0000-0003-2192-1346","observed_orcids":["https://orcid.org/0000-0003-2192-1346"]},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenneth P. Nephew","raw_affiliation_strings":["Indiana Univ.-Purdue Univ. Indianapolis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana Univ.-Purdue Univ. Indianapolis","institution_ids":["https://openalex.org/I55769427"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5061888144"],"corresponding_institution_ids":["https://openalex.org/I55769427"],"apc_list":{"value":2710,"currency":"EUR","value_usd":2970},"apc_paid":null,"fwci":1.2577,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.79203943,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"9","issue":"5","first_page":"389","last_page":"396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fulvestrant","display_name":"fulvestrant","score":0.9990000128746033},{"id":"https://openalex.org/keywords/selective-estrogen-receptor-downregulators","display_name":"selective estrogen receptor downregulators","score":0.8809999823570251},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cytokeratin-8","display_name":"cytokeratin 8","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cytokeratin-18","display_name":"cytokeratin 18","score":1.0},{"id":"https://openalex.org/keywords/antiestrogenic-activity","display_name":"antiestrogenic activity","score":0.8579999804496765},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7429999709129333},{"id":"https://openalex.org/keywords/nuclear-matrix","display_name":"nuclear matrix","score":0.7429999709129333},{"id":"https://openalex.org/keywords/4-hydroxytamoxifen","display_name":"4-hydroxytamoxifen","score":0.8270000219345093},{"id":"https://openalex.org/keywords/estrogen-receptor-beta","display_name":"estrogen receptor beta","score":0.699999988079071},{"id":"https://openalex.org/keywords/acquired-drug-resistance","display_name":"acquired drug resistance","score":0.6819999814033508},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C2780482068","wikidata":"https://www.wikidata.org/wiki/Q5508491","display_name":"Fulvestrant","level":5,"score":0.9237341284751892},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.653510332107544},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5505552291870117},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5231719613075256},{"id":"https://openalex.org/C96307122","wikidata":"https://www.wikidata.org/wiki/Q15329133","display_name":"Estrogen receptor beta","level":5,"score":0.5110874772071838},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4933296740055084},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.4572846293449402},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4280860722064972},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42640161514282227},{"id":"https://openalex.org/C201729690","wikidata":"https://www.wikidata.org/wiki/Q5401841","display_name":"Estrogen-related receptor alpha","level":5,"score":0.4101290702819824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3605022728443146},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3311339020729065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32636409997940063},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25810444355010986},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.15389570593833923},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077267","descriptor_name":"Fulvestrant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004965","descriptor_name":"Estrogen Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004965","descriptor_name":"Estrogen Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D020847","descriptor_name":"Estrogen Receptor Modulators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020847","descriptor_name":"Estrogen Receptor Modulators","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047629","descriptor_name":"Estrogen Receptor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047629","descriptor_name":"Estrogen Receptor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4161/cbt.9.5.10926","doi":"https://doi.org/10.4161/cbt.9.5.10926","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.9.5.10926","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.9.5.10926?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology &amp; Therapy","raw_type":"journal-article"},{"id":"pmid:20061804","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20061804","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer biology & therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/cbt.9.5.10926","doi":"https://doi.org/10.4161/cbt.9.5.10926","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.9.5.10926","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.9.5.10926?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology &amp; Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1555140389","display_name":null,"funder_award_id":"CA113001","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3239747755","display_name":"miRNA\u5728\u4e73\u817a\u764c\u5185\u5206\u6ccc\u6cbb\u7597\u836f\u7269\u6c1f\u7ef4\u53f8\u7fa4\u8010\u836f\u548c\u7ee7\u53d1\u6027\u4e73\u817a\u764c\u8f6c\u79fb\u4e2d\u7684\u4f5c\u7528\u673a\u5236","funder_award_id":"30873044","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3455293255","display_name":null,"funder_award_id":"CA085289","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3950809854","display_name":"DNA Methylation and Ovarian Cancer","funder_award_id":"R01CA085289","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4941813046","display_name":"Interrogating Epigenetic Changes in Cancer Genomes","funder_award_id":"U54CA113001","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306542","display_name":"Walther Cancer Foundation","ror":"https://ror.org/02seeba69"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332222","display_name":"University of Illinois at Urbana-Champaign","ror":"https://ror.org/047426m28"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338065","display_name":"Institute of Genetics","ror":"https://ror.org/03gwhmn95"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1987508761.pdf","grobid_xml":"https://content.openalex.org/works/W1987508761.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2022977599","https://openalex.org/W2018342610","https://openalex.org/W2019311111","https://openalex.org/W7098977919","https://openalex.org/W1193138090","https://openalex.org/W2975211683","https://openalex.org/W2067416937","https://openalex.org/W2089913761","https://openalex.org/W2030676208","https://openalex.org/W2068944608"],"abstract_inverted_index":{"Fulvestrant":[0],"(ICI":[1],"182,":[2],"780)":[3],"is":[4,170],"a":[5,99],"selective":[6],"estrogen":[7,15],"receptor":[8,29],"downregulator":[9],"(SERD)":[10],"and":[11,31,54,91,133,168,202,226],"potent":[12],"antiestrogen.":[13],"In":[14,108,180,191],"receptor-alpha-positive":[16],"ERalpha(+)":[17],"breast":[18,100,223,241],"cancer,":[19],"the":[20,25,35,47,61,68,72,110,118,137,147,155,164,174,217],"drug":[21],"immobilizes":[22],"ERalpha":[23,43,50,141,156],"in":[24,67,85,98,163,216,222,240],"nuclear":[26,175],"matrix,":[27],"inducing":[28],"polyubiquitination":[30],"subsequent":[32,203],"degradation":[33,44],"via":[34],"26S":[36],"proteasome.":[37],"We":[38],"previously":[39],"reported":[40],"that":[41,154,210,227],"fulvestrant-induced":[42],"depends":[45],"on":[46,117],"interaction":[48,129,199],"of":[49,63,71,83,93,112,121,149,166,220],"with":[51,161,200],"cytokeratins":[52,66,230],"8":[53],"18":[55],"(CK8/CK18).":[56],"Here":[57],"we":[58,78,152],"further":[59,145],"investigate":[60],"role":[62,215],"these":[64,131,207,228],"two":[65,229],"antagonistic":[69],"activity":[70,82,120,139],"SERD.":[73],"Using":[74],"ER-responsive":[75],"reporter":[76],"assays,":[77,182],"demonstrate":[79,153],"greater":[80],"antiestrogenic":[81,119,218],"fulvestrant":[84,106,150,167,183,193,221],"CK8/CK18(+)":[86],"vs.":[87],"CK8/CK18(-)":[88],"cancer":[89,101,224,242],"cells":[90,225],"loss":[92],"CK8/CK18":[94,113,162,201],"expression":[95],"was":[96,124],"observed":[97],"cell":[102],"model":[103],"for":[104,236],"acquired":[105],"resistance.":[107],"contrast,":[109],"presence":[111,165],"had":[114],"no":[115],"effect":[116],"4-hydroxytamoxifen,":[122],"which":[123],"unable":[125],"to":[126,144,173],"induce":[127,196],"an":[128,197,213],"between":[130],"CKs":[132],"ERalpha.":[134],"By":[135],"utilizing":[136],"ligand":[138],"inversion":[140],"mutant":[142,157],"L540Q":[143,169],"examine":[146],"mechanism":[148],"action,":[151],"does":[158],"not":[159,171,195],"interact":[160],"immobilized":[172],"matrix":[176],"after":[177],"antiestrogen":[178],"treatment.":[179],"transcription":[181],"displayed":[184],"agonist":[185],"activity,":[186],"stimulating":[187],"L540Q-mediated":[188],"gene":[189],"expression.":[190],"addition,":[192],"did":[194],"ERbeta":[198,204],"degradation.":[205],"Collectively,":[206],"results":[208],"suggest":[209],"CK8/18":[211],"play":[212],"important":[214],"action":[219],"could":[231],"serve":[232],"as":[233],"prognostic":[234],"markers":[235],"SERD":[237],"therapy":[238],"response":[239],"patients.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
