{"id":"https://openalex.org/W1987488965","doi":"https://doi.org/10.2741/1192","title":"The transfer of protons in water wires inside proteins","display_name":"The transfer of protons in water wires inside proteins","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W1987488965","doi":"https://doi.org/10.2741/1192","mag":"1987488965","pmid":"https://pubmed.ncbi.nlm.nih.gov/12957840"},"language":"en","primary_location":{"id":"doi:10.2741/1192","doi":"https://doi.org/10.2741/1192","is_oa":true,"landing_page_url":"https://doi.org/10.2741/1192","pdf_url":"https://article.imrpress.com/bri/Landmark/articles/pdf/Landmark1192.pdf","source":{"id":"https://openalex.org/S185455647","display_name":"Frontiers in bioscience","issn_l":"1093-4715","issn":["1093-4715","1093-9946","1094-3935"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70"],"host_organization":"https://openalex.org/P4310320848","host_organization_name":"Frontiers in Bioscience","host_organization_lineage":["https://openalex.org/P4310320848"],"host_organization_lineage_names":["Frontiers in Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioscience","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://article.imrpress.com/bri/Landmark/articles/pdf/Landmark1192.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088989450","display_name":"Samuel Cukierman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Samuel Cukierman","raw_affiliation_strings":["Department of Physiology, Loyola University Medical School, 2160 South First Avenue, Maywood, IL 60153, USA. scukier@lumc.edu","Department of Physiology, Loyola University Medical School, 2160 South First Avenue, Maywood, IL 60153, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Loyola University Medical School, 2160 South First Avenue, Maywood, IL 60153, USA. scukier@lumc.edu","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I1925986","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"Department of Physiology, Loyola University Medical School, 2160 South First Avenue, Maywood, IL 60153, USA","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I1925986"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5088989450"],"corresponding_institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I1925986","https://openalex.org/I4210159390"],"apc_list":null,"apc_paid":null,"fwci":0.1605,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.15384615,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"6","first_page":"s1118","last_page":"1139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.49050000309944153,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.49050000309944153,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.18310000002384186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11177","display_name":"Spectroscopy and Quantum Chemical Studies","score":0.12120000272989273,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proton-transfer","display_name":"proton transfer","score":0.9829999804496765},{"id":"https://openalex.org/keywords/water-wires","display_name":"water wires","score":0.824999988079071},{"id":"https://openalex.org/keywords/gramicidin-channels","display_name":"gramicidin channels","score":0.6769999861717224},{"id":"https://openalex.org/keywords/membrane-proteins","display_name":"membrane proteins","score":0.6650000214576721},{"id":"https://openalex.org/keywords/proton-pumping","display_name":"proton translocation","score":0.8130000233650208},{"id":"https://openalex.org/keywords/single-molecule-spectroscopy","display_name":"single-molecule spectroscopy","score":0.6610000133514404},{"id":"https://openalex.org/keywords/structure-function-relationship","display_name":"structure-function relationship","score":0.7110000252723694},{"id":"https://openalex.org/keywords/protein-hydration","display_name":"protein hydration","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C54516573","wikidata":"https://www.wikidata.org/wiki/Q2294","display_name":"Proton","level":2,"score":0.6851968169212341},{"id":"https://openalex.org/C2779650302","wikidata":"https://www.wikidata.org/wiki/Q418980","display_name":"Gramicidin","level":3,"score":0.6591107845306396},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.597868800163269},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.5432433485984802},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5335773825645447},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5028499960899353},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.46829476952552795},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.41740506887435913},{"id":"https://openalex.org/C2992143177","wikidata":"https://www.wikidata.org/wiki/Q7973862","display_name":"Water transfer","level":2,"score":0.4113025367259979},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3373585343360901},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.30730950832366943},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.19749388098716736},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.19744673371315002},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1669142246246338},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14289897680282593},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.0},{"id":"https://openalex.org/C524765639","wikidata":"https://www.wikidata.org/wiki/Q1501619","display_name":"Water resource management","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2741/1192","doi":"https://doi.org/10.2741/1192","is_oa":true,"landing_page_url":"https://doi.org/10.2741/1192","pdf_url":"https://article.imrpress.com/bri/Landmark/articles/pdf/Landmark1192.pdf","source":{"id":"https://openalex.org/S185455647","display_name":"Frontiers in bioscience","issn_l":"1093-4715","issn":["1093-4715","1093-9946","1094-3935"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70"],"host_organization":"https://openalex.org/P4310320848","host_organization_name":"Frontiers in Bioscience","host_organization_lineage":["https://openalex.org/P4310320848"],"host_organization_lineage_names":["Frontiers in Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioscience","raw_type":"journal-article"},{"id":"pmid:12957840","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12957840","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioscience : a journal and virtual library","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2741/1192","doi":"https://doi.org/10.2741/1192","is_oa":true,"landing_page_url":"https://doi.org/10.2741/1192","pdf_url":"https://article.imrpress.com/bri/Landmark/articles/pdf/Landmark1192.pdf","source":{"id":"https://openalex.org/S185455647","display_name":"Frontiers in bioscience","issn_l":"1093-4715","issn":["1093-4715","1093-9946","1094-3935"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70"],"host_organization":"https://openalex.org/P4310320848","host_organization_name":"Frontiers in Bioscience","host_organization_lineage":["https://openalex.org/P4310320848"],"host_organization_lineage_names":["Frontiers in Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioscience","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4936502799","display_name":null,"funder_award_id":"GM 50674","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1987488965.pdf","grobid_xml":"https://content.openalex.org/works/W1987488965.grobid-xml"},"referenced_works_count":128,"referenced_works":["https://openalex.org/W7682143","https://openalex.org/W588601481","https://openalex.org/W596058680","https://openalex.org/W1497812043","https://openalex.org/W1515146239","https://openalex.org/W1534138084","https://openalex.org/W1554874616","https://openalex.org/W1560426894","https://openalex.org/W1573051457","https://openalex.org/W1580315781","https://openalex.org/W1854510133","https://openalex.org/W1857651432","https://openalex.org/W1878645139","https://openalex.org/W1909944853","https://openalex.org/W1964332144","https://openalex.org/W1964477055","https://openalex.org/W1967888351","https://openalex.org/W1971641212","https://openalex.org/W1973889696","https://openalex.org/W1974514572","https://openalex.org/W1976323578","https://openalex.org/W1976453452","https://openalex.org/W1976959842","https://openalex.org/W1977859020","https://openalex.org/W1977991511","https://openalex.org/W1980996319","https://openalex.org/W1989983140","https://openalex.org/W1990909752","https://openalex.org/W1991727421","https://openalex.org/W1991837786","https://openalex.org/W1991838495","https://openalex.org/W1991851546","https://openalex.org/W1991993300","https://openalex.org/W1992303171","https://openalex.org/W1994850352","https://openalex.org/W1995249251","https://openalex.org/W1996473697","https://openalex.org/W1998553158","https://openalex.org/W1998972448","https://openalex.org/W2002033516","https://openalex.org/W2003566326","https://openalex.org/W2004933597","https://openalex.org/W2010372934","https://openalex.org/W2010721225","https://openalex.org/W2011486797","https://openalex.org/W2011745346","https://openalex.org/W2012592738","https://openalex.org/W2015312201","https://openalex.org/W2016343967","https://openalex.org/W2017692997","https://openalex.org/W2022107727","https://openalex.org/W2022714443","https://openalex.org/W2027446511","https://openalex.org/W2029042254","https://openalex.org/W2030762880","https://openalex.org/W2031098293","https://openalex.org/W2032271349","https://openalex.org/W2033768125","https://openalex.org/W2034534892","https://openalex.org/W2034637787","https://openalex.org/W2035792160","https://openalex.org/W2038312530","https://openalex.org/W2038770257","https://openalex.org/W2039310225","https://openalex.org/W2040611121","https://openalex.org/W2042169196","https://openalex.org/W2042447779","https://openalex.org/W2045120197","https://openalex.org/W2045248457","https://openalex.org/W2045819042","https://openalex.org/W2047719207","https://openalex.org/W2048988772","https://openalex.org/W2051221402","https://openalex.org/W2053301395","https://openalex.org/W2053316347","https://openalex.org/W2053752083","https://openalex.org/W2056709978","https://openalex.org/W2059335329","https://openalex.org/W2061019578","https://openalex.org/W2061305344","https://openalex.org/W2062092582","https://openalex.org/W2064927965","https://openalex.org/W2065372326","https://openalex.org/W2065476796","https://openalex.org/W2067777267","https://openalex.org/W2075046439","https://openalex.org/W2075678109","https://openalex.org/W2078184681","https://openalex.org/W2078344803","https://openalex.org/W2080547160","https://openalex.org/W2081926166","https://openalex.org/W2082314566","https://openalex.org/W2084074778","https://openalex.org/W2085517713","https://openalex.org/W2086384190","https://openalex.org/W2091060555","https://openalex.org/W2091454160","https://openalex.org/W2091796090","https://openalex.org/W2093175745","https://openalex.org/W2093614761","https://openalex.org/W2094371902","https://openalex.org/W2095264703","https://openalex.org/W2095776023","https://openalex.org/W2099975374","https://openalex.org/W2102709391","https://openalex.org/W2103566186","https://openalex.org/W2104796556","https://openalex.org/W2106769522","https://openalex.org/W2115357061","https://openalex.org/W2118560848","https://openalex.org/W2122074593","https://openalex.org/W2124614417","https://openalex.org/W2130109471","https://openalex.org/W2131137311","https://openalex.org/W2131830480","https://openalex.org/W2139882516","https://openalex.org/W2140583034","https://openalex.org/W2150264392","https://openalex.org/W2151216215","https://openalex.org/W2156295929","https://openalex.org/W2160843443","https://openalex.org/W2174691349","https://openalex.org/W2468012387","https://openalex.org/W2739616593","https://openalex.org/W3150448185","https://openalex.org/W4206706389","https://openalex.org/W4236463097","https://openalex.org/W6633274211"],"related_works":["https://openalex.org/W1977748684","https://openalex.org/W1988964426","https://openalex.org/W2047719207","https://openalex.org/W2091454160","https://openalex.org/W2078802011","https://openalex.org/W2056182553","https://openalex.org/W2503200728","https://openalex.org/W2075043902","https://openalex.org/W202734031","https://openalex.org/W2146752617"],"abstract_inverted_index":{"The":[0,85],"translocation":[1],"of":[2,26,30,69,95,98],"protons":[3],"across":[4],"membrane":[5],"proteins":[6,37,81,102],"is":[7],"an":[8],"essential":[9],"phenomenon":[10],"in":[11,14,23,33,59,77,101],"biology.":[12],"Only":[13],"recent":[15],"years":[16],"however,":[17],"have":[18,52],"we":[19],"started":[20],"to":[21,44,55],"study":[22],"detail":[24],"some":[25,68],"the":[27,39,70,90,93],"basic":[28],"features":[29],"proton":[31,57,75,99],"transfer":[32,58,76,100],"water":[34,78],"molecules":[35,79],"inside":[36,80],"at":[38],"single":[40],"molecule":[41],"level.":[42],"Due":[43],"their":[45,87],"truly":[46],"unique":[47],"features,":[48],"gramicidin-based":[49],"ion":[50],"channels":[51],"been":[53],"used":[54],"probe":[56],"both":[60],"experimental":[61,72],"and":[62,89],"computational":[63],"fronts.":[64],"In":[65],"this":[66],"article,":[67],"new":[71],"findings":[73],"on":[74],"will":[82],"be":[83],"reviewed.":[84],"results,":[86],"interpretations,":[88],"perspectives":[91],"toward":[92],"understanding":[94],"structure-function":[96],"illations":[97],"are":[103],"discussed.":[104]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
