{"id":"https://openalex.org/W198744895","doi":null,"title":"Characterization of membranes removed during open-sky vitrectomy.","display_name":"Characterization of membranes removed during open-sky vitrectomy.","publication_year":1983,"publication_date":"1983-10-01","ids":{"openalex":"https://openalex.org/W198744895","mag":"198744895","pmid":"https://pubmed.ncbi.nlm.nih.gov/6352552"},"language":"en","primary_location":{"id":"pmid:6352552","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6352552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030990474","display_name":"Benigno D. Peczon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B D Peczon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J K Wolfe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J K Wolfe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064160717","display_name":"Ilene K. Gipson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I K Gipson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T Hirose","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Hirose","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009433608","display_name":"Sheldon M. Buzney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S M Buzney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058168730","display_name":"Charles L. Schepens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C L Schepens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8528,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.74249213,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"10","first_page":"1382","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12484","display_name":"Retinopathy of Prematurity Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitreous-membrane","display_name":"vitreous membrane","score":0.6740000247955322},{"id":"https://openalex.org/keywords/vitreous-collagen","display_name":"vitreous collagen","score":0.527999997138977},{"id":"https://openalex.org/keywords/fibrin","display_name":"fibrin","score":0.8420000076293945},{"id":"https://openalex.org/keywords/collagenase-digestion","display_name":"collagenase digestion","score":0.5830000042915344},{"id":"https://openalex.org/keywords/plasmin-digestion","display_name":"plasmin digestion","score":0.7519999742507935},{"id":"https://openalex.org/keywords/anti-fibrinogen-antibodies","display_name":"anti-fibrinogen antibodies","score":0.6980000138282776},{"id":"https://openalex.org/keywords/hydroxyproline","display_name":"hydroxyproline","score":0.8309999704360962},{"id":"https://openalex.org/keywords/membrane-composition","display_name":"membrane composition","score":0.5090000033378601},{"id":"https://openalex.org/keywords/vitreous-body","display_name":"vitreous humor","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C2776661909","wikidata":"https://www.wikidata.org/wiki/Q419226","display_name":"Hydroxylysine","level":4,"score":0.8971891403198242},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.7109125852584839},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6726102232933044},{"id":"https://openalex.org/C2779797417","wikidata":"https://www.wikidata.org/wiki/Q12460151","display_name":"Hydroxyproline","level":2,"score":0.5935308337211609},{"id":"https://openalex.org/C2781071845","wikidata":"https://www.wikidata.org/wiki/Q21173374","display_name":"Plasmin","level":3,"score":0.5887221693992615},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.5626257061958313},{"id":"https://openalex.org/C116084860","wikidata":"https://www.wikidata.org/wiki/Q48255","display_name":"Gel electrophoresis","level":2,"score":0.5368879437446594},{"id":"https://openalex.org/C2778913249","wikidata":"https://www.wikidata.org/wiki/Q422241","display_name":"Sodium dodecyl sulfate","level":2,"score":0.5251966714859009},{"id":"https://openalex.org/C93877712","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Electron microscope","level":2,"score":0.5203409194946289},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49458643794059753},{"id":"https://openalex.org/C101660505","wikidata":"https://www.wikidata.org/wiki/Q898301","display_name":"Polyacrylamide gel electrophoresis","level":3,"score":0.41278648376464844},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.4117574989795685},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.27125000953674316},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16147509217262268},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14732274413108826},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.06445997953414917},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004586","descriptor_name":"Electrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014821","descriptor_name":"Vitrectomy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014822","descriptor_name":"Vitreous Body","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014822","descriptor_name":"Vitreous Body","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:6352552","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6352552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:198744895","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6352552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W72326027","https://openalex.org/W80657159","https://openalex.org/W1493830372","https://openalex.org/W1562590055","https://openalex.org/W1589999021","https://openalex.org/W1625660792","https://openalex.org/W1975043689","https://openalex.org/W1981438065","https://openalex.org/W1987289388","https://openalex.org/W1989236629","https://openalex.org/W1996944068","https://openalex.org/W2024783864","https://openalex.org/W2026475911","https://openalex.org/W2028841570","https://openalex.org/W2035941664","https://openalex.org/W2043795458","https://openalex.org/W2045202161","https://openalex.org/W2065077880","https://openalex.org/W2089514226","https://openalex.org/W2133365087"],"related_works":["https://openalex.org/W1998905137","https://openalex.org/W2024354451","https://openalex.org/W1608920139","https://openalex.org/W2378457818","https://openalex.org/W886091042","https://openalex.org/W1992252909","https://openalex.org/W4246725404","https://openalex.org/W123788813","https://openalex.org/W2052997990","https://openalex.org/W7049009155"],"abstract_inverted_index":{"Membranes":[0],"removed":[1],"during":[2,183],"open-sky":[3],"vitrectomy":[4,184],"have":[5],"been":[6],"characterized":[7],"by":[8,52,56,71,126,144],"electron":[9,72,145],"microscopy,":[10],"reaction":[11],"with":[12,62,76,132],"anti-human":[13,63,133],"fibrinogen,":[14,64,134],"susceptibility":[15],"to":[16,151],"enzymatic":[17],"digestion,":[18],"amino":[19],"acid":[20],"analysis,":[21],"and":[22,34,46,65,118,135],"electrophoresis":[23,78],"in":[24,97,106,154],"sodium":[25],"dodecyl":[26],"sulfate.":[27],"There":[28],"were":[29,48,139],"significant":[30],"differences":[31],"between":[32],"longstanding":[33],"newly":[35,156],"formed":[36,157],"membranes.":[37,158],"Longstanding":[38],"membranes":[39],"contained":[40,111],"substantial":[41],"amounts":[42,121],"of":[43,50,69,92,102,109,116,122,142,166,171,174,177,181,189],"hydroxyproline,":[44,113],"glycine,":[45,123],"hydroxylysine,":[47,117],"capable":[49],"digestion":[51,75],"collagenase":[53],"but":[54],"not":[55,140],"plasmin,":[57,127],"yielded":[58,128],"faint":[59],"positive":[60,130],"results":[61,131],"showed":[66,136],"fibrils":[67],"characteristic":[68,141],"collagen":[70,88,143],"microscopy.":[73,146],"After":[74],"pepsin,":[77],"revealed":[79],"bands":[80,149],"that":[81,138,162,191],"migrated":[82],"the":[83,107,175,187],"same":[84],"distance":[85],"as":[86],"vitreous":[87],"chains.":[89],"This":[90],"type":[91,101,165,180],"membrane":[93,167,182],"is":[94,168],"evidently":[95],"collagenous":[96],"nature.":[98],"A":[99],"second":[100,164,179],"membrane,":[103],"which":[104],"developed":[105],"course":[108],"vitrectomy,":[110],"no":[112],"only":[114],"traces":[115],"relatively":[119],"small":[120],"was":[124],"digested":[125],"strong":[129],"fibers":[137],"Electrophoresis":[147],"demonstrated":[148],"similar":[150],"authentic":[152],"fibrin":[153,193],"these":[155],"These":[159],"data":[160],"suggest":[161],"this":[163,178],"composed":[169],"largely":[170],"fibrin.":[172],"Prevention":[173],"formation":[176],"may":[185],"require":[186],"addition":[188],"agents":[190],"inhibit":[192],"formation.":[194]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}