{"id":"https://openalex.org/W1987405447","doi":"https://doi.org/10.1212/wnl.0b013e3181cbb89a","title":"Is there a link between cancer and Alzheimer disease?","display_name":"Is there a link between cancer and Alzheimer disease?","publication_year":2009,"publication_date":"2009-12-24","ids":{"openalex":"https://openalex.org/W1987405447","doi":"https://doi.org/10.1212/wnl.0b013e3181cbb89a","mag":"1987405447","pmid":"https://pubmed.ncbi.nlm.nih.gov/20032287"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.0b013e3181cbb89a","doi":"https://doi.org/10.1212/wnl.0b013e3181cbb89a","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0b013e3181cbb89a","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014075642","display_name":"David Alan Bennett","orcid":"https://orcid.org/0000-0003-3689-554X","observed_orcids":["https://orcid.org/0000-0003-3689-554X"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Bennett","raw_affiliation_strings":["From the Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070294274","display_name":"Sue E. Leurgans","orcid":"https://orcid.org/0000-0003-2536-1665","observed_orcids":["https://orcid.org/0000-0003-2536-1665"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sue Leurgans","raw_affiliation_strings":["From the Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I1285301757"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1285301757"],"apc_list":null,"apc_paid":null,"fwci":2.5536,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.88246817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"74","issue":"2","first_page":"100","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.9779999852180481},{"id":"https://openalex.org/keywords/dementia-risk","display_name":"dementia risk","score":0.6890000104904175},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.5960000157356262},{"id":"https://openalex.org/keywords/oncogenic-signaling","display_name":"oncogenic signaling","score":0.7789999842643738},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.6069999933242798},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7477229833602905},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7121952176094055},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.6111383438110352},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5856351256370544},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5249878168106079},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.5151573419570923},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4760605990886688},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4679590165615082},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.42730337381362915},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.41835272312164307},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.41066974401474},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2548036575317383},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19948473572731018},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.10064810514450073}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015984","descriptor_name":"Causality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1212/wnl.0b013e3181cbb89a","doi":"https://doi.org/10.1212/wnl.0b013e3181cbb89a","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0b013e3181cbb89a","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:20032287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20032287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Comment"},{"id":"pmid:20922851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20922851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Comment"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1965262464","https://openalex.org/W2010637511","https://openalex.org/W2017500142","https://openalex.org/W2054172272","https://openalex.org/W2054449698","https://openalex.org/W2056050422","https://openalex.org/W2057847137","https://openalex.org/W2064861163","https://openalex.org/W2100693719","https://openalex.org/W2128430127","https://openalex.org/W2169099940"],"related_works":["https://openalex.org/W2017500142","https://openalex.org/W2064075508","https://openalex.org/W2055057263","https://openalex.org/W4321076125","https://openalex.org/W1860125465","https://openalex.org/W1096808295","https://openalex.org/W2555314899","https://openalex.org/W3201138764","https://openalex.org/W4402280947","https://openalex.org/W4205773701"],"abstract_inverted_index":{"Cancer":[0,9],"and":[1,15,22,70,112,143,162,184,202],"Alzheimer":[2],"disease":[3,39],"(AD)":[4],"are":[5,63],"common":[6],"age-related":[7],"conditions.":[8],"arises":[10],"from":[11,100],"dysfunction":[12],"of":[13,75,92,122,133,179],"genetic":[14],"epigenetic":[16],"processes":[17],"that":[18,27,30,51],"control":[19],"cellular":[20],"differentiation":[21],"proliferation.":[23],"Recent":[24],"data":[25,62,99],"suggest":[26,50],"molecular":[28,84],"machinery":[29],"is":[31,54,117,129],"involved":[32],"in":[33,37,172,191],"maintaining":[34],"neural":[35],"function":[36],"neurodegenerative":[38,87],"may":[40],"be":[41],"shared":[42],"with":[43,58],"oncogenetic":[44],"pathways.":[45],"For":[46],"example,":[47],"some":[48],"studies":[49],"cancer":[52,69,111],"incidence":[53],"lower":[55],"among":[56],"persons":[57,136],"Parkinson":[59],"disease.1":[60],"Few":[61],"available":[64,171],"regarding":[65],"a":[66,118,192],"link":[67],"between":[68,110],"AD.2":[71],"However,":[72],"the":[73,101,108,173,206],"presence":[74],"an":[76,130,139],"association":[77],"could":[78],"further":[79],"stimulate":[80],"investigations":[81],"related":[82],"to":[83,106,151,189],"changes":[85],"underlying":[86],"diseases.":[88],"In":[89],"this":[90],"issue":[91],"Neurology":[93],"\u00ae,":[94],"Roe":[95],"et":[96],"al.3":[97],"use":[98],"Cardiovascular":[102,114,174],"Health":[103,115,175],"Cognition":[104,127],"Study":[105,116,128],"investigate":[107],"relationship":[109],"AD.\n\nThe":[113],"population-based":[119],"cohort":[120],"study":[121,132],"nearly":[123],"5,900":[124],"persons.":[125],"The":[126],"ancillary":[131],"about":[134],"3,600":[135],"who":[137,204],"had":[138],"MRI":[140],"brain":[141],"scan":[142],"completed":[144],"annual":[145],"brief":[146],"cognitive":[147,169],"testing":[148],"for":[149,165,199],"up":[150],"5":[152],"years.":[153],"Several":[154],"years":[155],"later,":[156],"subjects":[157],"were":[158,187,197],"divided":[159],"into":[160],"high-":[161],"low-risk":[163],"groups":[164],"dementia":[166],"based":[167],"on":[168],"tests":[170],"Study.":[176],"A":[177],"sample":[178],"surviving":[180],"high-risk":[181],"white":[182],"subjects,":[183],"all":[185],"minorities,":[186],"invited":[188],"participate":[190],"clinical":[193],"evaluation.":[194,207],"Medical":[195],"records":[196],"obtained":[198],"deceased":[200],"participants":[201],"those":[203],"refused":[205],"\u2026":[208]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}