{"id":"https://openalex.org/W1987391689","doi":"https://doi.org/10.1186/1471-2164-11-9","title":"An integrated functional genomic study of acute phenobarbital exposure in the rat","display_name":"An integrated functional genomic study of acute phenobarbital exposure in the rat","publication_year":2010,"publication_date":"2010-01-06","ids":{"openalex":"https://openalex.org/W1987391689","doi":"https://doi.org/10.1186/1471-2164-11-9","mag":"1987391689","pmid":"https://pubmed.ncbi.nlm.nih.gov/20053287","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2826316"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2164-11-9","doi":"https://doi.org/10.1186/1471-2164-11-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-11-9","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-11-9","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-11-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074005299","display_name":"Claire L. Waterman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claire L Waterman","raw_affiliation_strings":["Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK","Department of Biochemistry, University of Cambridge , Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Biochemistry, University of Cambridge , Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088596046","display_name":"Richard A. Currie","orcid":"https://orcid.org/0000-0002-6528-3326","observed_orcids":["https://orcid.org/0000-0002-6528-3326"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard A Currie","raw_affiliation_strings":["Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK","Syngenta, Jealott's Hill International Research Centre, Bracknell, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK","institution_ids":[]},{"raw_affiliation_string":"Syngenta, Jealott's Hill International Research Centre, Bracknell, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084974155","display_name":"Lisa Cottrell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa A Cottrell","raw_affiliation_strings":["Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK","Syngenta, Jealott's Hill International Research Centre, Bracknell, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK","institution_ids":[]},{"raw_affiliation_string":"Syngenta, Jealott's Hill International Research Centre, Bracknell, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035618042","display_name":"Jacky Dow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacky Dow","raw_affiliation_strings":["Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK","Syngenta, Jealott's Hill International Research Centre, Bracknell, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK","institution_ids":[]},{"raw_affiliation_string":"Syngenta, Jealott's Hill International Research Centre, Bracknell, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038088103","display_name":"JAYNE A. WRIGHT","orcid":"https://orcid.org/0000-0003-2246-8555","observed_orcids":["https://orcid.org/0000-0003-2246-8555"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jayne Wright","raw_affiliation_strings":["Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK","Syngenta, Jealott's Hill International Research Centre, Bracknell, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK","institution_ids":[]},{"raw_affiliation_string":"Syngenta, Jealott's Hill International Research Centre, Bracknell, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011694957","display_name":"Catherine J. Waterfield","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine J Waterfield","raw_affiliation_strings":["Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK","Syngenta, Jealott's Hill International Research Centre, Bracknell, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK","institution_ids":[]},{"raw_affiliation_string":"Syngenta, Jealott's Hill International Research Centre, Bracknell, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076795620","display_name":"Julian Leether Griffin","orcid":"https://orcid.org/0000-0003-1336-7744","observed_orcids":["https://orcid.org/0000-0003-1336-7744"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Julian L Griffin","raw_affiliation_strings":["Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK","Department of Biochemistry, University of Cambridge , Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Biochemistry, University of Cambridge , Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5076795620"],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":4.6404,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.95275127,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":"1","first_page":"9","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.34299999475479126,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.34299999475479126,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.2257000058889389,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.2084999978542328,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenobarbital","display_name":"phenobarbital","score":0.9990000128746033},{"id":"https://openalex.org/keywords/liver-glycogen","display_name":"liver glycogen","score":0.8159999847412109},{"id":"https://openalex.org/keywords/plasma-triglycerides","display_name":"plasma triglycerides","score":0.9100000262260437},{"id":"https://openalex.org/keywords/fatty-acid-uptake","display_name":"fatty acid uptake","score":0.8820000290870667},{"id":"https://openalex.org/keywords/succinic-acid","display_name":"succinic acid","score":0.7820000052452087},{"id":"https://openalex.org/keywords/heme-biosynthesis","display_name":"heme biosynthesis","score":1.0},{"id":"https://openalex.org/keywords/glutathione-synthesis","display_name":"glutathione synthesis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cytochrome-p450-induction","display_name":"cytochrome P450 induction","score":0.9789999723434448},{"id":"https://openalex.org/keywords/smooth-endoplasmic-reticulum","display_name":"smooth endoplasmic reticulum","score":0.8849999904632568},{"id":"https://openalex.org/keywords/lipid-remodeling","display_name":"lipid remodeling","score":0.8289999961853027},{"id":"https://openalex.org/keywords/fisher-rats","display_name":"Fisher rats","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.8396415710449219},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7007734179496765},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.677264928817749},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.6186564564704895},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.5485672354698181},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5310065746307373},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.48526903986930847},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.474748432636261},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.4698407053947449},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.4373414218425751},{"id":"https://openalex.org/C2776991927","wikidata":"https://www.wikidata.org/wiki/Q14860867","display_name":"Fatty acid metabolism","level":3,"score":0.42602866888046265},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41907137632369995},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4054572582244873},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.22173967957496643},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.15907689929008484},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15760275721549988},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1388275921344757},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10452520847320557}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010634","descriptor_name":"Phenobarbital","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D010949","descriptor_name":"Plasma","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010949","descriptor_name":"Plasma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1186/1471-2164-11-9","doi":"https://doi.org/10.1186/1471-2164-11-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-11-9","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-11-9","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2826316","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2826316","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"Text"},{"id":"pmid:20053287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20053287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC genomics","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.356.8955","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.356.8955","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/e9/2e/BMC_Genomics_2010_Jan_6_11_9.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:dcf858897cc142afa3fcc40006e3a0ab","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/dcf858897cc142afa3fcc40006e3a0ab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Genomics, Vol 11, Iss 1, p 9 (2010)","raw_type":"article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/81786","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/81786","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/237557","doi":null,"is_oa":true,"landing_page_url":"http://www.dspace.cam.ac.uk/handle/1810/237557","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/1471-2164-11-9","doi":"https://doi.org/10.1186/1471-2164-11-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-11-9","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-11-9","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2740492794","display_name":"A 500 MHz NMR spectrometer for high-throughput metabolomics to examine multi- factorial diseases in mammalian systems.","funder_award_id":"078652/Z/05/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G7491091767","display_name":"A 500 MHz NMR spectrometer for high-throughput metabolomics to examine multi-factorial diseases in mammalian systems.","funder_award_id":"078652","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1987391689.pdf","grobid_xml":"https://content.openalex.org/works/W1987391689.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W285314676","https://openalex.org/W1532082124","https://openalex.org/W1556918972","https://openalex.org/W1972873791","https://openalex.org/W1975038884","https://openalex.org/W1977104952","https://openalex.org/W1977226572","https://openalex.org/W1987107155","https://openalex.org/W1989953524","https://openalex.org/W2002972983","https://openalex.org/W2004746596","https://openalex.org/W2025741992","https://openalex.org/W2028064159","https://openalex.org/W2036408130","https://openalex.org/W2037778316","https://openalex.org/W2039641626","https://openalex.org/W2044067342","https://openalex.org/W2046169833","https://openalex.org/W2051979216","https://openalex.org/W2053952031","https://openalex.org/W2058130117","https://openalex.org/W2075239973","https://openalex.org/W2079683622","https://openalex.org/W2085181720","https://openalex.org/W2097333015","https://openalex.org/W2112611645","https://openalex.org/W2119018298","https://openalex.org/W2120714068","https://openalex.org/W2129558195","https://openalex.org/W2139035014","https://openalex.org/W2145022634","https://openalex.org/W2147536943","https://openalex.org/W2148482305","https://openalex.org/W2152174756","https://openalex.org/W2167062654","https://openalex.org/W2170949754","https://openalex.org/W2307440810","https://openalex.org/W2332188677"],"related_works":["https://openalex.org/W7100196771","https://openalex.org/W2152357674","https://openalex.org/W2155844407","https://openalex.org/W2170656342","https://openalex.org/W2417318305","https://openalex.org/W2134296519","https://openalex.org/W2613899536","https://openalex.org/W3216733358","https://openalex.org/W7100848059","https://openalex.org/W3094784242"],"abstract_inverted_index":{"BACKGROUND:":[0],"Non-genotoxic":[1],"carcinogens":[2],"are":[3,58,225],"notoriously":[4],"difficult":[5],"to":[6,51,78,116,127,157,189],"identify":[7,79],"as":[8,222],"they":[9],"do":[10],"not":[11],"damage":[12],"DNA":[13],"directly":[14],"and":[15,49,66,74,84,121,141,185,206],"have":[16,37],"diverse":[17],"modes":[18],"of":[19,30,47,60,99,102,167,174,183,227],"action,":[20],"necessitating":[21],"long":[22],"term":[23,62],"in":[24,40,88,119,130,155,200,216,219],"vivo":[25],"studies.":[26],"The":[27,180],"early":[28,53,197],"effects":[29],"the":[31,41,89,103,135,175],"classic":[32],"rodent":[33],"non-genotoxic":[34],"hepatocarcinogen":[35],"phenobarbital":[36],"been":[38],"investigated":[39],"Fisher":[42],"rat":[43],"using":[44],"a":[45,117,165,191],"combination":[46],"metabolomics":[48,83],"transcriptomics,":[50],"investige":[52],"stage":[54,198],"mechanistic":[55],"changes":[56,87,187,199,218],"that":[57],"predictive":[59],"longer":[61],"pathology.":[63],"RESULTS:":[64],"Liver":[65],"blood":[67],"plasma":[68,122],"were":[69,92,124],"profiled":[70],"across":[71],"14":[72],"days,":[73],"multivariate":[75],"statistics":[76],"used":[77],"perturbed":[80],"pathways.":[81,110],"Both":[82],"transcriptomics":[85],"detected":[86],"liver":[90],"which":[91,224],"dose":[93],"dependent,":[94],"even":[95],"after":[96],"one":[97],"day":[98],"exposure.":[100],"Integration":[101],"two":[104],"datasets":[105],"associated":[106,144],"perturbations":[107],"with":[108,145],"specific":[109],"Hepatic":[111,137],"glycogen":[112],"was":[113,139,143,151],"decreased":[114,125],"due":[115,126],"decrease":[118],"synthesis,":[120],"triglycerides":[123],"an":[128],"increase":[129],"fatty":[131],"acid":[132],"uptake":[133],"by":[134],"liver.":[136],"succinate":[138,223],"increased":[140,146],"this":[142],"heme":[147],"biosynthesis.":[148],"Glutathione":[149],"synthesis":[150],"also":[152],"increased,":[153],"presumably":[154],"response":[156],"oxidative":[158,204],"stress.":[159],"Liquid":[160],"Chromatography":[161],"Mass":[162],"Spectrometry":[163],"demonstrated":[164],"remodeling":[166],"lipid":[168],"species,":[169],"possibly":[170],"resulting":[171],"from":[172],"proliferation":[173],"smooth":[176],"endoplasmic":[177],"reticulum.":[178],"CONCLUSIONS:":[179],"data":[181],"fusion":[182],"metabolomic":[184],"transcriptomic":[186],"proved":[188],"be":[190],"highly":[192],"sensitive":[193],"approach":[194,212],"for":[195],"monitoring":[196],"altered":[201],"hepatic":[202],"metabolism,":[203],"stress":[205],"cytochrome":[207],"P450":[208],"induction":[209],"simultaneously.":[210],"This":[211],"is":[213],"particularly":[214],"useful":[215],"interpreting":[217],"metabolites":[220],"such":[221],"hubs":[226],"metabolism.":[228]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
