{"id":"https://openalex.org/W1987372128","doi":"https://doi.org/10.1177/1352458514568173","title":"Trichuris suis ova therapy in relapsing multiple sclerosis is safe but without signals of beneficial effect","display_name":"Trichuris suis ova therapy in relapsing multiple sclerosis is safe but without signals of beneficial effect","publication_year":2015,"publication_date":"2015-02-19","ids":{"openalex":"https://openalex.org/W1987372128","doi":"https://doi.org/10.1177/1352458514568173","mag":"1987372128","pmid":"https://pubmed.ncbi.nlm.nih.gov/25698173"},"language":"en","primary_location":{"id":"doi:10.1177/1352458514568173","doi":"https://doi.org/10.1177/1352458514568173","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1352458514568173","pdf_url":null,"source":{"id":"https://openalex.org/S136332993","display_name":"Multiple Sclerosis Journal","issn_l":"1352-4585","issn":["1352-4585","1477-0970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiple Sclerosis Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049388462","display_name":"A. I. Voldsgaard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I4210145217","display_name":"Danish Multiple Sclerosis Center","ror":"https://ror.org/04anq5q02","country_code":"DK","type":"facility","lineage":["https://openalex.org/I124055696","https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145217","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"A Voldsgaard","raw_affiliation_strings":["Danish Multiple Sclerosis Center, Copenhagen University Hospital, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Multiple Sclerosis Center, Copenhagen University Hospital, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I4210145217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055334147","display_name":"Peter Bager","orcid":"https://orcid.org/0000-0002-3577-8459","observed_orcids":["https://orcid.org/0000-0002-3577-8459"]},"institutions":[{"id":"https://openalex.org/I101527212","display_name":"Statens Serum Institut","ror":"https://ror.org/0417ye583","country_code":"DK","type":"facility","lineage":["https://openalex.org/I101527212"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"P Bager","raw_affiliation_strings":["Department of Epidemiology Research, Statens Serum Institut, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology Research, Statens Serum Institut, Denmark","institution_ids":["https://openalex.org/I101527212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032485598","display_name":"Ellen Garde","orcid":"https://orcid.org/0000-0002-9906-6880","observed_orcids":["https://orcid.org/0000-0002-9906-6880"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"E Garde","raw_affiliation_strings":["Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Denmark","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P \u00c5keson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"P \u00c5keson","raw_affiliation_strings":["Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Denmark","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109965371","display_name":"AM Leffers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"AM Leffers","raw_affiliation_strings":["Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Denmark","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109097353","display_name":"CG Madsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"CG Madsen","raw_affiliation_strings":["Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Denmark","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044838662","display_name":"Christian M. O. Kapel","orcid":"https://orcid.org/0000-0002-9539-457X","observed_orcids":["https://orcid.org/0000-0002-9539-457X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"C Kapel","raw_affiliation_strings":["Faculty of Life Sciences, University of Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083123613","display_name":"Allan Roepstorff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"A Roepstorff","raw_affiliation_strings":["Faculty of Life Sciences, University of Copenhagen, Denmark/Deceased"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, University of Copenhagen, Denmark/Deceased","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062561634","display_name":"Stig Milan Thamsborg","orcid":"https://orcid.org/0000-0003-3304-7422","observed_orcids":["https://orcid.org/0000-0003-3304-7422"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"SM Thamsborg","raw_affiliation_strings":["Faculty of Life Sciences, University of Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001189522","display_name":"Mads Melbye","orcid":"https://orcid.org/0000-0001-8264-6785","observed_orcids":["https://orcid.org/0000-0001-8264-6785"]},"institutions":[{"id":"https://openalex.org/I101527212","display_name":"Statens Serum Institut","ror":"https://ror.org/0417ye583","country_code":"DK","type":"facility","lineage":["https://openalex.org/I101527212"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"M Melbye","raw_affiliation_strings":["Department of Epidemiology Research, Statens Serum Institut, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology Research, Statens Serum Institut, Denmark","institution_ids":["https://openalex.org/I101527212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048696924","display_name":"Hartwig Roman Siebner","orcid":"https://orcid.org/0000-0002-3756-9431","observed_orcids":["https://orcid.org/0000-0002-3756-9431"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"H Siebner","raw_affiliation_strings":["Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Denmark","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088492600","display_name":"Helle Bach S\u00f8ndergaard","orcid":"https://orcid.org/0000-0001-9435-0658","observed_orcids":["https://orcid.org/0000-0001-9435-0658"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I4210145217","display_name":"Danish Multiple Sclerosis Center","ror":"https://ror.org/04anq5q02","country_code":"DK","type":"facility","lineage":["https://openalex.org/I124055696","https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145217","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"HB S\u00f8ndergaard","raw_affiliation_strings":["Danish Multiple Sclerosis Center, Copenhagen University Hospital, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Multiple Sclerosis Center, Copenhagen University Hospital, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I4210145217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003414068","display_name":"Finn Thorup Sellebjerg","orcid":"https://orcid.org/0000-0002-1333-9623","observed_orcids":["https://orcid.org/0000-0002-1333-9623"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I4210145217","display_name":"Danish Multiple Sclerosis Center","ror":"https://ror.org/04anq5q02","country_code":"DK","type":"facility","lineage":["https://openalex.org/I124055696","https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145217","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"F Sellebjerg","raw_affiliation_strings":["Danish Multiple Sclerosis Center, Copenhagen University Hospital, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Multiple Sclerosis Center, Copenhagen University Hospital, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I4210145217"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066796645","display_name":"Per Soelberg S\u00f8rensen","orcid":"https://orcid.org/0000-0002-2818-3780","observed_orcids":["https://orcid.org/0000-0002-2818-3780"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I4210145217","display_name":"Danish Multiple Sclerosis Center","ror":"https://ror.org/04anq5q02","country_code":"DK","type":"facility","lineage":["https://openalex.org/I124055696","https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145217","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"P Soelberg S\u00f8rensen","raw_affiliation_strings":["Danish Multiple Sclerosis Center, Copenhagen University Hospital, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Multiple Sclerosis Center, Copenhagen University Hospital, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I4210145217"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5066796645"],"corresponding_institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I4210145217"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":6.43,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.97368077,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"21","issue":"13","first_page":"1723","last_page":"1729"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helminth-therapy","display_name":"helminth therapy","score":0.8799999952316284},{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/safety","display_name":"safety","score":0.32100000977516174},{"id":"https://openalex.org/keywords/mri-lesion-activity","display_name":"MRI lesion activity","score":0.7770000100135803},{"id":"https://openalex.org/keywords/eosinophilia","display_name":"eosinophilia","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cytokine-expression","display_name":"cytokine expression","score":0.6729999780654907},{"id":"https://openalex.org/keywords/immunological-biomarkers","display_name":"immunological biomarkers","score":0.6970000267028809},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.6439999938011169},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7695937156677246},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7326802015304565},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.620599627494812},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5925456881523132},{"id":"https://openalex.org/C2780892749","wikidata":"https://www.wikidata.org/wiki/Q929518","display_name":"Expanded Disability Status Scale","level":3,"score":0.5465644598007202},{"id":"https://openalex.org/C2779861936","wikidata":"https://www.wikidata.org/wiki/Q738375","display_name":"Trichuris","level":3,"score":0.49121159315109253},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.47204574942588806},{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.42011627554893494},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2444813847541809},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.13048779964447021},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.10371768474578857}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004802","descriptor_name":"Eosinophilia","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014258","descriptor_name":"Trichuris","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061147","descriptor_name":"Therapy with Helminths","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D061147","descriptor_name":"Therapy with Helminths","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1177/1352458514568173","doi":"https://doi.org/10.1177/1352458514568173","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1352458514568173","pdf_url":null,"source":{"id":"https://openalex.org/S136332993","display_name":"Multiple Sclerosis Journal","issn_l":"1352-4585","issn":["1352-4585","1477-0970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiple Sclerosis Journal","raw_type":"journal-article"},{"id":"pmid:25698173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25698173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiple sclerosis (Houndmills, Basingstoke, England)","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/dbba85d3-bbcb-40a1-824a-d3bf47b61eb6","doi":null,"is_oa":false,"landing_page_url":"https://curis.ku.dk/portal/da/publications/trichurs-suis-ova-theraphy-in-relapsing-multiple-sclerosis-is-safe-but-without-signals-of-beneficial-effect(dbba85d3-bbcb-40a1-824a-d3bf47b61eb6).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Voldsgaard, A, Bager, P, Garde, E, \u00c5keson, P, Leffers, A M, Madsen, C G, Kapel, C M O, Thamsborg, S M, Roepstorff, A K, Melbye, M, Siebner, H R, S\u00f8ndergaard, H B, Sellebjerg, F & S\u00f8rensen, P S 2015, 'Trichurs suis ova theraphy in relapsing multiple sclerosis is safe but without signals of beneficial effect', Multiple Sclerosis Journal, vol. 21, no. 13. https://doi.org/10.1177/1352458514568173","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G2412609279","display_name":null,"funder_award_id":"R59-2010-5399","funder_id":"https://openalex.org/F4320321999","funder_display_name":"Lundbeckfonden"}],"funders":[{"id":"https://openalex.org/F4320321999","display_name":"Lundbeckfonden","ror":"https://ror.org/03hz8wd80"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1489443154","https://openalex.org/W1973648078","https://openalex.org/W1976873769","https://openalex.org/W1979413298","https://openalex.org/W2008010238","https://openalex.org/W2014125845","https://openalex.org/W2028469268","https://openalex.org/W2033117298","https://openalex.org/W2034563187","https://openalex.org/W2043600489","https://openalex.org/W2048362681","https://openalex.org/W2098251798","https://openalex.org/W2107277218","https://openalex.org/W2110386728","https://openalex.org/W2129769418","https://openalex.org/W2130298480","https://openalex.org/W2130924672","https://openalex.org/W2136652614","https://openalex.org/W2144812374","https://openalex.org/W2582777050"],"related_works":["https://openalex.org/W2766022874","https://openalex.org/W2129769418","https://openalex.org/W2160682079","https://openalex.org/W2313077295","https://openalex.org/W1979413298","https://openalex.org/W4313359429","https://openalex.org/W2061143468","https://openalex.org/W2008010238","https://openalex.org/W3126968917","https://openalex.org/W4391530525"],"abstract_inverted_index":{"BACKGROUND:":[0],"An":[1],"observational":[2,107],"study":[3,44,53],"has":[4],"suggested":[5],"that":[6],"relapsing-remitting":[7],"multiple":[8,22,61,220],"sclerosis":[9,23,221],"patients":[10,56,94,102,112,189,200],"with":[11,37,57,131,149],"helminth":[12,118],"infections":[13],"have":[14],"lower":[15],"disease":[16,70,97],"activity":[17,34],"and":[18,30,82,141,180,195,207],"progression":[19],"than":[20],"uninfected":[21],"patients.":[24],"OBJECTIVE:":[25],"To":[26],"evaluate":[27],"the":[28,87,117,171,177,184],"safety":[29,139],"efficacy":[31],"on":[32],"MRI":[33],"of":[35,60,84,109,143,205,218],"treatment":[36,186,194],"TSO":[38],"in":[39,170,176,183],"relapsing":[40,58,219],"MS.":[41],"METHODS:":[42],"The":[43,203],"was":[45,66,153,227],"an":[46,106],"open-label,":[47],"magnetic":[48,133],"resonance":[49,134,161],"imaging":[50,162],"assessor-blinded,":[51],"baseline-to-treatment":[52],"including":[54],"ten":[55],"forms":[59],"sclerosis.":[62],"Median":[63],"(range)":[64],"age":[65],"41":[67],"(24-55)":[68],"years,":[69,74],"duration":[71],"9":[72],"(4-34)":[73],"Expanded":[75],"Disability":[76],"Status":[77],"Scale":[78],"score":[79],"2.5":[80],"(1-5.0),":[81],"number":[83],"relapses":[85],"within":[86],"last":[88],"two":[89,196],"years":[90],"3":[91],"(2-5).":[92],"Four":[93],"received":[95,103,113],"no":[96],"modifying":[98],"therapy,":[99],"while":[100],"six":[101],"IFN-\u03b2.":[104],"After":[105],"period":[108,179],"8":[110],"weeks,":[111],"2500":[114],"ova":[115],"from":[116,156],"Trichuris":[119,150,223],"suis":[120,151,224],"orally":[121,152],"every":[122],"second":[123],"week":[124],"for":[125],"12":[126],"weeks.":[127],"Patients":[128],"were":[129],"followed":[130],"serial":[132],"imaging,":[135],"neurological":[136],"examinations,":[137],"laboratory":[138],"tests":[140],"expression":[142,204],"immunological":[144],"biomarker":[145],"genes.":[146],"RESULTS:":[147],"Treatment":[148],"well-tolerated":[154],"apart":[155],"some":[157],"gastrointestinal":[158],"symptoms.":[159],"Magnetic":[160],"revealed":[163],"6":[164],"new":[165],"or":[166],"enlarged":[167],"T2":[168],"lesions":[169,175,182],"run-in":[172],"period,":[173],"7":[174],"early":[178],"21":[181],"late":[185],"period.":[187],"Two":[188],"suffered":[190],"a":[191,215],"relapse":[192],"before":[193],"during":[197],"treatment.":[198],"Eight":[199],"developed":[201],"eosinophilia.":[202],"cytokines":[206],"transcription":[208],"factors":[209],"did":[210],"not":[211],"change.":[212],"CONCLUSIONS:":[213],"In":[214],"small":[216],"group":[217],"patients,":[222],"oral":[225],"therapy":[226],"well":[228],"tolerated":[229],"but":[230],"without":[231],"beneficial":[232],"effect.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
