{"id":"https://openalex.org/W198737157","doi":null,"title":"Modeling germline BRCA2 mutations in zebrafish","display_name":"Modeling germline BRCA2 mutations in zebrafish","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W198737157","mag":"198737157"},"language":"en","primary_location":{"id":"pmh:oai:drum.lib.umd.edu:1903/11143","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1903/11143","pdf_url":"http://hdl.handle.net/1903/11143","source":{"id":"https://openalex.org/S4306401518","display_name":"University Libraries (University of Maryland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1903/11143","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070749237","display_name":"Heather R. Shive","orcid":"https://orcid.org/0000-0001-9148-2591","observed_orcids":["https://orcid.org/0000-0001-9148-2591"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Heather R. Shive","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9148-2591","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5070749237"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.07840000092983246,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.9269999861717224},{"id":"https://openalex.org/keywords/germline-mutations","display_name":"germline mutations","score":0.7549999952316284},{"id":"https://openalex.org/keywords/zebrafish-model","display_name":"zebrafish model","score":0.8450000286102295},{"id":"https://openalex.org/keywords/ovarian-development","display_name":"ovarian development","score":0.9169999957084656},{"id":"https://openalex.org/keywords/gonadogenesis","display_name":"gonadogenesis","score":0.7829999923706055},{"id":"https://openalex.org/keywords/meiotic-arrest","display_name":"meiotic arrest","score":0.7630000114440918},{"id":"https://openalex.org/keywords/germ-cell-apoptosis","display_name":"germ cell apoptosis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/testicular-cancer","display_name":"testicular cancer","score":0.7329999804496765},{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.8529999852180481},{"id":"https://openalex.org/keywords/hereditary-breast-and-ovarian-cancer-syndrome","display_name":"hereditary breast and ovarian cancer","score":0.902999997138977},{"id":"https://openalex.org/keywords/nonsense-mutation","display_name":"nonsense mutation","score":0.5920000076293945},{"id":"https://openalex.org/keywords/germ-cell-migration","display_name":"germ cell migration","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.8204915523529053},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.7713121771812439},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4657009243965149},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44627317786216736},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.4451500475406647},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.37068089842796326},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36899328231811523},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1123034656047821}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:drum.lib.umd.edu:1903/11143","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1903/11143","pdf_url":"http://hdl.handle.net/1903/11143","source":{"id":"https://openalex.org/S4306401518","display_name":"University Libraries (University of Maryland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:198737157","doi":null,"is_oa":false,"landing_page_url":"https://drum.lib.umd.edu/handle/1903/11143","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:drum.lib.umd.edu:1903/11143","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1903/11143","pdf_url":"http://hdl.handle.net/1903/11143","source":{"id":"https://openalex.org/S4306401518","display_name":"University Libraries (University of Maryland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","score":0.5699999928474426,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W198737157.pdf","grobid_xml":"https://content.openalex.org/works/W198737157.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1984377389","https://openalex.org/W2064422983","https://openalex.org/W2120636655","https://openalex.org/W4226076333","https://openalex.org/W7099268943","https://openalex.org/W7095861145","https://openalex.org/W2917640817","https://openalex.org/W7097058594","https://openalex.org/W2073915625","https://openalex.org/W4241925289"],"abstract_inverted_index":{"Human":[0],"ovarian":[1,41,109,161,179,240],"cancer":[2,29],"is":[3,19,52,163,259,272],"a":[4,78,82,92,233,243],"leading":[5],"cause":[6],"of":[7,16,56,160,171,188],"morbidity":[8],"and":[9,40,49,97,108,117,225,254,280],"mortality":[10],"in":[11,26,62,85,95,103,142,154,168,192,208,214,220,238,249,252],"women,":[12],"but":[13],"the":[14,27,44,148,172,186],"pathophysiology":[15],"this":[17],"disease":[18],"not":[20,53,164],"well-defined.":[21],"Humans":[22],"with":[23,81,105,139,216],"inherited":[24],"mutations":[25,101],"breast":[28,39,107],"2":[30],"gene":[31,60],"(BRCA2)":[32],"are":[33,64],"at":[34],"increased":[35],"risk":[36],"for":[37,236,246,276],"developing":[38],"cancer;":[42],"however,":[43,121],"relationship":[45],"between":[46],"BRCA2":[47,100],"mutation":[48,58,69,84,93,177,219,248,258],"these":[50],"cancers":[51],"understood.":[54],"Studies":[55],"Brca2":[57,68],"by":[59],"targeting":[61],"mice":[63],"limited,":[65],"as":[66,136],"homozygous":[67,113,183,199,217,224],"typically":[70],"leads":[71],"to":[72,99,119,125,147,166,203,263],"early":[73,169],"embryonic":[74,149,173],"lethality.":[75],"We":[76],"established":[77],"zebrafish":[79,114,200,239,270],"line":[80,271],"nonsense":[83],"brca2":[86,111,132,155,181,197,222,226,237,247,267],"exon":[87],"11":[88],"(brca2":[89],"Q658X":[90,112,133,156,182,198,223,227,268],"),":[91],"similar":[94],"location":[96],"type":[98],"found":[102],"humans":[104],"hereditary":[106],"cancer.":[110],"were":[115,201],"viable":[116],"survived":[118],"adulthood;":[120],"juvenile":[122],"homozygotes":[123,134],"failed":[124],"develop":[126],"ovaries":[127],"during":[128],"sexual":[129],"differentiation.":[130],"Instead,":[131],"developed":[135],"infertile":[137],"males":[138],"meiotic":[140],"arrest":[141],"spermatocytes.":[143],"Germ":[144],"cell":[145,190],"migration":[146],"gonadal":[150],"ridge":[151],"was":[152,211],"unimpaired":[153],"homozygotes;":[157],"thus,":[158],"failure":[159],"development":[162,180],"due":[165],"defects":[167],"establishment":[170],"gonad.":[174],"Homozygous":[175],"tp53":[176,218,257],"rescued":[178],"zebrafish,":[184,253],"reflecting":[185],"importance":[187],"germ":[189],"apoptosis":[191],"gonad":[193],"morphogenesis.":[194],"In":[195],"adulthood,":[196],"predisposed":[202],"testicular":[204],"neoplasias.":[205],"Additionally,":[206],"tumorigenesis":[207,251],"multiple":[209],"tissues":[210],"significantly":[212],"accelerated":[213],"combination":[215],"both":[221,278],"heterozygous":[228],"zebrafish.":[229],"These":[230],"studies":[231],"reveal":[232],"critical":[234],"role":[235],"development,":[241],"demonstrate":[242],"conserved":[244],"association":[245],"reproductive":[250],"indicate":[255],"that":[256],"an":[260,273],"important":[261,274],"contributor":[262],"brca2-associated":[264,281],"carcinogenesis.":[265,282],"The":[266],"-mutant":[269],"resource":[275],"studying":[277],"gonadogenesis":[279]},"counts_by_year":[],"updated_date":"2026-08-30T07:30:35.949966","created_date":"2016-06-24T00:00:00"}
