{"id":"https://openalex.org/W1987369971","doi":"https://doi.org/10.1046/j.1471-4159.1994.62010396.x","title":"Rapid Communication: A cis\u2010Acting Element, T\u03b1\u20101, in the Upstream Region of Rod \u03b1\u2010Transducin Gene that Binds a Developmentally Regulated Retina\u2010Specific Nuclear Factor","display_name":"Rapid Communication: A cis\u2010Acting Element, T\u03b1\u20101, in the Upstream Region of Rod \u03b1\u2010Transducin Gene that Binds a Developmentally Regulated Retina\u2010Specific Nuclear Factor","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W1987369971","doi":"https://doi.org/10.1046/j.1471-4159.1994.62010396.x","mag":"1987369971","pmid":"https://pubmed.ncbi.nlm.nih.gov/8263543"},"language":"en","primary_location":{"id":"doi:10.1046/j.1471-4159.1994.62010396.x","doi":"https://doi.org/10.1046/j.1471-4159.1994.62010396.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1471-4159.1994.62010396.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050216645","display_name":"Iqbal Ahmad","orcid":"https://orcid.org/0000-0003-1920-9835","observed_orcids":["https://orcid.org/0000-0003-1920-9835"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iqbal Ahmad","raw_affiliation_strings":["Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06510","Yale University  ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06510","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale University  ;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038747394","display_name":"Yu Xiu","orcid":"https://orcid.org/0000-0002-3342-7110","observed_orcids":["https://orcid.org/0000-0002-3342-7110"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiu Yu","raw_affiliation_strings":["Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, U.S.A","Yale University  ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, U.S.A","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale University  ;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001481519","display_name":"Colin James Barnstable","orcid":"https://orcid.org/0000-0002-7011-4068","observed_orcids":["https://orcid.org/0000-0002-7011-4068"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Colin J. Barnstable","raw_affiliation_strings":["Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, U.S.A","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001481519"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":1.1386,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.76350579,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"62","issue":"1","first_page":"396","last_page":"399"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cis-regulatory-elements","display_name":"cis-regulatory elements","score":0.7960000038146973},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.628000020980835},{"id":"https://openalex.org/keywords/tissue-specific-expression","display_name":"tissue-specific gene expression","score":0.7910000085830688},{"id":"https://openalex.org/keywords/rod-photoreceptors","display_name":"rod photoreceptors","score":0.8339999914169312},{"id":"https://openalex.org/keywords/photoreceptor-maturation","display_name":"photoreceptor maturation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/g-protein-transducin","display_name":"G protein transducin","score":0.8009999990463257},{"id":"https://openalex.org/keywords/promoter-evolution","display_name":"promoter evolution","score":0.597000002861023},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C149574991","wikidata":"https://www.wikidata.org/wiki/Q420428","display_name":"Transducin","level":4,"score":0.9144443273544312},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7290686368942261},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.5786232948303223},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5527026057243347},{"id":"https://openalex.org/C30028475","wikidata":"https://www.wikidata.org/wiki/Q24785022","display_name":"Opsin","level":4,"score":0.48822978138923645},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4578096270561218},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.44295674562454224},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43796506524086},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36455219984054565},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3589740991592407},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.27385690808296204},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.2571442723274231},{"id":"https://openalex.org/C202033177","wikidata":"https://www.wikidata.org/wiki/Q423107","display_name":"Rhodopsin","level":3,"score":0.15191742777824402},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08810940384864807},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.07937619090080261}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015293","descriptor_name":"Transducin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017299","descriptor_name":"Rod Opsins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017948","descriptor_name":"Retinal Rod Photoreceptor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1471-4159.1994.62010396.x","doi":"https://doi.org/10.1046/j.1471-4159.1994.62010396.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1471-4159.1994.62010396.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:8263543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8263543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1977349855","display_name":null,"funder_award_id":"NS 20483","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4128366658","display_name":null,"funder_award_id":"EY 07115","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G7741064887","display_name":"MOLECULAR ANAYLSIS OF NEURAL CELL DEVELOPMENT","funder_award_id":"5r01ns020483-14","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W249019913","https://openalex.org/W1512108330","https://openalex.org/W1534821377","https://openalex.org/W1602525846","https://openalex.org/W1964200801","https://openalex.org/W1965863612","https://openalex.org/W1970357302","https://openalex.org/W1983776139","https://openalex.org/W2000818465","https://openalex.org/W2013978625","https://openalex.org/W2032651182","https://openalex.org/W2047883528","https://openalex.org/W2051349203","https://openalex.org/W2052108057","https://openalex.org/W2073293904","https://openalex.org/W2079858948","https://openalex.org/W2080738247","https://openalex.org/W2080875376","https://openalex.org/W2082069867","https://openalex.org/W2082768757","https://openalex.org/W2150691484","https://openalex.org/W2346797488","https://openalex.org/W2404990193"],"related_works":["https://openalex.org/W2057002159","https://openalex.org/W2061210395","https://openalex.org/W2064542546","https://openalex.org/W2000274486","https://openalex.org/W2414777818","https://openalex.org/W1994152829","https://openalex.org/W2340283524","https://openalex.org/W249019913","https://openalex.org/W2049596148","https://openalex.org/W2369880899"],"abstract_inverted_index":{"The":[0,91],"G":[1],"protein":[2],"transducin":[3],"(T)":[4],"is":[5,63],"an":[6],"integral":[7],"component":[8],"of":[9,28,50,54,79,93,107],"the":[10,25,29,59,77,84,104],"signal":[11],"transduction":[12],"pathway":[13],"in":[14,24,86,103],"photoreceptors.":[15],"We":[16],"have":[17,122],"identified":[18],"a":[19,46,100,112,126],"cis-acting":[20,101],"element,":[21],"T":[22,43,60,94,116,128],"alpha-1,":[23],"upstream":[26],"region":[27],"mouse":[30],"rod":[31,80],"alpha-T":[32],"(Tr":[33],"alpha)":[34],"gene":[35,89,109],"that":[36,110],"may":[37,121],"be":[38],"important":[39],"for":[40],"tissue-specific":[41],"expression.":[42,90],"alpha-1":[44,61,95,117],"binds":[45,111],"retina-specific":[47,114,137],"nuclear":[48],"factor":[49],"apparent":[51],"molecular":[52],"mass":[53],"90":[55],"kDa.":[56],"Binding":[57],"to":[58,76,132],"site":[62],"developmentally":[64],"regulated":[65],"and":[66,72,83,118],"peaks":[67],"between":[68],"postnatal":[69],"days":[70],"6":[71],"9.":[73],"This":[74],"corresponds":[75],"time":[78],"photoreceptor":[81,134],"maturation":[82],"rise":[85],"Tr":[87],"alpha":[88],"sequence":[92],"shows":[96],"homology":[97],"with":[98],"RET-1,":[99],"element":[102],"proximal":[105],"promoter":[106],"opsin":[108],"distinct":[113],"factor.":[115],"RET-1":[119],"sequences":[120],"been":[123],"derived":[124],"from":[125],"prototype":[127],"alpha-1/RET-1":[129],"sequence,":[130],"evolved":[131],"confer":[133],"specificity":[135],"on":[136],"genes.":[138]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}